Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9805
Gene name Gene Name - the full gene name approved by the HGNC.
Secernin 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SCRN1
Synonyms (NCBI Gene) Gene synonyms aliases
SES1
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p14.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene likely encodes a member of the secernin family of proteins. A similar protein in rat functions in regulation of exocytosis in mast cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT031060 hsa-miR-21-5p Microarray 18591254
MIRT032457 hsa-let-7b-5p Proteomics 18668040
MIRT050057 hsa-miR-26a-5p CLASH 23622248
MIRT036155 hsa-miR-320c CLASH 23622248
MIRT447929 hsa-miR-4426 PAR-CLIP 22100165
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003674 Function Molecular_function ND
GO:0005515 Function Protein binding IPI 25416956
GO:0005634 Component Nucleus IDA 10942595
GO:0005737 Component Cytoplasm IEA
GO:0006508 Process Proteolysis IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
614965 22192 ENSG00000136193
Protein
UniProt ID Q12765
Protein name Secernin-1
Protein function Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03577 Peptidase_C69 34 234 Peptidase family C69 Family
Sequence
MAAAPPSYCFVAFPPRAKDGLVVFGKNSARPRDEVQEVVYFSAADHEPESKVECTYISID
QVPRTYAIMISRPAWLWGAEMGANEHGVCIANEAINTREPAAEIEALLGMDLVRLGLERG
ETAKEALDVIVSLLEEHGQGGNYFEDANSCHSFQSAYLIVDRDEAWVLETIGKYWAAEKV
TEGVRCICSQLSLTTKMDAEHPELRSYAQSQGWWTGEGEFNFSEVFSPVEDHLD
CGAGKD
SLEKQEESITVQTMMNTLRDKASGVCIDSEFFLTTASGVSVLPQNRSSPCIHYFTGTPDP
SRSIFKPFIFVDDVKLVPKTQSPCFGDDDPAKKEPRFQEKPDRRHELYKAHEWARAIIES
DQEQGRKLRSTMLELEKQGLEAMEEILTSSEPLDPAEVGDLFYDCVDTEIKFFK
Sequence length 414
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Arthritis Degenerative polyarthritis rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470 18784066
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)
16367923
Psoriasis Psoriasis rs281875215, rs587777763, rs281875213, rs281875212 25854761
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 24098497
Colorectal Neoplasms Stimulate 25814779
Colorectal Neoplasms Associate 37691034
Epstein Barr Virus Infections Associate 23829175
Leukemia Myeloid Acute Associate 24378410
Lymphoma Non Hodgkin Associate 18927283
Neoplasms Stimulate 25814779
Oculocerebrorenal Syndrome Associate 20133602
Prostatic Neoplasms Inhibit 25667921
Squamous Cell Carcinoma of Head and Neck Associate 37691034