TSC22D2 (TSC22 domain family member 2)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9819
Gene name Gene Name - the full gene name approved by the HGNC.
TSC22 domain family member 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TSC22D2
Synonyms (NCBI Gene) Gene synonyms aliases
TILZ4a, TILZ4b, TILZ4c
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q25.1
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(868)
miRTarBase ID miRNA Experiments Reference
MIRT019779 hsa-miR-375 Microarray 20215506
MIRT027596 hsa-miR-98-5p Microarray 19088304
MIRT029295 hsa-miR-26b-5p Microarray 19088304
MIRT046928 hsa-miR-221-3p CLASH 23622248
MIRT044409 hsa-miR-320a CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(2)
GO ID Ontology Definition Evidence Reference
GO:0006357 Process Regulation of transcription by RNA polymerase II IEA
GO:0006970 Process Response to osmotic stress IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
617724 29095 ENSG00000196428
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID O75157
Protein name TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4)
Protein function Reduces the level of nuclear PKM isoform M2 which results in repression of cyclin CCND1 transcription and reduced cell growth.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01166 TSC22 694 → 750 TSC-22/dip/bun family Coiled-coil
Sequence 
MSKMPAKKKSCFQITSVTTAQVATSITEDTESLDDPDESRTEDVSSEIFDVSRATDYGPE
EVCERSSSEETLNNVGDAETPGTVSPNLLLDGQLAAAAAAPANGGGVVSARSVSGALAST
LAAAATSAPAPGAPGGPQLAGSSAGPVTAAPSQPPTTCSSRFRVIKLDHGSGEPYRRGRW
TCMEYYERDSDSSVLTRSGDCIRHSSTFDQTAERDSGLGATGGSVVVVVASMQGAHGPES
GTDSSLTAVSQLPPSEKMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPLPPFPGAAT
GPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQFAYP
QPQIPPGHLLPVQPSGQSEYLQQHVAGLQPPSPAQPSSTGAAASPATAATLPVGTGQNAS
SVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPTGVPPATVGGVVQPCLGPAGAGQPQS
VPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLAQSQQ
LSSHTPVSRSSSIIQHVGLPLAPGTHSAPTSLPQSDLSQFQTQTQPLVGQVDDTRRKSEP
LPQPPLSLIAENKPVVKPPVADSLANPLQLTPMNSLATSVFSIAIPVDGDEDRNPSTAFY
QAFHLNTLKESKSLWDSASGGGVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELV
ERNSLLERENALLKSLSSNDQLSQLPTQQANPGSTSQQQAVIAQPPQPTQPPQQPNVSSA
Sequence length 780
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Moyamoya disease Moyamoya Disease, Moyamoya disease 1 rs121434527, rs121434528, rs387906592, rs397514563, rs797045187, rs1555675538, rs1568149971, rs1599150380, rs2079443410 29273593
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Moyamoya Disease Moyamoya Disease GWAS
Show/Hide Text Mining Associations (4)
Associations from Text Mining
Disease Name Relationship Type References
Abortion Spontaneous Associate 36750132
Neoplasms Associate 27337956
Pancreatic Neoplasms Associate 36894917
Polycystic Ovary Syndrome Associate 36750132