Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9870
Gene name	Apoptosis resistant E3 ubiquitin protein ligase 1
Gene symbol	AREL1
Synonyms (NCBI Gene)	FIEL1KIAA0317
Chromosome	14
Chromosome location	14q24.3

136

Show/Hide all (136)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016243	hsa-miR-548b-3p	Sequencing	20371350
MIRT016609	hsa-miR-193b-3p	Microarray	20304954
MIRT626037	hsa-miR-100-3p	HITS-CLIP	23824327
MIRT280167	hsa-miR-1470	HITS-CLIP	23824327
MIRT380488	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT660561	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT660560	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT626036	hsa-miR-4469	HITS-CLIP	23824327
MIRT626035	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT626034	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT626033	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT626032	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT626031	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT626030	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT660559	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT660558	hsa-miR-1200	HITS-CLIP	23824327
MIRT660557	hsa-miR-4279	HITS-CLIP	23824327
MIRT626037	hsa-miR-100-3p	HITS-CLIP	23824327
MIRT280161	hsa-miR-3168	HITS-CLIP	23824327
MIRT280158	hsa-miR-148b-5p	HITS-CLIP	23824327
MIRT280165	hsa-miR-6874-3p	HITS-CLIP	23824327
MIRT280164	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT280167	hsa-miR-1470	HITS-CLIP	23824327
MIRT380488	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT626036	hsa-miR-4469	HITS-CLIP	23824327
MIRT626035	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT626034	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT626033	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT626032	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT626031	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT626030	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT539156	hsa-miR-497-3p	PAR-CLIP	22012620
MIRT539155	hsa-miR-495-3p	PAR-CLIP	22012620
MIRT539154	hsa-miR-5688	PAR-CLIP	22012620
MIRT539153	hsa-miR-7-1-3p	PAR-CLIP	22012620
MIRT539152	hsa-miR-7-2-3p	PAR-CLIP	22012620
MIRT539151	hsa-miR-371b-3p	PAR-CLIP	22012620
MIRT539150	hsa-miR-371a-3p	PAR-CLIP	22012620
MIRT539149	hsa-miR-33b-3p	PAR-CLIP	22012620
MIRT539148	hsa-miR-515-3p	PAR-CLIP	22012620
MIRT539147	hsa-miR-519e-3p	PAR-CLIP	22012620
MIRT539146	hsa-miR-302c-5p	PAR-CLIP	22012620
MIRT495107	hsa-miR-6507-3p	PAR-CLIP	23708386
MIRT495108	hsa-miR-3910	PAR-CLIP	23708386
MIRT495106	hsa-miR-4695-5p	PAR-CLIP	23708386
MIRT495105	hsa-miR-4459	PAR-CLIP	23708386
MIRT495104	hsa-miR-4317	PAR-CLIP	23708386
MIRT495103	hsa-miR-1256	PAR-CLIP	23708386
MIRT495102	hsa-miR-192-3p	PAR-CLIP	23708386
MIRT481657	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT481656	hsa-let-7a-5p	PAR-CLIP	23592263
MIRT481655	hsa-let-7b-5p	PAR-CLIP	23592263
MIRT481654	hsa-let-7c-5p	PAR-CLIP	23592263
MIRT481653	hsa-let-7d-5p	PAR-CLIP	23592263
MIRT481652	hsa-let-7e-5p	PAR-CLIP	23592263
MIRT481651	hsa-let-7f-5p	PAR-CLIP	23592263
MIRT481650	hsa-let-7g-5p	PAR-CLIP	23592263
MIRT481649	hsa-let-7i-5p	PAR-CLIP	23592263
MIRT481648	hsa-miR-4458	PAR-CLIP	23592263
MIRT481647	hsa-miR-4500	PAR-CLIP	23592263
MIRT481646	hsa-miR-98-5p	PAR-CLIP	23592263
MIRT481645	hsa-miR-202-3p	PAR-CLIP	23592263
MIRT481644	hsa-miR-3665	PAR-CLIP	23592263
MIRT481642	hsa-miR-6081	PAR-CLIP	23592263
MIRT481643	hsa-miR-4710	PAR-CLIP	23592263
MIRT481641	hsa-miR-4504	PAR-CLIP	23592263
MIRT481640	hsa-miR-1294	PAR-CLIP	23592263
MIRT481639	hsa-miR-6800-5p	PAR-CLIP	23592263
MIRT481638	hsa-miR-135b-3p	PAR-CLIP	23592263
MIRT626037	hsa-miR-100-3p	HITS-CLIP	23824327
MIRT280167	hsa-miR-1470	HITS-CLIP	23824327
MIRT380488	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT660561	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT660560	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT626036	hsa-miR-4469	HITS-CLIP	23824327
MIRT626035	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT626034	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT626033	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT626032	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT626031	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT626030	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT660559	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT660558	hsa-miR-1200	HITS-CLIP	23824327
MIRT660557	hsa-miR-4279	HITS-CLIP	23824327
MIRT626037	hsa-miR-100-3p	HITS-CLIP	23824327
MIRT280161	hsa-miR-3168	HITS-CLIP	23824327
MIRT280158	hsa-miR-148b-5p	HITS-CLIP	23824327
MIRT280165	hsa-miR-6874-3p	HITS-CLIP	23824327
MIRT280164	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT280167	hsa-miR-1470	HITS-CLIP	23824327
MIRT380488	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT626036	hsa-miR-4469	HITS-CLIP	23824327
MIRT626035	hsa-miR-516a-3p	HITS-CLIP	23824327
MIRT626034	hsa-miR-516b-3p	HITS-CLIP	23824327
MIRT626033	hsa-miR-7162-5p	HITS-CLIP	23824327
MIRT626032	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT626031	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT626030	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT539156	hsa-miR-497-3p	PAR-CLIP	22012620
MIRT539155	hsa-miR-495-3p	PAR-CLIP	22012620
MIRT539154	hsa-miR-5688	PAR-CLIP	22012620
MIRT539153	hsa-miR-7-1-3p	PAR-CLIP	22012620
MIRT539152	hsa-miR-7-2-3p	PAR-CLIP	22012620
MIRT539151	hsa-miR-371b-3p	PAR-CLIP	22012620
MIRT539150	hsa-miR-371a-3p	PAR-CLIP	22012620
MIRT539149	hsa-miR-33b-3p	PAR-CLIP	22012620
MIRT539148	hsa-miR-515-3p	PAR-CLIP	22012620
MIRT539147	hsa-miR-519e-3p	PAR-CLIP	22012620
MIRT539146	hsa-miR-302c-5p	PAR-CLIP	22012620
MIRT495107	hsa-miR-6507-3p	PAR-CLIP	23708386
MIRT495108	hsa-miR-3910	PAR-CLIP	23708386
MIRT495106	hsa-miR-4695-5p	PAR-CLIP	23708386
MIRT495105	hsa-miR-4459	PAR-CLIP	23708386
MIRT495104	hsa-miR-4317	PAR-CLIP	23708386
MIRT495103	hsa-miR-1256	PAR-CLIP	23708386
MIRT495102	hsa-miR-192-3p	PAR-CLIP	23708386
MIRT481657	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT481656	hsa-let-7a-5p	PAR-CLIP	23592263
MIRT481655	hsa-let-7b-5p	PAR-CLIP	23592263
MIRT481654	hsa-let-7c-5p	PAR-CLIP	23592263
MIRT481653	hsa-let-7d-5p	PAR-CLIP	23592263
MIRT481652	hsa-let-7e-5p	PAR-CLIP	23592263
MIRT481651	hsa-let-7f-5p	PAR-CLIP	23592263
MIRT481650	hsa-let-7g-5p	PAR-CLIP	23592263
MIRT481649	hsa-let-7i-5p	PAR-CLIP	23592263
MIRT481648	hsa-miR-4458	PAR-CLIP	23592263
MIRT481647	hsa-miR-4500	PAR-CLIP	23592263
MIRT481646	hsa-miR-98-5p	PAR-CLIP	23592263
MIRT481645	hsa-miR-202-3p	PAR-CLIP	23592263
MIRT481644	hsa-miR-3665	PAR-CLIP	23592263
MIRT481642	hsa-miR-6081	PAR-CLIP	23592263
MIRT481643	hsa-miR-4710	PAR-CLIP	23592263
MIRT481641	hsa-miR-4504	PAR-CLIP	23592263
MIRT481640	hsa-miR-1294	PAR-CLIP	23592263
MIRT481639	hsa-miR-6800-5p	PAR-CLIP	23592263
MIRT481638	hsa-miR-135b-3p	PAR-CLIP	23592263

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	23479728
GO:0004842	Function	Ubiquitin-protein transferase activity	IEA
GO:0005515	Function	Protein binding	IPI	23479728, 31578312
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	23479728
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	23479728
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0016567	Process	Protein ubiquitination	IDA	31578312
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IBA
GO:0043066	Process	Negative regulation of apoptotic process	IDA	23479728
GO:0050727	Process	Regulation of inflammatory response	IEA
GO:0050727	Process	Regulation of inflammatory response	ISS
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	25752577
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0070979	Process	Protein K11-linked ubiquitination	IDA	25752577
GO:1990390	Process	Protein K33-linked ubiquitination	IDA	25752577

MIM	HGNC	e!Ensembl
615380	20363	ENSG00000119682

O15033

Protein name

Apoptosis-resistant E3 ubiquitin protein ligase 1 (EC 2.3.2.26) (Apoptosis-resistant HECT-type E3 ubiquitin transferase 1)

Protein function

E3 ubiquitin-protein ligase that catalyzes 'Lys-11'- or 'Lys-33'-linked polyubiquitin chains, with some preference for 'Lys-33' linkages (PubMed:25752577). E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in

PDB

6JX5 , 6LOH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00630	Filamin	54 → 155	Filamin/ABP280 repeat	Domain
PF00632	HECT	512 → 823	HECT-domain (ubiquitin-transferase)	Domain

Sequence

MFYVIGGITVSVVAFFFTIKFLFELAARVVSFLQNEDRERRGDRTIYDYVRGNYLDPRSC
KVSWDWKDPYEVGHSMAFRVHLFYKNGQPFPAHRPVGLRVHISHVELAVEIPVTQEVLQE
PNSNVVKVAFTVRKAGRYEITVKLGGLNVAYSPYYKIFQPGMVVPSKTKIVCHFSTLVLT
CGQPHTLQIVPRDEYDNPTNNSMSLRDEHNYTLSIHELGPQEEESTGVSFEKSVTSNRQT
FQVFLRLTLHSRGCFHACISYQNQPINNGEFDIIVLSEDEKNIVERNVSTSGVSIYFEAY
LYNATNCSSTPWHLPPMHMTSSQRRPSTAVDEEDEDSPSECHTPEKVKKPKKVYCYVSPK
QFSVKEFYLKIIPWRLYTFRVCPGTKFSYLGPDPVHKLLTLVVDDGIQPPVELSCKERNI
LAATFIRSLHKNIGGSETFQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATR
NFSISDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPN
PNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFET
DDPEFYKSKVCFILNNDMSEMELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYL
NLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAV
VVGGSWHFREKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIAAPT
HSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGML

Sequence length

823

Interactions

View interactions

	Reactome
			Antigen processing: Ubiquitination & Proteasome degradation

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Lung cancer	Uncertain significance	rs201017145	RCV005939050
Melanoma	Uncertain significance	rs201017145	RCV005939049
Uterine corpus endometrial carcinoma	Uncertain significance	rs201017145	RCV005939051

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Carcinoma Non Small Cell Lung	Associate	25045014
Lung Neoplasms	Associate	25045014
Multiple System Atrophy	Associate	32151281
Small Cell Lung Carcinoma	Associate	25045014

AREL1 (apoptosis resistant E3 ubiquitin protein ligase 1)