MTSS1 (MTSS I-BAR domain containing 1)

Gene

• Entrez ID: 9788
• Gene name: MTSS I-BAR domain containing 1
• Gene symbol: MTSS1
• Synonyms (NCBI Gene): MIM, MIMA, MIMB
• Chromosome: 8
• Chromosome location: 8q24.13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22681717
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22681717
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22681717
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22681717
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	23383207
MIRT024949	hsa-miR-215-5p	Microarray	19074876
MIRT026400	hsa-miR-192-5p	Microarray	19074876
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	23474751
MIRT054181	hsa-miR-135a-5p	Luciferase reporter assay, qRT-PCR, Western blot	23017832
MIRT625747	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT625746	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT625745	hsa-miR-33a-3p	HITS-CLIP	23824327
MIRT625744	hsa-miR-5193	HITS-CLIP	23824327
MIRT625743	hsa-miR-3183	HITS-CLIP	23824327
MIRT625742	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT625741	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT625740	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT625739	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT625738	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT625737	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT732322	hsa-miR-96-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	2662933
MIRT732322	hsa-miR-96-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	2662933
MIRT735321	hsa-miR-21-3p	qRT-PCR	33290159
MIRT735323	hsa-miR-27a-3p	qRT-PCR	33290159
MIRT625747	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT625746	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT625745	hsa-miR-33a-3p	HITS-CLIP	23824327
MIRT625744	hsa-miR-5193	HITS-CLIP	23824327
MIRT625743	hsa-miR-3183	HITS-CLIP	23824327
MIRT625742	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT625741	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT625740	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT625739	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT625738	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT625737	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT006300	hsa-miR-182-5p	qRT-PCR	37887350
MIRT1165439	hsa-miR-1	CLIP-seq
MIRT1165440	hsa-miR-103a	CLIP-seq
MIRT1165441	hsa-miR-107	CLIP-seq
MIRT1165442	hsa-miR-1271	CLIP-seq
MIRT1165443	hsa-miR-127-5p	CLIP-seq
MIRT1165444	hsa-miR-135a	CLIP-seq
MIRT1165445	hsa-miR-135b	CLIP-seq
MIRT1165446	hsa-miR-15a	CLIP-seq
MIRT1165447	hsa-miR-15b	CLIP-seq
MIRT1165448	hsa-miR-16	CLIP-seq
MIRT1165449	hsa-miR-182	CLIP-seq
MIRT1165450	hsa-miR-1827	CLIP-seq
MIRT1165451	hsa-miR-195	CLIP-seq
MIRT1165452	hsa-miR-206	CLIP-seq
MIRT1165453	hsa-miR-223	CLIP-seq
MIRT1165454	hsa-miR-3140-3p	CLIP-seq
MIRT1165455	hsa-miR-3152-3p	CLIP-seq
MIRT1165456	hsa-miR-323-3p	CLIP-seq
MIRT1165457	hsa-miR-342-3p	CLIP-seq
MIRT1165458	hsa-miR-3673	CLIP-seq
MIRT1165459	hsa-miR-376c	CLIP-seq
MIRT1165460	hsa-miR-3929	CLIP-seq
MIRT1165461	hsa-miR-3938	CLIP-seq
MIRT1165462	hsa-miR-3975	CLIP-seq
MIRT1165463	hsa-miR-3976	CLIP-seq
MIRT1165464	hsa-miR-424	CLIP-seq
MIRT1165465	hsa-miR-4266	CLIP-seq
MIRT1165466	hsa-miR-4272	CLIP-seq
MIRT1165467	hsa-miR-4419a	CLIP-seq
MIRT1165468	hsa-miR-4419b	CLIP-seq
MIRT1165469	hsa-miR-4464	CLIP-seq
MIRT1165470	hsa-miR-4477a	CLIP-seq
MIRT1165471	hsa-miR-4478	CLIP-seq
MIRT1165472	hsa-miR-450b-5p	CLIP-seq
MIRT1165473	hsa-miR-4510	CLIP-seq
MIRT1165474	hsa-miR-4694-3p	CLIP-seq
MIRT1165475	hsa-miR-4695-5p	CLIP-seq
MIRT1165476	hsa-miR-4697-3p	CLIP-seq
MIRT1165477	hsa-miR-4699-3p	CLIP-seq
MIRT1165478	hsa-miR-4712-5p	CLIP-seq
MIRT1165479	hsa-miR-4714-3p	CLIP-seq
MIRT1165480	hsa-miR-4748	CLIP-seq
MIRT1165481	hsa-miR-4779	CLIP-seq
MIRT1165482	hsa-miR-497	CLIP-seq
MIRT1165483	hsa-miR-507	CLIP-seq
MIRT1165484	hsa-miR-513c	CLIP-seq
MIRT1165485	hsa-miR-514b-5p	CLIP-seq
MIRT1165486	hsa-miR-518a-5p	CLIP-seq
MIRT1165487	hsa-miR-520d-5p	CLIP-seq
MIRT1165488	hsa-miR-522	CLIP-seq
MIRT1165489	hsa-miR-524-5p	CLIP-seq
MIRT1165490	hsa-miR-527	CLIP-seq
MIRT1165491	hsa-miR-548aa	CLIP-seq
MIRT1165492	hsa-miR-548ac	CLIP-seq
MIRT1165493	hsa-miR-548d-3p	CLIP-seq
MIRT1165494	hsa-miR-548z	CLIP-seq
MIRT1165495	hsa-miR-557	CLIP-seq
MIRT1165496	hsa-miR-613	CLIP-seq
MIRT1165497	hsa-miR-642b	CLIP-seq
MIRT1165498	hsa-miR-670	CLIP-seq
MIRT1165499	hsa-miR-770-5p	CLIP-seq
MIRT1165500	hsa-miR-935	CLIP-seq
MIRT1165501	hsa-miR-96	CLIP-seq
MIRT1165442	hsa-miR-1271	CLIP-seq
MIRT2047846	hsa-miR-1280	CLIP-seq
MIRT2047847	hsa-miR-1301	CLIP-seq
MIRT1165449	hsa-miR-182	CLIP-seq
MIRT2047848	hsa-miR-198	CLIP-seq
MIRT2047849	hsa-miR-2355-5p	CLIP-seq
MIRT2047850	hsa-miR-2681	CLIP-seq
MIRT2047851	hsa-miR-3125	CLIP-seq
MIRT1165454	hsa-miR-3140-3p	CLIP-seq
MIRT1165455	hsa-miR-3152-3p	CLIP-seq
MIRT2047852	hsa-miR-3200-3p	CLIP-seq
MIRT2047853	hsa-miR-3611	CLIP-seq
MIRT2047854	hsa-miR-3916	CLIP-seq
MIRT2047855	hsa-miR-3944-5p	CLIP-seq
MIRT2047856	hsa-miR-4286	CLIP-seq
MIRT2047857	hsa-miR-4422	CLIP-seq
MIRT1165472	hsa-miR-450b-5p	CLIP-seq
MIRT2047858	hsa-miR-452	CLIP-seq
MIRT2047859	hsa-miR-455-3p	CLIP-seq
MIRT2047860	hsa-miR-4676-3p	CLIP-seq
MIRT1165477	hsa-miR-4699-3p	CLIP-seq
MIRT2047861	hsa-miR-4724-3p	CLIP-seq
MIRT2047862	hsa-miR-4778-5p	CLIP-seq
MIRT2047863	hsa-miR-4797-3p	CLIP-seq
MIRT2047864	hsa-miR-5047	CLIP-seq
MIRT1165483	hsa-miR-507	CLIP-seq
MIRT1165484	hsa-miR-513c	CLIP-seq
MIRT1165485	hsa-miR-514b-5p	CLIP-seq
MIRT1165486	hsa-miR-518a-5p	CLIP-seq
MIRT2047865	hsa-miR-520a-5p	CLIP-seq
MIRT2047866	hsa-miR-525-5p	CLIP-seq
MIRT1165490	hsa-miR-527	CLIP-seq
MIRT2047867	hsa-miR-544	CLIP-seq
MIRT1165491	hsa-miR-548aa	CLIP-seq
MIRT1165492	hsa-miR-548ac	CLIP-seq
MIRT1165493	hsa-miR-548d-3p	CLIP-seq
MIRT1165494	hsa-miR-548z	CLIP-seq
MIRT1165495	hsa-miR-557	CLIP-seq
MIRT2047868	hsa-miR-578	CLIP-seq
MIRT2047869	hsa-miR-581	CLIP-seq
MIRT1165501	hsa-miR-96	CLIP-seq
MIRT1165440	hsa-miR-103a	CLIP-seq
MIRT1165441	hsa-miR-107	CLIP-seq
MIRT1165446	hsa-miR-15a	CLIP-seq
MIRT1165447	hsa-miR-15b	CLIP-seq
MIRT1165448	hsa-miR-16	CLIP-seq
MIRT1165450	hsa-miR-1827	CLIP-seq
MIRT1165451	hsa-miR-195	CLIP-seq
MIRT1165464	hsa-miR-424	CLIP-seq
MIRT2276637	hsa-miR-4733-5p	CLIP-seq
MIRT1165482	hsa-miR-497	CLIP-seq
MIRT2276638	hsa-miR-509-3p	CLIP-seq
MIRT2276639	hsa-miR-548m	CLIP-seq
MIRT2276640	hsa-miR-607	CLIP-seq
MIRT2454600	hsa-miR-1276	CLIP-seq
MIRT2276640	hsa-miR-607	CLIP-seq
MIRT2575489	hsa-miR-3117-5p	CLIP-seq
MIRT1165454	hsa-miR-3140-3p	CLIP-seq
MIRT2575490	hsa-miR-338-5p	CLIP-seq
MIRT2575491	hsa-miR-4731-3p	CLIP-seq
MIRT2575492	hsa-miR-4801	CLIP-seq
MIRT2685519	hsa-miR-4729	CLIP-seq
MIRT2276640	hsa-miR-607	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001726	Component	Ruffle	NAS	12570871
GO:0003785	Function	Actin monomer binding	IDA	12570871
GO:0005102	Function	Signaling receptor binding	IPI	12570871
GO:0005515	Function	Protein binding	IPI	15383276, 15688017
GO:0005737	Component	Cytoplasm	TAS	12570871
GO:0007009	Process	Plasma membrane organization	IEA
GO:0007155	Process	Cell adhesion	NAS	12570871
GO:0007169	Process	Transmembrane receptor protein tyrosine kinase signaling pathway	TAS	12570871
GO:0015629	Component	Actin cytoskeleton	IDA	12570871
GO:0030035	Process	Microspike assembly	NAS	12570871
GO:0030036	Process	Actin cytoskeleton organization	TAS	12082544
GO:0030139	Component	Endocytic vesicle	TAS	12570871
GO:0042802	Function	Identical protein binding	IPI	14752106
GO:0050680	Process	Negative regulation of epithelial cell proliferation	ISS
GO:0061333	Process	Renal tubule morphogenesis	ISS
GO:0071498	Process	Cellular response to fluid shear stress	ISS
GO:0072102	Process	Glomerulus morphogenesis	ISS
GO:0072160	Process	Nephron tubule epithelial cell differentiation	ISS
GO:2001013	Process	Epithelial cell proliferation involved in renal tubule morphogenesis	ISS

Other IDs

• MIM: 608486
• HGNC: 20443
• e!Ensembl: ENSG00000170873

Protein

• UniProt ID: O43312
• Protein name: Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein)
• Protein function: May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.
• PDB: 2D1K
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08397	IMD	16 → 237	IRSp53/MIM homology domain	Family
  PF02205	WH2	724 → 750	WH2 motif	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood. {ECO:0000269|PubMed:12082544}.
• Sequence:

  MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQK
  VADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVAN
  QLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKGRGDIQPQLDSALQDVNDKYLLLEETE
  KQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSS
  EQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYR
  YRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQLSNGFSHYSLSSESH
  VGPTGAGLFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSWKDWAKPGPYDQ
  PLVNTLQRRKEKREPDPNGGGPTTASGPPAAAEEAQRPRSMTVSAATRPGEEMEACEELA
  LALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQ
  EFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVR
  RGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSVGEGPQGVTSM
  PSSMWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQEREPPSATVSPGQIPESDPADL
  SPRDTPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS

• Sequence length: 755

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Arthritis	Juvenile arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	19565504
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs80356663, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs371977235, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	29221444
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	16367923

Unknown
Disease term	Disease name	Evidence	References	Source
Irritable Bowel Syndrome	Irritable Bowel Syndrome			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Atherosclerosis	Associate	26829059
Breast Neoplasms	Associate	21103787, 21344236, 39519115
Breast Neoplasms	Inhibit	24318128
Carcinogenesis	Associate	16367923, 20712855
Carcinoma Hepatocellular	Associate	22681717
Carcinoma Non Small Cell Lung	Associate	30229825
Carcinoma Renal Cell	Inhibit	28739745
Carcinoma Squamous Cell	Associate	25625275
Cholangiocarcinoma	Associate	23852458
Chronic Periodontitis	Associate	26705104
Colorectal Neoplasms	Associate	23017832
Esophageal Neoplasms	Associate	21696600
Esophageal Squamous Cell Carcinoma	Associate	21696600
Glioma	Associate	31545491, 32729377
Heart Failure	Associate	31554410
Kidney Neoplasms	Inhibit	28739745
Klatskin Tumor	Inhibit	23852458
Leukemia Myeloid Acute	Associate	25996952
Leukemia Promyelocytic Acute	Associate	25996952
Lung Diseases	Associate	25625275
Lymphatic Metastasis	Associate	21696600
Lymphatic Metastasis	Inhibit	23852458, 26198729, 32052679
Myotonic Dystrophy	Associate	24027017
Neoplasm Metastasis	Inhibit	16367923, 20712855, 23852458
Neoplasm Metastasis	Associate	25287652, 25625275, 30949866, 32729377, 35149005
Neoplasms	Inhibit	20712855, 24318128, 25287652, 25996952, 26198729, 28739745, 32052679, 39519115
Neoplasms	Associate	21696600, 22681717, 23852458, 24318128, 25625275, 26829059, 33686422
Ovarian Neoplasms	Associate	24961659, 35768865
Pancreatic Neoplasms	Associate	26198729
Pancreatic Neoplasms	Stimulate	32929338
Prostatitis	Associate	27164937
Squamous Cell Carcinoma of Head and Neck	Associate	30949866
Stomach Neoplasms	Associate	16367923, 20712855, 33686422
Triple Negative Breast Neoplasms	Inhibit	32052679
Uniparental disomy paternal chromosome 14	Associate	27406249