IQSEC1 (IQ motif and Sec7 domain ArfGEF 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 9922 |
| Gene name | IQ motif and Sec7 domain ArfGEF 1 |
| Gene symbol | IQSEC1 |
| Synonyms (NCBI Gene) |
ARF-GEP100ARFGEP100BRAG2GEP100IDDSSBA
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| Chromosome | 3 |
| Chromosome location | 3p25.2-p25.1 |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q6DN90 | |||||||||||||||
| Protein name | IQ motif and SEC7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein) (BRAG2) | |||||||||||||||
| Protein function | Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:11226253, PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nu | |||||||||||||||
| PDB | 3QWM , 4C0A , 5NLV , 5NLY , 6FNE , 7VMB | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis. {ECO:0000269|PubMed:11226253, ECO:0000269|Pub | |||||||||||||||
| Sequence |
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| Sequence length | 963 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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