Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9860
Gene name Gene Name - the full gene name approved by the HGNC.
Leucine rich repeats and immunoglobulin like domains 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LRIG2
Synonyms (NCBI Gene) Gene synonyms aliases
LIG-2, LIG2, UFS2
Disease Acronyms (UniProt) Disease acronyms from UniProt database
UFS2
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signalling, resulting in increased proliferation. Its expression in the cytoplasm of glioma cel
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs587776945 A>- Pathogenic Coding sequence variant, frameshift variant, genic upstream transcript variant, 5 prime UTR variant
rs587776946 C>T Pathogenic Stop gained, coding sequence variant
rs587776947 C>- Pathogenic Coding sequence variant, frameshift variant
rs1399525051 G>T Likely-pathogenic Coding sequence variant, genic upstream transcript variant, 5 prime UTR variant, stop gained
rs1557914199 C>A Likely-pathogenic Intron variant, coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT725402 hsa-miR-3200-5p HITS-CLIP 19536157
MIRT725401 hsa-miR-16-2-3p HITS-CLIP 19536157
MIRT725400 hsa-miR-195-3p HITS-CLIP 19536157
MIRT725398 hsa-miR-4251 HITS-CLIP 19536157
MIRT725399 hsa-miR-4329 HITS-CLIP 19536157
Transcription factors
Transcription factor Regulation Reference
FOS Unknown 22721266
TAF1 Unknown 22721266
YY1 Unknown 22721266
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005102 Function Signaling receptor binding IEA
GO:0005515 Function Protein binding IPI 25353163, 30015847
GO:0005615 Component Extracellular space IBA 21873635
GO:0005737 Component Cytoplasm IEA
GO:0005886 Component Plasma membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608869 20889 ENSG00000198799
Protein
UniProt ID O94898
Protein name Leucine-rich repeats and immunoglobulin-like domains protein 2 (LIG-2)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13855 LRR_8 144 194 Leucine rich repeat Repeat
PF13855 LRR_8 240 299 Leucine rich repeat Repeat
PF13855 LRR_8 289 347 Leucine rich repeat Repeat
PF13855 LRR_8 311 371 Leucine rich repeat Repeat
PF13855 LRR_8 335 398 Leucine rich repeat Repeat
PF01463 LRRCT 468 493 Leucine rich repeat C-terminal domain Family
PF13927 Ig_3 497 584 Domain
PF07679 I-set 602 692 Immunoglobulin I-set domain Domain
PF07679 I-set 696 783 Immunoglobulin I-set domain Domain
Tissue specificity TISSUE SPECIFICITY: Detected in all tissues analyzed. {ECO:0000269|PubMed:15145052}.
Sequence
MAPAPLGVPEEQLLGCRSRVLSRLLFIAQTALLLLPAAGAGLCPAPCSCRIPLLDCSRRK
LPAPSWRALSGLLPPDTAILDFSHNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTS
NITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRIT
TLEAGCFDNLSSSL
LVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDS
LRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRM
LQQLYVSQNAIE
RISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSN
LQTLDLRNNEI
SWAIEDASEAFAGLTSLTKLILQGNQI
KSITKKAFIGLESLEHLDLNNN
AIMSIQENAFSQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQ
SILNVDLKDFVCD
DFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEIL
YDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTN
HFGSNYSQKAKLTVNE
MPSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVF
FIANVKIEDMGIYSCMAQNTAGGLSANASLTV
LETPSFIRPLEDKTVTRGETAVLQCIAG
GSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIY
LNV
ISSPNCDSSQSSIGHEDDGWTTVGIVIIVVVCCVVGTSLIWVIVIYHMRRKNEDYSI
TNTEELNLPADIPSYLSSQGTLSEPQEGYSNSEAGSHQQLMPPANGYIHKGTDGGTGTRV
ICSDCYDNANIYSRTREYCPYTYIAEEDVLDQTLSSLMVQMPKETYLVHPPQDTTALESL
IPSANREPSAFPTNHERISEKKLPSTQMSGETLQRPVWNINRELGLPHPPFSQQPVHESP
QLHQNEGLAGREPDCSASSMSCHRLQDHAFDFSRTRNIQDGSEGT
Sequence length 1065
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Axon guidance  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Cryptorchidism Cryptorchidism rs121912555, rs104894697, rs104894698, rs398122886
Hypertension Hypertensive disease rs13306026
Renal insufficiency Renal Insufficiency rs1596536873
Urofacial syndrome UROFACIAL SYNDROME 2 rs267606866, rs397515338, rs1469962264, rs267606864, rs267606865, rs778121647, rs587776945, rs587776946, rs587776947, rs397515452, rs1570764426
Unknown
Disease term Disease name Evidence References Source
Ochoa Syndrome Ochoa syndrome GenCC
Hypothyroidism Hypothyroidism GWAS
Associations from Text Mining
Disease Name Relationship Type References
Carcinogenesis Associate 23313374, 27855655
Glioblastoma Associate 19421009
Glioma Associate 19421009, 20446891
Hypoglycemia leucine induced Associate 27855655
LIG4 Syndrome Associate 27855655
Meningioma Associate 22484910
Pathological Conditions Anatomical Associate 27855655
Succinate Coa Ligase Deficiency Associate 27855655
Urinary Bladder Diseases Associate 23313374
Urofacial syndrome Associate 23313374, 27855655