Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9855
Gene name	FERM, ARH/RhoGEF and pleckstrin domain protein 2
Gene symbol	FARP2
Synonyms (NCBI Gene)	FIRFRGPLEKHC3
Chromosome	2
Chromosome location	2q37.3

Show/Hide all (48)

miRTarBase ID	miRNA	Experiments
MIRT989450	hsa-miR-1225-5p	CLIP-seq
MIRT989451	hsa-miR-3150a-3p	CLIP-seq
MIRT989452	hsa-miR-3175	CLIP-seq
MIRT989453	hsa-miR-34a	CLIP-seq
MIRT989454	hsa-miR-34c-5p	CLIP-seq
MIRT989455	hsa-miR-449a	CLIP-seq
MIRT989456	hsa-miR-449b	CLIP-seq
MIRT989457	hsa-miR-4708-5p	CLIP-seq
MIRT989458	hsa-miR-939	CLIP-seq
MIRT1993225	hsa-miR-1827	CLIP-seq
MIRT1993226	hsa-miR-185	CLIP-seq
MIRT989451	hsa-miR-3150a-3p	CLIP-seq
MIRT989452	hsa-miR-3175	CLIP-seq
MIRT1993227	hsa-miR-3194-3p	CLIP-seq
MIRT1993228	hsa-miR-326	CLIP-seq
MIRT1993229	hsa-miR-330-5p	CLIP-seq
MIRT1993230	hsa-miR-4306	CLIP-seq
MIRT1993231	hsa-miR-4644	CLIP-seq
MIRT1993232	hsa-miR-4667-5p	CLIP-seq
MIRT1993233	hsa-miR-4700-5p	CLIP-seq
MIRT1993234	hsa-miR-637	CLIP-seq
MIRT989458	hsa-miR-939	CLIP-seq
MIRT2227101	hsa-miR-1207-5p	CLIP-seq
MIRT989450	hsa-miR-1225-5p	CLIP-seq
MIRT2227102	hsa-miR-1227	CLIP-seq
MIRT2227103	hsa-miR-1231	CLIP-seq
MIRT1993226	hsa-miR-185	CLIP-seq
MIRT989451	hsa-miR-3150a-3p	CLIP-seq
MIRT989452	hsa-miR-3175	CLIP-seq
MIRT1993227	hsa-miR-3194-3p	CLIP-seq
MIRT1993228	hsa-miR-326	CLIP-seq
MIRT1993229	hsa-miR-330-5p	CLIP-seq
MIRT989453	hsa-miR-34a	CLIP-seq
MIRT989454	hsa-miR-34c-5p	CLIP-seq
MIRT2227104	hsa-miR-4251	CLIP-seq
MIRT2227105	hsa-miR-4288	CLIP-seq
MIRT1993230	hsa-miR-4306	CLIP-seq
MIRT2227106	hsa-miR-4329	CLIP-seq
MIRT989455	hsa-miR-449a	CLIP-seq
MIRT989456	hsa-miR-449b	CLIP-seq
MIRT1993231	hsa-miR-4644	CLIP-seq
MIRT1993232	hsa-miR-4667-5p	CLIP-seq
MIRT2227107	hsa-miR-4687-3p	CLIP-seq
MIRT1993233	hsa-miR-4700-5p	CLIP-seq
MIRT2227108	hsa-miR-4763-3p	CLIP-seq
MIRT2227109	hsa-miR-632	CLIP-seq
MIRT1993234	hsa-miR-637	CLIP-seq
MIRT989458	hsa-miR-939	CLIP-seq

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	12351724
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	ISS
GO:0005737	Component	Cytoplasm	IDA	12351724
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0007155	Process	Cell adhesion	IEA
GO:0007155	Process	Cell adhesion	ISS
GO:0007165	Process	Signal transduction	IEA
GO:0008092	Function	Cytoskeletal protein binding	IEA
GO:0016322	Process	Neuron remodeling	IDA	12351724
GO:0016601	Process	Rac protein signal transduction	IDA	12351724
GO:0022405	Process	Hair cycle process	IEA
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0030036	Process	Actin cytoskeleton organization	ISS
GO:0030316	Process	Osteoclast differentiation	IEA
GO:0030316	Process	Osteoclast differentiation	ISS
GO:0033623	Process	Regulation of integrin activation	IEA
GO:0033623	Process	Regulation of integrin activation	ISS
GO:0048468	Process	Cell development	IEA
GO:0071526	Process	Semaphorin-plexin signaling pathway	IEA
GO:0071526	Process	Semaphorin-plexin signaling pathway	ISS
GO:0071800	Process	Podosome assembly	IEA
GO:0071800	Process	Podosome assembly	ISS

MIM	HGNC	e!Ensembl
617586	16460	ENSG00000006607

O94887

Protein name

FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3)

Protein function

Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast di

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09379	FERM_N	48 → 111	FERM N-terminal domain	Domain
PF00373	FERM_M	127 → 234	FERM central domain	Domain
PF09380	FERM_C	238 → 328	FERM C-terminal PH-like domain	Domain
PF08736	FA	333 → 376	FERM adjacent (FA)	Family
PF00621	RhoGEF	539 → 724	RhoGEF domain	Domain
PF00169	PH	756 → 852	PH domain	Domain
PF00169	PH	930 → 1026	PH domain	Domain

Sequence

MGEIEGTYRVLQTAGMRLGAQTPVGVSTLEPGQTLLPRMQEKHLHLRVKLLDNTMEIFDI
EPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPIIRQIRRPKNVVLRLA
VKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSHLLQSEIGDYDETLD
REHLKVNEYLPGQQHCLEKILEFHQKHVGQTPAESDFQVLEIARKLEMYGIRFHMASDRE
GTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLL
GSRDECKNFWKICVEYHTFFRLLDQPKPKAKAVFFSRGSSFRYSGRTQKQLVDYFKDSGM
KRIPYERRHSKTHTSVRALTADLPKQSISFPEGLRTPASPSSANAFYSLSPSTLVPSGLP
EFKDSSSSLTDPQVSYVKSPAAERRSGAVAGGPDTPSAQPLGPPALQPGPGLSTKSPQPS
PSSRKSPLSLSPAFQVPLGPAEQGSSPLLSPVLSDAGGAGMDCEEPRHKRVPADEAYFIV
KEILATERTYLKDLEVITVWFRSAVVKEDAMPATLMTLLFSNIDPIYEFHRGFLREVEQR
LALWEGPSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKRCKKLEAV
YKEFELQKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVT
TTLQHILIRLENLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFFLFSD
MLLYTSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEK
EKWMLDLNSAIQAAKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGH
GQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSHGWQKLWVVFTNFCLFF
YKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEV
IQGASSSAGRAPSIVQDGPQPSSGLEGMVRGKEE

Sequence length

1054

Interactions

View interactions

	KEGG		Reactome
	Rap1 signaling pathway Adherens junction		SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs145651106	RCV005908374
Gastric cancer	Uncertain significance	rs185331144	RCV005930700
Hepatocellular carcinoma	Uncertain significance	rs185331144	RCV005930699
Lymphoma	Benign	rs145651106	RCV005908375
Melanoma	Uncertain significance; Likely benign	rs770450806, rs137904208	RCV005932346 RCV005913355

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	34115610, 37562399
Carcinoma Non Small Cell Lung	Associate	37562399
Carcinoma Renal Cell	Associate	37940859
Carcinoma Squamous Cell	Associate	34672420
Colorectal Neoplasms	Associate	24247407, 24307987
Glioma	Associate	36566214
Leukemia	Associate	27094381
Leukemia B Cell	Associate	20855867
Leukemia Lymphocytic Chronic B Cell	Associate	20062064, 20855867
Leukemia Lymphocytic Chronic B Cell	Stimulate	20062064
Melanoma	Associate	35354376
Myopia	Associate	36036911
Neoplasms	Associate	34373545
Osteosarcoma	Associate	36254233
Stomach Neoplasms	Associate	34868391
Urinary Bladder Neoplasms	Associate	34418989

FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2)