GIT2 (GIT ArfGAP 2)

Gene

• Entrez ID: 9815
• Gene name: GIT ArfGAP 2
• Gene symbol: GIT2
• Synonyms (NCBI Gene): CAT-2, CAT2, PKL
• Chromosome: 12
• Chromosome location: 12q24.11
• Summary: This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhe

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022651	hsa-miR-124-3p	Microarray	18668037
MIRT050071	hsa-miR-26a-5p	CLASH	23622248
MIRT440570	hsa-miR-210-3p	HITS-CLIP	22473208
MIRT440568	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT133161	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT133162	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT440570	hsa-miR-210-3p	HITS-CLIP	22473208
MIRT440568	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT727580	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT727581	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT727579	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT1019485	hsa-miR-1205	CLIP-seq
MIRT1019486	hsa-miR-1208	CLIP-seq
MIRT1019487	hsa-miR-1253	CLIP-seq
MIRT1019488	hsa-miR-1271	CLIP-seq
MIRT1019489	hsa-miR-182	CLIP-seq
MIRT1019490	hsa-miR-1973	CLIP-seq
MIRT1019491	hsa-miR-2052	CLIP-seq
MIRT1019492	hsa-miR-2116	CLIP-seq
MIRT1019493	hsa-miR-34b	CLIP-seq
MIRT1019494	hsa-miR-3614-5p	CLIP-seq
MIRT1019495	hsa-miR-3665	CLIP-seq
MIRT1019496	hsa-miR-4420	CLIP-seq
MIRT1019497	hsa-miR-4470	CLIP-seq
MIRT1019498	hsa-miR-4677-5p	CLIP-seq
MIRT1019499	hsa-miR-4753-3p	CLIP-seq
MIRT1019500	hsa-miR-495	CLIP-seq
MIRT1019501	hsa-miR-548g	CLIP-seq
MIRT1019502	hsa-miR-580	CLIP-seq
MIRT1019503	hsa-miR-657	CLIP-seq
MIRT1019504	hsa-miR-9	CLIP-seq
MIRT1019505	hsa-miR-942	CLIP-seq
MIRT1019506	hsa-miR-96	CLIP-seq
MIRT1019507	hsa-miR-103a	CLIP-seq
MIRT1019508	hsa-miR-107	CLIP-seq
MIRT1019486	hsa-miR-1208	CLIP-seq
MIRT1019509	hsa-miR-1231	CLIP-seq
MIRT1019510	hsa-miR-1245b-3p	CLIP-seq
MIRT1019488	hsa-miR-1271	CLIP-seq
MIRT1019511	hsa-miR-130a	CLIP-seq
MIRT1019512	hsa-miR-130b	CLIP-seq
MIRT1019513	hsa-miR-149	CLIP-seq
MIRT1019514	hsa-miR-1537	CLIP-seq
MIRT1019489	hsa-miR-182	CLIP-seq
MIRT1019515	hsa-miR-18a	CLIP-seq
MIRT1019516	hsa-miR-18b	CLIP-seq
MIRT1019517	hsa-miR-19a	CLIP-seq
MIRT1019518	hsa-miR-19b	CLIP-seq
MIRT1019491	hsa-miR-2052	CLIP-seq
MIRT1019492	hsa-miR-2116	CLIP-seq
MIRT1019519	hsa-miR-301a	CLIP-seq
MIRT1019520	hsa-miR-301b	CLIP-seq
MIRT1019521	hsa-miR-3064-5p	CLIP-seq
MIRT1019522	hsa-miR-3120-5p	CLIP-seq
MIRT1019523	hsa-miR-3126-5p	CLIP-seq
MIRT1019524	hsa-miR-337-3p	CLIP-seq
MIRT1019525	hsa-miR-338-5p	CLIP-seq
MIRT1019526	hsa-miR-33a	CLIP-seq
MIRT1019527	hsa-miR-33b	CLIP-seq
MIRT1019528	hsa-miR-3529	CLIP-seq
MIRT1019529	hsa-miR-3652	CLIP-seq
MIRT1019530	hsa-miR-3666	CLIP-seq
MIRT1019531	hsa-miR-3673	CLIP-seq
MIRT1019532	hsa-miR-3685	CLIP-seq
MIRT1019533	hsa-miR-3714	CLIP-seq
MIRT1019534	hsa-miR-379	CLIP-seq
MIRT1019535	hsa-miR-384	CLIP-seq
MIRT1019536	hsa-miR-3910	CLIP-seq
MIRT1019537	hsa-miR-3927	CLIP-seq
MIRT1019538	hsa-miR-4264	CLIP-seq
MIRT1019539	hsa-miR-4269	CLIP-seq
MIRT1019540	hsa-miR-4295	CLIP-seq
MIRT1019541	hsa-miR-4310	CLIP-seq
MIRT1019542	hsa-miR-4328	CLIP-seq
MIRT1019543	hsa-miR-4419a	CLIP-seq
MIRT1019496	hsa-miR-4420	CLIP-seq
MIRT1019544	hsa-miR-4430	CLIP-seq
MIRT1019545	hsa-miR-4468	CLIP-seq
MIRT1019497	hsa-miR-4470	CLIP-seq
MIRT1019546	hsa-miR-4505	CLIP-seq
MIRT1019547	hsa-miR-4510	CLIP-seq
MIRT1019548	hsa-miR-4511	CLIP-seq
MIRT1019549	hsa-miR-454	CLIP-seq
MIRT1019550	hsa-miR-4671-3p	CLIP-seq
MIRT1019498	hsa-miR-4677-5p	CLIP-seq
MIRT1019551	hsa-miR-4690-5p	CLIP-seq
MIRT1019552	hsa-miR-4700-3p	CLIP-seq
MIRT1019553	hsa-miR-4708-3p	CLIP-seq
MIRT1019554	hsa-miR-4710	CLIP-seq
MIRT1019555	hsa-miR-4716-5p	CLIP-seq
MIRT1019556	hsa-miR-4719	CLIP-seq
MIRT1019557	hsa-miR-4724-5p	CLIP-seq
MIRT1019558	hsa-miR-4735-3p	CLIP-seq
MIRT1019559	hsa-miR-4765	CLIP-seq
MIRT1019560	hsa-miR-4776-3p	CLIP-seq
MIRT1019561	hsa-miR-4794	CLIP-seq
MIRT1019562	hsa-miR-4797-3p	CLIP-seq
MIRT1019563	hsa-miR-493	CLIP-seq
MIRT1019500	hsa-miR-495	CLIP-seq
MIRT1019564	hsa-miR-5095	CLIP-seq
MIRT1019565	hsa-miR-542-3p	CLIP-seq
MIRT1019566	hsa-miR-548ad	CLIP-seq
MIRT1019567	hsa-miR-548an	CLIP-seq
MIRT1019568	hsa-miR-548b-3p	CLIP-seq
MIRT1019501	hsa-miR-548g	CLIP-seq
MIRT1019569	hsa-miR-548k	CLIP-seq
MIRT1019570	hsa-miR-548n	CLIP-seq
MIRT1019571	hsa-miR-561	CLIP-seq
MIRT1019572	hsa-miR-600	CLIP-seq
MIRT1019504	hsa-miR-9	CLIP-seq
MIRT1019506	hsa-miR-96	CLIP-seq
MIRT1019573	hsa-miR-1303	CLIP-seq
MIRT1019494	hsa-miR-3614-5p	CLIP-seq
MIRT1019574	hsa-miR-432	CLIP-seq
MIRT1019575	hsa-miR-4443	CLIP-seq
MIRT1019576	hsa-miR-668	CLIP-seq
MIRT1019577	hsa-miR-890	CLIP-seq
MIRT2001950	hsa-miR-3647-3p	CLIP-seq
MIRT1019533	hsa-miR-3714	CLIP-seq
MIRT2234980	hsa-miR-25	CLIP-seq
MIRT2234981	hsa-miR-32	CLIP-seq
MIRT2234982	hsa-miR-363	CLIP-seq
MIRT2234983	hsa-miR-367	CLIP-seq
MIRT1019533	hsa-miR-3714	CLIP-seq
MIRT2234984	hsa-miR-4484	CLIP-seq
MIRT1019567	hsa-miR-548an	CLIP-seq
MIRT2234985	hsa-miR-92a	CLIP-seq
MIRT2234986	hsa-miR-92b	CLIP-seq
MIRT1019551	hsa-miR-4690-5p	CLIP-seq
MIRT1019507	hsa-miR-103a	CLIP-seq
MIRT1019508	hsa-miR-107	CLIP-seq
MIRT2538774	hsa-miR-10a	CLIP-seq
MIRT2538775	hsa-miR-10b	CLIP-seq
MIRT2538776	hsa-miR-1184	CLIP-seq
MIRT1019510	hsa-miR-1245b-3p	CLIP-seq
MIRT2538777	hsa-miR-1251	CLIP-seq
MIRT2538778	hsa-miR-1293	CLIP-seq
MIRT2538779	hsa-miR-1296	CLIP-seq
MIRT2538780	hsa-miR-133a	CLIP-seq
MIRT2538781	hsa-miR-133b	CLIP-seq
MIRT2538782	hsa-miR-142-5p	CLIP-seq
MIRT2538783	hsa-miR-1910	CLIP-seq
MIRT2538784	hsa-miR-1914	CLIP-seq
MIRT2538785	hsa-miR-210	CLIP-seq
MIRT2538786	hsa-miR-2277-3p	CLIP-seq
MIRT2538787	hsa-miR-2277-5p	CLIP-seq
MIRT2234980	hsa-miR-25	CLIP-seq
MIRT2538788	hsa-miR-28-5p	CLIP-seq
MIRT2538789	hsa-miR-3139	CLIP-seq
MIRT2234981	hsa-miR-32	CLIP-seq
MIRT2538790	hsa-miR-335	CLIP-seq
MIRT1019524	hsa-miR-337-3p	CLIP-seq
MIRT2538791	hsa-miR-340	CLIP-seq
MIRT2234982	hsa-miR-363	CLIP-seq
MIRT1019495	hsa-miR-3665	CLIP-seq
MIRT2234983	hsa-miR-367	CLIP-seq
MIRT1019531	hsa-miR-3673	CLIP-seq
MIRT1019532	hsa-miR-3685	CLIP-seq
MIRT2538792	hsa-miR-371-5p	CLIP-seq
MIRT1019535	hsa-miR-384	CLIP-seq
MIRT1019536	hsa-miR-3910	CLIP-seq
MIRT2538793	hsa-miR-3914	CLIP-seq
MIRT1019538	hsa-miR-4264	CLIP-seq
MIRT2538794	hsa-miR-4281	CLIP-seq
MIRT2538795	hsa-miR-4290	CLIP-seq
MIRT1019541	hsa-miR-4310	CLIP-seq
MIRT2538796	hsa-miR-4326	CLIP-seq
MIRT1019542	hsa-miR-4328	CLIP-seq
MIRT2538797	hsa-miR-4330	CLIP-seq
MIRT2538798	hsa-miR-4479	CLIP-seq
MIRT2538799	hsa-miR-4483	CLIP-seq
MIRT2234984	hsa-miR-4484	CLIP-seq
MIRT2538800	hsa-miR-4506	CLIP-seq
MIRT2538801	hsa-miR-4512	CLIP-seq
MIRT2538802	hsa-miR-455-3p	CLIP-seq
MIRT2538803	hsa-miR-4633-3p	CLIP-seq
MIRT2538804	hsa-miR-4655-5p	CLIP-seq
MIRT2538805	hsa-miR-4684-5p	CLIP-seq
MIRT2538806	hsa-miR-4687-5p	CLIP-seq
MIRT2538807	hsa-miR-4695-3p	CLIP-seq
MIRT2538808	hsa-miR-4701-5p	CLIP-seq
MIRT1019555	hsa-miR-4716-5p	CLIP-seq
MIRT2538809	hsa-miR-4724-3p	CLIP-seq
MIRT2538810	hsa-miR-4768-5p	CLIP-seq
MIRT1019562	hsa-miR-4797-3p	CLIP-seq
MIRT2538811	hsa-miR-4797-5p	CLIP-seq
MIRT2538812	hsa-miR-502-5p	CLIP-seq
MIRT1019567	hsa-miR-548an	CLIP-seq
MIRT2538813	hsa-miR-548m	CLIP-seq
MIRT2538814	hsa-miR-570	CLIP-seq
MIRT2538815	hsa-miR-588	CLIP-seq
MIRT2538816	hsa-miR-598	CLIP-seq
MIRT1019572	hsa-miR-600	CLIP-seq
MIRT1019503	hsa-miR-657	CLIP-seq
MIRT2538817	hsa-miR-708	CLIP-seq
MIRT2538818	hsa-miR-744	CLIP-seq
MIRT2538819	hsa-miR-875-3p	CLIP-seq
MIRT2234985	hsa-miR-92a	CLIP-seq
MIRT2234986	hsa-miR-92b	CLIP-seq
MIRT1019507	hsa-miR-103a	CLIP-seq
MIRT1019508	hsa-miR-107	CLIP-seq
MIRT2538776	hsa-miR-1184	CLIP-seq
MIRT1019510	hsa-miR-1245b-3p	CLIP-seq
MIRT2538777	hsa-miR-1251	CLIP-seq
MIRT2538778	hsa-miR-1293	CLIP-seq
MIRT2538779	hsa-miR-1296	CLIP-seq
MIRT2538780	hsa-miR-133a	CLIP-seq
MIRT2538781	hsa-miR-133b	CLIP-seq
MIRT2538784	hsa-miR-1914	CLIP-seq
MIRT2538785	hsa-miR-210	CLIP-seq
MIRT2538787	hsa-miR-2277-5p	CLIP-seq
MIRT2234980	hsa-miR-25	CLIP-seq
MIRT2234981	hsa-miR-32	CLIP-seq
MIRT1019524	hsa-miR-337-3p	CLIP-seq
MIRT2234982	hsa-miR-363	CLIP-seq
MIRT1019495	hsa-miR-3665	CLIP-seq
MIRT2234983	hsa-miR-367	CLIP-seq
MIRT1019531	hsa-miR-3673	CLIP-seq
MIRT1019532	hsa-miR-3685	CLIP-seq
MIRT2538792	hsa-miR-371-5p	CLIP-seq
MIRT1019535	hsa-miR-384	CLIP-seq
MIRT1019536	hsa-miR-3910	CLIP-seq
MIRT2538793	hsa-miR-3914	CLIP-seq
MIRT1019538	hsa-miR-4264	CLIP-seq
MIRT2538794	hsa-miR-4281	CLIP-seq
MIRT2538795	hsa-miR-4290	CLIP-seq
MIRT1019541	hsa-miR-4310	CLIP-seq
MIRT2538796	hsa-miR-4326	CLIP-seq
MIRT1019542	hsa-miR-4328	CLIP-seq
MIRT2538797	hsa-miR-4330	CLIP-seq
MIRT2681568	hsa-miR-4436a	CLIP-seq
MIRT2681569	hsa-miR-4471	CLIP-seq
MIRT2538798	hsa-miR-4479	CLIP-seq
MIRT2538799	hsa-miR-4483	CLIP-seq
MIRT2234984	hsa-miR-4484	CLIP-seq
MIRT2538800	hsa-miR-4506	CLIP-seq
MIRT2538801	hsa-miR-4512	CLIP-seq
MIRT2538803	hsa-miR-4633-3p	CLIP-seq
MIRT2538804	hsa-miR-4655-5p	CLIP-seq
MIRT2538805	hsa-miR-4684-5p	CLIP-seq
MIRT2538806	hsa-miR-4687-5p	CLIP-seq
MIRT2538807	hsa-miR-4695-3p	CLIP-seq
MIRT2538808	hsa-miR-4701-5p	CLIP-seq
MIRT1019555	hsa-miR-4716-5p	CLIP-seq
MIRT2538809	hsa-miR-4724-3p	CLIP-seq
MIRT2538810	hsa-miR-4768-5p	CLIP-seq
MIRT1019562	hsa-miR-4797-3p	CLIP-seq
MIRT2538811	hsa-miR-4797-5p	CLIP-seq
MIRT2538812	hsa-miR-502-5p	CLIP-seq
MIRT1019567	hsa-miR-548an	CLIP-seq
MIRT2538815	hsa-miR-588	CLIP-seq
MIRT2538816	hsa-miR-598	CLIP-seq
MIRT1019572	hsa-miR-600	CLIP-seq
MIRT1019503	hsa-miR-657	CLIP-seq
MIRT2538818	hsa-miR-744	CLIP-seq
MIRT2538819	hsa-miR-875-3p	CLIP-seq
MIRT2234985	hsa-miR-92a	CLIP-seq
MIRT2234986	hsa-miR-92b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	16628223, 21295525, 21988832, 22728435, 31980649, 32296183, 33961781, 35271311
GO:0005654	Component	Nucleoplasm	IDA	10942595
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0007420	Process	Brain development	IBA
GO:0007420	Process	Brain development	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	IBA
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	TAS	10896954
GO:0031267	Function	Small GTPase binding	IBA
GO:0032012	Process	Regulation of ARF protein signal transduction	IBA
GO:0032012	Process	Regulation of ARF protein signal transduction	IEA
GO:0036465	Process	Synaptic vesicle recycling	IBA
GO:0045202	Component	Synapse	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0098793	Component	Presynapse	IEA

Other IDs

• MIM: 608564
• HGNC: 4273
• e!Ensembl: ENSG00000139436

Protein

• UniProt ID: Q14161
• Protein name: ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)
• Protein function: GTPase-activating protein for ADP ribosylation factor family members, including ARF1.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01412	ArfGap	1 → 120	Putative GTPase activating protein for Arf	Domain
  PF08518	GIT_SHD	266 → 294	Spa2 homology domain (SHD) of GIT	Family
  PF08518	GIT_SHD	330 → 358	Spa2 homology domain (SHD) of GIT	Family
  PF16559	GIT_CC	414 → 478	GIT coiled-coil Rho guanine nucleotide exchange factor	Coiled-coil
  PF12205	GIT1_C	636 → 752	G protein-coupled receptor kinase-interacting protein 1 C term	Domain

• Sequence:

  MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL
  LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL
  PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI
  LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD
  HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA
  TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS
  SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDL
  SDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLQTLQSENSNLRKQAT
  TNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASRPEESRMR
  LQPFPAHIGRSALVTSSSSLPSFPSTLSWSRDESARRASRLEKQNSTPESDYDNTPNDME
  PDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRA
  AQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPG
  DPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENNN

• Sequence length: 759

Pathways

KEGG:

Endocytosis
Yersinia infection