Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	9768
Gene name	PCNA clamp associated factor
Gene symbol	PCLAF
Synonyms (NCBI Gene)	KIAA0101L5NS5ATP9OEATCOEATC-1OEATC1PAFPAF15p15(PAF)p15/PAFp15PAF
Chromosome	15
Chromosome location	15q22.31

152

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miRTarBase ID	miRNA	Experiments	Reference
MIRT642593	hsa-miR-455-5p	HITS-CLIP	19536157
MIRT642591	hsa-miR-1250-3p	HITS-CLIP	19536157
MIRT642590	hsa-miR-153-5p	HITS-CLIP	19536157
MIRT720519	hsa-miR-6872-3p	HITS-CLIP	19536157
MIRT642589	hsa-miR-149-5p	HITS-CLIP	19536157
MIRT642588	hsa-miR-1254	HITS-CLIP	19536157
MIRT642587	hsa-miR-3116	HITS-CLIP	19536157
MIRT642586	hsa-miR-661	HITS-CLIP	19536157
MIRT720518	hsa-miR-4284	HITS-CLIP	19536157
MIRT720517	hsa-miR-24-3p	HITS-CLIP	19536157
MIRT072611	hsa-miR-1227-3p	HITS-CLIP	19536157
MIRT642580	hsa-miR-4715-3p	HITS-CLIP	19536157
MIRT642579	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT715868	hsa-miR-552-3p	HITS-CLIP	19536157
MIRT715867	hsa-miR-512-5p	HITS-CLIP	19536157
MIRT715866	hsa-miR-3934-5p	HITS-CLIP	19536157
MIRT715865	hsa-miR-1273g-3p	HITS-CLIP	19536157
MIRT715864	hsa-miR-4793-3p	HITS-CLIP	19536157
MIRT715863	hsa-miR-4252	HITS-CLIP	19536157
MIRT715862	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT715861	hsa-miR-7703	HITS-CLIP	19536157
MIRT642594	hsa-miR-4438	HITS-CLIP	23824327
MIRT642593	hsa-miR-455-5p	HITS-CLIP	23824327
MIRT642592	hsa-miR-6504-3p	HITS-CLIP	23824327
MIRT642591	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT642590	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT642589	hsa-miR-149-5p	HITS-CLIP	23824327
MIRT642588	hsa-miR-1254	HITS-CLIP	23824327
MIRT642587	hsa-miR-3116	HITS-CLIP	23824327
MIRT642586	hsa-miR-661	HITS-CLIP	23824327
MIRT072611	hsa-miR-1227-3p	HITS-CLIP	23824327
MIRT642585	hsa-miR-5095	HITS-CLIP	23824327
MIRT642584	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT642583	hsa-miR-5696	HITS-CLIP	23824327
MIRT642582	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT642581	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT642580	hsa-miR-4715-3p	HITS-CLIP	23824327
MIRT642579	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT638558	hsa-miR-551b-5p	HITS-CLIP	23824327
MIRT638557	hsa-miR-3156-5p	HITS-CLIP	23824327
MIRT638556	hsa-miR-8063	HITS-CLIP	23824327
MIRT638555	hsa-miR-4698	HITS-CLIP	23824327
MIRT638554	hsa-miR-4705	HITS-CLIP	23824327
MIRT638553	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT638552	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT638551	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT638550	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT638549	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT638548	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT506892	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT506891	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT506890	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT506889	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT506888	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT506887	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT506886	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT506885	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT506884	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT506883	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT506882	hsa-miR-519a-3p	PAR-CLIP	20371350
MIRT506881	hsa-miR-519b-3p	PAR-CLIP	20371350
MIRT506880	hsa-miR-519c-3p	PAR-CLIP	20371350
MIRT506879	hsa-miR-4789-3p	PAR-CLIP	20371350
MIRT506878	hsa-miR-4643	PAR-CLIP	20371350
MIRT506877	hsa-miR-539-5p	PAR-CLIP	20371350
MIRT506876	hsa-miR-466	PAR-CLIP	20371350
MIRT506892	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT506891	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT506890	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT506889	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT506888	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT506887	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT506886	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT506885	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT506884	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT506883	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT506882	hsa-miR-519a-3p	PAR-CLIP	20371350
MIRT506881	hsa-miR-519b-3p	PAR-CLIP	20371350
MIRT506880	hsa-miR-519c-3p	PAR-CLIP	20371350
MIRT506877	hsa-miR-539-5p	PAR-CLIP	20371350
MIRT506892	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT506891	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT506890	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT506889	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT506888	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT506887	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT506886	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT506885	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT506884	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT506883	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT506882	hsa-miR-519a-3p	PAR-CLIP	20371350
MIRT506881	hsa-miR-519b-3p	PAR-CLIP	20371350
MIRT506880	hsa-miR-519c-3p	PAR-CLIP	20371350
MIRT506877	hsa-miR-539-5p	PAR-CLIP	20371350
MIRT506892	hsa-miR-548az-5p	PAR-CLIP	21572407
MIRT506891	hsa-miR-548t-5p	PAR-CLIP	21572407
MIRT506882	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT506881	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT506880	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT506879	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT506878	hsa-miR-4643	PAR-CLIP	21572407
MIRT506877	hsa-miR-539-5p	PAR-CLIP	21572407
MIRT506876	hsa-miR-466	PAR-CLIP	21572407
MIRT506892	hsa-miR-548az-5p	PAR-CLIP	23446348
MIRT506891	hsa-miR-548t-5p	PAR-CLIP	23446348
MIRT506890	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT506889	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT506888	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT506887	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT506886	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT506885	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT506884	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT506883	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT506882	hsa-miR-519a-3p	PAR-CLIP	23446348
MIRT506881	hsa-miR-519b-3p	PAR-CLIP	23446348
MIRT506880	hsa-miR-519c-3p	PAR-CLIP	23446348
MIRT506879	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT506878	hsa-miR-4643	PAR-CLIP	23446348
MIRT506877	hsa-miR-539-5p	PAR-CLIP	23446348
MIRT506876	hsa-miR-466	PAR-CLIP	23446348
MIRT506892	hsa-miR-548az-5p	PAR-CLIP	23446348
MIRT506891	hsa-miR-548t-5p	PAR-CLIP	23446348
MIRT506890	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT506889	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT506888	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT506887	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT506886	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT506885	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT506884	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT506883	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT506882	hsa-miR-519a-3p	PAR-CLIP	23446348
MIRT506881	hsa-miR-519b-3p	PAR-CLIP	23446348
MIRT506880	hsa-miR-519c-3p	PAR-CLIP	23446348
MIRT506878	hsa-miR-4643	PAR-CLIP	23446348
MIRT506877	hsa-miR-539-5p	PAR-CLIP	23446348
MIRT506892	hsa-miR-548az-5p	PAR-CLIP	23446348
MIRT506891	hsa-miR-548t-5p	PAR-CLIP	23446348
MIRT506890	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT506889	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT506888	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT506887	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT506886	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT506885	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT506884	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT506883	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT506882	hsa-miR-519a-3p	PAR-CLIP	23446348
MIRT506881	hsa-miR-519b-3p	PAR-CLIP	23446348
MIRT506880	hsa-miR-519c-3p	PAR-CLIP	23446348
MIRT506879	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT506878	hsa-miR-4643	PAR-CLIP	23446348
MIRT506877	hsa-miR-539-5p	PAR-CLIP	23446348
MIRT506876	hsa-miR-466	PAR-CLIP	23446348

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Transcription factor	Regulation	Reference
ATF3	Unknown	19219066
E2F4	Repression	23593430
E2F6	Repression	23593430

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003682	Function	Chromatin binding	IBA
GO:0003682	Function	Chromatin binding	IDA	23000965
GO:0005515	Function	Protein binding	IPI	21628590, 21673012, 23000965, 25762514, 26496610, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	21628590, 21673012, 23000965
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA
GO:0006260	Process	DNA replication	IDA	23000965
GO:0006281	Process	DNA repair	IEA
GO:0006974	Process	DNA damage response	IDA	21628590, 23000965
GO:0006974	Process	DNA damage response	IEA
GO:0007098	Process	Centrosome cycle	IMP	21673012
GO:0009411	Process	Response to UV	IDA	23000965
GO:0019985	Process	Translesion synthesis	IBA
GO:0019985	Process	Translesion synthesis	IMP	23000965
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	21673012
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051726	Process	Regulation of cell cycle	IEA
GO:0051726	Process	Regulation of cell cycle	IMP	21628590
GO:0060090	Function	Molecular adaptor activity	EXP	25762514
GO:0060090	Function	Molecular adaptor activity	IDA	25762514
GO:0060090	Function	Molecular adaptor activity	IPI	25762514

MIM	HGNC	e!Ensembl
610696	28961	ENSG00000166803

Q15004

Protein name

PCNA-associated factor (Hepatitis C virus NS5A-transactivated protein 9) (HCV NS5A-transactivated protein 9) (Overexpressed in anaplastic thyroid carcinoma 1) (OEATC-1) (PCNA-associated factor of 15 kDa) (PAF15) (p15PAF) (PCNA-clamp-associated factor)

Protein function

PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA p

PDB

4D2G , 6EHT , 6GWS , 6IIW

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15715	PAF	1 → 111	PCNA-associated factor histone like domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed predominantly in liver, pancreas and placenta. Not detected in heart or brain. Highly expressed in a number of tumors, especially esophageal tumors, in anaplastic thyroid carcinomas, adrenocortical carcinomas, and in non-smal

Sequence

MVRTKADSVPGTYRKVVAARAPRKVLGSSTSATNSTSVSSRKAENKYAGGNPVCVRPTPK
WQKGIGEFFRLSPKDSEKENQIPEEAGSSGLGKAKRKACPLQPDHTNDEKE

Sequence length

111

Interactions

View interactions

	Reactome
			Termination of translesion DNA synthesis

PCLAF (PCNA clamp associated factor)