Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	9946
Gene name	Crystallin zeta like 1
Gene symbol	CRYZL1
Synonyms (NCBI Gene)	4P11FERRY4Fy-4QOH-1
Chromosome	21
Chromosome location	21q22.11
Summary	This gene encodes a protein that has sequence similarity to zeta crystallin, also known as quinone oxidoreductase. This zeta crystallin-like protein also contains an NAD(P)H binding site. Alternatively spliced transcript variants have been observed but th

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miRTarBase ID	miRNA	Experiments
MIRT911218	hsa-miR-3065-5p	CLIP-seq
MIRT911219	hsa-miR-3647-3p	CLIP-seq
MIRT2509352	hsa-miR-1252	CLIP-seq
MIRT2509353	hsa-miR-134	CLIP-seq
MIRT2509354	hsa-miR-142-3p	CLIP-seq
MIRT2509355	hsa-miR-15a	CLIP-seq
MIRT2509356	hsa-miR-15b	CLIP-seq
MIRT2509357	hsa-miR-16	CLIP-seq
MIRT2509358	hsa-miR-1909	CLIP-seq
MIRT2509359	hsa-miR-195	CLIP-seq
MIRT2509360	hsa-miR-21	CLIP-seq
MIRT2509361	hsa-miR-3118	CLIP-seq
MIRT2509362	hsa-miR-3164	CLIP-seq
MIRT2509363	hsa-miR-3202	CLIP-seq
MIRT2509364	hsa-miR-335	CLIP-seq
MIRT2509365	hsa-miR-374c	CLIP-seq
MIRT2509366	hsa-miR-424	CLIP-seq
MIRT2509367	hsa-miR-4328	CLIP-seq
MIRT2509368	hsa-miR-4533	CLIP-seq
MIRT2509369	hsa-miR-4659a-3p	CLIP-seq
MIRT2509370	hsa-miR-4659b-3p	CLIP-seq
MIRT2509371	hsa-miR-4688	CLIP-seq
MIRT2509372	hsa-miR-4690-5p	CLIP-seq
MIRT2509373	hsa-miR-4766-3p	CLIP-seq
MIRT2509374	hsa-miR-4766-5p	CLIP-seq
MIRT2509375	hsa-miR-4772-3p	CLIP-seq
MIRT2509376	hsa-miR-490-5p	CLIP-seq
MIRT2509377	hsa-miR-497	CLIP-seq
MIRT2509378	hsa-miR-548p	CLIP-seq
MIRT2509379	hsa-miR-590-3p	CLIP-seq
MIRT2509380	hsa-miR-590-5p	CLIP-seq
MIRT2509381	hsa-miR-628-5p	CLIP-seq
MIRT2509382	hsa-miR-648	CLIP-seq
MIRT2509383	hsa-miR-655	CLIP-seq
MIRT2509353	hsa-miR-134	CLIP-seq
MIRT2509354	hsa-miR-142-3p	CLIP-seq
MIRT2509355	hsa-miR-15a	CLIP-seq
MIRT2509356	hsa-miR-15b	CLIP-seq
MIRT2509357	hsa-miR-16	CLIP-seq
MIRT2509359	hsa-miR-195	CLIP-seq
MIRT2509360	hsa-miR-21	CLIP-seq
MIRT2509361	hsa-miR-3118	CLIP-seq
MIRT2509362	hsa-miR-3164	CLIP-seq
MIRT2509364	hsa-miR-335	CLIP-seq
MIRT2509365	hsa-miR-374c	CLIP-seq
MIRT2509366	hsa-miR-424	CLIP-seq
MIRT2509367	hsa-miR-4328	CLIP-seq
MIRT2509369	hsa-miR-4659a-3p	CLIP-seq
MIRT2509370	hsa-miR-4659b-3p	CLIP-seq
MIRT2509373	hsa-miR-4766-3p	CLIP-seq
MIRT2509374	hsa-miR-4766-5p	CLIP-seq
MIRT2509375	hsa-miR-4772-3p	CLIP-seq
MIRT2509376	hsa-miR-490-5p	CLIP-seq
MIRT2509377	hsa-miR-497	CLIP-seq
MIRT2509378	hsa-miR-548p	CLIP-seq
MIRT2509380	hsa-miR-590-5p	CLIP-seq
MIRT2509381	hsa-miR-628-5p	CLIP-seq
MIRT2509382	hsa-miR-648	CLIP-seq
MIRT2509383	hsa-miR-655	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003960	Function	Quinone reductase (NADPH) activity	NAS	10191096
GO:0005515	Function	Protein binding	IPI	26496610, 28514442, 33961781, 37267906
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IDA	37267905
GO:0005769	Component	Early endosome	IEA
GO:0005829	Component	Cytosol	HDA	16780588
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0042802	Function	Identical protein binding	IDA	37267906
GO:0050661	Function	NADP binding	NAS	10191096
GO:1901661	Process	Quinone metabolic process	NAS	10191096

MIM	HGNC	e!Ensembl
603920	2420	ENSG00000205758

O95825

Protein name

Quinone oxidoreductase-like protein 1 (EC 1.-.-.-) (Ferry endosomal RAB5 effector complex subunit 4) (Fy-4) (Protein 4P11) (Quinone oxidoreductase homolog 1) (QOH-1) (Zeta-crystallin homolog)

Protein function

Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary) (PubMed:37267905, PubMed:37267906). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localizat

PDB

7ND2 , 8A3O

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MKGLYFQQSSTDEEITFVFQEKEDLPVTEDNFVKLQVKACALSQINTKLLAEMKMKKDLF
PVGREIAGIVLDVGSKVSFFQPDDEVVGILPLDSEDPGLCEVVRVHEHYLVHKPEKVTWT
EAAGSIRDGVRAYTALHYLSHLSPGKSVLIMDGASAFGTIAIQLAHHRGAKVISTACSLE
DKQCLERFRPPIARVIDVSNGKVHVAESCLEETGGLGVDIVLDAGVRLYSKDDEPAVKLQ
LLPHKHDIITLLGVGGHWVTTEENLQLDPPDSHCLFLKGATLAFLNDEVWNLSNVQQGKY
LCILKDVMEKLSTGVFRPQLDEPIPLYEAKVSMEAVQKNQGRKKQVVQF

Sequence length

349

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

CRYZL1 (crystallin zeta like 1)