ZNF518A (zinc finger protein 518A)

Gene

• Entrez ID: 9849
• Gene name: Zinc finger protein 518A
• Gene symbol: ZNF518A
• Synonyms (NCBI Gene): ZNF518
• Chromosome: 10
• Chromosome location: 10q24.1
• Summary: The protein encoded by this gene is a member of the krueppel C2H2-type zinc finger protein family. The encoded protein contains five zinc fingers and is likely a nuclear transcriptional regulator. Numerous transcript variants encoding two different isofor

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017067	hsa-miR-335-5p	Microarray	18185580
MIRT1527879	hsa-miR-101	CLIP-seq
MIRT1527880	hsa-miR-1236	CLIP-seq
MIRT1527881	hsa-miR-1253	CLIP-seq
MIRT1527882	hsa-miR-1305	CLIP-seq
MIRT1527883	hsa-miR-1323	CLIP-seq
MIRT1527884	hsa-miR-136	CLIP-seq
MIRT1527885	hsa-miR-142-3p	CLIP-seq
MIRT1527886	hsa-miR-194	CLIP-seq
MIRT1527887	hsa-miR-19a	CLIP-seq
MIRT1527888	hsa-miR-19b	CLIP-seq
MIRT1527889	hsa-miR-205	CLIP-seq
MIRT1527890	hsa-miR-2052	CLIP-seq
MIRT1527891	hsa-miR-2053	CLIP-seq
MIRT1527892	hsa-miR-2054	CLIP-seq
MIRT1527893	hsa-miR-21	CLIP-seq
MIRT1527894	hsa-miR-223	CLIP-seq
MIRT1527895	hsa-miR-2355-3p	CLIP-seq
MIRT1527896	hsa-miR-297	CLIP-seq
MIRT1527897	hsa-miR-300	CLIP-seq
MIRT1527898	hsa-miR-3143	CLIP-seq
MIRT1527899	hsa-miR-3148	CLIP-seq
MIRT1527900	hsa-miR-3149	CLIP-seq
MIRT1527901	hsa-miR-3150a-5p	CLIP-seq
MIRT1527902	hsa-miR-3150b-5p	CLIP-seq
MIRT1527903	hsa-miR-3168	CLIP-seq
MIRT1527904	hsa-miR-3174	CLIP-seq
MIRT1527905	hsa-miR-3200-5p	CLIP-seq
MIRT1527906	hsa-miR-323-3p	CLIP-seq
MIRT1527907	hsa-miR-323b-5p	CLIP-seq
MIRT1527908	hsa-miR-346	CLIP-seq
MIRT1527909	hsa-miR-3591-3p	CLIP-seq
MIRT1527910	hsa-miR-3613-3p	CLIP-seq
MIRT1527911	hsa-miR-362-5p	CLIP-seq
MIRT1527912	hsa-miR-3692	CLIP-seq
MIRT1527913	hsa-miR-381	CLIP-seq
MIRT1527914	hsa-miR-3940-5p	CLIP-seq
MIRT1527915	hsa-miR-411	CLIP-seq
MIRT1527916	hsa-miR-4251	CLIP-seq
MIRT1527917	hsa-miR-4256	CLIP-seq
MIRT1527918	hsa-miR-4282	CLIP-seq
MIRT1527919	hsa-miR-4287	CLIP-seq
MIRT1527920	hsa-miR-4288	CLIP-seq
MIRT1527921	hsa-miR-4307	CLIP-seq
MIRT1527922	hsa-miR-4424	CLIP-seq
MIRT1527923	hsa-miR-4477a	CLIP-seq
MIRT1527924	hsa-miR-4507	CLIP-seq
MIRT1527925	hsa-miR-4511	CLIP-seq
MIRT1527926	hsa-miR-4520a-3p	CLIP-seq
MIRT1527927	hsa-miR-4520b-3p	CLIP-seq
MIRT1527928	hsa-miR-4524	CLIP-seq
MIRT1527929	hsa-miR-4529-3p	CLIP-seq
MIRT1527930	hsa-miR-4646-3p	CLIP-seq
MIRT1527931	hsa-miR-4666-3p	CLIP-seq
MIRT1527932	hsa-miR-4670-3p	CLIP-seq
MIRT1527933	hsa-miR-4685-3p	CLIP-seq
MIRT1527934	hsa-miR-4697-3p	CLIP-seq
MIRT1527935	hsa-miR-4698	CLIP-seq
MIRT1527936	hsa-miR-4699-3p	CLIP-seq
MIRT1527937	hsa-miR-4704-3p	CLIP-seq
MIRT1527938	hsa-miR-4724-5p	CLIP-seq
MIRT1527939	hsa-miR-4725-5p	CLIP-seq
MIRT1527940	hsa-miR-4731-3p	CLIP-seq
MIRT1527941	hsa-miR-4735-5p	CLIP-seq
MIRT1527942	hsa-miR-4775	CLIP-seq
MIRT1527943	hsa-miR-4780	CLIP-seq
MIRT1527944	hsa-miR-4789-5p	CLIP-seq
MIRT1527945	hsa-miR-4801	CLIP-seq
MIRT1527946	hsa-miR-498	CLIP-seq
MIRT1527947	hsa-miR-500b	CLIP-seq
MIRT1527948	hsa-miR-501-5p	CLIP-seq
MIRT1527949	hsa-miR-504	CLIP-seq
MIRT1527950	hsa-miR-513a-3p	CLIP-seq
MIRT1527951	hsa-miR-518a-5p	CLIP-seq
MIRT1527952	hsa-miR-527	CLIP-seq
MIRT1527953	hsa-miR-543	CLIP-seq
MIRT1527954	hsa-miR-548ae	CLIP-seq
MIRT1527955	hsa-miR-548aj	CLIP-seq
MIRT1527956	hsa-miR-548am	CLIP-seq
MIRT1527957	hsa-miR-548b-3p	CLIP-seq
MIRT1527958	hsa-miR-548o	CLIP-seq
MIRT1527959	hsa-miR-548x	CLIP-seq
MIRT1527960	hsa-miR-587	CLIP-seq
MIRT1527961	hsa-miR-590-3p	CLIP-seq
MIRT1527962	hsa-miR-590-5p	CLIP-seq
MIRT1527963	hsa-miR-607	CLIP-seq
MIRT1527964	hsa-miR-623	CLIP-seq
MIRT1527965	hsa-miR-632	CLIP-seq
MIRT1527966	hsa-miR-646	CLIP-seq
MIRT1527967	hsa-miR-654-3p	CLIP-seq
MIRT1527968	hsa-miR-676	CLIP-seq
MIRT1527969	hsa-miR-875-3p	CLIP-seq
MIRT1527970	hsa-miR-885-5p	CLIP-seq
MIRT1527971	hsa-miR-889	CLIP-seq
MIRT1527972	hsa-miR-921	CLIP-seq
MIRT2159648	hsa-miR-1179	CLIP-seq
MIRT2159649	hsa-miR-1183	CLIP-seq
MIRT2159650	hsa-miR-125a-5p	CLIP-seq
MIRT2159651	hsa-miR-125b	CLIP-seq
MIRT1527882	hsa-miR-1305	CLIP-seq
MIRT2159652	hsa-miR-135a	CLIP-seq
MIRT2159653	hsa-miR-135b	CLIP-seq
MIRT1527884	hsa-miR-136	CLIP-seq
MIRT1527885	hsa-miR-142-3p	CLIP-seq
MIRT1527887	hsa-miR-19a	CLIP-seq
MIRT1527888	hsa-miR-19b	CLIP-seq
MIRT1527889	hsa-miR-205	CLIP-seq
MIRT1527893	hsa-miR-21	CLIP-seq
MIRT1527894	hsa-miR-223	CLIP-seq
MIRT1527896	hsa-miR-297	CLIP-seq
MIRT2159654	hsa-miR-3119	CLIP-seq
MIRT1527900	hsa-miR-3149	CLIP-seq
MIRT1527904	hsa-miR-3174	CLIP-seq
MIRT2159655	hsa-miR-3185	CLIP-seq
MIRT1527905	hsa-miR-3200-5p	CLIP-seq
MIRT2159656	hsa-miR-3647-3p	CLIP-seq
MIRT2159657	hsa-miR-3671	CLIP-seq
MIRT2159658	hsa-miR-4255	CLIP-seq
MIRT1527917	hsa-miR-4256	CLIP-seq
MIRT1527918	hsa-miR-4282	CLIP-seq
MIRT2159659	hsa-miR-4319	CLIP-seq
MIRT1527922	hsa-miR-4424	CLIP-seq
MIRT2159660	hsa-miR-452	CLIP-seq
MIRT2159661	hsa-miR-4652-3p	CLIP-seq
MIRT2159662	hsa-miR-4676-3p	CLIP-seq
MIRT1527934	hsa-miR-4697-3p	CLIP-seq
MIRT1527937	hsa-miR-4704-3p	CLIP-seq
MIRT1527939	hsa-miR-4725-5p	CLIP-seq
MIRT2159663	hsa-miR-4732-3p	CLIP-seq
MIRT2159664	hsa-miR-4761-5p	CLIP-seq
MIRT1527942	hsa-miR-4775	CLIP-seq
MIRT2159665	hsa-miR-4778-5p	CLIP-seq
MIRT2159666	hsa-miR-4799-5p	CLIP-seq
MIRT2159667	hsa-miR-485-3p	CLIP-seq
MIRT2159668	hsa-miR-487a	CLIP-seq
MIRT1527946	hsa-miR-498	CLIP-seq
MIRT1527949	hsa-miR-504	CLIP-seq
MIRT1527950	hsa-miR-513a-3p	CLIP-seq
MIRT2159669	hsa-miR-544	CLIP-seq
MIRT1527954	hsa-miR-548ae	CLIP-seq
MIRT1527955	hsa-miR-548aj	CLIP-seq
MIRT1527956	hsa-miR-548am	CLIP-seq
MIRT2159670	hsa-miR-548m	CLIP-seq
MIRT1527959	hsa-miR-548x	CLIP-seq
MIRT1527961	hsa-miR-590-3p	CLIP-seq
MIRT1527962	hsa-miR-590-5p	CLIP-seq
MIRT1527963	hsa-miR-607	CLIP-seq
MIRT1527966	hsa-miR-646	CLIP-seq
MIRT2159671	hsa-miR-670	CLIP-seq
MIRT1527970	hsa-miR-885-5p	CLIP-seq
MIRT1527972	hsa-miR-921	CLIP-seq
MIRT2159649	hsa-miR-1183	CLIP-seq
MIRT1527880	hsa-miR-1236	CLIP-seq
MIRT2378863	hsa-miR-129-3p	CLIP-seq
MIRT1527884	hsa-miR-136	CLIP-seq
MIRT1527885	hsa-miR-142-3p	CLIP-seq
MIRT1527886	hsa-miR-194	CLIP-seq
MIRT1527893	hsa-miR-21	CLIP-seq
MIRT2378864	hsa-miR-23a	CLIP-seq
MIRT2378865	hsa-miR-23b	CLIP-seq
MIRT2378866	hsa-miR-23c	CLIP-seq
MIRT1527896	hsa-miR-297	CLIP-seq
MIRT2378867	hsa-miR-30a	CLIP-seq
MIRT2378868	hsa-miR-30b	CLIP-seq
MIRT2378869	hsa-miR-30c	CLIP-seq
MIRT2378870	hsa-miR-30d	CLIP-seq
MIRT2378871	hsa-miR-30e	CLIP-seq
MIRT2378872	hsa-miR-3133	CLIP-seq
MIRT1527898	hsa-miR-3143	CLIP-seq
MIRT1527900	hsa-miR-3149	CLIP-seq
MIRT1527904	hsa-miR-3174	CLIP-seq
MIRT2378873	hsa-miR-3182	CLIP-seq
MIRT1527905	hsa-miR-3200-5p	CLIP-seq
MIRT2378874	hsa-miR-3622a-5p	CLIP-seq
MIRT2159656	hsa-miR-3647-3p	CLIP-seq
MIRT2378875	hsa-miR-3653	CLIP-seq
MIRT2378876	hsa-miR-3658	CLIP-seq
MIRT2378877	hsa-miR-3682-5p	CLIP-seq
MIRT1527912	hsa-miR-3692	CLIP-seq
MIRT2378878	hsa-miR-380	CLIP-seq
MIRT2159658	hsa-miR-4255	CLIP-seq
MIRT1527917	hsa-miR-4256	CLIP-seq
MIRT1527918	hsa-miR-4282	CLIP-seq
MIRT1527921	hsa-miR-4307	CLIP-seq
MIRT2378879	hsa-miR-4423-3p	CLIP-seq
MIRT2378880	hsa-miR-4495	CLIP-seq
MIRT1527925	hsa-miR-4511	CLIP-seq
MIRT2159660	hsa-miR-452	CLIP-seq
MIRT2378881	hsa-miR-4639-5p	CLIP-seq
MIRT1527931	hsa-miR-4666-3p	CLIP-seq
MIRT1527932	hsa-miR-4670-3p	CLIP-seq
MIRT2159662	hsa-miR-4676-3p	CLIP-seq
MIRT2378882	hsa-miR-4679	CLIP-seq
MIRT2378883	hsa-miR-4687-5p	CLIP-seq
MIRT1527935	hsa-miR-4698	CLIP-seq
MIRT1527936	hsa-miR-4699-3p	CLIP-seq
MIRT1527938	hsa-miR-4724-5p	CLIP-seq
MIRT1527939	hsa-miR-4725-5p	CLIP-seq
MIRT2378884	hsa-miR-4740-3p	CLIP-seq
MIRT2159664	hsa-miR-4761-5p	CLIP-seq
MIRT2378885	hsa-miR-4764-3p	CLIP-seq
MIRT2159665	hsa-miR-4778-5p	CLIP-seq
MIRT2159666	hsa-miR-4799-5p	CLIP-seq
MIRT2378886	hsa-miR-489	CLIP-seq
MIRT1527946	hsa-miR-498	CLIP-seq
MIRT1527949	hsa-miR-504	CLIP-seq
MIRT1527953	hsa-miR-543	CLIP-seq
MIRT2378887	hsa-miR-545	CLIP-seq
MIRT2378888	hsa-miR-548a-3p	CLIP-seq
MIRT1527954	hsa-miR-548ae	CLIP-seq
MIRT1527955	hsa-miR-548aj	CLIP-seq
MIRT1527956	hsa-miR-548am	CLIP-seq
MIRT1527957	hsa-miR-548b-3p	CLIP-seq
MIRT2378889	hsa-miR-548c-3p	CLIP-seq
MIRT2378890	hsa-miR-548e	CLIP-seq
MIRT2378891	hsa-miR-548f	CLIP-seq
MIRT2378892	hsa-miR-548g	CLIP-seq
MIRT2378893	hsa-miR-548p	CLIP-seq
MIRT1527959	hsa-miR-548x	CLIP-seq
MIRT2378894	hsa-miR-570	CLIP-seq
MIRT1527962	hsa-miR-590-5p	CLIP-seq
MIRT2378895	hsa-miR-616	CLIP-seq
MIRT2378896	hsa-miR-634	CLIP-seq
MIRT1527970	hsa-miR-885-5p	CLIP-seq
MIRT1527972	hsa-miR-921	CLIP-seq
MIRT1527880	hsa-miR-1236	CLIP-seq
MIRT1527886	hsa-miR-194	CLIP-seq
MIRT1527912	hsa-miR-3692	CLIP-seq
MIRT2378878	hsa-miR-380	CLIP-seq
MIRT2378880	hsa-miR-4495	CLIP-seq
MIRT1527931	hsa-miR-4666-3p	CLIP-seq
MIRT2671079	hsa-miR-188-3p	CLIP-seq
MIRT2671080	hsa-miR-3122	CLIP-seq
MIRT2671081	hsa-miR-3913-5p	CLIP-seq
MIRT2671082	hsa-miR-4668-3p	CLIP-seq
MIRT2671083	hsa-miR-4747-5p	CLIP-seq
MIRT2378889	hsa-miR-548c-3p	CLIP-seq
MIRT2671084	hsa-miR-605	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 617733
• HGNC: 29009
• e!Ensembl: ENSG00000177853

Protein

• UniProt ID: Q6AHZ1
• Protein name: Zinc finger protein 518A
• Protein function: Through its association with the EHMT1-EHMT2/G9A and PRC2/EED-EZH2 histone methyltransferase complexes may function in gene silencing, regulating repressive post-translational methylation of histone tails at promoters of target genes. {ECO:00002
• Sequence:

  MPSEQKQLFCDEKQTTLKKDYDVKNEIVDRSAPKPKISGSIHYALKNVKIDLPKINIPNE
  VLLKHEVDKYRKLFQSKQQTARKSISIKTVSCVEECTLLHKSERAEEEGVKMSAKILNFS
  CLKCRDNTRYSPNDLQKHFQMWHHGELPSYPCEMCNFSANDFQVFKQHRRTHRSTLVKCD
  ICNNESVYTLLNLTKHFTSTHCVNGNFQCEKCKFSTQDVGTFVQHIHRHNEIHYKCGKCH
  HVCFTKGELQKHLHIHSGTFPFTCQYCSYGATRREHLVRHVITLHKEHLYAKEKLEKDKY
  EKRMAKTSAGLKLILKRYKIGASRKTFWKRKKINSGSDRSIEKNTQVLKKMNKTQTKSED
  QSHVVQEHLSEEKDERLHCENNDKAPESESEKPTPLSTGQGNRAEEGPNASSGFMKTAVL
  GPTLKNVMMKNNKLAVSPNYNATFMGFKMMDGKQHIVLKLVPIKQNVCSPGSQSGAAKDG
  TANLQPQTLDTNGFLTGVTTELNDTVYMKAATPFSCSSSILSGKASSEKEMTLISQRNNM
  LQTMDYEKSVSSLSATSELVTASVNLTTKFETRDNVDFWGNHLTQSHPEVLGTTIKSPDK
  VNCVAKPNAYNSGDMHNYCINYGNCELPVESSNQGSLPFHNYSKVNNSNKRRRFSGTAVY
  ENPQRESSSSKTVVQQPISESFLSLVRQESSKPDSLLASISLLNDKDGTLKAKSEIEEQY
  VLEKGQNIDGQNLYSNENQNLECATEKSKWEDFSNVDSPMMPRITSVFSLQSQQASEFLP
  PEVNQLLQDVLKIKPDVKQDSSNTPNKGLPLHCDQSFQKHEREGKIVESSKDFKVQGIFP
  VPPGSVGINVPTNDLNLKFGKEKQVSSIPQDVRDSEKMPRISGFGTLLKTQSDAIITQQL
  VKDKLRATTQNLGSFYMQSPLLNSEQKKTIIVQTSKGFLIPLNITNKPGLPVIPGNALPL
  VNSQGIPASLFVNKKPGMVLTLNNGKLEGVSAVKTEGAPARGTVTKEPCKTPILKVEPNN
  NCLTPGLCSSIGSCLSMKSSSENTLPLKGPYILKPTSSVKAVLIPNMLSEQQSTKLNISD
  SVKQQNEIFPKPPLYTFLPDGKQAVFLKCVMPNKTELLKPKLVQNSTYQNIQPKKPEGTP
  QRILLKIFNPVLNVTAANNLSVSNSASSLQKDNVPSNQIIGGEQKEPESRDALPFLLDDL
  MPANEIVITSTATCPESSEEPICVSDCSESRVLRCKTNCRIERNFNRKKTSKKIFSKTKT
  HGSKDSETAFVSRNRNCKRKCRDSYQEPPRRKATLHRKCKEKAKPEDVRETFGFSRPRLS
  KDSIRTLRLFPFSSKQLVKCPRRNQPVVVLNHPDADAPEVVSVMKTIAKFNGHVLKVSLS
  KRTINALLKPVCYNPPKTTYDDFSKRHKTFKPVSSVKERFVLKLTLKKTSKNNYQIVKTT
  SENILKAKFNCWFCGRVFDNQDTWAGHGQRHLMEATRDWNMLE

• Sequence length: 1483

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Ovarian Diseases	Associate	39261734	★☆☆☆☆ Found in Text Mining only