Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9948
Gene name Gene Name - the full gene name approved by the HGNC.
WD repeat domain 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
WDR1
Synonyms (NCBI Gene) Gene synonyms aliases
AIP1, HEL-S-52, NORI-1, PFITS
Disease Acronyms (UniProt) Disease acronyms from UniProt database
PFITS
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4p16.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019985 hsa-miR-375 Microarray 20215506
MIRT028095 hsa-miR-93-5p Sequencing 20371350
MIRT049572 hsa-miR-92a-3p CLASH 23622248
MIRT039865 hsa-miR-615-3p CLASH 23622248
MIRT036948 hsa-miR-877-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002102 Component Podosome IEA
GO:0002446 Process Neutrophil mediated immunity IEA
GO:0002576 Process Platelet degranulation TAS
GO:0005576 Component Extracellular region TAS
GO:0005829 Component Cytosol TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604734 12754 ENSG00000071127
Protein
UniProt ID O75083
Protein name WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)
Protein function Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotacti
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00400 WD40 179 217 WD domain, G-beta repeat Repeat
PF00400 WD40 223 262 WD domain, G-beta repeat Repeat
PF00400 WD40 310 350 WD domain, G-beta repeat Repeat
PF00400 WD40 523 560 WD domain, G-beta repeat Repeat
Tissue specificity TISSUE SPECIFICITY: Expressed in peripheral blood mononuclear cells (at protein level). {ECO:0000269|PubMed:29751004}.
Sequence
MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQ
VVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVV
GEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFK
FKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYD
GKTGEKVCALGGSKAHDGGIYAI
SWSPDSTHLLSASGDKTSKIWD
VSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGY
INYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFA
GKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGY
AVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLK
DEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAW
SPDNEHFASGGMDMMVYVWT
LSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVK
EWTITY
Sequence length 606
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Platelet degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Atrial fibrillation Atrial Fibrillation rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557
View all (6 more)
29892015
Osteoporosis Osteoporosis, Age-Related, Osteoporosis, Osteoporosis, Senile, Post-Traumatic Osteoporosis rs72658152, rs72667023, rs587776916, rs72656370, rs768615287 18924182
Unknown
Disease term Disease name Evidence References Source
Paroxysmal atrial fibrillation Paroxysmal atrial fibrillation 29892015 ClinVar
Neuroticism Neuroticism GWAS
Atrial Fibrillation Atrial Fibrillation GWAS
Dementia Dementia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Non Small Cell Lung Associate 35861209
Cardiovascular Diseases Associate 27609643
Cleft Palate Associate 24516586
Frontotemporal Dementia Associate 32792518
Glioma Associate 28339748
Hemolytic Uremic Syndrome Associate 22836280
Hereditary Autoinflammatory Diseases Associate 27994071
Immunologic Deficiency Syndromes Inhibit 27557945
Immunologic Deficiency Syndromes Associate 27994071
Leukoplakia Stimulate 36776920