FCHSD2 (FCH and double SH3 domains 2)

Gene

• Entrez ID: 9873
• Gene name: FCH and double SH3 domains 2
• Gene symbol: FCHSD2
• Synonyms (NCBI Gene): NWK, NWK1, SH3MD3
• Chromosome: 11
• Chromosome location: 11q13.4

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023044	hsa-miR-124-3p	Microarray	18668037
MIRT658157	hsa-miR-449b-3p	HITS-CLIP	23824327
MIRT658155	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT658156	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT658154	hsa-miR-4662a-5p	HITS-CLIP	23824327
MIRT658153	hsa-miR-4474-5p	HITS-CLIP	23824327
MIRT060652	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT658152	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT023044	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT567588	hsa-miR-548an	PAR-CLIP	20371350
MIRT567587	hsa-miR-3622a-5p	PAR-CLIP	20371350
MIRT567586	hsa-miR-6074	PAR-CLIP	20371350
MIRT567584	hsa-miR-4272	PAR-CLIP	20371350
MIRT567585	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT567583	hsa-miR-1323	PAR-CLIP	20371350
MIRT567582	hsa-miR-548o-3p	PAR-CLIP	20371350
MIRT131512	hsa-miR-4668-5p	PAR-CLIP	20371350
MIRT440647	hsa-miR-210-3p	HITS-CLIP	22473208
MIRT440647	hsa-miR-210-3p	HITS-CLIP	22473208
MIRT727661	hsa-miR-27a-3p	HITS-CLIP	22473208
MIRT727659	hsa-miR-27b-3p	HITS-CLIP	22473208
MIRT658157	hsa-miR-449b-3p	HITS-CLIP	23824327
MIRT658155	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT658156	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT658154	hsa-miR-4662a-5p	HITS-CLIP	23824327
MIRT658153	hsa-miR-4474-5p	HITS-CLIP	23824327
MIRT060652	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT658152	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT023044	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT567588	hsa-miR-548an	PAR-CLIP	20371350
MIRT567587	hsa-miR-3622a-5p	PAR-CLIP	20371350
MIRT567586	hsa-miR-6074	PAR-CLIP	20371350
MIRT567584	hsa-miR-4272	PAR-CLIP	20371350
MIRT567585	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT567583	hsa-miR-1323	PAR-CLIP	20371350
MIRT567582	hsa-miR-548o-3p	PAR-CLIP	20371350
MIRT131512	hsa-miR-4668-5p	PAR-CLIP	20371350
MIRT994026	hsa-miR-1193	CLIP-seq
MIRT994027	hsa-miR-1258	CLIP-seq
MIRT994028	hsa-miR-128	CLIP-seq
MIRT994029	hsa-miR-1913	CLIP-seq
MIRT994030	hsa-miR-219-5p	CLIP-seq
MIRT994031	hsa-miR-2276	CLIP-seq
MIRT994032	hsa-miR-27a	CLIP-seq
MIRT994033	hsa-miR-27b	CLIP-seq
MIRT994034	hsa-miR-324-3p	CLIP-seq
MIRT994035	hsa-miR-3616-3p	CLIP-seq
MIRT994036	hsa-miR-362-5p	CLIP-seq
MIRT994037	hsa-miR-3649	CLIP-seq
MIRT994038	hsa-miR-3661	CLIP-seq
MIRT994039	hsa-miR-3674	CLIP-seq
MIRT994040	hsa-miR-3692	CLIP-seq
MIRT994041	hsa-miR-3935	CLIP-seq
MIRT994042	hsa-miR-421	CLIP-seq
MIRT994043	hsa-miR-4274	CLIP-seq
MIRT994044	hsa-miR-4313	CLIP-seq
MIRT994045	hsa-miR-4423-3p	CLIP-seq
MIRT994046	hsa-miR-4445	CLIP-seq
MIRT994047	hsa-miR-4446-3p	CLIP-seq
MIRT994048	hsa-miR-4519	CLIP-seq
MIRT994049	hsa-miR-4659a-3p	CLIP-seq
MIRT994050	hsa-miR-4659b-3p	CLIP-seq
MIRT994051	hsa-miR-4721	CLIP-seq
MIRT994052	hsa-miR-4772-3p	CLIP-seq
MIRT994053	hsa-miR-4782-3p	CLIP-seq
MIRT994054	hsa-miR-4795-3p	CLIP-seq
MIRT994055	hsa-miR-492	CLIP-seq
MIRT994056	hsa-miR-500b	CLIP-seq
MIRT994057	hsa-miR-508-3p	CLIP-seq
MIRT994058	hsa-miR-513a-3p	CLIP-seq
MIRT994059	hsa-miR-544	CLIP-seq
MIRT994060	hsa-miR-619	CLIP-seq
MIRT994061	hsa-miR-631	CLIP-seq
MIRT994062	hsa-miR-671-5p	CLIP-seq
MIRT994063	hsa-miR-935	CLIP-seq
MIRT1548681	hsa-miR-1470	CLIP-seq
MIRT1548682	hsa-miR-4667-3p	CLIP-seq
MIRT1994756	hsa-miR-1197	CLIP-seq
MIRT1994757	hsa-miR-1208	CLIP-seq
MIRT994028	hsa-miR-128	CLIP-seq
MIRT1994758	hsa-miR-133a	CLIP-seq
MIRT1994759	hsa-miR-133b	CLIP-seq
MIRT1994760	hsa-miR-1972	CLIP-seq
MIRT1994761	hsa-miR-205	CLIP-seq
MIRT994032	hsa-miR-27a	CLIP-seq
MIRT994033	hsa-miR-27b	CLIP-seq
MIRT1994762	hsa-miR-3130-5p	CLIP-seq
MIRT1994763	hsa-miR-3144-5p	CLIP-seq
MIRT1994764	hsa-miR-3185	CLIP-seq
MIRT1994765	hsa-miR-3191	CLIP-seq
MIRT994036	hsa-miR-362-5p	CLIP-seq
MIRT1994766	hsa-miR-3689a-3p	CLIP-seq
MIRT1994767	hsa-miR-3689c	CLIP-seq
MIRT1994768	hsa-miR-4294	CLIP-seq
MIRT1994769	hsa-miR-4482	CLIP-seq
MIRT1994770	hsa-miR-4506	CLIP-seq
MIRT1994771	hsa-miR-455-3p	CLIP-seq
MIRT1994772	hsa-miR-4635	CLIP-seq
MIRT1994773	hsa-miR-4652-5p	CLIP-seq
MIRT994049	hsa-miR-4659a-3p	CLIP-seq
MIRT994050	hsa-miR-4659b-3p	CLIP-seq
MIRT1994774	hsa-miR-4668-3p	CLIP-seq
MIRT1994775	hsa-miR-4704-3p	CLIP-seq
MIRT1994776	hsa-miR-4709-3p	CLIP-seq
MIRT1994777	hsa-miR-4717-5p	CLIP-seq
MIRT1994778	hsa-miR-4728-5p	CLIP-seq
MIRT994056	hsa-miR-500b	CLIP-seq
MIRT1994779	hsa-miR-548c-3p	CLIP-seq
MIRT1994780	hsa-miR-548o	CLIP-seq
MIRT1994781	hsa-miR-548p	CLIP-seq
MIRT1994782	hsa-miR-576-3p	CLIP-seq
MIRT1994783	hsa-miR-605	CLIP-seq
MIRT1994784	hsa-miR-765	CLIP-seq
MIRT994063	hsa-miR-935	CLIP-seq
MIRT2228926	hsa-miR-1183	CLIP-seq
MIRT1994757	hsa-miR-1208	CLIP-seq
MIRT994028	hsa-miR-128	CLIP-seq
MIRT2228927	hsa-miR-186	CLIP-seq
MIRT994032	hsa-miR-27a	CLIP-seq
MIRT994033	hsa-miR-27b	CLIP-seq
MIRT2228928	hsa-miR-3133	CLIP-seq
MIRT2228929	hsa-miR-3607-3p	CLIP-seq
MIRT994036	hsa-miR-362-5p	CLIP-seq
MIRT2228930	hsa-miR-4252	CLIP-seq
MIRT2228931	hsa-miR-4691-3p	CLIP-seq
MIRT994056	hsa-miR-500b	CLIP-seq
MIRT994038	hsa-miR-3661	CLIP-seq
MIRT994061	hsa-miR-631	CLIP-seq
MIRT2532449	hsa-miR-1233	CLIP-seq
MIRT2532450	hsa-miR-1238	CLIP-seq
MIRT2532451	hsa-miR-1245	CLIP-seq
MIRT2532452	hsa-miR-1287	CLIP-seq
MIRT1994758	hsa-miR-133a	CLIP-seq
MIRT1994759	hsa-miR-133b	CLIP-seq
MIRT2532453	hsa-miR-1343	CLIP-seq
MIRT1548681	hsa-miR-1470	CLIP-seq
MIRT2532454	hsa-miR-15a	CLIP-seq
MIRT2532455	hsa-miR-15b	CLIP-seq
MIRT2532456	hsa-miR-16	CLIP-seq
MIRT2228927	hsa-miR-186	CLIP-seq
MIRT2532457	hsa-miR-1909	CLIP-seq
MIRT2532458	hsa-miR-1910	CLIP-seq
MIRT2532459	hsa-miR-1914	CLIP-seq
MIRT2532460	hsa-miR-195	CLIP-seq
MIRT1994761	hsa-miR-205	CLIP-seq
MIRT2532461	hsa-miR-2467-5p	CLIP-seq
MIRT2532462	hsa-miR-3065-5p	CLIP-seq
MIRT2532463	hsa-miR-3074-5p	CLIP-seq
MIRT2532464	hsa-miR-3127-5p	CLIP-seq
MIRT2532465	hsa-miR-3130-3p	CLIP-seq
MIRT2228928	hsa-miR-3133	CLIP-seq
MIRT2532466	hsa-miR-3135b	CLIP-seq
MIRT2532467	hsa-miR-3163	CLIP-seq
MIRT2532468	hsa-miR-320a	CLIP-seq
MIRT2532469	hsa-miR-320b	CLIP-seq
MIRT2532470	hsa-miR-320c	CLIP-seq
MIRT2532471	hsa-miR-320d	CLIP-seq
MIRT2532472	hsa-miR-320e	CLIP-seq
MIRT2228929	hsa-miR-3607-3p	CLIP-seq
MIRT2532473	hsa-miR-3616-5p	CLIP-seq
MIRT2532474	hsa-miR-3647-5p	CLIP-seq
MIRT994038	hsa-miR-3661	CLIP-seq
MIRT2532475	hsa-miR-3662	CLIP-seq
MIRT2532476	hsa-miR-3667-3p	CLIP-seq
MIRT2532477	hsa-miR-376a	CLIP-seq
MIRT2532478	hsa-miR-376b	CLIP-seq
MIRT2532479	hsa-miR-376c	CLIP-seq
MIRT2532480	hsa-miR-3907	CLIP-seq
MIRT2532481	hsa-miR-3918	CLIP-seq
MIRT2532482	hsa-miR-3944-5p	CLIP-seq
MIRT2532483	hsa-miR-424	CLIP-seq
MIRT2228930	hsa-miR-4252	CLIP-seq
MIRT2532484	hsa-miR-4282	CLIP-seq
MIRT2532485	hsa-miR-4318	CLIP-seq
MIRT2532486	hsa-miR-4420	CLIP-seq
MIRT2532487	hsa-miR-4429	CLIP-seq
MIRT2532488	hsa-miR-4436b-3p	CLIP-seq
MIRT2532489	hsa-miR-4469	CLIP-seq
MIRT2532490	hsa-miR-4511	CLIP-seq
MIRT2532491	hsa-miR-4524	CLIP-seq
MIRT1994771	hsa-miR-455-3p	CLIP-seq
MIRT994049	hsa-miR-4659a-3p	CLIP-seq
MIRT994050	hsa-miR-4659b-3p	CLIP-seq
MIRT2532492	hsa-miR-4660	CLIP-seq
MIRT1548682	hsa-miR-4667-3p	CLIP-seq
MIRT1994774	hsa-miR-4668-3p	CLIP-seq
MIRT2532493	hsa-miR-4691-5p	CLIP-seq
MIRT2532494	hsa-miR-4732-3p	CLIP-seq
MIRT2532495	hsa-miR-4733-3p	CLIP-seq
MIRT2532496	hsa-miR-4793-3p	CLIP-seq
MIRT2532497	hsa-miR-4795-5p	CLIP-seq
MIRT2532498	hsa-miR-497	CLIP-seq
MIRT2532499	hsa-miR-500a	CLIP-seq
MIRT2532500	hsa-miR-503	CLIP-seq
MIRT2532501	hsa-miR-511	CLIP-seq
MIRT994058	hsa-miR-513a-3p	CLIP-seq
MIRT1994779	hsa-miR-548c-3p	CLIP-seq
MIRT2532502	hsa-miR-549	CLIP-seq
MIRT2532503	hsa-miR-573	CLIP-seq
MIRT1994783	hsa-miR-605	CLIP-seq
MIRT2532504	hsa-miR-615-3p	CLIP-seq
MIRT994061	hsa-miR-631	CLIP-seq
MIRT2532505	hsa-miR-642b	CLIP-seq
MIRT2532506	hsa-miR-646	CLIP-seq
MIRT2532507	hsa-miR-668	CLIP-seq
MIRT2532508	hsa-miR-933	CLIP-seq
MIRT994063	hsa-miR-935	CLIP-seq
MIRT1994756	hsa-miR-1197	CLIP-seq
MIRT1994757	hsa-miR-1208	CLIP-seq
MIRT2532450	hsa-miR-1238	CLIP-seq
MIRT2532451	hsa-miR-1245	CLIP-seq
MIRT2680915	hsa-miR-1264	CLIP-seq
MIRT1994758	hsa-miR-133a	CLIP-seq
MIRT1994759	hsa-miR-133b	CLIP-seq
MIRT2532453	hsa-miR-1343	CLIP-seq
MIRT2680916	hsa-miR-155	CLIP-seq
MIRT2532457	hsa-miR-1909	CLIP-seq
MIRT2532458	hsa-miR-1910	CLIP-seq
MIRT1994761	hsa-miR-205	CLIP-seq
MIRT2680917	hsa-miR-210	CLIP-seq
MIRT2532462	hsa-miR-3065-5p	CLIP-seq
MIRT2532463	hsa-miR-3074-5p	CLIP-seq
MIRT2532464	hsa-miR-3127-5p	CLIP-seq
MIRT2228928	hsa-miR-3133	CLIP-seq
MIRT1994763	hsa-miR-3144-5p	CLIP-seq
MIRT2680918	hsa-miR-3190	CLIP-seq
MIRT1994765	hsa-miR-3191	CLIP-seq
MIRT2532468	hsa-miR-320a	CLIP-seq
MIRT2532469	hsa-miR-320b	CLIP-seq
MIRT2532470	hsa-miR-320c	CLIP-seq
MIRT2532471	hsa-miR-320d	CLIP-seq
MIRT2532472	hsa-miR-320e	CLIP-seq
MIRT2532473	hsa-miR-3616-5p	CLIP-seq
MIRT2532474	hsa-miR-3647-5p	CLIP-seq
MIRT2532475	hsa-miR-3662	CLIP-seq
MIRT2680919	hsa-miR-374c	CLIP-seq
MIRT2532477	hsa-miR-376a	CLIP-seq
MIRT2532478	hsa-miR-376b	CLIP-seq
MIRT2532479	hsa-miR-376c	CLIP-seq
MIRT2532480	hsa-miR-3907	CLIP-seq
MIRT2532481	hsa-miR-3918	CLIP-seq
MIRT2532482	hsa-miR-3944-5p	CLIP-seq
MIRT2532484	hsa-miR-4282	CLIP-seq
MIRT2532486	hsa-miR-4420	CLIP-seq
MIRT2532487	hsa-miR-4429	CLIP-seq
MIRT2532488	hsa-miR-4436b-3p	CLIP-seq
MIRT2532490	hsa-miR-4511	CLIP-seq
MIRT1994771	hsa-miR-455-3p	CLIP-seq
MIRT1994773	hsa-miR-4652-5p	CLIP-seq
MIRT994049	hsa-miR-4659a-3p	CLIP-seq
MIRT994050	hsa-miR-4659b-3p	CLIP-seq
MIRT1994774	hsa-miR-4668-3p	CLIP-seq
MIRT2532493	hsa-miR-4691-5p	CLIP-seq
MIRT2680920	hsa-miR-4752	CLIP-seq
MIRT2532497	hsa-miR-4795-5p	CLIP-seq
MIRT2532499	hsa-miR-500a	CLIP-seq
MIRT2532501	hsa-miR-511	CLIP-seq
MIRT994058	hsa-miR-513a-3p	CLIP-seq
MIRT1994779	hsa-miR-548c-3p	CLIP-seq
MIRT2532502	hsa-miR-549	CLIP-seq
MIRT2680921	hsa-miR-569	CLIP-seq
MIRT2532503	hsa-miR-573	CLIP-seq
MIRT1994782	hsa-miR-576-3p	CLIP-seq
MIRT1994783	hsa-miR-605	CLIP-seq
MIRT2532505	hsa-miR-642b	CLIP-seq
MIRT2680922	hsa-miR-655	CLIP-seq
MIRT2532507	hsa-miR-668	CLIP-seq
MIRT2680923	hsa-miR-7	CLIP-seq
MIRT2532508	hsa-miR-933	CLIP-seq
MIRT994063	hsa-miR-935	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	14627983, 18654987, 21516116, 25416956, 26871637, 29887380, 31515488, 32296183, 32814053
GO:0005547	Function	Phosphatidylinositol-3,4,5-trisphosphate binding	IDA	29887380
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IDA	29887380
GO:0005886	Component	Plasma membrane	IEA
GO:0005905	Component	Clathrin-coated pit	IDA	29887380
GO:0005905	Component	Clathrin-coated pit	IEA
GO:0006897	Process	Endocytosis	IEA
GO:0007274	Process	Neuromuscular synaptic transmission	IBA
GO:0008289	Function	Lipid binding	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0030833	Process	Regulation of actin filament polymerization	IBA
GO:0030838	Process	Positive regulation of actin filament polymerization	IEA
GO:0030838	Process	Positive regulation of actin filament polymerization	ISS
GO:0031594	Component	Neuromuscular junction	IBA
GO:0032420	Component	Stereocilium	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043325	Function	Phosphatidylinositol-3,4-bisphosphate binding	IDA	29887380
GO:0051495	Process	Positive regulation of cytoskeleton organization	IEA
GO:0055037	Component	Recycling endosome	IBA
GO:0061024	Process	Membrane organization	IEA
GO:0070161	Component	Anchoring junction	IEA
GO:0072583	Process	Clathrin-dependent endocytosis	IMP	29887380
GO:0110053	Process	Regulation of actin filament organization	IEA
GO:0120043	Component	Stereocilium shaft	IEA
GO:0120043	Component	Stereocilium shaft	ISS
GO:1902905	Process	Positive regulation of supramolecular fiber organization	IEA
GO:2000601	Process	Positive regulation of Arp2/3 complex-mediated actin nucleation	IMP	29887380

Other IDs

• MIM: 617556
• HGNC: 29114
• e!Ensembl: ENSG00000137478

Protein

• UniProt ID: O94868
• Protein name: F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3)
• Protein function: Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer ce
• PDB: 2DL5, 2DL7, 6GBU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00611	FCH	21 → 103	Fes/CIP4, and EFC/F-BAR homology domain	Family
  PF00018	SH3_1	475 → 522	SH3 domain	Domain
  PF14604	SH3_9	574 → 625	Variant SH3 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney. {ECO:0000269|PubMed:14627983}.
• Sequence:

  MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKL
  ASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENYKNFISEPARTVR
  SLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLF
  QSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGN
  VYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQ
  FQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVS
  EQSRAELEQKIDEARENIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENE
  RWARPPAVTSNGTLHSLNADTEREEGEEFEDNMDVFDDSSSSPSGTLRNYPLTCKVVYSY
  KASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNSLLSMLQSL
  AALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGAIIRILNKE
  NQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTPWMREIQISPSPKPHASLPPLPLYD
  QPPSSPYPSPDKRSSLYFPRSPSANEKSLHAESPGFSQASRHTPETSYGKLRPVRAAPPP
  PTQNHRRPAEKIEDVEITLV

• Sequence length: 740