Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
994
Gene name Gene Name - the full gene name approved by the HGNC.
Cell division cycle 25B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CDC25B
Synonyms (NCBI Gene) Gene synonyms aliases
MPIP2
Chromosome Chromosome number
20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20p13
Summary Summary of gene provided in NCBI Entrez Gene.
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear loca
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025904 hsa-miR-7-5p Microarray 19073608
MIRT026017 hsa-miR-148a-3p Reporter assay;Western blot;Other 21709669
MIRT030153 hsa-miR-26b-5p Microarray 19088304
MIRT052555 hsa-let-7a-5p CLASH 23622248
MIRT038444 hsa-miR-296-3p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
FOXM1 Activation 19276163
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000086 Process G2/M transition of mitotic cell cycle IBA 21873635
GO:0000086 Process G2/M transition of mitotic cell cycle TAS 12400006
GO:0000278 Process Mitotic cell cycle TAS 9188863
GO:0000922 Component Spindle pole IDA 15908796
GO:0001556 Process Oocyte maturation IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
116949 1726 ENSG00000101224
Protein
UniProt ID P30305
Protein name M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B)
Protein function Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of
PDB 1CWR , 1CWS , 1CWT , 1QB0 , 1YM9 , 1YMD , 1YMK , 1YML , 1YS0 , 2A2K , 2IFD , 2IFV , 2UZQ , 3FQT , 3FQU , 4WH7 , 4WH9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06617 M-inducer_phosp 113 383 M-phase inducer phosphatase Family
PF00581 Rhodanese 418 531 Rhodanese-like domain Domain
Sequence
Sequence length 580
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  MAPK signaling pathway
Cell cycle
Progesterone-mediated oocyte maturation
MicroRNAs in cancer
  Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Heart failure Heart Failure, Diastolic 29556499 ClinVar
Bipolar Disorder Bipolar Disorder GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Follicular Associate 12085185
Adenoma Stimulate 12085185
Arthritis Inhibit 28253537
Astrocytoma Associate 24344030
Bipolar Disorder Associate 29745862
Breast Neoplasms Associate 16551631, 20413845, 21707964, 25384584
Carcinogenesis Associate 17591782, 18559558
Carcinoma Hepatocellular Associate 36028814, 37156819
Carcinoma Pancreatic Ductal Associate 21709669
Carcinoma Squamous Cell Associate 20500813