JAKMIP2 (janus kinase and microtubule interacting protein 2)

Gene

• Entrez ID: 9832
• Gene name: Janus kinase and microtubule interacting protein 2
• Gene symbol: JAKMIP2
• Synonyms (NCBI Gene): JAMIP2, NECC1
• Chromosome: 5
• Chromosome location: 5q32
• Summary: The protein encoded by this gene is reported to be a component of the Golgi matrix. It may act as a golgin protein by negatively regulating transit of secretory cargo and by acting as a structural scaffold of the Golgi. Alternative splicing results in mul

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018139	hsa-miR-335-5p	Microarray	18185580
MIRT027136	hsa-miR-103a-3p	Sequencing	20371350
MIRT608787	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT608786	hsa-miR-8068	HITS-CLIP	21572407
MIRT608785	hsa-miR-6818-5p	HITS-CLIP	21572407
MIRT608784	hsa-miR-147a	HITS-CLIP	21572407
MIRT608783	hsa-miR-5010-3p	HITS-CLIP	21572407
MIRT608782	hsa-miR-4455	HITS-CLIP	21572407
MIRT608781	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT608787	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT608786	hsa-miR-8068	HITS-CLIP	24906430
MIRT608785	hsa-miR-6818-5p	HITS-CLIP	24906430
MIRT608784	hsa-miR-147a	HITS-CLIP	24906430
MIRT608783	hsa-miR-5010-3p	HITS-CLIP	24906430
MIRT608782	hsa-miR-4455	HITS-CLIP	24906430
MIRT608781	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT526307	hsa-miR-4307	PAR-CLIP	22012620
MIRT526306	hsa-miR-302b-5p	PAR-CLIP	22012620
MIRT526305	hsa-miR-302d-5p	PAR-CLIP	22012620
MIRT608784	hsa-miR-147a	HITS-CLIP	27418678
MIRT608784	hsa-miR-147a	HITS-CLIP	27418678
MIRT608784	hsa-miR-147a	HITS-CLIP	27418678
MIRT608784	hsa-miR-147a	HITS-CLIP	27418678
MIRT608784	hsa-miR-147a	HITS-CLIP	27418678
MIRT608782	hsa-miR-4455	HITS-CLIP	27418678
MIRT608782	hsa-miR-4455	HITS-CLIP	27418678
MIRT608782	hsa-miR-4455	HITS-CLIP	27418678
MIRT608782	hsa-miR-4455	HITS-CLIP	27418678
MIRT608782	hsa-miR-4455	HITS-CLIP	27418678
MIRT608783	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT608783	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT608783	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT608783	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT608783	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT608781	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608781	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608781	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608781	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608781	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608785	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608785	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608785	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608785	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608785	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608787	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608787	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608787	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608787	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608787	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608786	hsa-miR-8068	HITS-CLIP	27418678
MIRT608786	hsa-miR-8068	HITS-CLIP	27418678
MIRT608786	hsa-miR-8068	HITS-CLIP	27418678
MIRT608786	hsa-miR-8068	HITS-CLIP	27418678
MIRT608786	hsa-miR-8068	HITS-CLIP	27418678
MIRT608787	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT608786	hsa-miR-8068	HITS-CLIP	21572407
MIRT608785	hsa-miR-6818-5p	HITS-CLIP	21572407
MIRT608784	hsa-miR-147a	HITS-CLIP	21572407
MIRT608783	hsa-miR-5010-3p	HITS-CLIP	21572407
MIRT608782	hsa-miR-4455	HITS-CLIP	21572407
MIRT608781	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT526307	hsa-miR-4307	PAR-CLIP	22012620
MIRT526306	hsa-miR-302b-5p	PAR-CLIP	22012620
MIRT526305	hsa-miR-302d-5p	PAR-CLIP	22012620
MIRT1076255	hsa-miR-1297	CLIP-seq
MIRT1076256	hsa-miR-26a	CLIP-seq
MIRT1076257	hsa-miR-26b	CLIP-seq
MIRT1076258	hsa-miR-3941	CLIP-seq
MIRT1076259	hsa-miR-4465	CLIP-seq
MIRT1076260	hsa-miR-4539	CLIP-seq
MIRT1076261	hsa-miR-466	CLIP-seq
MIRT1076262	hsa-miR-4672	CLIP-seq
MIRT1076263	hsa-miR-4731-3p	CLIP-seq
MIRT1076264	hsa-miR-4801	CLIP-seq
MIRT1076265	hsa-miR-628-5p	CLIP-seq
MIRT2250802	hsa-miR-1305	CLIP-seq
MIRT2250803	hsa-miR-421	CLIP-seq
MIRT2250804	hsa-miR-4709-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 25910212, 27107012, 31515488, 32296183
GO:0005794	Component	Golgi apparatus	IDA
GO:0008017	Function	Microtubule binding	IEA
GO:0015630	Component	Microtubule cytoskeleton	IBA	21873635
GO:0019900	Function	Kinase binding	IEA

Other IDs

• MIM: 611197
• HGNC: 29067
• e!Ensembl: ENSG00000176049

Protein

• UniProt ID: Q96AA8
• Protein name: Janus kinase and microtubule-interacting protein 2 (CTCL tumor antigen HD-CL-04) (Neuroendocrine long coiled-coil protein 1)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16034	JAKMIP_CC3	409 → 602	JAKMIP CC3 domain	Coiled-coil

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in brain, moderately expressed in thymus, spleen and lung, and weakly expressed in kidney, liver and peripheral blood lymphocytes. Also expressed in adrenal and pituitary glands, as well as testis. {ECO:0000269|PubMed:
• Sequence:

  MSKKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRE
  LEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCA
  LRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIK
  AGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQ
  KEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLED
  RNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSE
  MREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHR
  RSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQ
  LTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDS
  HWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPP
  FNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVL
  SLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELE
  ATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQA
  HQRIRDLEDKTDIQKRQIKDLEEKSNRKHG

• Sequence length: 810

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208
Melanoma	melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050	22842228
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137

Unknown
Disease term	Disease name	Evidence	References	Source
Ovarian cancer	Ovarian cancer	Conditional KD of IL6 in the OCCA xenograft model delays tumor growth		GWAS, CBGDA

Associations from Text Mining
Disease Name	Relationship Type	References
Graves Disease	Associate	30796769