Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	978
Gene name	Cytidine deaminase
Gene symbol	CDA
Synonyms (NCBI Gene)	CDD
Chromosome	1
Chromosome location	1p36.12
Summary	This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several dea

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018180	hsa-miR-335-5p	Microarray	18185580
MIRT876664	hsa-miR-2110	CLIP-seq
MIRT876665	hsa-miR-3929	CLIP-seq
MIRT876666	hsa-miR-4271	CLIP-seq
MIRT876667	hsa-miR-4274	CLIP-seq
MIRT876668	hsa-miR-4419b	CLIP-seq
MIRT876669	hsa-miR-4478	CLIP-seq
MIRT876670	hsa-miR-4725-3p	CLIP-seq
MIRT876671	hsa-miR-4747-5p	CLIP-seq
MIRT2196831	hsa-miR-4677-3p	CLIP-seq
MIRT2385813	hsa-miR-3151	CLIP-seq
MIRT2500055	hsa-miR-122	CLIP-seq
MIRT2500056	hsa-miR-1285	CLIP-seq
MIRT2500057	hsa-miR-1299	CLIP-seq
MIRT2500058	hsa-miR-1915	CLIP-seq
MIRT2500059	hsa-miR-2114	CLIP-seq
MIRT2500060	hsa-miR-2355-5p	CLIP-seq
MIRT2500061	hsa-miR-3135b	CLIP-seq
MIRT2500062	hsa-miR-3155	CLIP-seq
MIRT2500063	hsa-miR-3155b	CLIP-seq
MIRT2500064	hsa-miR-3158-3p	CLIP-seq
MIRT2500065	hsa-miR-3187-5p	CLIP-seq
MIRT2500066	hsa-miR-339-5p	CLIP-seq
MIRT2500067	hsa-miR-3652	CLIP-seq
MIRT2500068	hsa-miR-3657	CLIP-seq
MIRT2500069	hsa-miR-3665	CLIP-seq
MIRT2500070	hsa-miR-3934	CLIP-seq
MIRT2500071	hsa-miR-4261	CLIP-seq
MIRT2500072	hsa-miR-4430	CLIP-seq
MIRT2500073	hsa-miR-4446-3p	CLIP-seq
MIRT2500074	hsa-miR-4492	CLIP-seq
MIRT2500075	hsa-miR-4498	CLIP-seq
MIRT2500076	hsa-miR-4505	CLIP-seq
MIRT2500077	hsa-miR-4675	CLIP-seq
MIRT2196831	hsa-miR-4677-3p	CLIP-seq
MIRT2500078	hsa-miR-4685-5p	CLIP-seq
MIRT2500079	hsa-miR-4731-5p	CLIP-seq
MIRT2500080	hsa-miR-4736	CLIP-seq
MIRT2500081	hsa-miR-4741	CLIP-seq
MIRT2500082	hsa-miR-484	CLIP-seq
MIRT2500083	hsa-miR-494	CLIP-seq
MIRT2500084	hsa-miR-510	CLIP-seq
MIRT2500085	hsa-miR-612	CLIP-seq
MIRT2500086	hsa-miR-762	CLIP-seq
MIRT2500087	hsa-miR-875-3p	CLIP-seq
MIRT2500055	hsa-miR-122	CLIP-seq
MIRT2500056	hsa-miR-1285	CLIP-seq
MIRT2500057	hsa-miR-1299	CLIP-seq
MIRT2500058	hsa-miR-1915	CLIP-seq
MIRT2500059	hsa-miR-2114	CLIP-seq
MIRT2500060	hsa-miR-2355-5p	CLIP-seq
MIRT2500061	hsa-miR-3135b	CLIP-seq
MIRT2500062	hsa-miR-3155	CLIP-seq
MIRT2500063	hsa-miR-3155b	CLIP-seq
MIRT2500064	hsa-miR-3158-3p	CLIP-seq
MIRT2500065	hsa-miR-3187-5p	CLIP-seq
MIRT2500066	hsa-miR-339-5p	CLIP-seq
MIRT2500067	hsa-miR-3652	CLIP-seq
MIRT2500068	hsa-miR-3657	CLIP-seq
MIRT2500069	hsa-miR-3665	CLIP-seq
MIRT2500070	hsa-miR-3934	CLIP-seq
MIRT2500071	hsa-miR-4261	CLIP-seq
MIRT2500072	hsa-miR-4430	CLIP-seq
MIRT2500073	hsa-miR-4446-3p	CLIP-seq
MIRT2500074	hsa-miR-4492	CLIP-seq
MIRT2500075	hsa-miR-4498	CLIP-seq
MIRT2500076	hsa-miR-4505	CLIP-seq
MIRT2500077	hsa-miR-4675	CLIP-seq
MIRT2196831	hsa-miR-4677-3p	CLIP-seq
MIRT2500078	hsa-miR-4685-5p	CLIP-seq
MIRT2500079	hsa-miR-4731-5p	CLIP-seq
MIRT2500080	hsa-miR-4736	CLIP-seq
MIRT2500081	hsa-miR-4741	CLIP-seq
MIRT2500082	hsa-miR-484	CLIP-seq
MIRT2500083	hsa-miR-494	CLIP-seq
MIRT2500084	hsa-miR-510	CLIP-seq
MIRT2500085	hsa-miR-612	CLIP-seq
MIRT2500086	hsa-miR-762	CLIP-seq
MIRT2500087	hsa-miR-875-3p	CLIP-seq

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Transcription factor	Regulation	Reference
GATA1	Activation	14744791

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001882	Function	Nucleoside binding	IDA	15689149
GO:0003824	Function	Catalytic activity	IEA
GO:0004126	Function	Cytidine deaminase activity	IBA
GO:0004126	Function	Cytidine deaminase activity	IDA	7923172, 9596658
GO:0004126	Function	Cytidine deaminase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 25910212, 31515488, 32296183
GO:0005576	Component	Extracellular region	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	9596658
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	NAS	16303324
GO:0005829	Component	Cytosol	TAS
GO:0008270	Function	Zinc ion binding	IBA
GO:0008270	Function	Zinc ion binding	IDA	15689149
GO:0008270	Function	Zinc ion binding	IEA
GO:0008655	Process	Pyrimidine-containing compound salvage	NAS	9596658
GO:0016787	Function	Hydrolase activity	IEA
GO:0019858	Process	Cytosine metabolic process	TAS	7923172
GO:0034774	Component	Secretory granule lumen	TAS
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	9596658, 31515488, 32296183
GO:0042803	Function	Protein homodimerization activity	IDA	15689149
GO:0044206	Process	UMP salvage	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0046898	Process	Response to cycloheximide	IEA
GO:0055086	Process	Nucleobase-containing small molecule metabolic process	IEA
GO:0071217	Process	Cellular response to external biotic stimulus	IEA
GO:0072527	Process	Pyrimidine-containing compound metabolic process	IEA
GO:1901135	Process	Carbohydrate derivative metabolic process	IEA
GO:1904724	Component	Tertiary granule lumen	TAS
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

MIM	HGNC	e!Ensembl
123920	1712	ENSG00000158825

P32320

Protein name

Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase)

Protein function

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

PDB

1MQ0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00383	dCMP_cyt_deam_1	12 → 118	Cytidine and deoxycytidylate deaminase zinc-binding region	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines.

Sequence

MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACY
PLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKP
DGTYIVMTVQELLPSSFGPEDLQKTQ

Sequence length

146

Interactions

View interactions

	KEGG		Reactome
	Pyrimidine metabolism Drug metabolism - other enzymes Metabolic pathways Nucleotide metabolism		Neutrophil degranulation Pyrimidine salvage

CDA (cytidine deaminase)