Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9873
Gene name Gene Name - the full gene name approved by the HGNC.	FCH and double SH3 domains 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FCHSD2
Synonyms (NCBI Gene) Gene synonyms aliases	NWK, NWK1, SH3MD3
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q13.4

Show/Hide all(270)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023044	hsa-miR-124-3p	Microarray	18668037
MIRT658157	hsa-miR-449b-3p	HITS-CLIP	23824327
MIRT658155	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT658156	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT658154	hsa-miR-4662a-5p	HITS-CLIP	23824327
MIRT658153	hsa-miR-4474-5p	HITS-CLIP	23824327
MIRT060652	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT658152	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT023044	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT567588	hsa-miR-548an	PAR-CLIP	20371350
MIRT567587	hsa-miR-3622a-5p	PAR-CLIP	20371350
MIRT567586	hsa-miR-6074	PAR-CLIP	20371350
MIRT567584	hsa-miR-4272	PAR-CLIP	20371350
MIRT567585	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT567583	hsa-miR-1323	PAR-CLIP	20371350
MIRT567582	hsa-miR-548o-3p	PAR-CLIP	20371350
MIRT131512	hsa-miR-4668-5p	PAR-CLIP	20371350
MIRT440647	hsa-miR-210-3p	HITS-CLIP	22473208
MIRT440647	hsa-miR-210-3p	HITS-CLIP	22473208
MIRT727661	hsa-miR-27a-3p	HITS-CLIP	22473208
MIRT727659	hsa-miR-27b-3p	HITS-CLIP	22473208
MIRT658157	hsa-miR-449b-3p	HITS-CLIP	23824327
MIRT658155	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT658156	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT658154	hsa-miR-4662a-5p	HITS-CLIP	23824327
MIRT658153	hsa-miR-4474-5p	HITS-CLIP	23824327
MIRT060652	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT658152	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT023044	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT567588	hsa-miR-548an	PAR-CLIP	20371350
MIRT567587	hsa-miR-3622a-5p	PAR-CLIP	20371350
MIRT567586	hsa-miR-6074	PAR-CLIP	20371350
MIRT567584	hsa-miR-4272	PAR-CLIP	20371350
MIRT567585	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT567583	hsa-miR-1323	PAR-CLIP	20371350
MIRT567582	hsa-miR-548o-3p	PAR-CLIP	20371350
MIRT131512	hsa-miR-4668-5p	PAR-CLIP	20371350
MIRT994026	hsa-miR-1193	CLIP-seq
MIRT994027	hsa-miR-1258	CLIP-seq
MIRT994028	hsa-miR-128	CLIP-seq
MIRT994029	hsa-miR-1913	CLIP-seq
MIRT994030	hsa-miR-219-5p	CLIP-seq
MIRT994031	hsa-miR-2276	CLIP-seq
MIRT994032	hsa-miR-27a	CLIP-seq
MIRT994033	hsa-miR-27b	CLIP-seq
MIRT994034	hsa-miR-324-3p	CLIP-seq
MIRT994035	hsa-miR-3616-3p	CLIP-seq
MIRT994036	hsa-miR-362-5p	CLIP-seq
MIRT994037	hsa-miR-3649	CLIP-seq
MIRT994038	hsa-miR-3661	CLIP-seq
MIRT994039	hsa-miR-3674	CLIP-seq
MIRT994040	hsa-miR-3692	CLIP-seq
MIRT994041	hsa-miR-3935	CLIP-seq
MIRT994042	hsa-miR-421	CLIP-seq
MIRT994043	hsa-miR-4274	CLIP-seq
MIRT994044	hsa-miR-4313	CLIP-seq
MIRT994045	hsa-miR-4423-3p	CLIP-seq
MIRT994046	hsa-miR-4445	CLIP-seq
MIRT994047	hsa-miR-4446-3p	CLIP-seq
MIRT994048	hsa-miR-4519	CLIP-seq
MIRT994049	hsa-miR-4659a-3p	CLIP-seq
MIRT994050	hsa-miR-4659b-3p	CLIP-seq
MIRT994051	hsa-miR-4721	CLIP-seq
MIRT994052	hsa-miR-4772-3p	CLIP-seq
MIRT994053	hsa-miR-4782-3p	CLIP-seq
MIRT994054	hsa-miR-4795-3p	CLIP-seq
MIRT994055	hsa-miR-492	CLIP-seq
MIRT994056	hsa-miR-500b	CLIP-seq
MIRT994057	hsa-miR-508-3p	CLIP-seq
MIRT994058	hsa-miR-513a-3p	CLIP-seq
MIRT994059	hsa-miR-544	CLIP-seq
MIRT994060	hsa-miR-619	CLIP-seq
MIRT994061	hsa-miR-631	CLIP-seq
MIRT994062	hsa-miR-671-5p	CLIP-seq
MIRT994063	hsa-miR-935	CLIP-seq
MIRT1548681	hsa-miR-1470	CLIP-seq
MIRT1548682	hsa-miR-4667-3p	CLIP-seq
MIRT1994756	hsa-miR-1197	CLIP-seq
MIRT1994757	hsa-miR-1208	CLIP-seq
MIRT994028	hsa-miR-128	CLIP-seq
MIRT1994758	hsa-miR-133a	CLIP-seq
MIRT1994759	hsa-miR-133b	CLIP-seq
MIRT1994760	hsa-miR-1972	CLIP-seq
MIRT1994761	hsa-miR-205	CLIP-seq
MIRT994032	hsa-miR-27a	CLIP-seq
MIRT994033	hsa-miR-27b	CLIP-seq
MIRT1994762	hsa-miR-3130-5p	CLIP-seq
MIRT1994763	hsa-miR-3144-5p	CLIP-seq
MIRT1994764	hsa-miR-3185	CLIP-seq
MIRT1994765	hsa-miR-3191	CLIP-seq
MIRT994036	hsa-miR-362-5p	CLIP-seq
MIRT1994766	hsa-miR-3689a-3p	CLIP-seq
MIRT1994767	hsa-miR-3689c	CLIP-seq
MIRT1994768	hsa-miR-4294	CLIP-seq
MIRT1994769	hsa-miR-4482	CLIP-seq
MIRT1994770	hsa-miR-4506	CLIP-seq
MIRT1994771	hsa-miR-455-3p	CLIP-seq
MIRT1994772	hsa-miR-4635	CLIP-seq
MIRT1994773	hsa-miR-4652-5p	CLIP-seq
MIRT994049	hsa-miR-4659a-3p	CLIP-seq
MIRT994050	hsa-miR-4659b-3p	CLIP-seq
MIRT1994774	hsa-miR-4668-3p	CLIP-seq
MIRT1994775	hsa-miR-4704-3p	CLIP-seq
MIRT1994776	hsa-miR-4709-3p	CLIP-seq
MIRT1994777	hsa-miR-4717-5p	CLIP-seq
MIRT1994778	hsa-miR-4728-5p	CLIP-seq
MIRT994056	hsa-miR-500b	CLIP-seq
MIRT1994779	hsa-miR-548c-3p	CLIP-seq
MIRT1994780	hsa-miR-548o	CLIP-seq
MIRT1994781	hsa-miR-548p	CLIP-seq
MIRT1994782	hsa-miR-576-3p	CLIP-seq
MIRT1994783	hsa-miR-605	CLIP-seq
MIRT1994784	hsa-miR-765	CLIP-seq
MIRT994063	hsa-miR-935	CLIP-seq
MIRT2228926	hsa-miR-1183	CLIP-seq
MIRT1994757	hsa-miR-1208	CLIP-seq
MIRT994028	hsa-miR-128	CLIP-seq
MIRT2228927	hsa-miR-186	CLIP-seq
MIRT994032	hsa-miR-27a	CLIP-seq
MIRT994033	hsa-miR-27b	CLIP-seq
MIRT2228928	hsa-miR-3133	CLIP-seq
MIRT2228929	hsa-miR-3607-3p	CLIP-seq
MIRT994036	hsa-miR-362-5p	CLIP-seq
MIRT2228930	hsa-miR-4252	CLIP-seq
MIRT2228931	hsa-miR-4691-3p	CLIP-seq
MIRT994056	hsa-miR-500b	CLIP-seq
MIRT994038	hsa-miR-3661	CLIP-seq
MIRT994061	hsa-miR-631	CLIP-seq
MIRT2532449	hsa-miR-1233	CLIP-seq
MIRT2532450	hsa-miR-1238	CLIP-seq
MIRT2532451	hsa-miR-1245	CLIP-seq
MIRT2532452	hsa-miR-1287	CLIP-seq
MIRT1994758	hsa-miR-133a	CLIP-seq
MIRT1994759	hsa-miR-133b	CLIP-seq
MIRT2532453	hsa-miR-1343	CLIP-seq
MIRT1548681	hsa-miR-1470	CLIP-seq
MIRT2532454	hsa-miR-15a	CLIP-seq
MIRT2532455	hsa-miR-15b	CLIP-seq
MIRT2532456	hsa-miR-16	CLIP-seq
MIRT2228927	hsa-miR-186	CLIP-seq
MIRT2532457	hsa-miR-1909	CLIP-seq
MIRT2532458	hsa-miR-1910	CLIP-seq
MIRT2532459	hsa-miR-1914	CLIP-seq
MIRT2532460	hsa-miR-195	CLIP-seq
MIRT1994761	hsa-miR-205	CLIP-seq
MIRT2532461	hsa-miR-2467-5p	CLIP-seq
MIRT2532462	hsa-miR-3065-5p	CLIP-seq
MIRT2532463	hsa-miR-3074-5p	CLIP-seq
MIRT2532464	hsa-miR-3127-5p	CLIP-seq
MIRT2532465	hsa-miR-3130-3p	CLIP-seq
MIRT2228928	hsa-miR-3133	CLIP-seq
MIRT2532466	hsa-miR-3135b	CLIP-seq
MIRT2532467	hsa-miR-3163	CLIP-seq
MIRT2532468	hsa-miR-320a	CLIP-seq
MIRT2532469	hsa-miR-320b	CLIP-seq
MIRT2532470	hsa-miR-320c	CLIP-seq
MIRT2532471	hsa-miR-320d	CLIP-seq
MIRT2532472	hsa-miR-320e	CLIP-seq
MIRT2228929	hsa-miR-3607-3p	CLIP-seq
MIRT2532473	hsa-miR-3616-5p	CLIP-seq
MIRT2532474	hsa-miR-3647-5p	CLIP-seq
MIRT994038	hsa-miR-3661	CLIP-seq
MIRT2532475	hsa-miR-3662	CLIP-seq
MIRT2532476	hsa-miR-3667-3p	CLIP-seq
MIRT2532477	hsa-miR-376a	CLIP-seq
MIRT2532478	hsa-miR-376b	CLIP-seq
MIRT2532479	hsa-miR-376c	CLIP-seq
MIRT2532480	hsa-miR-3907	CLIP-seq
MIRT2532481	hsa-miR-3918	CLIP-seq
MIRT2532482	hsa-miR-3944-5p	CLIP-seq
MIRT2532483	hsa-miR-424	CLIP-seq
MIRT2228930	hsa-miR-4252	CLIP-seq
MIRT2532484	hsa-miR-4282	CLIP-seq
MIRT2532485	hsa-miR-4318	CLIP-seq
MIRT2532486	hsa-miR-4420	CLIP-seq
MIRT2532487	hsa-miR-4429	CLIP-seq
MIRT2532488	hsa-miR-4436b-3p	CLIP-seq
MIRT2532489	hsa-miR-4469	CLIP-seq
MIRT2532490	hsa-miR-4511	CLIP-seq
MIRT2532491	hsa-miR-4524	CLIP-seq
MIRT1994771	hsa-miR-455-3p	CLIP-seq
MIRT994049	hsa-miR-4659a-3p	CLIP-seq
MIRT994050	hsa-miR-4659b-3p	CLIP-seq
MIRT2532492	hsa-miR-4660	CLIP-seq
MIRT1548682	hsa-miR-4667-3p	CLIP-seq
MIRT1994774	hsa-miR-4668-3p	CLIP-seq
MIRT2532493	hsa-miR-4691-5p	CLIP-seq
MIRT2532494	hsa-miR-4732-3p	CLIP-seq
MIRT2532495	hsa-miR-4733-3p	CLIP-seq
MIRT2532496	hsa-miR-4793-3p	CLIP-seq
MIRT2532497	hsa-miR-4795-5p	CLIP-seq
MIRT2532498	hsa-miR-497	CLIP-seq
MIRT2532499	hsa-miR-500a	CLIP-seq
MIRT2532500	hsa-miR-503	CLIP-seq
MIRT2532501	hsa-miR-511	CLIP-seq
MIRT994058	hsa-miR-513a-3p	CLIP-seq
MIRT1994779	hsa-miR-548c-3p	CLIP-seq
MIRT2532502	hsa-miR-549	CLIP-seq
MIRT2532503	hsa-miR-573	CLIP-seq
MIRT1994783	hsa-miR-605	CLIP-seq
MIRT2532504	hsa-miR-615-3p	CLIP-seq
MIRT994061	hsa-miR-631	CLIP-seq
MIRT2532505	hsa-miR-642b	CLIP-seq
MIRT2532506	hsa-miR-646	CLIP-seq
MIRT2532507	hsa-miR-668	CLIP-seq
MIRT2532508	hsa-miR-933	CLIP-seq
MIRT994063	hsa-miR-935	CLIP-seq
MIRT1994756	hsa-miR-1197	CLIP-seq
MIRT1994757	hsa-miR-1208	CLIP-seq
MIRT2532450	hsa-miR-1238	CLIP-seq
MIRT2532451	hsa-miR-1245	CLIP-seq
MIRT2680915	hsa-miR-1264	CLIP-seq
MIRT1994758	hsa-miR-133a	CLIP-seq
MIRT1994759	hsa-miR-133b	CLIP-seq
MIRT2532453	hsa-miR-1343	CLIP-seq
MIRT2680916	hsa-miR-155	CLIP-seq
MIRT2532457	hsa-miR-1909	CLIP-seq
MIRT2532458	hsa-miR-1910	CLIP-seq
MIRT1994761	hsa-miR-205	CLIP-seq
MIRT2680917	hsa-miR-210	CLIP-seq
MIRT2532462	hsa-miR-3065-5p	CLIP-seq
MIRT2532463	hsa-miR-3074-5p	CLIP-seq
MIRT2532464	hsa-miR-3127-5p	CLIP-seq
MIRT2228928	hsa-miR-3133	CLIP-seq
MIRT1994763	hsa-miR-3144-5p	CLIP-seq
MIRT2680918	hsa-miR-3190	CLIP-seq
MIRT1994765	hsa-miR-3191	CLIP-seq
MIRT2532468	hsa-miR-320a	CLIP-seq
MIRT2532469	hsa-miR-320b	CLIP-seq
MIRT2532470	hsa-miR-320c	CLIP-seq
MIRT2532471	hsa-miR-320d	CLIP-seq
MIRT2532472	hsa-miR-320e	CLIP-seq
MIRT2532473	hsa-miR-3616-5p	CLIP-seq
MIRT2532474	hsa-miR-3647-5p	CLIP-seq
MIRT2532475	hsa-miR-3662	CLIP-seq
MIRT2680919	hsa-miR-374c	CLIP-seq
MIRT2532477	hsa-miR-376a	CLIP-seq
MIRT2532478	hsa-miR-376b	CLIP-seq
MIRT2532479	hsa-miR-376c	CLIP-seq
MIRT2532480	hsa-miR-3907	CLIP-seq
MIRT2532481	hsa-miR-3918	CLIP-seq
MIRT2532482	hsa-miR-3944-5p	CLIP-seq
MIRT2532484	hsa-miR-4282	CLIP-seq
MIRT2532486	hsa-miR-4420	CLIP-seq
MIRT2532487	hsa-miR-4429	CLIP-seq
MIRT2532488	hsa-miR-4436b-3p	CLIP-seq
MIRT2532490	hsa-miR-4511	CLIP-seq
MIRT1994771	hsa-miR-455-3p	CLIP-seq
MIRT1994773	hsa-miR-4652-5p	CLIP-seq
MIRT994049	hsa-miR-4659a-3p	CLIP-seq
MIRT994050	hsa-miR-4659b-3p	CLIP-seq
MIRT1994774	hsa-miR-4668-3p	CLIP-seq
MIRT2532493	hsa-miR-4691-5p	CLIP-seq
MIRT2680920	hsa-miR-4752	CLIP-seq
MIRT2532497	hsa-miR-4795-5p	CLIP-seq
MIRT2532499	hsa-miR-500a	CLIP-seq
MIRT2532501	hsa-miR-511	CLIP-seq
MIRT994058	hsa-miR-513a-3p	CLIP-seq
MIRT1994779	hsa-miR-548c-3p	CLIP-seq
MIRT2532502	hsa-miR-549	CLIP-seq
MIRT2680921	hsa-miR-569	CLIP-seq
MIRT2532503	hsa-miR-573	CLIP-seq
MIRT1994782	hsa-miR-576-3p	CLIP-seq
MIRT1994783	hsa-miR-605	CLIP-seq
MIRT2532505	hsa-miR-642b	CLIP-seq
MIRT2680922	hsa-miR-655	CLIP-seq
MIRT2532507	hsa-miR-668	CLIP-seq
MIRT2680923	hsa-miR-7	CLIP-seq
MIRT2532508	hsa-miR-933	CLIP-seq
MIRT994063	hsa-miR-935	CLIP-seq

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	14627983, 18654987, 21516116, 25416956, 29887380, 31515488
GO:0005547	Function	Phosphatidylinositol-3,4,5-trisphosphate binding	IDA	29887380
GO:0005886	Component	Plasma membrane	IDA	29887380
GO:0005905	Component	Clathrin-coated pit	IDA	29887380
GO:0007274	Process	Neuromuscular synaptic transmission	IBA	21873635
GO:0015031	Process	Protein transport	IEA
GO:0030833	Process	Regulation of actin filament polymerization	IBA	21873635
GO:0030838	Process	Positive regulation of actin filament polymerization	ISS
GO:0031594	Component	Neuromuscular junction	IBA	21873635
GO:0043325	Function	Phosphatidylinositol-3,4-bisphosphate binding	IDA	29887380
GO:0055037	Component	Recycling endosome	IBA	21873635
GO:0072583	Process	Clathrin-dependent endocytosis	IMP	29887380
GO:0120043	Component	Stereocilium shaft	ISS
GO:2000601	Process	Positive regulation of Arp2/3 complex-mediated actin nucleation	IMP	29887380

MIM	HGNC	e!Ensembl
617556	29114	ENSG00000137478

Protein

UniProt ID

O94868

Protein name

F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3)

Protein function

Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer ce

PDB

2DL5 , 2DL7 , 6GBU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00611	FCH	21 → 103	Fes/CIP4, and EFC/F-BAR homology domain	Family
PF00018	SH3_1	475 → 522	SH3 domain	Domain
PF14604	SH3_9	574 → 625	Variant SH3 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney. {ECO:0000269|PubMed:14627983}.

Sequence

MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKL
ASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENYKNFISEPARTVR
SLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLF
QSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGN
VYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQ
FQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVS
EQSRAELEQKIDEARENIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENE
RWARPPAVTSNGTLHSLNADTEREEGEEFEDNMDVFDDSSSSPSGTLRNYPLTCKVVYSY
KASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNSLLSMLQSL
AALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGAIIRILNKE
NQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTPWMREIQISPSPKPHASLPPLPLYD
QPPSSPYPSPDKRSSLYFPRSPSANEKSLHAESPGFSQASRHTPETSYGKLRPVRAAPPP
PTQNHRRPAEKIEDVEITLV

Sequence length

740

Interactions

View interactions

Show/Hide Causal Diseases (3)

Disease term	Disease name	dbSNP ID	References
Causal
Arthritis	Juvenile arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	19565504
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237 View all (293 more)	22885922
Endometrial carcinoma	Endometrial Carcinoma	rs34612342, rs587776667, rs587776701, rs63750955, rs587776706, rs121434629, rs80359605, rs121913530, rs104894365, rs79184941, rs121913478, rs63750781, rs193922343, rs267608094, rs267608077 View all (247 more)	30093612

Show/Hide Unknown Diseases (5)

Disease term	Disease name	References	Source
Unknown
Crohn disease	Crohn Disease	23266558	ClinVar
Systemic lupus erythematosus	Systemic lupus erythematosus		GWAS
Crohn Disease	Crohn Disease		GWAS
Psoriasis	Psoriasis		GWAS
Insomnia	Insomnia		GWAS

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinoma Non Small Cell Lung	Associate	30249660, 32678845
Fetal Diseases	Associate	36585686
Heart Diseases	Associate	37542143
Lupus Erythematosus Systemic	Associate	26663301
Neoplasms	Inhibit	30249660
Neoplasms	Associate	32678845

FCHSD2 (FCH and double SH3 domains 2)