Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9784
Gene name Gene Name - the full gene name approved by the HGNC.	Sorting nexin 17
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SNX17
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p23.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022223	hsa-miR-124-3p	Microarray	18668037
MIRT040825	hsa-miR-18a-3p	CLASH	23622248
MIRT496117	hsa-miR-4500	PAR-CLIP	22291592
MIRT496116	hsa-let-7a-5p	PAR-CLIP	22291592
MIRT496115	hsa-let-7b-5p	PAR-CLIP	22291592
MIRT496114	hsa-let-7c-5p	PAR-CLIP	22291592
MIRT496113	hsa-let-7d-5p	PAR-CLIP	22291592
MIRT496112	hsa-miR-98-5p	PAR-CLIP	22291592
MIRT496111	hsa-let-7e-5p	PAR-CLIP	22291592
MIRT496110	hsa-let-7f-5p	PAR-CLIP	22291592
MIRT496109	hsa-let-7g-5p	PAR-CLIP	22291592
MIRT496108	hsa-miR-4458	PAR-CLIP	22291592
MIRT496107	hsa-let-7i-5p	PAR-CLIP	22291592
MIRT496106	hsa-miR-6873-5p	PAR-CLIP	22291592
MIRT496105	hsa-miR-1910-3p	PAR-CLIP	22291592
MIRT496104	hsa-miR-6511a-5p	PAR-CLIP	22291592
MIRT496103	hsa-miR-6808-5p	PAR-CLIP	22291592
MIRT496102	hsa-miR-6893-5p	PAR-CLIP	22291592
MIRT496101	hsa-miR-940	PAR-CLIP	22291592
MIRT496100	hsa-miR-2682-5p	PAR-CLIP	22291592
MIRT496099	hsa-miR-34b-5p	PAR-CLIP	22291592
MIRT496098	hsa-miR-449c-5p	PAR-CLIP	22291592
MIRT496097	hsa-miR-6750-5p	PAR-CLIP	22291592
MIRT496096	hsa-miR-6822-5p	PAR-CLIP	22291592
MIRT496095	hsa-miR-4257	PAR-CLIP	22291592
MIRT496094	hsa-miR-6806-5p	PAR-CLIP	22291592
MIRT726479	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT726478	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT496117	hsa-miR-4500	PAR-CLIP	22291592
MIRT496116	hsa-let-7a-5p	PAR-CLIP	22291592
MIRT496115	hsa-let-7b-5p	PAR-CLIP	22291592
MIRT496114	hsa-let-7c-5p	PAR-CLIP	22291592
MIRT496113	hsa-let-7d-5p	PAR-CLIP	22291592
MIRT496112	hsa-miR-98-5p	PAR-CLIP	22291592
MIRT496111	hsa-let-7e-5p	PAR-CLIP	22291592
MIRT496110	hsa-let-7f-5p	PAR-CLIP	22291592
MIRT496109	hsa-let-7g-5p	PAR-CLIP	22291592
MIRT496108	hsa-miR-4458	PAR-CLIP	22291592
MIRT496107	hsa-let-7i-5p	PAR-CLIP	22291592
MIRT496106	hsa-miR-6873-5p	PAR-CLIP	22291592
MIRT496105	hsa-miR-1910-3p	PAR-CLIP	22291592
MIRT496104	hsa-miR-6511a-5p	PAR-CLIP	22291592
MIRT496103	hsa-miR-6808-5p	PAR-CLIP	22291592
MIRT496102	hsa-miR-6893-5p	PAR-CLIP	22291592
MIRT496101	hsa-miR-940	PAR-CLIP	22291592
MIRT496100	hsa-miR-2682-5p	PAR-CLIP	22291592
MIRT496099	hsa-miR-34b-5p	PAR-CLIP	22291592
MIRT496098	hsa-miR-449c-5p	PAR-CLIP	22291592
MIRT496097	hsa-miR-6750-5p	PAR-CLIP	22291592
MIRT496096	hsa-miR-6822-5p	PAR-CLIP	22291592
MIRT496095	hsa-miR-4257	PAR-CLIP	22291592
MIRT496094	hsa-miR-6806-5p	PAR-CLIP	22291592
MIRT1377150	hsa-miR-1275	CLIP-seq
MIRT1377151	hsa-miR-1470	CLIP-seq
MIRT1377152	hsa-miR-151-3p	CLIP-seq
MIRT1377153	hsa-miR-1913	CLIP-seq
MIRT1377154	hsa-miR-1915	CLIP-seq
MIRT1377155	hsa-miR-19a	CLIP-seq
MIRT1377156	hsa-miR-19b	CLIP-seq
MIRT1377157	hsa-miR-2110	CLIP-seq
MIRT1377158	hsa-miR-2113	CLIP-seq
MIRT1377159	hsa-miR-3127-3p	CLIP-seq
MIRT1377160	hsa-miR-3194-5p	CLIP-seq
MIRT1377161	hsa-miR-324-3p	CLIP-seq
MIRT1377162	hsa-miR-326	CLIP-seq
MIRT1377163	hsa-miR-330-5p	CLIP-seq
MIRT1377164	hsa-miR-3607-3p	CLIP-seq
MIRT1377165	hsa-miR-3686	CLIP-seq
MIRT1377166	hsa-miR-4269	CLIP-seq
MIRT1377167	hsa-miR-4271	CLIP-seq
MIRT1377168	hsa-miR-4471	CLIP-seq
MIRT1377169	hsa-miR-4525	CLIP-seq
MIRT1377170	hsa-miR-4640-5p	CLIP-seq
MIRT1377171	hsa-miR-4641	CLIP-seq
MIRT1377172	hsa-miR-4652-3p	CLIP-seq
MIRT1377173	hsa-miR-4665-5p	CLIP-seq
MIRT1377174	hsa-miR-4667-5p	CLIP-seq
MIRT1377175	hsa-miR-4690-3p	CLIP-seq
MIRT1377176	hsa-miR-4700-5p	CLIP-seq
MIRT1377177	hsa-miR-4723-5p	CLIP-seq
MIRT1377178	hsa-miR-4725-3p	CLIP-seq
MIRT1377179	hsa-miR-4726-5p	CLIP-seq
MIRT1377180	hsa-miR-4735-5p	CLIP-seq
MIRT1377181	hsa-miR-548m	CLIP-seq
MIRT1377182	hsa-miR-625	CLIP-seq
MIRT1377183	hsa-miR-637	CLIP-seq
MIRT2112203	hsa-miR-1271	CLIP-seq
MIRT2112204	hsa-miR-182	CLIP-seq
MIRT2112205	hsa-miR-196a	CLIP-seq
MIRT2112206	hsa-miR-196b	CLIP-seq
MIRT1377157	hsa-miR-2110	CLIP-seq
MIRT2112207	hsa-miR-3132	CLIP-seq
MIRT2112208	hsa-miR-3154	CLIP-seq
MIRT2112209	hsa-miR-3179	CLIP-seq
MIRT1377162	hsa-miR-326	CLIP-seq
MIRT1377163	hsa-miR-330-5p	CLIP-seq
MIRT2112210	hsa-miR-331-3p	CLIP-seq
MIRT1377164	hsa-miR-3607-3p	CLIP-seq
MIRT2112211	hsa-miR-3616-3p	CLIP-seq
MIRT1377165	hsa-miR-3686	CLIP-seq
MIRT2112212	hsa-miR-3926	CLIP-seq
MIRT2112213	hsa-miR-3927	CLIP-seq
MIRT2112214	hsa-miR-3936	CLIP-seq
MIRT1377167	hsa-miR-4271	CLIP-seq
MIRT2112215	hsa-miR-4436b-3p	CLIP-seq
MIRT2112216	hsa-miR-4451	CLIP-seq
MIRT1377168	hsa-miR-4471	CLIP-seq
MIRT1377170	hsa-miR-4640-5p	CLIP-seq
MIRT2112217	hsa-miR-4642	CLIP-seq
MIRT1377172	hsa-miR-4652-3p	CLIP-seq
MIRT1377174	hsa-miR-4667-5p	CLIP-seq
MIRT1377176	hsa-miR-4700-5p	CLIP-seq
MIRT1377178	hsa-miR-4725-3p	CLIP-seq
MIRT1377179	hsa-miR-4726-5p	CLIP-seq
MIRT1377180	hsa-miR-4735-5p	CLIP-seq
MIRT1377181	hsa-miR-548m	CLIP-seq
MIRT2112218	hsa-miR-548s	CLIP-seq
MIRT1377183	hsa-miR-637	CLIP-seq
MIRT2112219	hsa-miR-96	CLIP-seq
MIRT2112203	hsa-miR-1271	CLIP-seq
MIRT1377150	hsa-miR-1275	CLIP-seq
MIRT1377152	hsa-miR-151-3p	CLIP-seq
MIRT2112204	hsa-miR-182	CLIP-seq
MIRT1377155	hsa-miR-19a	CLIP-seq
MIRT1377156	hsa-miR-19b	CLIP-seq
MIRT1377158	hsa-miR-2113	CLIP-seq
MIRT2112207	hsa-miR-3132	CLIP-seq
MIRT2335468	hsa-miR-3136-3p	CLIP-seq
MIRT2335469	hsa-miR-3166	CLIP-seq
MIRT1377162	hsa-miR-326	CLIP-seq
MIRT2335470	hsa-miR-328	CLIP-seq
MIRT1377163	hsa-miR-330-5p	CLIP-seq
MIRT2112211	hsa-miR-3616-3p	CLIP-seq
MIRT2335471	hsa-miR-3714	CLIP-seq
MIRT2335472	hsa-miR-4267	CLIP-seq
MIRT1377166	hsa-miR-4269	CLIP-seq
MIRT2335473	hsa-miR-4281	CLIP-seq
MIRT2335474	hsa-miR-4326	CLIP-seq
MIRT2335475	hsa-miR-4419a	CLIP-seq
MIRT2112215	hsa-miR-4436b-3p	CLIP-seq
MIRT2112216	hsa-miR-4451	CLIP-seq
MIRT2335476	hsa-miR-4510	CLIP-seq
MIRT2335477	hsa-miR-4514	CLIP-seq
MIRT1377169	hsa-miR-4525	CLIP-seq
MIRT1377170	hsa-miR-4640-5p	CLIP-seq
MIRT1377171	hsa-miR-4641	CLIP-seq
MIRT2112217	hsa-miR-4642	CLIP-seq
MIRT1377173	hsa-miR-4665-5p	CLIP-seq
MIRT1377174	hsa-miR-4667-5p	CLIP-seq
MIRT2335478	hsa-miR-4691-5p	CLIP-seq
MIRT2335479	hsa-miR-4692	CLIP-seq
MIRT1377176	hsa-miR-4700-5p	CLIP-seq
MIRT1377177	hsa-miR-4723-5p	CLIP-seq
MIRT1377179	hsa-miR-4726-5p	CLIP-seq
MIRT1377180	hsa-miR-4735-5p	CLIP-seq
MIRT2335480	hsa-miR-4766-5p	CLIP-seq
MIRT2335481	hsa-miR-584	CLIP-seq
MIRT1377182	hsa-miR-625	CLIP-seq
MIRT1377183	hsa-miR-637	CLIP-seq
MIRT2112219	hsa-miR-96	CLIP-seq
MIRT1377170	hsa-miR-4640-5p	CLIP-seq
MIRT1377179	hsa-miR-4726-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001822	Process	Kidney development	IEA
GO:0003279	Process	Cardiac septum development	IEA
GO:0005102	Function	Signaling receptor binding	NAS	12169628
GO:0005515	Function	Protein binding	IPI	16712798, 17474147, 28892079, 32296183, 32814053
GO:0005768	Component	Endosome	IDA	23382219, 28892079
GO:0005769	Component	Early endosome	IBA	21873635
GO:0005769	Component	Early endosome	IDA	12169628
GO:0005794	Component	Golgi apparatus	IDA	10942595
GO:0005829	Component	Cytosol	IDA	16712798
GO:0006707	Process	Cholesterol catabolic process	IC	12169628
GO:0006886	Process	Intracellular protein transport	IBA	21873635
GO:0006886	Process	Intracellular protein transport	NAS	12169628
GO:0006898	Process	Receptor-mediated endocytosis	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0008022	Function	Protein C-terminus binding	IPI	11237770
GO:0010008	Component	Endosome membrane	IDA	23382219
GO:0016020	Component	Membrane	NAS	12169628
GO:0016197	Process	Endosomal transport	NAS	12169628
GO:0030100	Process	Regulation of endocytosis	NAS	12169628
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IDA	16712798
GO:0032456	Process	Endocytic recycling	IMP	28892079
GO:0032991	Component	Protein-containing complex	IDA	23382219
GO:0035091	Function	Phosphatidylinositol binding	IBA	21873635
GO:0035091	Function	Phosphatidylinositol binding	IDA	16712798
GO:0035904	Process	Aorta development	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0050750	Function	Low-density lipoprotein particle receptor binding	IDA	12169628
GO:0060976	Process	Coronary vasculature development	IEA
GO:1990126	Process	Retrograde transport, endosome to plasma membrane	IBA	21873635
GO:1990126	Process	Retrograde transport, endosome to plasma membrane	IMP	28892079

MIM	HGNC	e!Ensembl
605963	14979	ENSG00000115234

Protein

UniProt ID

Q15036

Protein name

Sorting nexin-17

Protein function

Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (

PDB

3FOG , 3LUI , 4GXB , 4TKN , 7RM8 , 9AU7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00787	PX	23 → 105	PX domain	Domain
PF18116	SNX17_FERM_C	270 → 384	Sorting Nexin 17 FERM C-terminal domain	Domain

Sequence

MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFP
PKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLE
VLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQ
EFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIERGWILVT
KEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQ
LRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGSTSSPGRGRGEVRLELAFEYLMSKDRLQ
WVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLE
SPDATRESMVKLSSKLSAVSLRGIGSPSTDASASDVHGNFAFEGIGDEDL

Sequence length

470

Interactions

View interactions

SNX17 (sorting nexin 17)