Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9787
Gene name	DLG associated protein 5
Gene symbol	DLGAP5
Synonyms (NCBI Gene)	DLG7HURP
Chromosome	14
Chromosome location	14q22.3

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Show/Hide all (123)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024792	hsa-miR-215-5p	Microarray	19074876
MIRT026832	hsa-miR-192-5p	Microarray	19074876
MIRT042751	hsa-miR-339-5p	CLASH	23622248
MIRT527550	hsa-miR-7844-5p	PAR-CLIP	21572407
MIRT527549	hsa-miR-3133	PAR-CLIP	21572407
MIRT527548	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT527547	hsa-miR-302a-3p	PAR-CLIP	21572407
MIRT527546	hsa-miR-302b-3p	PAR-CLIP	21572407
MIRT527545	hsa-miR-302c-3p	PAR-CLIP	21572407
MIRT527544	hsa-miR-302d-3p	PAR-CLIP	21572407
MIRT527543	hsa-miR-302e	PAR-CLIP	21572407
MIRT527542	hsa-miR-372-3p	PAR-CLIP	21572407
MIRT527541	hsa-miR-373-3p	PAR-CLIP	21572407
MIRT527540	hsa-miR-520a-3p	PAR-CLIP	21572407
MIRT527539	hsa-miR-520b	PAR-CLIP	21572407
MIRT527538	hsa-miR-520c-3p	PAR-CLIP	21572407
MIRT527537	hsa-miR-520d-3p	PAR-CLIP	21572407
MIRT527536	hsa-miR-520e	PAR-CLIP	21572407
MIRT527535	hsa-miR-33a-3p	PAR-CLIP	21572407
MIRT527534	hsa-miR-374c-3p	PAR-CLIP	21572407
MIRT527533	hsa-miR-4744	PAR-CLIP	21572407
MIRT527550	hsa-miR-7844-5p	PAR-CLIP	22012620
MIRT527549	hsa-miR-3133	PAR-CLIP	22012620
MIRT527548	hsa-miR-186-5p	PAR-CLIP	22012620
MIRT527547	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT527546	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT527545	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT527544	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT527543	hsa-miR-302e	PAR-CLIP	22012620
MIRT527542	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT527541	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT527540	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT527539	hsa-miR-520b	PAR-CLIP	22012620
MIRT527538	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT527537	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT527536	hsa-miR-520e	PAR-CLIP	22012620
MIRT527535	hsa-miR-33a-3p	PAR-CLIP	22012620
MIRT527534	hsa-miR-374c-3p	PAR-CLIP	22012620
MIRT527533	hsa-miR-4744	PAR-CLIP	22012620
MIRT527550	hsa-miR-7844-5p	PAR-CLIP	21572407
MIRT527549	hsa-miR-3133	PAR-CLIP	21572407
MIRT527548	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT527547	hsa-miR-302a-3p	PAR-CLIP	21572407
MIRT527546	hsa-miR-302b-3p	PAR-CLIP	21572407
MIRT527545	hsa-miR-302c-3p	PAR-CLIP	21572407
MIRT527544	hsa-miR-302d-3p	PAR-CLIP	21572407
MIRT527543	hsa-miR-302e	PAR-CLIP	21572407
MIRT527542	hsa-miR-372-3p	PAR-CLIP	21572407
MIRT527541	hsa-miR-373-3p	PAR-CLIP	21572407
MIRT527540	hsa-miR-520a-3p	PAR-CLIP	21572407
MIRT527539	hsa-miR-520b	PAR-CLIP	21572407
MIRT527538	hsa-miR-520c-3p	PAR-CLIP	21572407
MIRT527537	hsa-miR-520d-3p	PAR-CLIP	21572407
MIRT527536	hsa-miR-520e	PAR-CLIP	21572407
MIRT527535	hsa-miR-33a-3p	PAR-CLIP	21572407
MIRT527534	hsa-miR-374c-3p	PAR-CLIP	21572407
MIRT527533	hsa-miR-4744	PAR-CLIP	21572407
MIRT527550	hsa-miR-7844-5p	PAR-CLIP	22012620
MIRT527549	hsa-miR-3133	PAR-CLIP	22012620
MIRT527548	hsa-miR-186-5p	PAR-CLIP	22012620
MIRT527547	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT527546	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT527545	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT527544	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT527543	hsa-miR-302e	PAR-CLIP	22012620
MIRT527542	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT527541	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT527540	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT527539	hsa-miR-520b	PAR-CLIP	22012620
MIRT527538	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT527537	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT527536	hsa-miR-520e	PAR-CLIP	22012620
MIRT527535	hsa-miR-33a-3p	PAR-CLIP	22012620
MIRT527534	hsa-miR-374c-3p	PAR-CLIP	22012620
MIRT527533	hsa-miR-4744	PAR-CLIP	22012620
MIRT756189	hsa-miR-409-5p	Luciferase reporter assayWestern blottingqRT-PCR	35765271
MIRT938730	hsa-miR-1252	CLIP-seq
MIRT938731	hsa-miR-1290	CLIP-seq
MIRT938732	hsa-miR-204	CLIP-seq
MIRT938733	hsa-miR-211	CLIP-seq
MIRT938734	hsa-miR-3167	CLIP-seq
MIRT938735	hsa-miR-3647-3p	CLIP-seq
MIRT938736	hsa-miR-4286	CLIP-seq
MIRT938737	hsa-miR-4517	CLIP-seq
MIRT938738	hsa-miR-4719	CLIP-seq
MIRT938739	hsa-miR-4755-5p	CLIP-seq
MIRT938740	hsa-miR-4778-5p	CLIP-seq
MIRT938741	hsa-miR-4780	CLIP-seq
MIRT938742	hsa-miR-515-5p	CLIP-seq
MIRT938743	hsa-miR-539	CLIP-seq
MIRT938744	hsa-miR-580	CLIP-seq
MIRT938745	hsa-miR-623	CLIP-seq
MIRT938746	hsa-miR-653	CLIP-seq
MIRT938747	hsa-miR-876-5p	CLIP-seq
MIRT1977726	hsa-miR-4282	CLIP-seq
MIRT938738	hsa-miR-4719	CLIP-seq
MIRT1977727	hsa-miR-513a-3p	CLIP-seq
MIRT938742	hsa-miR-515-5p	CLIP-seq
MIRT938732	hsa-miR-204	CLIP-seq
MIRT938733	hsa-miR-211	CLIP-seq
MIRT938736	hsa-miR-4286	CLIP-seq
MIRT938739	hsa-miR-4755-5p	CLIP-seq
MIRT938741	hsa-miR-4780	CLIP-seq
MIRT938744	hsa-miR-580	CLIP-seq
MIRT938745	hsa-miR-623	CLIP-seq
MIRT938732	hsa-miR-204	CLIP-seq
MIRT938733	hsa-miR-211	CLIP-seq
MIRT2516903	hsa-miR-410	CLIP-seq
MIRT938736	hsa-miR-4286	CLIP-seq
MIRT2516904	hsa-miR-4521	CLIP-seq
MIRT938739	hsa-miR-4755-5p	CLIP-seq
MIRT938741	hsa-miR-4780	CLIP-seq
MIRT938744	hsa-miR-580	CLIP-seq
MIRT938745	hsa-miR-623	CLIP-seq
MIRT938732	hsa-miR-204	CLIP-seq
MIRT938733	hsa-miR-211	CLIP-seq
MIRT2516903	hsa-miR-410	CLIP-seq
MIRT938736	hsa-miR-4286	CLIP-seq
MIRT2516904	hsa-miR-4521	CLIP-seq
MIRT938739	hsa-miR-4755-5p	CLIP-seq
MIRT938741	hsa-miR-4780	CLIP-seq
MIRT938744	hsa-miR-580	CLIP-seq
MIRT938745	hsa-miR-623	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15145941, 15987997, 25416956, 37219487
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	12527899
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005819	Component	Spindle	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0007052	Process	Mitotic spindle organization	IBA
GO:0007059	Process	Chromosome segregation	IBA
GO:0007079	Process	Mitotic chromosome movement towards spindle pole	NAS	12527899
GO:0007346	Process	Regulation of mitotic cell cycle	IBA
GO:0008017	Function	Microtubule binding	IBA
GO:0023052	Process	Signaling	IEA
GO:0031616	Component	Spindle pole centrosome	IBA
GO:0031616	Component	Spindle pole centrosome	IDA	12527899
GO:0045842	Process	Positive regulation of mitotic metaphase/anaphase transition	NAS	12527899
GO:0051382	Process	Kinetochore assembly	IBA
GO:0051642	Process	Centrosome localization	IBA
GO:0072686	Component	Mitotic spindle	IDA

MIM	HGNC	e!Ensembl
617859	16864	ENSG00000126787

Q15398

Protein name

Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP)

Protein function

Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in

PDB

7ZX4 , 8X9P , 9DUQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03359	GKAP	318 → 602	Guanylate-kinase-associated protein (GKAP) protein	Family

Tissue specificity

TISSUE SPECIFICITY: Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta. {ECO:0000269|PubMed:12527899}.

Sequence

MSSSHFASRHRKDISTEMIRTKIAHRKSLSQKENRHKEYERNRHFGLKDVNIPTLEGRIL
VELDETSQGLVPEKTNVKPRAMKTILGDQRKQMLQKYKEEKQLQKLKEQREKAKRGIFKV
GRYRPDMPCFLLSNQNAVKAEPKKAIPSSVRITRSKAKDQMEQTKIDNESDVRAIRPGPR
QTSEKKVSDKEKKVVQPVMPTSLRMTRSATQAAKQVPRTVSSTTARKPVTRAANENEPEG
KVPSKGRPAKNVETKPDKGISCKVDSEENTLNSQTNATSGMNPDGVLSKMENLPEINTAK
IKGKNSFAPKDFMFQPLDGLKTYQVTPMTPRSANAFLTPSYTWTPLKTEVDESQATKEIL
AQKCKTYSTKTIQQDSNKLPCPLGPLTVWHEEHVLNKNEATTKNLNGLPIKEVPSLERNE
GRIAQPHHGVPYFRNILQSETEKLTSHCFEWDRKLELDIPDDAKDLIRTAVGQTRLLMKE
RFKQFEGLVDDCEYKRGIKETTCTDLDGFWDMVSFQIEDVIHKFNNLIKLEESGWQVNNN
MNHNMNKNVFRKKVVSGIASKPKQDDAGRIAARNRLAAIKNAMRERIRQEECAETAVSVI
PKEVDKIVFDAGFFRVESPVKLFSGLSVSSEGPSQRLGTPKSVNKAVSQSRNEMGIPQQT
TSPENAGPQNTKSEHVKKTLFLSIPESRSSIEDAQCPGLPDLIEENHVVNKTDLKVDCLS
SERMSLPLLAGGVADDINTNKKEGISDVVEGMELNSSITSQDVLMSSPEKNTASQNSILE
EGETKISQSELFDNKSLTTECHLLDSPGLNCSNPFTQLERRHQEHARHISFGGNLITFSP
LQPGEF

Sequence length

846

Interactions

View interactions

	Reactome
			NOTCH3 Intracellular Domain Regulates Transcription

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Hepatocellular carcinoma	Uncertain significance	rs80024343	RCV005927188
Malignant lymphoma, large B-cell, diffuse	Uncertain significance	rs80024343	RCV005927189

Show/Hide Text Mining Associations (49)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
3C syndrome	Associate	32573962
Adenocarcinoma of Lung	Associate	23874428, 35204661, 35689561, 36499051, 36712920, 37266661, 37910672
Adenocarcinoma of Lung	Stimulate	32149133, 33398330
Azoospermia	Associate	35219767
Breast Neoplasms	Associate	25756514, 30476929, 33499770, 37958803
Breast Neoplasms	Stimulate	34675265
Carcinogenesis	Associate	22363440, 24324629, 35403252
Carcinogenesis	Stimulate	29484418
Carcinoma Hepatocellular	Associate	22022601, 24324629, 29484418, 30616080, 33784984, 36120772, 40243557, 40621461
Carcinoma Non Small Cell Lung	Associate	28101582, 29484418
Carcinoma Pancreatic Ductal	Associate	29483831, 35403252
Carcinoma Squamous Cell	Associate	36499051
Carcinoma Transitional Cell	Associate	29484418
Carcinosarcoma	Associate	36186000
Colorectal Neoplasms	Stimulate	22363440
Colorectal Neoplasms	Associate	35774271, 36123948
Coronary Artery Disease	Associate	32573962
COVID 19	Associate	36389792, 39259097
Death	Stimulate	33499770
Dermatitis Contact	Associate	33318199
Dissection Thoracic Aorta	Associate	31380418
Drug Hypersensitivity	Associate	33318199
Endometrial Neoplasms	Associate	36186000
Esophageal Neoplasms	Associate	32443386
Glioma	Associate	33956061
Glioma	Stimulate	35676807
Head and Neck Neoplasms	Associate	33160365
HIV Infections	Associate	36389792
Hypoxia	Associate	37481543
Leukemia Myeloid Acute	Associate	35634845
Lung Neoplasms	Associate	28808310, 37910672
Meningioma	Associate	21157382
Neoplasm Metastasis	Associate	23874428, 30616080
Neoplasms	Associate	22396495, 24074379, 29484418, 30616080, 31454442
Neoplasms	Inhibit	24324629
Neoplasms	Stimulate	28808310, 35676807
Neoplasms Squamous Cell	Associate	29484418
Neuroblastoma	Associate	23251412
Ovarian Diseases	Associate	36186000
Ovarian Neoplasms	Associate	22396495, 31729978
Pancreatic Neoplasms	Stimulate	29483831
Personality Disorders	Associate	21157382
Polycystic Ovary Syndrome	Associate	35370991
Prostatic Neoplasms	Associate	29233929, 31454442
Prostatic Neoplasms Castration Resistant	Associate	31454442
Retinoblastoma	Associate	32443297
Sepsis	Associate	39259097
Stomach Neoplasms	Associate	30365066
Thyroid Carcinoma Anaplastic	Associate	27796151

DLGAP5 (DLG associated protein 5)