RB1CC1 (RB1 inducible coiled-coil 1)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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9821 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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RB1 inducible coiled-coil 1 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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RB1CC1 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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ATG17, CC1, FIP200, PPP1R131 |
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Chromosome
Chromosome number
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8 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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8q11.23 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Al |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | Q8TDY2 | ||||||||||
| Protein name | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | ||||||||||
| Protein function | Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane struc | ||||||||||
| PDB | 6DCE , 6GMA , 7CZG , 7CZM , 7D0E , 7EA2 , 7EAA , 8SOI , 8SQZ , 8SRM , 8W6B , 8YFK , 8YFL , 8YFM , 8YFN , 9C82 , 9D34 | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expression levels correlated closely with those of RB1 in cancer cell lines as well as in various normal human tissues. Abundantly expressed in human musculoskeletal and cultured osteosarcoma cells. {ECO:0000269|PubMed:11850849, ECO:00 | ||||||||||
| Sequence |
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| Sequence length | 1594 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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