Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9891
Gene name	NUAK family kinase 1
Gene symbol	NUAK1
Synonyms (NCBI Gene)	ARK5
Chromosome	12
Chromosome location	12q23.3

153

Show/Hide all (153)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021136	hsa-miR-186-5p	Sequencing	20371350
MIRT023849	hsa-miR-1-3p	Microarray	18668037
MIRT028149	hsa-miR-93-5p	Sequencing	20371350
MIRT050078	hsa-miR-26a-5p	CLASH	23622248
MIRT438079	hsa-miR-211-5p	Luciferase reporter assayWestern blotqRT-PCR	23934065
MIRT438079	hsa-miR-211-5p	Luciferase reporter assayWestern blotqRT-PCR	23934065
MIRT438079	hsa-miR-211-5p	Luciferase reporter assayWestern blotqRT-PCR	23934065
MIRT438079	hsa-miR-211-5p	Luciferase reporter assayWestern blotqRT-PCR	23934065
MIRT438079	hsa-miR-211-5p	Luciferase reporter assayWestern blotqRT-PCR	23934065
MIRT438079	hsa-miR-211-5p	Luciferase reporter assayWestern blotqRT-PCR	23934065
MIRT438079	hsa-miR-211-5p	Luciferase reporter assayWestern blotqRT-PCR	23934065
MIRT438079	hsa-miR-211-5p	Luciferase reporter assayWestern blotqRT-PCR	23934065
MIRT655709	hsa-miR-556-3p	HITS-CLIP	23824327
MIRT440086	hsa-miR-770-5p	HITS-CLIP	24374217
MIRT440086	hsa-miR-770-5p	HITS-CLIP	24374217
MIRT733136	hsa-miR-30b-5p	Luciferase reporter assayqRT-PCRWestern blotting	31949655
MIRT655709	hsa-miR-556-3p	HITS-CLIP	23824327
MIRT756449	hsa-miR-424-5p	Luciferase reporter assay	34097192
MIRT1196381	hsa-miR-103a	CLIP-seq
MIRT1196382	hsa-miR-105	CLIP-seq
MIRT1196383	hsa-miR-107	CLIP-seq
MIRT1196384	hsa-miR-1200	CLIP-seq
MIRT1196385	hsa-miR-1238	CLIP-seq
MIRT1196386	hsa-miR-126	CLIP-seq
MIRT1196387	hsa-miR-127-5p	CLIP-seq
MIRT1196388	hsa-miR-1290	CLIP-seq
MIRT739840	hsa-miR-1470	CLIP-seq
MIRT1196389	hsa-miR-15a	CLIP-seq
MIRT1196390	hsa-miR-15b	CLIP-seq
MIRT1196391	hsa-miR-16	CLIP-seq
MIRT1196392	hsa-miR-182	CLIP-seq
MIRT1196393	hsa-miR-193a-5p	CLIP-seq
MIRT1196394	hsa-miR-195	CLIP-seq
MIRT1196395	hsa-miR-196a	CLIP-seq
MIRT1196396	hsa-miR-196b	CLIP-seq
MIRT1196397	hsa-miR-1973	CLIP-seq
MIRT1196398	hsa-miR-214	CLIP-seq
MIRT1196399	hsa-miR-22	CLIP-seq
MIRT1196400	hsa-miR-224	CLIP-seq
MIRT1196401	hsa-miR-2355-5p	CLIP-seq
MIRT1196402	hsa-miR-28-5p	CLIP-seq
MIRT1196403	hsa-miR-3124-3p	CLIP-seq
MIRT1196404	hsa-miR-3127-3p	CLIP-seq
MIRT1196405	hsa-miR-3139	CLIP-seq
MIRT1196406	hsa-miR-3140-5p	CLIP-seq
MIRT1196407	hsa-miR-3148	CLIP-seq
MIRT1196408	hsa-miR-3167	CLIP-seq
MIRT1196409	hsa-miR-3173-3p	CLIP-seq
MIRT1196410	hsa-miR-3614-5p	CLIP-seq
MIRT1196411	hsa-miR-3619-5p	CLIP-seq
MIRT1196412	hsa-miR-3667-3p	CLIP-seq
MIRT1196413	hsa-miR-3689d	CLIP-seq
MIRT1196414	hsa-miR-3691-5p	CLIP-seq
MIRT1196415	hsa-miR-3923	CLIP-seq
MIRT1196416	hsa-miR-3927	CLIP-seq
MIRT1196417	hsa-miR-3929	CLIP-seq
MIRT1196418	hsa-miR-424	CLIP-seq
MIRT1196419	hsa-miR-4419b	CLIP-seq
MIRT1196420	hsa-miR-4436b-3p	CLIP-seq
MIRT1196421	hsa-miR-4457	CLIP-seq
MIRT1196422	hsa-miR-4462	CLIP-seq
MIRT1196423	hsa-miR-4469	CLIP-seq
MIRT1196424	hsa-miR-4470	CLIP-seq
MIRT1196425	hsa-miR-4478	CLIP-seq
MIRT1196426	hsa-miR-4491	CLIP-seq
MIRT1196427	hsa-miR-4530	CLIP-seq
MIRT1196428	hsa-miR-4635	CLIP-seq
MIRT1196429	hsa-miR-4640-3p	CLIP-seq
MIRT1196430	hsa-miR-4640-5p	CLIP-seq
MIRT1196431	hsa-miR-4655-3p	CLIP-seq
MIRT1196432	hsa-miR-4657	CLIP-seq
MIRT739839	hsa-miR-4667-3p	CLIP-seq
MIRT1196433	hsa-miR-4687-3p	CLIP-seq
MIRT739837	hsa-miR-4687-5p	CLIP-seq
MIRT1196434	hsa-miR-4691-5p	CLIP-seq
MIRT1196435	hsa-miR-4705	CLIP-seq
MIRT1196436	hsa-miR-4726-5p	CLIP-seq
MIRT1196437	hsa-miR-4752	CLIP-seq
MIRT739841	hsa-miR-4760-3p	CLIP-seq
MIRT1196438	hsa-miR-4765	CLIP-seq
MIRT1196439	hsa-miR-483-3p	CLIP-seq
MIRT1196440	hsa-miR-488	CLIP-seq
MIRT1196441	hsa-miR-497	CLIP-seq
MIRT1196442	hsa-miR-545	CLIP-seq
MIRT1196443	hsa-miR-548aa	CLIP-seq
MIRT1196444	hsa-miR-548n	CLIP-seq
MIRT1196445	hsa-miR-548t	CLIP-seq
MIRT1196446	hsa-miR-548u	CLIP-seq
MIRT1196447	hsa-miR-570	CLIP-seq
MIRT1196448	hsa-miR-583	CLIP-seq
MIRT1196449	hsa-miR-603	CLIP-seq
MIRT1196450	hsa-miR-616	CLIP-seq
MIRT1196451	hsa-miR-708	CLIP-seq
MIRT1196452	hsa-miR-761	CLIP-seq
MIRT739838	hsa-miR-766	CLIP-seq
MIRT1196453	hsa-miR-767-3p	CLIP-seq
MIRT1196454	hsa-miR-876-5p	CLIP-seq
MIRT1196381	hsa-miR-103a	CLIP-seq
MIRT1196383	hsa-miR-107	CLIP-seq
MIRT2056983	hsa-miR-145	CLIP-seq
MIRT1196401	hsa-miR-2355-5p	CLIP-seq
MIRT1196412	hsa-miR-3667-3p	CLIP-seq
MIRT1196413	hsa-miR-3689d	CLIP-seq
MIRT1196415	hsa-miR-3923	CLIP-seq
MIRT2056984	hsa-miR-4287	CLIP-seq
MIRT2056985	hsa-miR-4299	CLIP-seq
MIRT2056986	hsa-miR-4312	CLIP-seq
MIRT1196423	hsa-miR-4469	CLIP-seq
MIRT2056987	hsa-miR-4685-3p	CLIP-seq
MIRT1196435	hsa-miR-4705	CLIP-seq
MIRT2056988	hsa-miR-4708-3p	CLIP-seq
MIRT1196439	hsa-miR-483-3p	CLIP-seq
MIRT1196448	hsa-miR-583	CLIP-seq
MIRT2056989	hsa-miR-668	CLIP-seq
MIRT2056990	hsa-miR-873	CLIP-seq
MIRT1196381	hsa-miR-103a	CLIP-seq
MIRT1196383	hsa-miR-107	CLIP-seq
MIRT2056983	hsa-miR-145	CLIP-seq
MIRT1196389	hsa-miR-15a	CLIP-seq
MIRT1196390	hsa-miR-15b	CLIP-seq
MIRT1196391	hsa-miR-16	CLIP-seq
MIRT1196394	hsa-miR-195	CLIP-seq
MIRT1196398	hsa-miR-214	CLIP-seq
MIRT2285412	hsa-miR-3065-3p	CLIP-seq
MIRT2285413	hsa-miR-3185	CLIP-seq
MIRT2285414	hsa-miR-3187-3p	CLIP-seq
MIRT1196411	hsa-miR-3619-5p	CLIP-seq
MIRT1196417	hsa-miR-3929	CLIP-seq
MIRT1196418	hsa-miR-424	CLIP-seq
MIRT1196419	hsa-miR-4419b	CLIP-seq
MIRT1196420	hsa-miR-4436b-3p	CLIP-seq
MIRT1196425	hsa-miR-4478	CLIP-seq
MIRT1196427	hsa-miR-4530	CLIP-seq
MIRT1196428	hsa-miR-4635	CLIP-seq
MIRT1196430	hsa-miR-4640-5p	CLIP-seq
MIRT1196433	hsa-miR-4687-3p	CLIP-seq
MIRT1196436	hsa-miR-4726-5p	CLIP-seq
MIRT1196441	hsa-miR-497	CLIP-seq
MIRT1196452	hsa-miR-761	CLIP-seq
MIRT2391792	hsa-miR-339-5p	CLIP-seq
MIRT1196412	hsa-miR-3667-3p	CLIP-seq
MIRT2056984	hsa-miR-4287	CLIP-seq
MIRT2056985	hsa-miR-4299	CLIP-seq
MIRT1196423	hsa-miR-4469	CLIP-seq
MIRT2056987	hsa-miR-4685-3p	CLIP-seq
MIRT2391793	hsa-miR-4713-5p	CLIP-seq
MIRT2056989	hsa-miR-668	CLIP-seq
MIRT2056985	hsa-miR-4299	CLIP-seq
MIRT2056989	hsa-miR-668	CLIP-seq
MIRT2686668	hsa-miR-3157-5p	CLIP-seq
MIRT2056985	hsa-miR-4299	CLIP-seq
MIRT2686669	hsa-miR-4691-3p	CLIP-seq
MIRT2056989	hsa-miR-668	CLIP-seq

Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001650	Component	Fibrillar center	IDA
GO:0002039	Function	P53 binding	IPI	21317932
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	19927127, 20354225, 21317932
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	TAS
GO:0005515	Function	Protein binding	IPI	16306228, 19927127, 20354225, 21317932, 25329316, 25852190, 32707033
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	21317932
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	21317932
GO:0005737	Component	Cytoplasm	IEA
GO:0006468	Process	Protein phosphorylation	IDA	25329316
GO:0006974	Process	DNA damage response	IEA
GO:0007155	Process	Cell adhesion	IEA
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030155	Process	Regulation of cell adhesion	IDA	20354225
GO:0042127	Process	Regulation of cell population proliferation	TAS	21317932
GO:0046872	Function	Metal ion binding	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	TAS
GO:2000772	Process	Regulation of cellular senescence	IDA	19927127

MIM	HGNC	e!Ensembl
608130	14311	ENSG00000074590

O60285

Protein name

NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1)

Protein function

Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	55 → 306	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed at high levels in heart and brain, and at lower levels in skeletal muscle, kidney, ovary, placenta, lung and liver. Highly up-regulated in colorectal cancer cell lines. {ECO:0000269|PubMed:14982852}.

Sequence

MEGAAAPVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQET
LGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYE
VFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLK
LENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALG
VLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPSDARGLIRWMLMVNPDRRATIEDI
ANHWWVNWGYKSSVCDCDALHDSESPLLARIIDWHHRSTGLQADTEAKMKGLAKPTTSEV
MLERQRSLKKSKKENDFAQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGV
VGPALPSTFKMEQDLCRTGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYS
SPERSESSELLDSNDVMGSSIPSPSPPDPARVTSHSLSCRRKGILKHSSKYSAGTMDPAL
VSPEMPTLESLSEPGVPAEGLSRSYSRPSSVISDDSVLSSDSFDLLDLQENRPARQRIRS
CVSAENFLQIQDFEGLQNRPRPQYLKRYRNRLADSSFSLLTDMDDVTQVYKQALEICSKL
N

Sequence length

661

Interactions

View interactions

	Reactome
			Regulation of TP53 Activity through Phosphorylation

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
NUAK1-related disorder	Uncertain significance; Likely benign	rs2541495252, rs141618950	RCV003919711 RCV003912027

Show/Hide Text Mining Associations (33)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Ataxia Telangiectasia	Associate	12409306
Breast Neoplasms	Associate	29566768, 32418991
Bronchopulmonary Dysplasia	Associate	34465876
Carcinoma Hepatocellular	Associate	23516026, 32755597
Carcinoma Pancreatic Ductal	Associate	36975767
Carcinoma Renal Cell	Associate	37996927
Carcinoma Squamous Cell	Associate	24565165, 38131232
Cerebral Hemorrhage	Associate	37473923
Cholangiocarcinoma	Associate	28832761, 31360102
Chronic Periodontitis	Associate	23459936
Colorectal Neoplasms	Associate	14982852
Developmental Disabilities	Associate	37236919
Diabetes Mellitus	Associate	29106388
Diabetic Nephropathies	Stimulate	22266139
Fibrosis	Associate	36435939
Genetic Diseases Inborn	Associate	12409306
Head and Neck Neoplasms	Associate	26882562
Hypoxia	Associate	16014625
Hypoxia Brain	Associate	37996927
Lymphatic Metastasis	Associate	26882562
Melanoma	Associate	23934065
Microsatellite Instability	Associate	19888451
Neoplasm Metastasis	Stimulate	14982852
Neoplasms	Associate	12409306, 14982852, 16014625, 19888451, 23516026, 27137215, 29106388, 35872695, 36975767, 37996927
Neoplasms	Stimulate	33000197
Neurodegenerative Diseases	Associate	29106388
Pancreatic Neoplasms	Associate	14982852, 33000197, 36975767
Schizophrenia	Associate	37236919
Smoke Inhalation Injury	Associate	23459936
Squamous Cell Carcinoma of Head and Neck	Associate	26882562
Stomach Neoplasms	Associate	35872695
Triple Negative Breast Neoplasms	Associate	34326372
Uterine Cervical Neoplasms	Associate	38131232

NUAK1 (NUAK family kinase 1)