Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9774
Gene name Gene Name - the full gene name approved by the HGNC.
BCL2 associated transcription factor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
BCLAF1
Synonyms (NCBI Gene) Gene synonyms aliases
BTF, bK211L9.1
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q23.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-lik
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003063 kshv-miR-K12-5-3p Luciferase reporter assay 19098914
MIRT003063 kshv-miR-K12-5-3p Luciferase reporter assay 19098914
MIRT003063 kshv-miR-K12-5-3p Luciferase reporter assay 19098914
MIRT003063 kshv-miR-K12-5-3p Luciferase reporter assay 19098914
MIRT003063 kshv-miR-K12-5-3p Luciferase reporter assay 19098914
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003677 Function DNA binding IBA 21873635
GO:0003677 Function DNA binding IDA 10330179
GO:0003712 Function Transcription coregulator activity IBA 21873635
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0005515 Function Protein binding IPI 10837489, 15009215, 23541952
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612588 16863 ENSG00000029363
Protein
UniProt ID Q9NYF8
Protein name Bcl-2-associated transcription factor 1 (Btf) (BCLAF1 and THRAP3 family member 1)
Protein function Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
PDB 7RJN , 7RJR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15440 THRAP3_BCLAF1 108 767 THRAP3/BCLAF1 family Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous.
Sequence
MGRSNSRSHSSRSKSRSQSSSRSRSRSHSRKKRYSSRSRSRTYSRSRSRDRMYSRDYRRD
YRNNRGMRRPYGYRGRGRGYYQGGGGRYHRGGYRPVWNRRHSRSPRRGRSRSRSPKRRSV
SSQRSRSRSRRSYRSSRSPRSSSSRSSSPYSKSPVSKRRGSQEKQTKKAEGEPQEESPLK
SKSQEEPKDTFEHDPSESIDEFNKSSATSGDIWPGLSAYDNSPRSPHSPSPIATPPSQSS
SCSDAPMLSTVHSAKNTPSQHSHSIQHSPERSGSGSVGNGSSRYSPSQNSPIHHIPSRRS
PAKTIAPQNAPRDESRGRSSFYPDGGDQETAKTGKFLKRFTDEESRVFLLDRGNTRDKEA
SKEKGSEKGRAEGEWEDQEALDYFSDKESGKQKFNDSEGDDTEETEDYRQFRKSVLADQG
KSFATASHRNTEEEGLKYKSKVSLKGNRESDGFREEKNYKLKETGYVVERPSTTKDKHKE
EDKNSERITVKKETQSPEQVKSEKLKDLFDYSPPLHKNLDAREKSTFREESPLRIKMIAS
DSHRPEVKLKMAPVPLDDSNRPASLTKDRLLASTLVHSVKKEQEFRSIFDHIKLPQASKS
TSESFIQHIVSLVHHVKEQYFKSAAMTLNERFTSYQKATEEHSTRQKSPEIHRRIDISPS
TLRKHTRLAGEERVFKEENQKGDKKLRCDSADLRHDIDRRRKERSKERGDSKGSRESSGS
RKQEKTPKDYKEYKSYKDDSKHKREQDHSRSSSSSASPSSPSSREEK
ESKKEREEEFKTH
HEMKEYSGFAGVSRPRGTFFRIRGRGRARGVFAGTNTGPNNSNTTFQKRPKEEEWDPEYT
PKSKKYFLHDDRDDGVDYWAKRGRGRGTFQRGRGRFNFKKSGSSPKWTHDKYQGDGIVED
EEETMENNEEKKDRRKEEKE
Sequence length 920
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lung carcinoma Small cell carcinoma of lung rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)
22941189
Unknown
Disease term Disease name Evidence References Source
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Amyotrophic Lateral Sclerosis Associate 36418457, 38056214
Atherosclerosis Associate 36720950
Breast Neoplasms Associate 32497068, 35150481
Carcinoma Hepatocellular Stimulate 37906282
Colorectal Neoplasms Associate 35660018
Esophageal Squamous Cell Carcinoma Associate 24402574
Hereditary Breast and Ovarian Cancer Syndrome Associate 32497068
Leukemia Large Granular Lymphocytic Associate 28407008
Leukemia Myeloid Acute Associate 28216661
Lymphoma Large B Cell Diffuse Associate 29969367