TRIL (TLR4 interactor with leucine rich repeats)

Gene

• Entrez ID: 9865
• Gene name: TLR4 interactor with leucine rich repeats
• Gene symbol: TRIL
• Synonyms (NCBI Gene): -
• Chromosome: 7
• Chromosome location: 7p14.3
• Summary: TRIL is a component of the TLR4 (MIM 603030) complex and is induced in a number of cell types by lipopolysaccharide (LPS) (Carpenter et al., 2009 [PubMed 19710467]).[supplied by OMIM, Apr 2010]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1452859	hsa-miR-1296	CLIP-seq
MIRT1452860	hsa-miR-205	CLIP-seq
MIRT1452861	hsa-miR-2054	CLIP-seq
MIRT1452862	hsa-miR-23a	CLIP-seq
MIRT1452863	hsa-miR-23b	CLIP-seq
MIRT1452864	hsa-miR-23c	CLIP-seq
MIRT1452865	hsa-miR-2909	CLIP-seq
MIRT1452866	hsa-miR-30a	CLIP-seq
MIRT1452867	hsa-miR-30b	CLIP-seq
MIRT1452868	hsa-miR-30c	CLIP-seq
MIRT1452869	hsa-miR-30d	CLIP-seq
MIRT1452870	hsa-miR-30e	CLIP-seq
MIRT1452871	hsa-miR-3121-3p	CLIP-seq
MIRT1452872	hsa-miR-3123	CLIP-seq
MIRT1452873	hsa-miR-3667-3p	CLIP-seq
MIRT1452874	hsa-miR-4317	CLIP-seq
MIRT1452875	hsa-miR-4436b-3p	CLIP-seq
MIRT1452876	hsa-miR-4477a	CLIP-seq
MIRT1452877	hsa-miR-4495	CLIP-seq
MIRT1452878	hsa-miR-4711-5p	CLIP-seq
MIRT1452879	hsa-miR-4720-3p	CLIP-seq
MIRT1452880	hsa-miR-4729	CLIP-seq
MIRT1452881	hsa-miR-4761-3p	CLIP-seq
MIRT1452882	hsa-miR-4772-3p	CLIP-seq
MIRT1452883	hsa-miR-4804-3p	CLIP-seq
MIRT1452884	hsa-miR-576-3p	CLIP-seq
MIRT1452885	hsa-miR-591	CLIP-seq
MIRT1452886	hsa-miR-603	CLIP-seq
MIRT1452887	hsa-miR-605	CLIP-seq
MIRT1452888	hsa-miR-891b	CLIP-seq
MIRT2135637	hsa-miR-10a	CLIP-seq
MIRT2135638	hsa-miR-10b	CLIP-seq
MIRT2135639	hsa-miR-1285	CLIP-seq
MIRT2135640	hsa-miR-1293	CLIP-seq
MIRT1452861	hsa-miR-2054	CLIP-seq
MIRT2135641	hsa-miR-3150b-3p	CLIP-seq
MIRT2135642	hsa-miR-3187-5p	CLIP-seq
MIRT1452873	hsa-miR-3667-3p	CLIP-seq
MIRT2135643	hsa-miR-370	CLIP-seq
MIRT2135644	hsa-miR-4483	CLIP-seq
MIRT2135645	hsa-miR-4689	CLIP-seq
MIRT2135646	hsa-miR-4699-3p	CLIP-seq
MIRT2135647	hsa-miR-4710	CLIP-seq
MIRT2135648	hsa-miR-4731-5p	CLIP-seq
MIRT2135649	hsa-miR-4732-3p	CLIP-seq
MIRT2135650	hsa-miR-4784	CLIP-seq
MIRT2135651	hsa-miR-4792	CLIP-seq
MIRT2135652	hsa-miR-4803	CLIP-seq
MIRT2135653	hsa-miR-556-3p	CLIP-seq
MIRT2135654	hsa-miR-579	CLIP-seq
MIRT2135655	hsa-miR-589	CLIP-seq
MIRT2135656	hsa-miR-612	CLIP-seq
MIRT2356768	hsa-miR-1200	CLIP-seq
MIRT2356769	hsa-miR-1256	CLIP-seq
MIRT2356770	hsa-miR-128	CLIP-seq
MIRT2135640	hsa-miR-1293	CLIP-seq
MIRT2356771	hsa-miR-132	CLIP-seq
MIRT2356772	hsa-miR-149	CLIP-seq
MIRT2356773	hsa-miR-1908	CLIP-seq
MIRT2356774	hsa-miR-1910	CLIP-seq
MIRT2356775	hsa-miR-1976	CLIP-seq
MIRT1452861	hsa-miR-2054	CLIP-seq
MIRT2356776	hsa-miR-2110	CLIP-seq
MIRT2356777	hsa-miR-212	CLIP-seq
MIRT2356778	hsa-miR-221	CLIP-seq
MIRT2356779	hsa-miR-222	CLIP-seq
MIRT2356780	hsa-miR-223	CLIP-seq
MIRT1452862	hsa-miR-23a	CLIP-seq
MIRT1452863	hsa-miR-23b	CLIP-seq
MIRT1452864	hsa-miR-23c	CLIP-seq
MIRT2356781	hsa-miR-27a	CLIP-seq
MIRT2356782	hsa-miR-27b	CLIP-seq
MIRT2356783	hsa-miR-29a	CLIP-seq
MIRT2356784	hsa-miR-29b	CLIP-seq
MIRT2356785	hsa-miR-29c	CLIP-seq
MIRT2356786	hsa-miR-302f	CLIP-seq
MIRT2356787	hsa-miR-3064-5p	CLIP-seq
MIRT2356788	hsa-miR-3074-3p	CLIP-seq
MIRT1452866	hsa-miR-30a	CLIP-seq
MIRT1452867	hsa-miR-30b	CLIP-seq
MIRT1452868	hsa-miR-30c	CLIP-seq
MIRT1452869	hsa-miR-30d	CLIP-seq
MIRT1452870	hsa-miR-30e	CLIP-seq
MIRT2356789	hsa-miR-3117-5p	CLIP-seq
MIRT1452871	hsa-miR-3121-3p	CLIP-seq
MIRT2356790	hsa-miR-3126-3p	CLIP-seq
MIRT2356791	hsa-miR-3128	CLIP-seq
MIRT2356792	hsa-miR-3145-5p	CLIP-seq
MIRT2356793	hsa-miR-3150a-3p	CLIP-seq
MIRT2135641	hsa-miR-3150b-3p	CLIP-seq
MIRT2356794	hsa-miR-3157-5p	CLIP-seq
MIRT2356795	hsa-miR-3163	CLIP-seq
MIRT2356796	hsa-miR-3175	CLIP-seq
MIRT2356797	hsa-miR-3182	CLIP-seq
MIRT2356798	hsa-miR-3189-3p	CLIP-seq
MIRT2356799	hsa-miR-3614-3p	CLIP-seq
MIRT2356800	hsa-miR-3617	CLIP-seq
MIRT2356801	hsa-miR-3664-5p	CLIP-seq
MIRT1452873	hsa-miR-3667-3p	CLIP-seq
MIRT2356802	hsa-miR-3684	CLIP-seq
MIRT2356803	hsa-miR-380	CLIP-seq
MIRT2356804	hsa-miR-411	CLIP-seq
MIRT2356805	hsa-miR-4251	CLIP-seq
MIRT2356806	hsa-miR-4256	CLIP-seq
MIRT2356807	hsa-miR-4259	CLIP-seq
MIRT2356808	hsa-miR-4277	CLIP-seq
MIRT2356809	hsa-miR-4279	CLIP-seq
MIRT2356810	hsa-miR-4282	CLIP-seq
MIRT2356811	hsa-miR-4324	CLIP-seq
MIRT2356812	hsa-miR-4423-3p	CLIP-seq
MIRT2356813	hsa-miR-4436b-5p	CLIP-seq
MIRT1452876	hsa-miR-4477a	CLIP-seq
MIRT2135644	hsa-miR-4483	CLIP-seq
MIRT1452877	hsa-miR-4495	CLIP-seq
MIRT2356814	hsa-miR-4528	CLIP-seq
MIRT2356815	hsa-miR-4645-5p	CLIP-seq
MIRT2356816	hsa-miR-4659a-3p	CLIP-seq
MIRT2356817	hsa-miR-4659b-3p	CLIP-seq
MIRT2356818	hsa-miR-4673	CLIP-seq
MIRT2135645	hsa-miR-4689	CLIP-seq
MIRT2356819	hsa-miR-4691-3p	CLIP-seq
MIRT2135646	hsa-miR-4699-3p	CLIP-seq
MIRT2356820	hsa-miR-4703-3p	CLIP-seq
MIRT2135647	hsa-miR-4710	CLIP-seq
MIRT2356821	hsa-miR-4714-5p	CLIP-seq
MIRT2356822	hsa-miR-4720-5p	CLIP-seq
MIRT2356823	hsa-miR-4728-5p	CLIP-seq
MIRT2356824	hsa-miR-4730	CLIP-seq
MIRT2135649	hsa-miR-4732-3p	CLIP-seq
MIRT2356825	hsa-miR-4738-3p	CLIP-seq
MIRT2356826	hsa-miR-4762-5p	CLIP-seq
MIRT2356827	hsa-miR-4773	CLIP-seq
MIRT2135650	hsa-miR-4784	CLIP-seq
MIRT2356828	hsa-miR-4789-3p	CLIP-seq
MIRT2135651	hsa-miR-4792	CLIP-seq
MIRT2356829	hsa-miR-4794	CLIP-seq
MIRT2356830	hsa-miR-4799-3p	CLIP-seq
MIRT2135652	hsa-miR-4803	CLIP-seq
MIRT2356831	hsa-miR-499-3p	CLIP-seq
MIRT2356832	hsa-miR-499a-3p	CLIP-seq
MIRT2356833	hsa-miR-502-5p	CLIP-seq
MIRT2356834	hsa-miR-508-5p	CLIP-seq
MIRT2356835	hsa-miR-513a-5p	CLIP-seq
MIRT2356836	hsa-miR-518a-5p	CLIP-seq
MIRT2356837	hsa-miR-527	CLIP-seq
MIRT2356838	hsa-miR-539	CLIP-seq
MIRT2356839	hsa-miR-544b	CLIP-seq
MIRT2356840	hsa-miR-548a-5p	CLIP-seq
MIRT2356841	hsa-miR-548ab	CLIP-seq
MIRT2356842	hsa-miR-548ak	CLIP-seq
MIRT2356843	hsa-miR-548b-5p	CLIP-seq
MIRT2356844	hsa-miR-548c-5p	CLIP-seq
MIRT2356845	hsa-miR-548d-5p	CLIP-seq
MIRT2356846	hsa-miR-548h	CLIP-seq
MIRT2356847	hsa-miR-548i	CLIP-seq
MIRT2356848	hsa-miR-548j	CLIP-seq
MIRT2356849	hsa-miR-548k	CLIP-seq
MIRT2356850	hsa-miR-548l	CLIP-seq
MIRT2356851	hsa-miR-548u	CLIP-seq
MIRT2356852	hsa-miR-548w	CLIP-seq
MIRT2356853	hsa-miR-548y	CLIP-seq
MIRT2356854	hsa-miR-559	CLIP-seq
MIRT2356855	hsa-miR-567	CLIP-seq
MIRT2135655	hsa-miR-589	CLIP-seq
MIRT2356856	hsa-miR-617	CLIP-seq
MIRT2356857	hsa-miR-627	CLIP-seq
MIRT2356858	hsa-miR-641	CLIP-seq
MIRT2356859	hsa-miR-646	CLIP-seq
MIRT2356860	hsa-miR-663	CLIP-seq
MIRT2356861	hsa-miR-760	CLIP-seq
MIRT2356862	hsa-miR-767-5p	CLIP-seq
MIRT2356863	hsa-miR-924	CLIP-seq
MIRT2356864	hsa-miR-939	CLIP-seq
MIRT2356865	hsa-miR-944	CLIP-seq
MIRT1452861	hsa-miR-2054	CLIP-seq
MIRT1452873	hsa-miR-3667-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001530	Function	Lipopolysaccharide binding	IBA
GO:0001530	Function	Lipopolysaccharide binding	IDA	19710467
GO:0002376	Process	Immune system process	IEA
GO:0002718	Process	Regulation of cytokine production involved in immune response	IBA
GO:0002718	Process	Regulation of cytokine production involved in immune response	IDA	19710467
GO:0005515	Function	Protein binding	IPI	35253622
GO:0005886	Component	Plasma membrane	IBA
GO:0006954	Process	Inflammatory response	IEA
GO:0016020	Component	Membrane	IEA
GO:0034142	Process	Toll-like receptor 4 signaling pathway	IBA
GO:0034142	Process	Toll-like receptor 4 signaling pathway	IDA	19710467
GO:0038023	Function	Signaling receptor activity	IBA
GO:0045087	Process	Innate immune response	IEA
GO:0046696	Component	Lipopolysaccharide receptor complex	IBA
GO:0046696	Component	Lipopolysaccharide receptor complex	IDA	19710467

Other IDs

• MIM: 613356
• HGNC: 22200
• e!Ensembl: ENSG00000255690

Protein

• UniProt ID: Q7L0X0
• Protein name: TLR4 interactor with leucine rich repeats (Leucine-rich repeat-containing protein KIAA0644)
• Protein function: Component of the TLR4 signaling complex. Mediates the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	63 → 119	Leucine rich repeat	Repeat
  PF13855	LRR_8	83 → 143	Leucine rich repeat	Repeat
  PF13855	LRR_8	107 → 167	Leucine rich repeat	Repeat
  PF13855	LRR_8	229 → 289	Leucine rich repeat	Repeat
  PF13855	LRR_8	301 → 360	Leucine rich repeat	Repeat
  PF01463	LRRCT	387 → 415	Leucine rich repeat C-terminal domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in the brain, ovary, small intestine and spleen. {ECO:0000269|PubMed:19710467}.
• Sequence:

  MEAARALRLLLVVCGCLALPPLAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHD
  VLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQ
  ALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGN
  LLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANN
  LQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPL
  HSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNG
  WTCDCRLRGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLDDQQLQNGSCADPSPS
  ASLTADRRRQPLPTAAGEEMTPPAGLAEELPPQPQLQQQGRFLAGVAWDGAARELVGNRS
  ALRLSRRGPGLQQPSPSVAAAAGPAPQSLDLHKKPQRGRPTRADPALAEPTPTASPGSAP
  SPAGDPWQRATKHRLGTEHQERAAQSDGGAGLPPLVSDPCDFNKFILCNLTVEAVGADSA
  SVRWAVREHRSPRPLGGARFRLLFDRFGQQPKFHRFVYLPESSDSATLRELRGDTPYLVC
  VEGVLGGRVCPVAPRDHCAGLVTLPEAGSRGGVDYQLLTLALLTVNALLVLLALAAWASR
  WLRRKLRARRKGGAPVHVRHMYSTRRPLRSMGTGVSADFSGFQSHRPRTTVCALSEADLI
  EFPCDRFMDSAGGGAGGSLRREDRLLQRFAD

• Sequence length: 811

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BREAST CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, BASAL CELL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VASCULAR BRAIN INJURY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Hypertension	Associate	38042639	★☆☆☆☆ Found in Text Mining only
Spinocerebellar Ataxias	Associate	30431579	★☆☆☆☆ Found in Text Mining only