Gene Gene information from NCBI Gene database.
Entrez ID 988
Gene name Cell division cycle 5 like
Gene symbol CDC5L
Synonyms (NCBI Gene)
CDC5CDC5-LIKECEF1PCDC5RPdJ319D22.1
Chromosome 6
Chromosome location 6p21.1
Summary The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cyc
miRNA miRNA information provided by mirtarbase database.
476
miRTarBase ID miRNA Experiments Reference
MIRT025505 hsa-miR-34a-5p Proteomics 21566225
MIRT025505 hsa-miR-34a-5p Proteomics 21566225
MIRT031890 hsa-miR-16-5p Proteomics 18668040
MIRT051492 hsa-let-7e-5p CLASH 23622248
MIRT041014 hsa-miR-505-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
43
GO ID Ontology Definition Evidence Reference
GO:0000077 Process DNA damage checkpoint signaling IMP 24332808
GO:0000398 Process MRNA splicing, via spliceosome IBA
GO:0000398 Process MRNA splicing, via spliceosome IC 11991638
GO:0000398 Process MRNA splicing, via spliceosome IDA 28076346
GO:0000398 Process MRNA splicing, via spliceosome IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602868 1743 ENSG00000096401
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q99459
Protein name Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein)
Protein function DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811,
PDB 2DIM , 2DIN , 5MQF , 5XJC , 5YZG , 5Z56 , 5Z57 , 5Z58 , 6FF4 , 6FF7 , 6ICZ , 6ID0 , 6ID1 , 6QDV , 6ZYM , 7A5P , 7AAV , 7ABG , 7ABH , 7ABI , 7DVQ , 7QTT , 7W59 , 7W5A , 7W5B , 8C6J , 8CH6 , 8I0P , 8I0R , 8I0S , 8I0T , 8I0U , 8I0V , 8I0W , 8RO2 , 9FMD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13921 Myb_DNA-bind_6 11 71 Domain
PF11831 Myb_Cef 404 655 pre-mRNA splicing factor component Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed in both fetal and adult tissues. {ECO:0000269|PubMed:9038199, ECO:0000269|PubMed:9598309, ECO:0000269|PubMed:9632794}.
Sequence
MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKK
TEWSREEEEKL
LHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKAAQRDNEEETTDDP
RKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEAR
RLAALQKRRELRAAGIEIQKKRKRKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFR
KLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAP
QISDAELQEVVKVGQASEIARQTAEESGITNSASSTLLSEYNVTNNSVALRTPRTPASQD
RILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGA
EGLTPRSGTTPKPVINSTPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGL
LGLPAPKNDFEIVLPENAEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEMKRMHKA
VQKDLPRPSEVNETILRPLNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKG
KTVGFGTNNSEHITYLEHNPYEKFSKEELKKAQDVLVQEMEVVKQGMSHGELSSE
AYNQV
WEECYSQVLYLPGQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKIL
LGGYQSRAMGLMKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRRLECLKEDVQRQQER
EKELQHRYADLLLEKETLKSKF
Sequence length 802
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Spliceosome   mRNA Splicing - Major Pathway
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
24
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
CDC5L-related disorder Uncertain significance; Likely benign; Benign rs2532512495, rs1016731902, rs747924598, rs762774387, rs556847454, rs144524558, rs377117589, rs11572006, rs11572048, rs373544801, rs11571911, rs141567880, rs150971616, rs548309345, rs144752067
View all (1 more)
RCV003397564
RCV003427763
RCV003412222
RCV003896765
RCV003897091
RCV003909442
RCV003914236
RCV003927338
RCV003942120
RCV003937324
RCV003937137
RCV003926774
RCV003914756
RCV003934262
RCV003956772
RCV003923257
Cholangiocarcinoma Benign rs2273667 RCV005916923
Congenital anomaly of kidney and urinary tract Uncertain significance rs368161524 RCV000416577
Hepatocellular carcinoma Benign rs2273667 RCV005916918
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Ataxia Telangiectasia Associate 19633697
Cakut Associate 24429398
Carcinoma Hepatocellular Associate 28387715, 32955083
Carcinoma Non Small Cell Lung Associate 37658700
Carcinoma Renal Cell Associate 27144525
Colorectal Neoplasms Associate 38376276
Diabetes Mellitus Associate 36978091
Diabetic Nephropathies Associate 36978091
Glioma Associate 26490980
Glycosuria Renal Associate 36978091