TSC22D2 (TSC22 domain family member 2)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 9819
Gene name TSC22 domain family member 2
Gene symbol TSC22D2
Synonyms (NCBI Gene)
TILZ4aTILZ4bTILZ4c
Chromosome 3
Chromosome location 3q25.1
miRNA miRNA information provided by mirtarbase database.
868
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (868)
miRTarBase ID miRNA Experiments Reference
MIRT019779 hsa-miR-375 Microarray 20215506
MIRT027596 hsa-miR-98-5p Microarray 19088304
MIRT029295 hsa-miR-26b-5p Microarray 19088304
MIRT046928 hsa-miR-221-3p CLASH 23622248
MIRT044409 hsa-miR-320a CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
4
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (4)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 22510880, 27337956, 27573352
GO:0006357 Process Regulation of transcription by RNA polymerase II IEA
GO:0006970 Process Response to osmotic stress IEA
GO:0045786 Process Negative regulation of cell cycle IMP 27573352
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
617724 29095 ENSG00000196428
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75157
Protein name TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4)
Protein function Reduces the level of nuclear PKM isoform M2 which results in repression of cyclin CCND1 transcription and reduced cell growth.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01166 TSC22 694 → 750 TSC-22/dip/bun family Coiled-coil
Sequence 
MSKMPAKKKSCFQITSVTTAQVATSITEDTESLDDPDESRTEDVSSEIFDVSRATDYGPE
EVCERSSSEETLNNVGDAETPGTVSPNLLLDGQLAAAAAAPANGGGVVSARSVSGALAST
LAAAATSAPAPGAPGGPQLAGSSAGPVTAAPSQPPTTCSSRFRVIKLDHGSGEPYRRGRW
TCMEYYERDSDSSVLTRSGDCIRHSSTFDQTAERDSGLGATGGSVVVVVASMQGAHGPES
GTDSSLTAVSQLPPSEKMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPLPPFPGAAT
GPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQFAYP
QPQIPPGHLLPVQPSGQSEYLQQHVAGLQPPSPAQPSSTGAAASPATAATLPVGTGQNAS
SVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPTGVPPATVGGVVQPCLGPAGAGQPQS
VPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLAQSQQ
LSSHTPVSRSSSIIQHVGLPLAPGTHSAPTSLPQSDLSQFQTQTQPLVGQVDDTRRKSEP
LPQPPLSLIAENKPVVKPPVADSLANPLQLTPMNSLATSVFSIAIPVDGDEDRNPSTAFY
QAFHLNTLKESKSLWDSASGGGVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELV
ERNSLLERENALLKSLSSNDQLSQLPTQQANPGSTSQQQAVIAQPPQPTQPPQQPNVSSA
Sequence length 780
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
2
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Hepatocellular carcinoma Likely benign rs199503353 RCV005932185
Keratoconus Uncertain significance rs151080920 RCV003235801
Show/Hide Text Mining Associations (4)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Abortion Spontaneous Associate 36750132
Neoplasms Associate 27337956
Pancreatic Neoplasms Associate 36894917
Polycystic Ovary Syndrome Associate 36750132