Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9815
Gene name Gene Name - the full gene name approved by the HGNC.	GIT ArfGAP 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GIT2
Synonyms (NCBI Gene) Gene synonyms aliases	CAT-2, CAT2, PKL
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q24.11
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhe

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022651	hsa-miR-124-3p	Microarray	18668037
MIRT050071	hsa-miR-26a-5p	CLASH	23622248
MIRT440570	hsa-miR-210-3p	HITS-CLIP	22473208
MIRT440568	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT133161	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT133162	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT440570	hsa-miR-210-3p	HITS-CLIP	22473208
MIRT440568	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT727580	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT727581	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT727579	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT1019485	hsa-miR-1205	CLIP-seq
MIRT1019486	hsa-miR-1208	CLIP-seq
MIRT1019487	hsa-miR-1253	CLIP-seq
MIRT1019488	hsa-miR-1271	CLIP-seq
MIRT1019489	hsa-miR-182	CLIP-seq
MIRT1019490	hsa-miR-1973	CLIP-seq
MIRT1019491	hsa-miR-2052	CLIP-seq
MIRT1019492	hsa-miR-2116	CLIP-seq
MIRT1019493	hsa-miR-34b	CLIP-seq
MIRT1019494	hsa-miR-3614-5p	CLIP-seq
MIRT1019495	hsa-miR-3665	CLIP-seq
MIRT1019496	hsa-miR-4420	CLIP-seq
MIRT1019497	hsa-miR-4470	CLIP-seq
MIRT1019498	hsa-miR-4677-5p	CLIP-seq
MIRT1019499	hsa-miR-4753-3p	CLIP-seq
MIRT1019500	hsa-miR-495	CLIP-seq
MIRT1019501	hsa-miR-548g	CLIP-seq
MIRT1019502	hsa-miR-580	CLIP-seq
MIRT1019503	hsa-miR-657	CLIP-seq
MIRT1019504	hsa-miR-9	CLIP-seq
MIRT1019505	hsa-miR-942	CLIP-seq
MIRT1019506	hsa-miR-96	CLIP-seq
MIRT1019507	hsa-miR-103a	CLIP-seq
MIRT1019508	hsa-miR-107	CLIP-seq
MIRT1019486	hsa-miR-1208	CLIP-seq
MIRT1019509	hsa-miR-1231	CLIP-seq
MIRT1019510	hsa-miR-1245b-3p	CLIP-seq
MIRT1019488	hsa-miR-1271	CLIP-seq
MIRT1019511	hsa-miR-130a	CLIP-seq
MIRT1019512	hsa-miR-130b	CLIP-seq
MIRT1019513	hsa-miR-149	CLIP-seq
MIRT1019514	hsa-miR-1537	CLIP-seq
MIRT1019489	hsa-miR-182	CLIP-seq
MIRT1019515	hsa-miR-18a	CLIP-seq
MIRT1019516	hsa-miR-18b	CLIP-seq
MIRT1019517	hsa-miR-19a	CLIP-seq
MIRT1019518	hsa-miR-19b	CLIP-seq
MIRT1019491	hsa-miR-2052	CLIP-seq
MIRT1019492	hsa-miR-2116	CLIP-seq
MIRT1019519	hsa-miR-301a	CLIP-seq
MIRT1019520	hsa-miR-301b	CLIP-seq
MIRT1019521	hsa-miR-3064-5p	CLIP-seq
MIRT1019522	hsa-miR-3120-5p	CLIP-seq
MIRT1019523	hsa-miR-3126-5p	CLIP-seq
MIRT1019524	hsa-miR-337-3p	CLIP-seq
MIRT1019525	hsa-miR-338-5p	CLIP-seq
MIRT1019526	hsa-miR-33a	CLIP-seq
MIRT1019527	hsa-miR-33b	CLIP-seq
MIRT1019528	hsa-miR-3529	CLIP-seq
MIRT1019529	hsa-miR-3652	CLIP-seq
MIRT1019530	hsa-miR-3666	CLIP-seq
MIRT1019531	hsa-miR-3673	CLIP-seq
MIRT1019532	hsa-miR-3685	CLIP-seq
MIRT1019533	hsa-miR-3714	CLIP-seq
MIRT1019534	hsa-miR-379	CLIP-seq
MIRT1019535	hsa-miR-384	CLIP-seq
MIRT1019536	hsa-miR-3910	CLIP-seq
MIRT1019537	hsa-miR-3927	CLIP-seq
MIRT1019538	hsa-miR-4264	CLIP-seq
MIRT1019539	hsa-miR-4269	CLIP-seq
MIRT1019540	hsa-miR-4295	CLIP-seq
MIRT1019541	hsa-miR-4310	CLIP-seq
MIRT1019542	hsa-miR-4328	CLIP-seq
MIRT1019543	hsa-miR-4419a	CLIP-seq
MIRT1019496	hsa-miR-4420	CLIP-seq
MIRT1019544	hsa-miR-4430	CLIP-seq
MIRT1019545	hsa-miR-4468	CLIP-seq
MIRT1019497	hsa-miR-4470	CLIP-seq
MIRT1019546	hsa-miR-4505	CLIP-seq
MIRT1019547	hsa-miR-4510	CLIP-seq
MIRT1019548	hsa-miR-4511	CLIP-seq
MIRT1019549	hsa-miR-454	CLIP-seq
MIRT1019550	hsa-miR-4671-3p	CLIP-seq
MIRT1019498	hsa-miR-4677-5p	CLIP-seq
MIRT1019551	hsa-miR-4690-5p	CLIP-seq
MIRT1019552	hsa-miR-4700-3p	CLIP-seq
MIRT1019553	hsa-miR-4708-3p	CLIP-seq
MIRT1019554	hsa-miR-4710	CLIP-seq
MIRT1019555	hsa-miR-4716-5p	CLIP-seq
MIRT1019556	hsa-miR-4719	CLIP-seq
MIRT1019557	hsa-miR-4724-5p	CLIP-seq
MIRT1019558	hsa-miR-4735-3p	CLIP-seq
MIRT1019559	hsa-miR-4765	CLIP-seq
MIRT1019560	hsa-miR-4776-3p	CLIP-seq
MIRT1019561	hsa-miR-4794	CLIP-seq
MIRT1019562	hsa-miR-4797-3p	CLIP-seq
MIRT1019563	hsa-miR-493	CLIP-seq
MIRT1019500	hsa-miR-495	CLIP-seq
MIRT1019564	hsa-miR-5095	CLIP-seq
MIRT1019565	hsa-miR-542-3p	CLIP-seq
MIRT1019566	hsa-miR-548ad	CLIP-seq
MIRT1019567	hsa-miR-548an	CLIP-seq
MIRT1019568	hsa-miR-548b-3p	CLIP-seq
MIRT1019501	hsa-miR-548g	CLIP-seq
MIRT1019569	hsa-miR-548k	CLIP-seq
MIRT1019570	hsa-miR-548n	CLIP-seq
MIRT1019571	hsa-miR-561	CLIP-seq
MIRT1019572	hsa-miR-600	CLIP-seq
MIRT1019504	hsa-miR-9	CLIP-seq
MIRT1019506	hsa-miR-96	CLIP-seq
MIRT1019573	hsa-miR-1303	CLIP-seq
MIRT1019494	hsa-miR-3614-5p	CLIP-seq
MIRT1019574	hsa-miR-432	CLIP-seq
MIRT1019575	hsa-miR-4443	CLIP-seq
MIRT1019576	hsa-miR-668	CLIP-seq
MIRT1019577	hsa-miR-890	CLIP-seq
MIRT2001950	hsa-miR-3647-3p	CLIP-seq
MIRT1019533	hsa-miR-3714	CLIP-seq
MIRT2234980	hsa-miR-25	CLIP-seq
MIRT2234981	hsa-miR-32	CLIP-seq
MIRT2234982	hsa-miR-363	CLIP-seq
MIRT2234983	hsa-miR-367	CLIP-seq
MIRT1019533	hsa-miR-3714	CLIP-seq
MIRT2234984	hsa-miR-4484	CLIP-seq
MIRT1019567	hsa-miR-548an	CLIP-seq
MIRT2234985	hsa-miR-92a	CLIP-seq
MIRT2234986	hsa-miR-92b	CLIP-seq
MIRT1019551	hsa-miR-4690-5p	CLIP-seq
MIRT1019507	hsa-miR-103a	CLIP-seq
MIRT1019508	hsa-miR-107	CLIP-seq
MIRT2538774	hsa-miR-10a	CLIP-seq
MIRT2538775	hsa-miR-10b	CLIP-seq
MIRT2538776	hsa-miR-1184	CLIP-seq
MIRT1019510	hsa-miR-1245b-3p	CLIP-seq
MIRT2538777	hsa-miR-1251	CLIP-seq
MIRT2538778	hsa-miR-1293	CLIP-seq
MIRT2538779	hsa-miR-1296	CLIP-seq
MIRT2538780	hsa-miR-133a	CLIP-seq
MIRT2538781	hsa-miR-133b	CLIP-seq
MIRT2538782	hsa-miR-142-5p	CLIP-seq
MIRT2538783	hsa-miR-1910	CLIP-seq
MIRT2538784	hsa-miR-1914	CLIP-seq
MIRT2538785	hsa-miR-210	CLIP-seq
MIRT2538786	hsa-miR-2277-3p	CLIP-seq
MIRT2538787	hsa-miR-2277-5p	CLIP-seq
MIRT2234980	hsa-miR-25	CLIP-seq
MIRT2538788	hsa-miR-28-5p	CLIP-seq
MIRT2538789	hsa-miR-3139	CLIP-seq
MIRT2234981	hsa-miR-32	CLIP-seq
MIRT2538790	hsa-miR-335	CLIP-seq
MIRT1019524	hsa-miR-337-3p	CLIP-seq
MIRT2538791	hsa-miR-340	CLIP-seq
MIRT2234982	hsa-miR-363	CLIP-seq
MIRT1019495	hsa-miR-3665	CLIP-seq
MIRT2234983	hsa-miR-367	CLIP-seq
MIRT1019531	hsa-miR-3673	CLIP-seq
MIRT1019532	hsa-miR-3685	CLIP-seq
MIRT2538792	hsa-miR-371-5p	CLIP-seq
MIRT1019535	hsa-miR-384	CLIP-seq
MIRT1019536	hsa-miR-3910	CLIP-seq
MIRT2538793	hsa-miR-3914	CLIP-seq
MIRT1019538	hsa-miR-4264	CLIP-seq
MIRT2538794	hsa-miR-4281	CLIP-seq
MIRT2538795	hsa-miR-4290	CLIP-seq
MIRT1019541	hsa-miR-4310	CLIP-seq
MIRT2538796	hsa-miR-4326	CLIP-seq
MIRT1019542	hsa-miR-4328	CLIP-seq
MIRT2538797	hsa-miR-4330	CLIP-seq
MIRT2538798	hsa-miR-4479	CLIP-seq
MIRT2538799	hsa-miR-4483	CLIP-seq
MIRT2234984	hsa-miR-4484	CLIP-seq
MIRT2538800	hsa-miR-4506	CLIP-seq
MIRT2538801	hsa-miR-4512	CLIP-seq
MIRT2538802	hsa-miR-455-3p	CLIP-seq
MIRT2538803	hsa-miR-4633-3p	CLIP-seq
MIRT2538804	hsa-miR-4655-5p	CLIP-seq
MIRT2538805	hsa-miR-4684-5p	CLIP-seq
MIRT2538806	hsa-miR-4687-5p	CLIP-seq
MIRT2538807	hsa-miR-4695-3p	CLIP-seq
MIRT2538808	hsa-miR-4701-5p	CLIP-seq
MIRT1019555	hsa-miR-4716-5p	CLIP-seq
MIRT2538809	hsa-miR-4724-3p	CLIP-seq
MIRT2538810	hsa-miR-4768-5p	CLIP-seq
MIRT1019562	hsa-miR-4797-3p	CLIP-seq
MIRT2538811	hsa-miR-4797-5p	CLIP-seq
MIRT2538812	hsa-miR-502-5p	CLIP-seq
MIRT1019567	hsa-miR-548an	CLIP-seq
MIRT2538813	hsa-miR-548m	CLIP-seq
MIRT2538814	hsa-miR-570	CLIP-seq
MIRT2538815	hsa-miR-588	CLIP-seq
MIRT2538816	hsa-miR-598	CLIP-seq
MIRT1019572	hsa-miR-600	CLIP-seq
MIRT1019503	hsa-miR-657	CLIP-seq
MIRT2538817	hsa-miR-708	CLIP-seq
MIRT2538818	hsa-miR-744	CLIP-seq
MIRT2538819	hsa-miR-875-3p	CLIP-seq
MIRT2234985	hsa-miR-92a	CLIP-seq
MIRT2234986	hsa-miR-92b	CLIP-seq
MIRT1019507	hsa-miR-103a	CLIP-seq
MIRT1019508	hsa-miR-107	CLIP-seq
MIRT2538776	hsa-miR-1184	CLIP-seq
MIRT1019510	hsa-miR-1245b-3p	CLIP-seq
MIRT2538777	hsa-miR-1251	CLIP-seq
MIRT2538778	hsa-miR-1293	CLIP-seq
MIRT2538779	hsa-miR-1296	CLIP-seq
MIRT2538780	hsa-miR-133a	CLIP-seq
MIRT2538781	hsa-miR-133b	CLIP-seq
MIRT2538784	hsa-miR-1914	CLIP-seq
MIRT2538785	hsa-miR-210	CLIP-seq
MIRT2538787	hsa-miR-2277-5p	CLIP-seq
MIRT2234980	hsa-miR-25	CLIP-seq
MIRT2234981	hsa-miR-32	CLIP-seq
MIRT1019524	hsa-miR-337-3p	CLIP-seq
MIRT2234982	hsa-miR-363	CLIP-seq
MIRT1019495	hsa-miR-3665	CLIP-seq
MIRT2234983	hsa-miR-367	CLIP-seq
MIRT1019531	hsa-miR-3673	CLIP-seq
MIRT1019532	hsa-miR-3685	CLIP-seq
MIRT2538792	hsa-miR-371-5p	CLIP-seq
MIRT1019535	hsa-miR-384	CLIP-seq
MIRT1019536	hsa-miR-3910	CLIP-seq
MIRT2538793	hsa-miR-3914	CLIP-seq
MIRT1019538	hsa-miR-4264	CLIP-seq
MIRT2538794	hsa-miR-4281	CLIP-seq
MIRT2538795	hsa-miR-4290	CLIP-seq
MIRT1019541	hsa-miR-4310	CLIP-seq
MIRT2538796	hsa-miR-4326	CLIP-seq
MIRT1019542	hsa-miR-4328	CLIP-seq
MIRT2538797	hsa-miR-4330	CLIP-seq
MIRT2681568	hsa-miR-4436a	CLIP-seq
MIRT2681569	hsa-miR-4471	CLIP-seq
MIRT2538798	hsa-miR-4479	CLIP-seq
MIRT2538799	hsa-miR-4483	CLIP-seq
MIRT2234984	hsa-miR-4484	CLIP-seq
MIRT2538800	hsa-miR-4506	CLIP-seq
MIRT2538801	hsa-miR-4512	CLIP-seq
MIRT2538803	hsa-miR-4633-3p	CLIP-seq
MIRT2538804	hsa-miR-4655-5p	CLIP-seq
MIRT2538805	hsa-miR-4684-5p	CLIP-seq
MIRT2538806	hsa-miR-4687-5p	CLIP-seq
MIRT2538807	hsa-miR-4695-3p	CLIP-seq
MIRT2538808	hsa-miR-4701-5p	CLIP-seq
MIRT1019555	hsa-miR-4716-5p	CLIP-seq
MIRT2538809	hsa-miR-4724-3p	CLIP-seq
MIRT2538810	hsa-miR-4768-5p	CLIP-seq
MIRT1019562	hsa-miR-4797-3p	CLIP-seq
MIRT2538811	hsa-miR-4797-5p	CLIP-seq
MIRT2538812	hsa-miR-502-5p	CLIP-seq
MIRT1019567	hsa-miR-548an	CLIP-seq
MIRT2538815	hsa-miR-588	CLIP-seq
MIRT2538816	hsa-miR-598	CLIP-seq
MIRT1019572	hsa-miR-600	CLIP-seq
MIRT1019503	hsa-miR-657	CLIP-seq
MIRT2538818	hsa-miR-744	CLIP-seq
MIRT2538819	hsa-miR-875-3p	CLIP-seq
MIRT2234985	hsa-miR-92a	CLIP-seq
MIRT2234986	hsa-miR-92b	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	16628223, 21295525, 21988832, 22728435, 31980649
GO:0005654	Component	Nucleoplasm	IDA	10942595
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	TAS	10896954
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
608564	4273	ENSG00000139436

Protein

UniProt ID

Q14161

Protein name

ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)

Protein function

GTPase-activating protein for ADP ribosylation factor family members, including ARF1.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01412	ArfGap	1 → 120	Putative GTPase activating protein for Arf	Domain
PF08518	GIT_SHD	266 → 294	Spa2 homology domain (SHD) of GIT	Family
PF08518	GIT_SHD	330 → 358	Spa2 homology domain (SHD) of GIT	Family
PF16559	GIT_CC	414 → 478	GIT coiled-coil Rho guanine nucleotide exchange factor	Coiled-coil
PF12205	GIT1_C	636 → 752	G protein-coupled receptor kinase-interacting protein 1 C term	Domain

Sequence

MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL
LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL
PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI
LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD
HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA
TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS
SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDL
SDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLQTLQSENSNLRKQAT
TNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASRPEESRMR
LQPFPAHIGRSALVTSSSSLPSFPSTLSWSRDESARRASRLEKQNSTPESDYDNTPNDME
PDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRA
AQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPG
DPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENNN

Sequence length

759

Interactions

View interactions

	KEGG
	Endocytosis Yersinia infection

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Metabolic Syndrome	Metabolic Syndrome			GWAS

Show/Hide Text Mining Associations (12)

Disease Name	Relationship Type	References
Associations from Text Mining
Age Related Hearing Impairment 1	Associate	34337005
Astrocytoma	Associate	29141672
Breast Neoplasms	Associate	26400320, 35687718
Dyslipidemias	Associate	29879492
Hypertension	Associate	30226566
Hypoalphalipoproteinemias	Associate	29879492
Inflammatory Bowel Diseases	Associate	37156999
Myocardial Infarction	Associate	30226566
Neoplasm Metastasis	Associate	35687718
Papillomavirus Infections	Associate	32164487
Renal Insufficiency Chronic	Associate	30226566
Schizophrenia	Associate	28117656

GIT2 (GIT ArfGAP 2)