Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	9766
Gene name	Sushi domain containing 6
Gene symbol	SUSD6
Synonyms (NCBI Gene)	DRAGOKIAA0247
Chromosome	14
Chromosome location	14q24.1

Show/Hide all (50)

miRTarBase ID	miRNA	Experiments	Reference
MIRT138798	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT138792	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT138798	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT138791	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT138801	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT138794	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT138804	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT138792	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT740277	hsa-miR-3617-3p	HITS-CLIP	19536157
MIRT740278	hsa-miR-4691-3p	HITS-CLIP	19536157
MIRT740279	hsa-miR-4528	HITS-CLIP	19536157
MIRT740280	hsa-miR-1250-3p	HITS-CLIP	19536157
MIRT740281	hsa-miR-1237-3p	HITS-CLIP	19536157
MIRT740282	hsa-miR-1248	HITS-CLIP	19536157
MIRT740283	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT740284	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT740285	hsa-miR-361-5p	HITS-CLIP	19536157
MIRT740286	hsa-miR-3157-5p	HITS-CLIP	19536157
MIRT740287	hsa-miR-6868-3p	HITS-CLIP	19536157
MIRT740288	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT740289	hsa-miR-374a-3p	HITS-CLIP	19536157
MIRT740290	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT740291	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT755066	hsa-miR-140-3p	PAR-CLIP	23592263
MIRT755067	hsa-miR-6873-5p	PAR-CLIP	23592263
MIRT755068	hsa-miR-4476	PAR-CLIP	23592263
MIRT755069	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT755070	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT755071	hsa-miR-1321	PAR-CLIP	23592263
MIRT755072	hsa-miR-4739	PAR-CLIP	23592263
MIRT755073	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT755074	hsa-miR-4446-3p	PAR-CLIP	23592263
MIRT755075	hsa-miR-4270	PAR-CLIP	23592263
MIRT755076	hsa-miR-4441	PAR-CLIP	23592263
MIRT755077	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT755078	hsa-miR-4419a	PAR-CLIP	23592263
MIRT755079	hsa-miR-4510	PAR-CLIP	23592263
MIRT755080	hsa-miR-6127	PAR-CLIP	23592263
MIRT755081	hsa-miR-6129	PAR-CLIP	23592263
MIRT755082	hsa-miR-6130	PAR-CLIP	23592263
MIRT755083	hsa-miR-6133	PAR-CLIP	23592263
MIRT755084	hsa-miR-7158-5p	PAR-CLIP	23592263
MIRT755085	hsa-miR-3202	PAR-CLIP	23592263
MIRT755086	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT755087	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT755088	hsa-miR-8085	PAR-CLIP	23592263
MIRT755089	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT755090	hsa-miR-4656	PAR-CLIP	23592263
MIRT755091	hsa-miR-3907	PAR-CLIP	23592263
MIRT755092	hsa-miR-188-3p	PAR-CLIP	23592263

Show/Hide all (4)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0006974	Process	DNA damage response	IBA
GO:0006974	Process	DNA damage response	IDA	24652652
GO:0016020	Component	Membrane	IEA

MIM	HGNC	e!Ensembl
616761	19956	ENSG00000100647

Q92537

Protein name

Sushi domain-containing protein 6 (Drug-activated gene overexpressed protein)

Protein function

May play a role in growth-suppressive activity and cell death (PubMed:24652652). May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (PubMed:20236627)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00084	Sushi	42 → 102	Sushi repeat (SCR repeat)	Domain

Sequence

MCHGRIAPKSTSVFAVASVGHGVFLPLVILCTLLGDGLASVCPLPPEPENGGYICHPRPC
RDPLTAGSVIEYLCAEGYMLKGDYKYLTCKNGEWKPAMEISCRLNEDKDTHTSLGVPTLS
IVASTASSVALILLLVVLFVLLQPKLKSFHHSRRDQGVSGDQVSIMVDGVQVALPSYEEA
VYGSSGHCVPPADPRVQIVLSEGSGPSGRSVPREQQLPDQGACSSAGGEDEAPGQSGLCE
AWGSRASETVMVHQATTSSWVAGSGNRQLAHKETADSENSDIQSLLSLTSEEYTDDIPLL
KEA

Sequence length

303

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Carcinogenesis	Associate	33914752	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Non Small Cell Lung	Inhibit	29451718	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	21619678	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Associate	37557169	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Associate	37557169	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Inhibit	29451718	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	29451718	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	33914752, 37557169	★★★★★ ★☆☆☆☆ Found in Text Mining only
Precancerous Conditions	Inhibit	29451718	★★★★★ ★☆☆☆☆ Found in Text Mining only

SUSD6 (sushi domain containing 6)