MTSS1 (MTSS I-BAR domain containing 1)

Gene

• Entrez ID: 9788
• Gene name: MTSS I-BAR domain containing 1
• Gene symbol: MTSS1
• Synonyms (NCBI Gene): MIM, MIMA, MIMB
• Chromosome: 8
• Chromosome location: 8q24.13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22322863
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22681717
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22681717
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22681717
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	22681717
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	23383207
MIRT024949	hsa-miR-215-5p	Microarray	19074876
MIRT026400	hsa-miR-192-5p	Microarray	19074876
MIRT006300	hsa-miR-182-5p	Luciferase reporter assay	23474751
MIRT054181	hsa-miR-135a-5p	Luciferase reporter assay, qRT-PCR, Western blot	23017832
MIRT625747	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT625746	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT625745	hsa-miR-33a-3p	HITS-CLIP	23824327
MIRT625744	hsa-miR-5193	HITS-CLIP	23824327
MIRT625743	hsa-miR-3183	HITS-CLIP	23824327
MIRT625742	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT625741	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT625740	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT625739	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT625738	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT625737	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT732322	hsa-miR-96-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	2662933
MIRT732322	hsa-miR-96-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	2662933
MIRT735321	hsa-miR-21-3p	qRT-PCR	33290159
MIRT735323	hsa-miR-27a-3p	qRT-PCR	33290159
MIRT625747	hsa-miR-7-1-3p	HITS-CLIP	23824327
MIRT625746	hsa-miR-7-2-3p	HITS-CLIP	23824327
MIRT625745	hsa-miR-33a-3p	HITS-CLIP	23824327
MIRT625744	hsa-miR-5193	HITS-CLIP	23824327
MIRT625743	hsa-miR-3183	HITS-CLIP	23824327
MIRT625742	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT625741	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT625740	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT625739	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT625738	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT625737	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT006300	hsa-miR-182-5p	qRT-PCR	37887350
MIRT1165439	hsa-miR-1	CLIP-seq
MIRT1165440	hsa-miR-103a	CLIP-seq
MIRT1165441	hsa-miR-107	CLIP-seq
MIRT1165442	hsa-miR-1271	CLIP-seq
MIRT1165443	hsa-miR-127-5p	CLIP-seq
MIRT1165444	hsa-miR-135a	CLIP-seq
MIRT1165445	hsa-miR-135b	CLIP-seq
MIRT1165446	hsa-miR-15a	CLIP-seq
MIRT1165447	hsa-miR-15b	CLIP-seq
MIRT1165448	hsa-miR-16	CLIP-seq
MIRT1165449	hsa-miR-182	CLIP-seq
MIRT1165450	hsa-miR-1827	CLIP-seq
MIRT1165451	hsa-miR-195	CLIP-seq
MIRT1165452	hsa-miR-206	CLIP-seq
MIRT1165453	hsa-miR-223	CLIP-seq
MIRT1165454	hsa-miR-3140-3p	CLIP-seq
MIRT1165455	hsa-miR-3152-3p	CLIP-seq
MIRT1165456	hsa-miR-323-3p	CLIP-seq
MIRT1165457	hsa-miR-342-3p	CLIP-seq
MIRT1165458	hsa-miR-3673	CLIP-seq
MIRT1165459	hsa-miR-376c	CLIP-seq
MIRT1165460	hsa-miR-3929	CLIP-seq
MIRT1165461	hsa-miR-3938	CLIP-seq
MIRT1165462	hsa-miR-3975	CLIP-seq
MIRT1165463	hsa-miR-3976	CLIP-seq
MIRT1165464	hsa-miR-424	CLIP-seq
MIRT1165465	hsa-miR-4266	CLIP-seq
MIRT1165466	hsa-miR-4272	CLIP-seq
MIRT1165467	hsa-miR-4419a	CLIP-seq
MIRT1165468	hsa-miR-4419b	CLIP-seq
MIRT1165469	hsa-miR-4464	CLIP-seq
MIRT1165470	hsa-miR-4477a	CLIP-seq
MIRT1165471	hsa-miR-4478	CLIP-seq
MIRT1165472	hsa-miR-450b-5p	CLIP-seq
MIRT1165473	hsa-miR-4510	CLIP-seq
MIRT1165474	hsa-miR-4694-3p	CLIP-seq
MIRT1165475	hsa-miR-4695-5p	CLIP-seq
MIRT1165476	hsa-miR-4697-3p	CLIP-seq
MIRT1165477	hsa-miR-4699-3p	CLIP-seq
MIRT1165478	hsa-miR-4712-5p	CLIP-seq
MIRT1165479	hsa-miR-4714-3p	CLIP-seq
MIRT1165480	hsa-miR-4748	CLIP-seq
MIRT1165481	hsa-miR-4779	CLIP-seq
MIRT1165482	hsa-miR-497	CLIP-seq
MIRT1165483	hsa-miR-507	CLIP-seq
MIRT1165484	hsa-miR-513c	CLIP-seq
MIRT1165485	hsa-miR-514b-5p	CLIP-seq
MIRT1165486	hsa-miR-518a-5p	CLIP-seq
MIRT1165487	hsa-miR-520d-5p	CLIP-seq
MIRT1165488	hsa-miR-522	CLIP-seq
MIRT1165489	hsa-miR-524-5p	CLIP-seq
MIRT1165490	hsa-miR-527	CLIP-seq
MIRT1165491	hsa-miR-548aa	CLIP-seq
MIRT1165492	hsa-miR-548ac	CLIP-seq
MIRT1165493	hsa-miR-548d-3p	CLIP-seq
MIRT1165494	hsa-miR-548z	CLIP-seq
MIRT1165495	hsa-miR-557	CLIP-seq
MIRT1165496	hsa-miR-613	CLIP-seq
MIRT1165497	hsa-miR-642b	CLIP-seq
MIRT1165498	hsa-miR-670	CLIP-seq
MIRT1165499	hsa-miR-770-5p	CLIP-seq
MIRT1165500	hsa-miR-935	CLIP-seq
MIRT1165501	hsa-miR-96	CLIP-seq
MIRT1165442	hsa-miR-1271	CLIP-seq
MIRT2047846	hsa-miR-1280	CLIP-seq
MIRT2047847	hsa-miR-1301	CLIP-seq
MIRT1165449	hsa-miR-182	CLIP-seq
MIRT2047848	hsa-miR-198	CLIP-seq
MIRT2047849	hsa-miR-2355-5p	CLIP-seq
MIRT2047850	hsa-miR-2681	CLIP-seq
MIRT2047851	hsa-miR-3125	CLIP-seq
MIRT1165454	hsa-miR-3140-3p	CLIP-seq
MIRT1165455	hsa-miR-3152-3p	CLIP-seq
MIRT2047852	hsa-miR-3200-3p	CLIP-seq
MIRT2047853	hsa-miR-3611	CLIP-seq
MIRT2047854	hsa-miR-3916	CLIP-seq
MIRT2047855	hsa-miR-3944-5p	CLIP-seq
MIRT2047856	hsa-miR-4286	CLIP-seq
MIRT2047857	hsa-miR-4422	CLIP-seq
MIRT1165472	hsa-miR-450b-5p	CLIP-seq
MIRT2047858	hsa-miR-452	CLIP-seq
MIRT2047859	hsa-miR-455-3p	CLIP-seq
MIRT2047860	hsa-miR-4676-3p	CLIP-seq
MIRT1165477	hsa-miR-4699-3p	CLIP-seq
MIRT2047861	hsa-miR-4724-3p	CLIP-seq
MIRT2047862	hsa-miR-4778-5p	CLIP-seq
MIRT2047863	hsa-miR-4797-3p	CLIP-seq
MIRT2047864	hsa-miR-5047	CLIP-seq
MIRT1165483	hsa-miR-507	CLIP-seq
MIRT1165484	hsa-miR-513c	CLIP-seq
MIRT1165485	hsa-miR-514b-5p	CLIP-seq
MIRT1165486	hsa-miR-518a-5p	CLIP-seq
MIRT2047865	hsa-miR-520a-5p	CLIP-seq
MIRT2047866	hsa-miR-525-5p	CLIP-seq
MIRT1165490	hsa-miR-527	CLIP-seq
MIRT2047867	hsa-miR-544	CLIP-seq
MIRT1165491	hsa-miR-548aa	CLIP-seq
MIRT1165492	hsa-miR-548ac	CLIP-seq
MIRT1165493	hsa-miR-548d-3p	CLIP-seq
MIRT1165494	hsa-miR-548z	CLIP-seq
MIRT1165495	hsa-miR-557	CLIP-seq
MIRT2047868	hsa-miR-578	CLIP-seq
MIRT2047869	hsa-miR-581	CLIP-seq
MIRT1165501	hsa-miR-96	CLIP-seq
MIRT1165440	hsa-miR-103a	CLIP-seq
MIRT1165441	hsa-miR-107	CLIP-seq
MIRT1165446	hsa-miR-15a	CLIP-seq
MIRT1165447	hsa-miR-15b	CLIP-seq
MIRT1165448	hsa-miR-16	CLIP-seq
MIRT1165450	hsa-miR-1827	CLIP-seq
MIRT1165451	hsa-miR-195	CLIP-seq
MIRT1165464	hsa-miR-424	CLIP-seq
MIRT2276637	hsa-miR-4733-5p	CLIP-seq
MIRT1165482	hsa-miR-497	CLIP-seq
MIRT2276638	hsa-miR-509-3p	CLIP-seq
MIRT2276639	hsa-miR-548m	CLIP-seq
MIRT2276640	hsa-miR-607	CLIP-seq
MIRT2454600	hsa-miR-1276	CLIP-seq
MIRT2276640	hsa-miR-607	CLIP-seq
MIRT2575489	hsa-miR-3117-5p	CLIP-seq
MIRT1165454	hsa-miR-3140-3p	CLIP-seq
MIRT2575490	hsa-miR-338-5p	CLIP-seq
MIRT2575491	hsa-miR-4731-3p	CLIP-seq
MIRT2575492	hsa-miR-4801	CLIP-seq
MIRT2685519	hsa-miR-4729	CLIP-seq
MIRT2276640	hsa-miR-607	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001726	Component	Ruffle	NAS	12570871
GO:0003779	Function	Actin binding	IBA
GO:0003779	Function	Actin binding	IEA
GO:0003785	Function	Actin monomer binding	IDA	12570871
GO:0005102	Function	Signaling receptor binding	IPI	12570871
GO:0005515	Function	Protein binding	IPI	15383276, 15688017
GO:0005543	Function	Phospholipid binding	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	12570871
GO:0005856	Component	Cytoskeleton	IEA
GO:0007009	Process	Plasma membrane organization	IEA
GO:0007155	Process	Cell adhesion	NAS	12570871
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	TAS	12570871
GO:0009898	Component	Cytoplasmic side of plasma membrane	IBA
GO:0015629	Component	Actin cytoskeleton	IBA
GO:0015629	Component	Actin cytoskeleton	IDA	12570871
GO:0030035	Process	Microspike assembly	NAS	12570871
GO:0030036	Process	Actin cytoskeleton organization	TAS	12082544
GO:0030139	Component	Endocytic vesicle	TAS	12570871
GO:0032233	Process	Positive regulation of actin filament bundle assembly	IBA
GO:0034334	Process	Adherens junction maintenance	IBA
GO:0042802	Function	Identical protein binding	IPI	14752106
GO:0050680	Process	Negative regulation of epithelial cell proliferation	ISS
GO:0061333	Process	Renal tubule morphogenesis	ISS
GO:0071498	Process	Cellular response to fluid shear stress	ISS
GO:0072102	Process	Glomerulus morphogenesis	ISS
GO:0072160	Process	Nephron tubule epithelial cell differentiation	ISS
GO:2001013	Process	Epithelial cell proliferation involved in renal tubule morphogenesis	ISS

Other IDs

• MIM: 608486
• HGNC: 20443
• e!Ensembl: ENSG00000170873

Protein

• UniProt ID: O43312
• Protein name: Protein MTSS 1 (Metastasis suppressor YGL-1) (Metastasis suppressor protein 1) (Missing in metastasis protein)
• Protein function: May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.
• PDB: 2D1K
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08397	IMD	16 → 237	IRSp53/MIM homology domain	Family
  PF02205	WH2	724 → 750	WH2 motif	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood. {ECO:0000269|PubMed:12082544}.
• Sequence:

  MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQK
  VADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVAN
  QLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKGRGDIQPQLDSALQDVNDKYLLLEETE
  KQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSS
  EQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYR
  YRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQLSNGFSHYSLSSESH
  VGPTGAGLFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSWKDWAKPGPYDQ
  PLVNTLQRRKEKREPDPNGGGPTTASGPPAAAEEAQRPRSMTVSAATRPGEEMEACEELA
  LALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQ
  EFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVR
  RGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSVGEGPQGVTSM
  PSSMWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQEREPPSATVSPGQIPESDPADL
  SPRDTPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS

• Sequence length: 755