Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9943
Gene name Gene Name - the full gene name approved by the HGNC.
Oxidative stress responsive kinase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
OXSR1
Synonyms (NCBI Gene) Gene synonyms aliases
OSR1
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3p22.2
Summary Summary of gene provided in NCBI Entrez Gene.
The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT029769 hsa-miR-26b-5p Microarray 19088304
MIRT030472 hsa-miR-24-3p Microarray 19748357
MIRT043941 hsa-miR-378a-3p CLASH 23622248
MIRT655571 hsa-miR-7113-5p HITS-CLIP 23824327
MIRT655572 hsa-miR-4685-5p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000287 Function Magnesium ion binding IDA 14707132
GO:0004672 Function Protein kinase activity IEA
GO:0004674 Function Protein serine/threonine kinase activity IBA
GO:0004674 Function Protein serine/threonine kinase activity IDA 14707132, 18270262, 19665974, 21321328, 24393035
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604046 8508 ENSG00000172939
Protein
UniProt ID O95747
Protein name Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein)
Protein function Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:213
PDB 2V3S , 2VWI , 3DAK , 7OKW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 17 291 Protein kinase domain Domain
PF12202 OSR1_C 434 491 Oxidative-stress-responsive kinase 1 C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed in all tissue examined. {ECO:0000269|PubMed:10083736}.
Sequence
Sequence length 527
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Parathyroid hormone synthesis, secretion and action  
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Astrocytoma Astrocytoma N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Asthma Associate 34983467
Squamous Cell Carcinoma of Head and Neck Associate 29802697
Status Asthmaticus Associate 34983467