CCP110 (centriolar coiled-coil protein 110)

Gene

• Entrez ID: 9738
• Gene name: Centriolar coiled-coil protein 110
• Gene symbol: CCP110
• Synonyms (NCBI Gene): CP110, Cep110
• Chromosome: 16
• Chromosome location: 16p12.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT006725	hsa-miR-129-2-3p	Luciferase reporter assay, qRT-PCR, Western blot	22684256
MIRT016275	hsa-miR-193b-3p	Microarray	20304954
MIRT659703	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT659701	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT659702	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT659700	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT142099	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT142095	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT142099	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT142094	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT142100	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT142096	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT142104	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT142095	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT006725	hsa-miR-129-2-3p	Luciferase reporter assay, qRT-PCR, Western blot	26487539
MIRT006725	hsa-miR-129-2-3p	Luciferase reporter assay, qRT-PCR, Western blot	26487539
MIRT659703	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT659701	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT659702	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT659700	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT873025	hsa-miR-106a	CLIP-seq
MIRT873026	hsa-miR-106b	CLIP-seq
MIRT873027	hsa-miR-1183	CLIP-seq
MIRT873028	hsa-miR-1231	CLIP-seq
MIRT873029	hsa-miR-1237	CLIP-seq
MIRT873030	hsa-miR-1289	CLIP-seq
MIRT873031	hsa-miR-129-3p	CLIP-seq
MIRT873032	hsa-miR-1323	CLIP-seq
MIRT873033	hsa-miR-140-5p	CLIP-seq
MIRT873034	hsa-miR-17	CLIP-seq
MIRT873035	hsa-miR-181a	CLIP-seq
MIRT873036	hsa-miR-181b	CLIP-seq
MIRT873037	hsa-miR-181c	CLIP-seq
MIRT873038	hsa-miR-181d	CLIP-seq
MIRT873039	hsa-miR-186	CLIP-seq
MIRT873040	hsa-miR-204	CLIP-seq
MIRT873041	hsa-miR-20a	CLIP-seq
MIRT873042	hsa-miR-20b	CLIP-seq
MIRT873043	hsa-miR-211	CLIP-seq
MIRT873044	hsa-miR-218	CLIP-seq
MIRT873045	hsa-miR-221	CLIP-seq
MIRT873046	hsa-miR-222	CLIP-seq
MIRT873047	hsa-miR-224	CLIP-seq
MIRT873048	hsa-miR-2964a-5p	CLIP-seq
MIRT873049	hsa-miR-302a	CLIP-seq
MIRT873050	hsa-miR-302b	CLIP-seq
MIRT873051	hsa-miR-302c	CLIP-seq
MIRT873052	hsa-miR-302d	CLIP-seq
MIRT873053	hsa-miR-302e	CLIP-seq
MIRT873054	hsa-miR-30a	CLIP-seq
MIRT873055	hsa-miR-30b	CLIP-seq
MIRT873056	hsa-miR-30c	CLIP-seq
MIRT873057	hsa-miR-30d	CLIP-seq
MIRT873058	hsa-miR-30e	CLIP-seq
MIRT873059	hsa-miR-3129-3p	CLIP-seq
MIRT873060	hsa-miR-3137	CLIP-seq
MIRT873061	hsa-miR-3138	CLIP-seq
MIRT873062	hsa-miR-3152-5p	CLIP-seq
MIRT873063	hsa-miR-3156-5p	CLIP-seq
MIRT873064	hsa-miR-3182	CLIP-seq
MIRT873065	hsa-miR-329	CLIP-seq
MIRT873066	hsa-miR-335	CLIP-seq
MIRT873067	hsa-miR-33a	CLIP-seq
MIRT873068	hsa-miR-33b	CLIP-seq
MIRT873069	hsa-miR-3591-3p	CLIP-seq
MIRT873070	hsa-miR-3591-5p	CLIP-seq
MIRT873071	hsa-miR-3613-3p	CLIP-seq
MIRT873072	hsa-miR-3614-3p	CLIP-seq
MIRT873073	hsa-miR-362-3p	CLIP-seq
MIRT873074	hsa-miR-3686	CLIP-seq
MIRT873075	hsa-miR-372	CLIP-seq
MIRT873076	hsa-miR-373	CLIP-seq
MIRT873077	hsa-miR-3935	CLIP-seq
MIRT873078	hsa-miR-3941	CLIP-seq
MIRT873079	hsa-miR-3973	CLIP-seq
MIRT873080	hsa-miR-4262	CLIP-seq
MIRT873081	hsa-miR-4288	CLIP-seq
MIRT873082	hsa-miR-4307	CLIP-seq
MIRT873083	hsa-miR-4436b-5p	CLIP-seq
MIRT873084	hsa-miR-4460	CLIP-seq
MIRT873085	hsa-miR-4481	CLIP-seq
MIRT873086	hsa-miR-4501	CLIP-seq
MIRT873087	hsa-miR-4502	CLIP-seq
MIRT873088	hsa-miR-4640-5p	CLIP-seq
MIRT873089	hsa-miR-4658	CLIP-seq
MIRT873090	hsa-miR-466	CLIP-seq
MIRT873091	hsa-miR-4672	CLIP-seq
MIRT873092	hsa-miR-4685-5p	CLIP-seq
MIRT873093	hsa-miR-4699-5p	CLIP-seq
MIRT873094	hsa-miR-4726-5p	CLIP-seq
MIRT873095	hsa-miR-4727-3p	CLIP-seq
MIRT873096	hsa-miR-4735-5p	CLIP-seq
MIRT873097	hsa-miR-4745-5p	CLIP-seq
MIRT873098	hsa-miR-4755-5p	CLIP-seq
MIRT873099	hsa-miR-4758-5p	CLIP-seq
MIRT873100	hsa-miR-4762-3p	CLIP-seq
MIRT873101	hsa-miR-4774-3p	CLIP-seq
MIRT873102	hsa-miR-4796-3p	CLIP-seq
MIRT873103	hsa-miR-513a-3p	CLIP-seq
MIRT873104	hsa-miR-519a	CLIP-seq
MIRT873105	hsa-miR-519b-3p	CLIP-seq
MIRT873106	hsa-miR-519c-3p	CLIP-seq
MIRT873107	hsa-miR-519d	CLIP-seq
MIRT873108	hsa-miR-520a-3p	CLIP-seq
MIRT873109	hsa-miR-520b	CLIP-seq
MIRT873110	hsa-miR-520c-3p	CLIP-seq
MIRT873111	hsa-miR-520d-3p	CLIP-seq
MIRT873112	hsa-miR-520e	CLIP-seq
MIRT873113	hsa-miR-520g	CLIP-seq
MIRT873114	hsa-miR-520h	CLIP-seq
MIRT873115	hsa-miR-543	CLIP-seq
MIRT873116	hsa-miR-548a-5p	CLIP-seq
MIRT873117	hsa-miR-548ab	CLIP-seq
MIRT873118	hsa-miR-548ak	CLIP-seq
MIRT873119	hsa-miR-548b-5p	CLIP-seq
MIRT873120	hsa-miR-548c-3p	CLIP-seq
MIRT873121	hsa-miR-548c-5p	CLIP-seq
MIRT873122	hsa-miR-548d-5p	CLIP-seq
MIRT873123	hsa-miR-548h	CLIP-seq
MIRT873124	hsa-miR-548i	CLIP-seq
MIRT873125	hsa-miR-548j	CLIP-seq
MIRT873126	hsa-miR-548n	CLIP-seq
MIRT873127	hsa-miR-548o	CLIP-seq
MIRT873128	hsa-miR-548p	CLIP-seq
MIRT873129	hsa-miR-548t	CLIP-seq
MIRT873130	hsa-miR-548w	CLIP-seq
MIRT873131	hsa-miR-548y	CLIP-seq
MIRT873132	hsa-miR-553	CLIP-seq
MIRT873133	hsa-miR-559	CLIP-seq
MIRT873134	hsa-miR-586	CLIP-seq
MIRT873135	hsa-miR-603	CLIP-seq
MIRT873136	hsa-miR-623	CLIP-seq
MIRT873137	hsa-miR-632	CLIP-seq
MIRT873138	hsa-miR-640	CLIP-seq
MIRT873139	hsa-miR-668	CLIP-seq
MIRT873140	hsa-miR-888	CLIP-seq
MIRT873141	hsa-miR-93	CLIP-seq
MIRT873027	hsa-miR-1183	CLIP-seq
MIRT1959037	hsa-miR-1200	CLIP-seq
MIRT1959038	hsa-miR-1207-5p	CLIP-seq
MIRT873028	hsa-miR-1231	CLIP-seq
MIRT873029	hsa-miR-1237	CLIP-seq
MIRT1959039	hsa-miR-1253	CLIP-seq
MIRT1959040	hsa-miR-1264	CLIP-seq
MIRT1959041	hsa-miR-1305	CLIP-seq
MIRT1959042	hsa-miR-136	CLIP-seq
MIRT873033	hsa-miR-140-5p	CLIP-seq
MIRT873039	hsa-miR-186	CLIP-seq
MIRT1959043	hsa-miR-1915	CLIP-seq
MIRT873045	hsa-miR-221	CLIP-seq
MIRT873046	hsa-miR-222	CLIP-seq
MIRT873047	hsa-miR-224	CLIP-seq
MIRT873048	hsa-miR-2964a-5p	CLIP-seq
MIRT873049	hsa-miR-302a	CLIP-seq
MIRT873050	hsa-miR-302b	CLIP-seq
MIRT873051	hsa-miR-302c	CLIP-seq
MIRT873052	hsa-miR-302d	CLIP-seq
MIRT873053	hsa-miR-302e	CLIP-seq
MIRT873054	hsa-miR-30a	CLIP-seq
MIRT873055	hsa-miR-30b	CLIP-seq
MIRT873056	hsa-miR-30c	CLIP-seq
MIRT873057	hsa-miR-30d	CLIP-seq
MIRT873058	hsa-miR-30e	CLIP-seq
MIRT1959044	hsa-miR-3128	CLIP-seq
MIRT873061	hsa-miR-3138	CLIP-seq
MIRT873063	hsa-miR-3156-5p	CLIP-seq
MIRT1959045	hsa-miR-3185	CLIP-seq
MIRT873067	hsa-miR-33a	CLIP-seq
MIRT873068	hsa-miR-33b	CLIP-seq
MIRT873069	hsa-miR-3591-3p	CLIP-seq
MIRT873071	hsa-miR-3613-3p	CLIP-seq
MIRT873072	hsa-miR-3614-3p	CLIP-seq
MIRT1959046	hsa-miR-3653	CLIP-seq
MIRT1959047	hsa-miR-3658	CLIP-seq
MIRT1959048	hsa-miR-3691-3p	CLIP-seq
MIRT1959049	hsa-miR-3713	CLIP-seq
MIRT873075	hsa-miR-372	CLIP-seq
MIRT873076	hsa-miR-373	CLIP-seq
MIRT1959050	hsa-miR-3911	CLIP-seq
MIRT1959051	hsa-miR-3942-3p	CLIP-seq
MIRT873081	hsa-miR-4288	CLIP-seq
MIRT1959052	hsa-miR-4324	CLIP-seq
MIRT1959053	hsa-miR-4438	CLIP-seq
MIRT1959054	hsa-miR-4455	CLIP-seq
MIRT1959055	hsa-miR-4477a	CLIP-seq
MIRT873085	hsa-miR-4481	CLIP-seq
MIRT873087	hsa-miR-4502	CLIP-seq
MIRT873089	hsa-miR-4658	CLIP-seq
MIRT1959056	hsa-miR-4668-5p	CLIP-seq
MIRT1959057	hsa-miR-4682	CLIP-seq
MIRT1959058	hsa-miR-4698	CLIP-seq
MIRT1959059	hsa-miR-4712-3p	CLIP-seq
MIRT1959060	hsa-miR-4720-5p	CLIP-seq
MIRT1959061	hsa-miR-4726-3p	CLIP-seq
MIRT873097	hsa-miR-4745-5p	CLIP-seq
MIRT873099	hsa-miR-4758-5p	CLIP-seq
MIRT873100	hsa-miR-4762-3p	CLIP-seq
MIRT1959062	hsa-miR-4763-3p	CLIP-seq
MIRT1959063	hsa-miR-4772-3p	CLIP-seq
MIRT1959064	hsa-miR-4795-3p	CLIP-seq
MIRT873102	hsa-miR-4796-3p	CLIP-seq
MIRT1959065	hsa-miR-4799-3p	CLIP-seq
MIRT1959066	hsa-miR-489	CLIP-seq
MIRT1959067	hsa-miR-498	CLIP-seq
MIRT1959068	hsa-miR-5095	CLIP-seq
MIRT873104	hsa-miR-519a	CLIP-seq
MIRT873105	hsa-miR-519b-3p	CLIP-seq
MIRT873106	hsa-miR-519c-3p	CLIP-seq
MIRT873108	hsa-miR-520a-3p	CLIP-seq
MIRT873109	hsa-miR-520b	CLIP-seq
MIRT873110	hsa-miR-520c-3p	CLIP-seq
MIRT873111	hsa-miR-520d-3p	CLIP-seq
MIRT873112	hsa-miR-520e	CLIP-seq
MIRT1959069	hsa-miR-544b	CLIP-seq
MIRT873137	hsa-miR-632	CLIP-seq
MIRT1959070	hsa-miR-635	CLIP-seq
MIRT873138	hsa-miR-640	CLIP-seq
MIRT873139	hsa-miR-668	CLIP-seq
MIRT873028	hsa-miR-1231	CLIP-seq
MIRT873028	hsa-miR-1231	CLIP-seq
MIRT1959039	hsa-miR-1253	CLIP-seq
MIRT1959045	hsa-miR-3185	CLIP-seq
MIRT873069	hsa-miR-3591-3p	CLIP-seq
MIRT1959059	hsa-miR-4712-3p	CLIP-seq
MIRT1959039	hsa-miR-1253	CLIP-seq
MIRT1959045	hsa-miR-3185	CLIP-seq
MIRT1959059	hsa-miR-4712-3p	CLIP-seq
MIRT2499025	hsa-miR-1	CLIP-seq
MIRT2499026	hsa-miR-101	CLIP-seq
MIRT2499027	hsa-miR-1182	CLIP-seq
MIRT873027	hsa-miR-1183	CLIP-seq
MIRT1959038	hsa-miR-1207-5p	CLIP-seq
MIRT873028	hsa-miR-1231	CLIP-seq
MIRT1959039	hsa-miR-1253	CLIP-seq
MIRT1959040	hsa-miR-1264	CLIP-seq
MIRT2499028	hsa-miR-1270	CLIP-seq
MIRT2499029	hsa-miR-1278	CLIP-seq
MIRT873030	hsa-miR-1289	CLIP-seq
MIRT1959041	hsa-miR-1305	CLIP-seq
MIRT2499030	hsa-miR-132	CLIP-seq
MIRT1959042	hsa-miR-136	CLIP-seq
MIRT2499031	hsa-miR-142-5p	CLIP-seq
MIRT873039	hsa-miR-186	CLIP-seq
MIRT2499032	hsa-miR-206	CLIP-seq
MIRT2499033	hsa-miR-212	CLIP-seq
MIRT873045	hsa-miR-221	CLIP-seq
MIRT873046	hsa-miR-222	CLIP-seq
MIRT873047	hsa-miR-224	CLIP-seq
MIRT873054	hsa-miR-30a	CLIP-seq
MIRT873055	hsa-miR-30b	CLIP-seq
MIRT873056	hsa-miR-30c	CLIP-seq
MIRT873057	hsa-miR-30d	CLIP-seq
MIRT873058	hsa-miR-30e	CLIP-seq
MIRT2499034	hsa-miR-3119	CLIP-seq
MIRT873060	hsa-miR-3137	CLIP-seq
MIRT873063	hsa-miR-3156-5p	CLIP-seq
MIRT873064	hsa-miR-3182	CLIP-seq
MIRT1959045	hsa-miR-3185	CLIP-seq
MIRT873067	hsa-miR-33a	CLIP-seq
MIRT873068	hsa-miR-33b	CLIP-seq
MIRT873069	hsa-miR-3591-3p	CLIP-seq
MIRT873070	hsa-miR-3591-5p	CLIP-seq
MIRT873071	hsa-miR-3613-3p	CLIP-seq
MIRT2499035	hsa-miR-3647-3p	CLIP-seq
MIRT1959046	hsa-miR-3653	CLIP-seq
MIRT1959047	hsa-miR-3658	CLIP-seq
MIRT873074	hsa-miR-3686	CLIP-seq
MIRT873077	hsa-miR-3935	CLIP-seq
MIRT2499036	hsa-miR-4256	CLIP-seq
MIRT2499037	hsa-miR-4263	CLIP-seq
MIRT2499038	hsa-miR-4282	CLIP-seq
MIRT873081	hsa-miR-4288	CLIP-seq
MIRT2499039	hsa-miR-4434	CLIP-seq
MIRT1959053	hsa-miR-4438	CLIP-seq
MIRT873084	hsa-miR-4460	CLIP-seq
MIRT1959055	hsa-miR-4477a	CLIP-seq
MIRT2499040	hsa-miR-4516	CLIP-seq
MIRT2499041	hsa-miR-4531	CLIP-seq
MIRT873088	hsa-miR-4640-5p	CLIP-seq
MIRT1959056	hsa-miR-4668-5p	CLIP-seq
MIRT873092	hsa-miR-4685-5p	CLIP-seq
MIRT1959058	hsa-miR-4698	CLIP-seq
MIRT1959059	hsa-miR-4712-3p	CLIP-seq
MIRT873094	hsa-miR-4726-5p	CLIP-seq
MIRT873095	hsa-miR-4727-3p	CLIP-seq
MIRT2499042	hsa-miR-4760-5p	CLIP-seq
MIRT1959062	hsa-miR-4763-3p	CLIP-seq
MIRT2499043	hsa-miR-4775	CLIP-seq
MIRT2499044	hsa-miR-4793-5p	CLIP-seq
MIRT2499045	hsa-miR-4802-3p	CLIP-seq
MIRT2499046	hsa-miR-520d-5p	CLIP-seq
MIRT2499047	hsa-miR-522	CLIP-seq
MIRT2499048	hsa-miR-524-5p	CLIP-seq
MIRT2499049	hsa-miR-548ac	CLIP-seq
MIRT2499050	hsa-miR-548ae	CLIP-seq
MIRT2499051	hsa-miR-548aj	CLIP-seq
MIRT2499052	hsa-miR-548am	CLIP-seq
MIRT2499053	hsa-miR-548d-3p	CLIP-seq
MIRT2499054	hsa-miR-548x	CLIP-seq
MIRT2499055	hsa-miR-548z	CLIP-seq
MIRT873132	hsa-miR-553	CLIP-seq
MIRT2499056	hsa-miR-570	CLIP-seq
MIRT2499057	hsa-miR-576-5p	CLIP-seq
MIRT2499058	hsa-miR-593	CLIP-seq
MIRT2499059	hsa-miR-613	CLIP-seq
MIRT2499060	hsa-miR-620	CLIP-seq
MIRT873137	hsa-miR-632	CLIP-seq
MIRT1959070	hsa-miR-635	CLIP-seq
MIRT873139	hsa-miR-668	CLIP-seq
MIRT2499025	hsa-miR-1	CLIP-seq
MIRT2499032	hsa-miR-206	CLIP-seq
MIRT873060	hsa-miR-3137	CLIP-seq
MIRT873063	hsa-miR-3156-5p	CLIP-seq
MIRT873064	hsa-miR-3182	CLIP-seq
MIRT873070	hsa-miR-3591-5p	CLIP-seq
MIRT873074	hsa-miR-3686	CLIP-seq
MIRT873077	hsa-miR-3935	CLIP-seq
MIRT2499036	hsa-miR-4256	CLIP-seq
MIRT2499037	hsa-miR-4263	CLIP-seq
MIRT873084	hsa-miR-4460	CLIP-seq
MIRT1959058	hsa-miR-4698	CLIP-seq
MIRT873095	hsa-miR-4727-3p	CLIP-seq
MIRT2499047	hsa-miR-522	CLIP-seq
MIRT2499057	hsa-miR-576-5p	CLIP-seq
MIRT2499059	hsa-miR-613	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	12361598, 16760425, 17719545, 18694559, 19460342, 20596027, 21620453, 22441691, 22632967, 23486064, 24421332, 24981860, 26638075, 27173435, 30375385, 33961781, 35709258
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA	12361598, 16760425, 21399614, 22684256, 30375385
GO:0005813	Component	Centrosome	IEA
GO:0005814	Component	Centriole	IBA
GO:0005814	Component	Centriole	IDA	17681131, 20596027, 30375385
GO:0005814	Component	Centriole	IEA
GO:0005815	Component	Microtubule organizing center	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005929	Component	Cilium	IEA
GO:0007099	Process	Centriole replication	IBA
GO:0007099	Process	Centriole replication	IEA
GO:0007099	Process	Centriole replication	IMP	16244668, 17681131
GO:0030030	Process	Cell projection organization	IEA
GO:0032053	Process	Ciliary basal body organization	IBA
GO:0032053	Process	Ciliary basal body organization	IEA
GO:0032053	Process	Ciliary basal body organization	ISS
GO:0032465	Process	Regulation of cytokinesis	IEA
GO:0032465	Process	Regulation of cytokinesis	IMP	16760425
GO:0032991	Component	Protein-containing complex	IDA	24421332
GO:0042995	Component	Cell projection	IEA
GO:0045724	Process	Positive regulation of cilium assembly	IEA
GO:0045724	Process	Positive regulation of cilium assembly	ISS
GO:0051298	Process	Centrosome duplication	IDA	20596027
GO:0051298	Process	Centrosome duplication	IEA
GO:0051298	Process	Centrosome duplication	IMP	12361598, 16760425, 23486064
GO:1902018	Process	Negative regulation of cilium assembly	IEA
GO:1902018	Process	Negative regulation of cilium assembly	IMP	17719545, 30375385

Other IDs

• MIM: 609544
• HGNC: 24342
• e!Ensembl: ENSG00000103540

Protein

• UniProt ID: O43303
• Protein name: Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110)
• Protein function: Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17681131,
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16025	CALM_bind	29 → 106		Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:12361598}.
• Sequence:

  MEEYEKFCEKSLARIQEASLSTESFLPAQSESISLIRFHGVAILSPLLNIEKRKEMQQEK
  QKALDVEARKQVNRKKALLTRVQEILDNVQVRKAPNASDFDQWEMETVYSNSEVRNLNVP
  ATFPNSFPSHTEHSTAAKLDKIAGILPLDNEDQCKTDGIDLARDSEGFNSPKQCDSSNIS
  HVENEAFPKTSSATPQETLISDGPFSVNEQQDLPLLAEVIPDPYVMSLQNLMKKSKEYIE
  REQSRRSLRGSINRIVNESHLDKEHDAVEVADCVKEKGQLTGKHCVSVIPDKPSLNKSNV
  LLQGASTQASSMSMPVLASFSKVDIPIRTGHPTVLESNSDFKVIPTFVTENNVIKSLTGS
  YAKLPSPEPSMSPKMHRRRSRTSSACHILINNPINACELSPKGKEQAMDLIIQDTDENTN
  VPEIMPKLPTDLAGVCSSKVYVGKNTSEVKEDVVLGKSNQVCQSSGNHLENKVTHGLVTV
  EGQLTSDERGAHIMNSTCAAMPKLHEPYASSQCIASPNFGTVSGLKPASMLEKNCSLQTE
  LNKSYDVKNPSPLLMQNQNTRQQMDTPMVSCGNEQFLDNSFEKVKRRLDLDIDGLQKENC
  PYVITSGITEQERQHLPEKRYPKGSGFVNKNKMLGTSSKESEELLKSKMLAFEEMRKRLE
  EQHAQQLSLLIAEQEREQERLQKEIEEQEKMLKEKKAMTAEASELDINNAVELEWRKISD
  SSLLETMLSQADSLHTSNSNSSGFTNSAMQYSFVSANEAPFYLWGSSTSGLTKLSVTRPF
  GRAKTRWSQVFSLEIQAKFNKITAVAKGFLTRRLMQTDKLKQLRQTVKDTMEFIRSFQSE
  APLKRGIVSAQDASLQERVLAQLRAALYGIHDIFFVMDAAERMSILHHDREVRKEKMLRQ
  MDKMKSPRVALSAATQKSLDRKKYMKAAEMGMPNKKFLVKQNPSETRVLQPNQGQNAPVH
  RLLSRQGTPKTSVKGVVQNRQKPSQSRVPNRVPVSGVYAGKIQRKRPNVATI

• Sequence length: 1012

Pathways

Reactome:

Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
Ub-specific processing proteases
AURKA Activation by TPX2

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Adrenocortical carcinoma, hereditary	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CILIOPATHIES	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CILIOPATHY	—	GenCC	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Dykes Markes Harper syndrome	Associate	33491601	★☆☆☆☆ Found in Text Mining only
Fatigue	Associate	33491601	★☆☆☆☆ Found in Text Mining only
Holoprosencephaly recurrent infections and monocytosis	Associate	33491601	★☆☆☆☆ Found in Text Mining only
Infections	Associate	29724823	★☆☆☆☆ Found in Text Mining only
Leukocytosis	Associate	33491601	★☆☆☆☆ Found in Text Mining only
Lymphoma	Associate	33491601	★☆☆☆☆ Found in Text Mining only
Myeloproliferative Disorders	Associate	25803811, 28242791	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	28242791	★☆☆☆☆ Found in Text Mining only
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	33491601	★☆☆☆☆ Found in Text Mining only
Tonsillitis	Associate	33491601	★☆☆☆☆ Found in Text Mining only