Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9909
Gene name Gene Name - the full gene name approved by the HGNC.	DENN domain containing 4B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DENND4B
Synonyms (NCBI Gene) Gene synonyms aliases	KIAA0476
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q21.3

Show/Hide all(1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs1557853919	G>A	Likely-pathogenic	Coding sequence variant, missense variant, non coding transcript variant

Show/Hide all(213)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051981	hsa-let-7b-5p	CLASH	23622248
MIRT050007	hsa-miR-28-5p	CLASH	23622248
MIRT049787	hsa-miR-92a-3p	CLASH	23622248
MIRT044839	hsa-miR-320a	CLASH	23622248
MIRT043613	hsa-miR-151a-3p	CLASH	23622248
MIRT041379	hsa-miR-193b-3p	CLASH	23622248
MIRT041150	hsa-miR-500a-3p	CLASH	23622248
MIRT037992	hsa-miR-501-3p	CLASH	23622248
MIRT571106	hsa-miR-1197	PAR-CLIP	20371350
MIRT571105	hsa-miR-4783-3p	PAR-CLIP	20371350
MIRT571104	hsa-miR-4254	PAR-CLIP	20371350
MIRT571103	hsa-miR-1249-5p	PAR-CLIP	20371350
MIRT571102	hsa-miR-6797-5p	PAR-CLIP	20371350
MIRT571100	hsa-miR-6515-5p	PAR-CLIP	20371350
MIRT049787	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT727884	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT727885	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT571106	hsa-miR-1197	PAR-CLIP	20371350
MIRT571105	hsa-miR-4783-3p	PAR-CLIP	20371350
MIRT571104	hsa-miR-4254	PAR-CLIP	20371350
MIRT571103	hsa-miR-1249-5p	PAR-CLIP	20371350
MIRT571102	hsa-miR-6797-5p	PAR-CLIP	20371350
MIRT571100	hsa-miR-6515-5p	PAR-CLIP	20371350
MIRT932436	hsa-miR-1229	CLIP-seq
MIRT932437	hsa-miR-1262	CLIP-seq
MIRT932438	hsa-miR-1293	CLIP-seq
MIRT932439	hsa-miR-132	CLIP-seq
MIRT932440	hsa-miR-1323	CLIP-seq
MIRT932441	hsa-miR-136	CLIP-seq
MIRT932442	hsa-miR-137	CLIP-seq
MIRT932443	hsa-miR-1587	CLIP-seq
MIRT932444	hsa-miR-1827	CLIP-seq
MIRT932445	hsa-miR-185	CLIP-seq
MIRT932446	hsa-miR-1908	CLIP-seq
MIRT932447	hsa-miR-194	CLIP-seq
MIRT932448	hsa-miR-204	CLIP-seq
MIRT932449	hsa-miR-205	CLIP-seq
MIRT932450	hsa-miR-211	CLIP-seq
MIRT932451	hsa-miR-212	CLIP-seq
MIRT932452	hsa-miR-2355-5p	CLIP-seq
MIRT932453	hsa-miR-25	CLIP-seq
MIRT932454	hsa-miR-3065-5p	CLIP-seq
MIRT932455	hsa-miR-31	CLIP-seq
MIRT932456	hsa-miR-3117-3p	CLIP-seq
MIRT932457	hsa-miR-3126-5p	CLIP-seq
MIRT932458	hsa-miR-3135b	CLIP-seq
MIRT932459	hsa-miR-3165	CLIP-seq
MIRT932460	hsa-miR-3169	CLIP-seq
MIRT932461	hsa-miR-3189-3p	CLIP-seq
MIRT932462	hsa-miR-32	CLIP-seq
MIRT932463	hsa-miR-3619-3p	CLIP-seq
MIRT932464	hsa-miR-3622b-5p	CLIP-seq
MIRT932465	hsa-miR-363	CLIP-seq
MIRT932466	hsa-miR-3652	CLIP-seq
MIRT932467	hsa-miR-3661	CLIP-seq
MIRT932468	hsa-miR-367	CLIP-seq
MIRT932469	hsa-miR-3681	CLIP-seq
MIRT932470	hsa-miR-3910	CLIP-seq
MIRT932471	hsa-miR-3913-3p	CLIP-seq
MIRT932472	hsa-miR-3929	CLIP-seq
MIRT932473	hsa-miR-4270	CLIP-seq
MIRT932474	hsa-miR-4286	CLIP-seq
MIRT932475	hsa-miR-4291	CLIP-seq
MIRT932476	hsa-miR-4306	CLIP-seq
MIRT932477	hsa-miR-4316	CLIP-seq
MIRT932478	hsa-miR-4419b	CLIP-seq
MIRT932479	hsa-miR-4430	CLIP-seq
MIRT932480	hsa-miR-4434	CLIP-seq
MIRT932481	hsa-miR-4436a	CLIP-seq
MIRT932482	hsa-miR-4437	CLIP-seq
MIRT932483	hsa-miR-4441	CLIP-seq
MIRT932484	hsa-miR-4446-5p	CLIP-seq
MIRT932485	hsa-miR-4448	CLIP-seq
MIRT932486	hsa-miR-4474-3p	CLIP-seq
MIRT932487	hsa-miR-4478	CLIP-seq
MIRT932488	hsa-miR-4483	CLIP-seq
MIRT932489	hsa-miR-4493	CLIP-seq
MIRT932490	hsa-miR-4511	CLIP-seq
MIRT932491	hsa-miR-4515	CLIP-seq
MIRT932492	hsa-miR-4516	CLIP-seq
MIRT932493	hsa-miR-4531	CLIP-seq
MIRT932494	hsa-miR-4639-3p	CLIP-seq
MIRT932495	hsa-miR-4644	CLIP-seq
MIRT932496	hsa-miR-4674	CLIP-seq
MIRT932497	hsa-miR-4675	CLIP-seq
MIRT932498	hsa-miR-4699-3p	CLIP-seq
MIRT932499	hsa-miR-4701-3p	CLIP-seq
MIRT932500	hsa-miR-4710	CLIP-seq
MIRT932501	hsa-miR-4741	CLIP-seq
MIRT932502	hsa-miR-4742-5p	CLIP-seq
MIRT932503	hsa-miR-4755-5p	CLIP-seq
MIRT932504	hsa-miR-4759	CLIP-seq
MIRT932505	hsa-miR-486-3p	CLIP-seq
MIRT932506	hsa-miR-489	CLIP-seq
MIRT932507	hsa-miR-492	CLIP-seq
MIRT932508	hsa-miR-500a	CLIP-seq
MIRT932509	hsa-miR-545	CLIP-seq
MIRT932510	hsa-miR-548an	CLIP-seq
MIRT932511	hsa-miR-548b-3p	CLIP-seq
MIRT932512	hsa-miR-548o	CLIP-seq
MIRT932513	hsa-miR-623	CLIP-seq
MIRT932514	hsa-miR-631	CLIP-seq
MIRT932515	hsa-miR-635	CLIP-seq
MIRT932516	hsa-miR-645	CLIP-seq
MIRT932517	hsa-miR-646	CLIP-seq
MIRT932518	hsa-miR-663	CLIP-seq
MIRT932519	hsa-miR-744	CLIP-seq
MIRT932520	hsa-miR-92a	CLIP-seq
MIRT932521	hsa-miR-92b	CLIP-seq
MIRT932456	hsa-miR-3117-3p	CLIP-seq
MIRT932460	hsa-miR-3169	CLIP-seq
MIRT1547928	hsa-miR-4277	CLIP-seq
MIRT932491	hsa-miR-4515	CLIP-seq
MIRT932504	hsa-miR-4759	CLIP-seq
MIRT932445	hsa-miR-185	CLIP-seq
MIRT932476	hsa-miR-4306	CLIP-seq
MIRT932495	hsa-miR-4644	CLIP-seq
MIRT932437	hsa-miR-1262	CLIP-seq
MIRT932438	hsa-miR-1293	CLIP-seq
MIRT932440	hsa-miR-1323	CLIP-seq
MIRT932442	hsa-miR-137	CLIP-seq
MIRT932444	hsa-miR-1827	CLIP-seq
MIRT932453	hsa-miR-25	CLIP-seq
MIRT1976085	hsa-miR-3065-3p	CLIP-seq
MIRT932454	hsa-miR-3065-5p	CLIP-seq
MIRT1976086	hsa-miR-3132	CLIP-seq
MIRT932462	hsa-miR-32	CLIP-seq
MIRT1976087	hsa-miR-361-3p	CLIP-seq
MIRT932465	hsa-miR-363	CLIP-seq
MIRT932467	hsa-miR-3661	CLIP-seq
MIRT932468	hsa-miR-367	CLIP-seq
MIRT932477	hsa-miR-4316	CLIP-seq
MIRT932481	hsa-miR-4436a	CLIP-seq
MIRT932488	hsa-miR-4483	CLIP-seq
MIRT932498	hsa-miR-4699-3p	CLIP-seq
MIRT932499	hsa-miR-4701-3p	CLIP-seq
MIRT932500	hsa-miR-4710	CLIP-seq
MIRT932507	hsa-miR-492	CLIP-seq
MIRT1976088	hsa-miR-495	CLIP-seq
MIRT932508	hsa-miR-500a	CLIP-seq
MIRT932512	hsa-miR-548o	CLIP-seq
MIRT932514	hsa-miR-631	CLIP-seq
MIRT932520	hsa-miR-92a	CLIP-seq
MIRT932521	hsa-miR-92b	CLIP-seq
MIRT932437	hsa-miR-1262	CLIP-seq
MIRT932438	hsa-miR-1293	CLIP-seq
MIRT932440	hsa-miR-1323	CLIP-seq
MIRT932442	hsa-miR-137	CLIP-seq
MIRT932444	hsa-miR-1827	CLIP-seq
MIRT932446	hsa-miR-1908	CLIP-seq
MIRT932452	hsa-miR-2355-5p	CLIP-seq
MIRT932453	hsa-miR-25	CLIP-seq
MIRT932454	hsa-miR-3065-5p	CLIP-seq
MIRT932455	hsa-miR-31	CLIP-seq
MIRT932456	hsa-miR-3117-3p	CLIP-seq
MIRT1976086	hsa-miR-3132	CLIP-seq
MIRT932460	hsa-miR-3169	CLIP-seq
MIRT932462	hsa-miR-32	CLIP-seq
MIRT932463	hsa-miR-3619-3p	CLIP-seq
MIRT932465	hsa-miR-363	CLIP-seq
MIRT932467	hsa-miR-3661	CLIP-seq
MIRT932468	hsa-miR-367	CLIP-seq
MIRT1547928	hsa-miR-4277	CLIP-seq
MIRT932477	hsa-miR-4316	CLIP-seq
MIRT932481	hsa-miR-4436a	CLIP-seq
MIRT932488	hsa-miR-4483	CLIP-seq
MIRT932491	hsa-miR-4515	CLIP-seq
MIRT932498	hsa-miR-4699-3p	CLIP-seq
MIRT932499	hsa-miR-4701-3p	CLIP-seq
MIRT932500	hsa-miR-4710	CLIP-seq
MIRT932502	hsa-miR-4742-5p	CLIP-seq
MIRT932504	hsa-miR-4759	CLIP-seq
MIRT932505	hsa-miR-486-3p	CLIP-seq
MIRT932507	hsa-miR-492	CLIP-seq
MIRT1976088	hsa-miR-495	CLIP-seq
MIRT932508	hsa-miR-500a	CLIP-seq
MIRT932512	hsa-miR-548o	CLIP-seq
MIRT932514	hsa-miR-631	CLIP-seq
MIRT932518	hsa-miR-663	CLIP-seq
MIRT932519	hsa-miR-744	CLIP-seq
MIRT932520	hsa-miR-92a	CLIP-seq
MIRT932521	hsa-miR-92b	CLIP-seq
MIRT932436	hsa-miR-1229	CLIP-seq
MIRT2515202	hsa-miR-1252	CLIP-seq
MIRT2515203	hsa-miR-1283	CLIP-seq
MIRT932441	hsa-miR-136	CLIP-seq
MIRT932448	hsa-miR-204	CLIP-seq
MIRT932450	hsa-miR-211	CLIP-seq
MIRT2515204	hsa-miR-3157-3p	CLIP-seq
MIRT932463	hsa-miR-3619-3p	CLIP-seq
MIRT932484	hsa-miR-4446-5p	CLIP-seq
MIRT932486	hsa-miR-4474-3p	CLIP-seq
MIRT932490	hsa-miR-4511	CLIP-seq
MIRT932494	hsa-miR-4639-3p	CLIP-seq
MIRT932497	hsa-miR-4675	CLIP-seq
MIRT932501	hsa-miR-4741	CLIP-seq
MIRT932503	hsa-miR-4755-5p	CLIP-seq
MIRT932511	hsa-miR-548b-3p	CLIP-seq
MIRT2515205	hsa-miR-591	CLIP-seq
MIRT932513	hsa-miR-623	CLIP-seq
MIRT932436	hsa-miR-1229	CLIP-seq
MIRT2515202	hsa-miR-1252	CLIP-seq
MIRT2515203	hsa-miR-1283	CLIP-seq
MIRT932441	hsa-miR-136	CLIP-seq
MIRT932448	hsa-miR-204	CLIP-seq
MIRT932450	hsa-miR-211	CLIP-seq
MIRT2515204	hsa-miR-3157-3p	CLIP-seq
MIRT932463	hsa-miR-3619-3p	CLIP-seq
MIRT932484	hsa-miR-4446-5p	CLIP-seq
MIRT932494	hsa-miR-4639-3p	CLIP-seq
MIRT932503	hsa-miR-4755-5p	CLIP-seq
MIRT2515205	hsa-miR-591	CLIP-seq
MIRT932513	hsa-miR-623	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	20937701
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005794	Component	Golgi apparatus	IDA	20937701
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0031410	Component	Cytoplasmic vesicle	IBA
GO:0032483	Process	Regulation of Rab protein signal transduction	IBA
GO:0032483	Process	Regulation of Rab protein signal transduction	IDA	20937701

MIM	HGNC	e!Ensembl
619843	29044	ENSG00000198837

Protein

UniProt ID

O75064

Protein name

DENN domain-containing protein 4B

Protein function

Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03456	uDENN	213 → 278	uDENN domain	Domain
PF02141	DENN	313 → 497	DENN (AEX-3) domain	Family
PF03455	dDENN	603 → 652	dDENN domain	Domain

Sequence

MAEERPPRLVDYFVVAGLAGNGAPIPEETWVPEPSGPLRPPRPAEPITDVAVIARALGEE
VPQGYTCIQASAGGHPLELSAGLLGGTQPVICYRRGRDKPPLVELGVLYEGKERPKPGFQ
VLDTTPYSHSANLAPPGPGHPRTYLTYRRAAEGAGLHALGITDLCLVLPSKGEGTPHTYC
RLPRNLNPGMWGPAVYLCYKVGLAKANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPM
GATIECWPAQTKYPVPVFSTFVLTGAAGDKVYGAALQFYEAFPRARLSERQARALGLLSA
VERGRALGGRAVRSRRAIAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHN
VPFPSPQRPRILVQMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTE
HKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYF
DLHDPPADVICVDLDTNTLFQTEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPE
EEASLEFLLTDYEAVCGRRARLEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVD
NLFFLQGFLKSRERSSHKLYSQLLHTQMFSQFIEECSFGSARHAALEFFDSCVEKVHPEQ
EKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQYCYDGFPELRAELFESLQEQ
PGALPVPGPSRSAPSSPAPRRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYGLWFLCLP
AYVRSAPSRVQALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMR
QAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVVLGAAQFRQPLRERQQQQQQ
QQQQQQQQQQEQVSAHQEAGSSQAEPYLERPSPTRPLQRQTTWAGRSLRDPASPPGRLVK
SGSLGSARGAQPTVEAGVAHMIEALGVLEPRGSPVPWHDGSLSDLSLTGEEPLPGGSPGG
SGSALSAQSTEALEGLSGRGPKAGGRQDEAGTPRRGLGARLQQLLTPSRHSPASRIPPPE
LPPDLPPPARRSPMDSLLHPRERPGSTASESSASLGSEWDLSESSLSNLSLRRSSERLSD
TPGSFQSPSLEILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSV
QTLDSRPSVPSPKSAGASGSKDAPVPGGPGPVLSDRRLCLALDEPQLCNGHMGGASRRVE
SGAWAYLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGL
VLASCDGPSHSQAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVW
PGPVPASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPTGLHLQRGIYREILFLTMAA
LGKDHVDIVAFDKKYKSAFNKLASSMGKEELRHRRAQMPTPKAIDCRKCFGAPPEC

Sequence length

1496

Interactions

View interactions

	Reactome
			RAB GEFs exchange GTP for GDP on RABs

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Prostate cancer	Prostate cancer, Prostate cancer (advanced)	N/A	N/A	GWAS

DENND4B (DENN domain containing 4B)