PCLAF (PCNA clamp associated factor)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9768
Gene name Gene Name - the full gene name approved by the HGNC.
PCNA clamp associated factor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PCLAF
Synonyms (NCBI Gene) Gene synonyms aliases
KIAA0101, L5, NS5ATP9, OEATC, OEATC-1, OEATC1, PAF, PAF15, p15(PAF), p15/PAF, p15PAF
Chromosome Chromosome number
15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q22.31
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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miRTarBase ID miRNA Experiments Reference
MIRT642593 hsa-miR-455-5p HITS-CLIP 19536157
MIRT642591 hsa-miR-1250-3p HITS-CLIP 19536157
MIRT642590 hsa-miR-153-5p HITS-CLIP 19536157
MIRT720519 hsa-miR-6872-3p HITS-CLIP 19536157
MIRT642589 hsa-miR-149-5p HITS-CLIP 19536157
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
Transcription factor Regulation Reference
ATF3 Unknown 19219066
E2F4 Repression 23593430
E2F6 Repression 23593430
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0003682 Function Chromatin binding IBA
GO:0003682 Function Chromatin binding IDA 23000965
GO:0005515 Function Protein binding IPI 21628590, 21673012, 23000965, 25762514, 26496610, 28514442, 32296183, 33961781
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IDA 21628590, 21673012, 23000965
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
610696 28961 ENSG00000166803
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q15004
Protein name PCNA-associated factor (Hepatitis C virus NS5A-transactivated protein 9) (HCV NS5A-transactivated protein 9) (Overexpressed in anaplastic thyroid carcinoma 1) (OEATC-1) (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF) (PCNA-clamp-associated factor)
Protein function PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA p
PDB 4D2G , 6EHT , 6GWS , 6IIW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15715 PAF 1 → 111 PCNA-associated factor histone like domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed predominantly in liver, pancreas and placenta. Not detected in heart or brain. Highly expressed in a number of tumors, especially esophageal tumors, in anaplastic thyroid carcinomas, adrenocortical carcinomas, and in non-smal
Sequence
Sequence length 111
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Termination of translesion DNA synthesis
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Alzheimer disease Alzheimer's disease or family history of Alzheimer's disease N/A N/A GWAS
Schizophrenia Schizophrenia N/A N/A GWAS
Show/Hide Text Mining Associations (92)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Stimulate 31093306
Adenocarcinoma of Lung Associate 33126397, 33231570
Adrenal Gland Neoplasms Associate 22096502
Adrenocortical Carcinoma Stimulate 22096502
Aggressive Periodontitis Associate 15242947
Anaphylaxis Associate 31292264
Anemia Associate 26575329
Anterior Cruciate Ligament Injuries Associate 15789362
Arthritis Rheumatoid Associate 24959711
Asthma Associate 10194471, 10952073