Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	972
Gene name Gene Name - the full gene name approved by the HGNC.	CD74 molecule
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CD74
Synonyms (NCBI Gene) Gene synonyms aliases	CLIP, DHLAG, HLADG, II, Ia-GAMMA, p33
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q33.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage mig

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miRTarBase ID	miRNA	Experiments
MIRT876158	hsa-miR-1182	CLIP-seq
MIRT876159	hsa-miR-1276	CLIP-seq
MIRT876160	hsa-miR-4269	CLIP-seq
MIRT876161	hsa-miR-4645-5p	CLIP-seq
MIRT876162	hsa-miR-4673	CLIP-seq
MIRT876163	hsa-miR-4733-3p	CLIP-seq
MIRT876164	hsa-miR-4755-3p	CLIP-seq
MIRT1546272	hsa-miR-1205	CLIP-seq
MIRT1546273	hsa-miR-2110	CLIP-seq
MIRT1546274	hsa-miR-24	CLIP-seq
MIRT1546275	hsa-miR-3121-3p	CLIP-seq
MIRT1546276	hsa-miR-3153	CLIP-seq
MIRT1546277	hsa-miR-3665	CLIP-seq
MIRT1546278	hsa-miR-4271	CLIP-seq
MIRT1546279	hsa-miR-4284	CLIP-seq
MIRT1546280	hsa-miR-4667-5p	CLIP-seq
MIRT1546281	hsa-miR-4693-3p	CLIP-seq
MIRT1546282	hsa-miR-4700-5p	CLIP-seq
MIRT1546283	hsa-miR-4725-3p	CLIP-seq
MIRT1546284	hsa-miR-4731-5p	CLIP-seq
MIRT1546285	hsa-miR-596	CLIP-seq
MIRT1546286	hsa-miR-657	CLIP-seq
MIRT876158	hsa-miR-1182	CLIP-seq
MIRT2196686	hsa-miR-3135b	CLIP-seq
MIRT2196687	hsa-miR-3175	CLIP-seq
MIRT2196688	hsa-miR-3652	CLIP-seq
MIRT2196689	hsa-miR-4430	CLIP-seq
MIRT876163	hsa-miR-4733-3p	CLIP-seq
MIRT2385778	hsa-let-7a	CLIP-seq
MIRT2385779	hsa-let-7b	CLIP-seq
MIRT2385780	hsa-let-7c	CLIP-seq
MIRT2385781	hsa-let-7d	CLIP-seq
MIRT2385782	hsa-let-7e	CLIP-seq
MIRT2385783	hsa-let-7f	CLIP-seq
MIRT2385784	hsa-let-7g	CLIP-seq
MIRT2385785	hsa-let-7i	CLIP-seq
MIRT876158	hsa-miR-1182	CLIP-seq
MIRT2385786	hsa-miR-1236	CLIP-seq
MIRT2385787	hsa-miR-1255a	CLIP-seq
MIRT2385788	hsa-miR-1255b	CLIP-seq
MIRT2385789	hsa-miR-1273f	CLIP-seq
MIRT2385790	hsa-miR-202	CLIP-seq
MIRT1546273	hsa-miR-2110	CLIP-seq
MIRT2385791	hsa-miR-3150a-3p	CLIP-seq
MIRT1546276	hsa-miR-3153	CLIP-seq
MIRT2196687	hsa-miR-3175	CLIP-seq
MIRT2385792	hsa-miR-3189-3p	CLIP-seq
MIRT1546278	hsa-miR-4271	CLIP-seq
MIRT2385793	hsa-miR-4458	CLIP-seq
MIRT2385794	hsa-miR-4500	CLIP-seq
MIRT1546280	hsa-miR-4667-5p	CLIP-seq
MIRT1546282	hsa-miR-4700-5p	CLIP-seq
MIRT1546283	hsa-miR-4725-3p	CLIP-seq
MIRT1546284	hsa-miR-4731-5p	CLIP-seq
MIRT876163	hsa-miR-4733-3p	CLIP-seq
MIRT2385795	hsa-miR-4765	CLIP-seq
MIRT2385796	hsa-miR-502-5p	CLIP-seq
MIRT2385797	hsa-miR-760	CLIP-seq
MIRT2385798	hsa-miR-939	CLIP-seq
MIRT2385799	hsa-miR-98	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
NFKB1	Unknown	8164652
RELA	Unknown	8164652

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0001516	Process	Prostaglandin biosynthetic process	IDA	12782713
GO:0001540	Function	Amyloid-beta binding	IPI	19849849
GO:0001934	Process	Positive regulation of protein phosphorylation	IDA	24942581
GO:0001961	Process	Positive regulation of cytokine-mediated signaling pathway	IBA
GO:0001961	Process	Positive regulation of cytokine-mediated signaling pathway	IEA
GO:0001961	Process	Positive regulation of cytokine-mediated signaling pathway	IMP	12782713
GO:0002250	Process	Adaptive immune response	IEA
GO:0002286	Process	T cell activation involved in immune response	IBA
GO:0002376	Process	Immune system process	IEA
GO:0002606	Process	Positive regulation of dendritic cell antigen processing and presentation	IEA
GO:0002792	Process	Negative regulation of peptide secretion	IDA	19849849
GO:0002830	Process	Positive regulation of type 2 immune response	IBA
GO:0002830	Process	Positive regulation of type 2 immune response	IEA
GO:0002906	Process	Negative regulation of mature B cell apoptotic process	IEA
GO:0004896	Function	Cytokine receptor activity	IBA
GO:0004896	Function	Cytokine receptor activity	IDA	17045821
GO:0004896	Function	Cytokine receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	17357109, 17435771, 19665027, 29190904, 30833792, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005634	Component	Nucleus	IDA	19423618
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	22952837, 24569872
GO:0005764	Component	Lysosome	IEA
GO:0005764	Component	Lysosome	ISS
GO:0005765	Component	Lysosomal membrane	TAS
GO:0005768	Component	Endosome	IEA
GO:0005770	Component	Late endosome	IEA
GO:0005770	Component	Late endosome	ISS
GO:0005771	Component	Multivesicular body	IEA
GO:0005773	Component	Vacuole	IDA	19849849
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IDA	19665027, 22952837, 24569872
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006457	Process	Protein folding	IEA
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006886	Process	Intracellular protein transport	ISS
GO:0006952	Process	Defense response	IEA
GO:0006955	Process	Immune response	IEA
GO:0009897	Component	External side of plasma membrane	IEA
GO:0009986	Component	Cell surface	IBA
GO:0009986	Component	Cell surface	IDA	17045821, 19665027, 22952837
GO:0010628	Process	Positive regulation of gene expression	IMP	19423618
GO:0012507	Component	ER to Golgi transport vesicle membrane	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IDA	12782713
GO:0016020	Component	Membrane	IEA
GO:0016064	Process	Immunoglobulin mediated immune response	IEA
GO:0016064	Process	Immunoglobulin mediated immune response	ISS
GO:0019882	Process	Antigen processing and presentation	IBA
GO:0019882	Process	Antigen processing and presentation	IEA
GO:0019882	Process	Antigen processing and presentation	IEA
GO:0019883	Process	Antigen processing and presentation of endogenous antigen	NAS	10981873
GO:0019886	Process	Antigen processing and presentation of exogenous peptide antigen via MHC class II	IEA
GO:0019955	Function	Cytokine binding	IEA
GO:0019955	Function	Cytokine binding	IPI	17567581
GO:0023026	Function	MHC class II protein complex binding	IDA	1448172
GO:0030336	Process	Negative regulation of cell migration	IMP	20198449, 22952837
GO:0030658	Component	Transport vesicle membrane	TAS
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0030669	Component	Clathrin-coated endocytic vesicle membrane	TAS
GO:0030890	Process	Positive regulation of B cell proliferation	IMP	12782713
GO:0031394	Process	Positive regulation of prostaglandin biosynthetic process	IMP	24569872
GO:0032588	Component	Trans-Golgi network membrane	TAS
GO:0032722	Process	Positive regulation of chemokine production	IMP	19423618
GO:0032755	Process	Positive regulation of interleukin-6 production	IMP	24569872
GO:0032757	Process	Positive regulation of interleukin-8 production	IMP	24569872
GO:0032991	Component	Protein-containing complex	IDA	19665027
GO:0033674	Process	Positive regulation of kinase activity	IDA	24942581
GO:0034341	Process	Response to type II interferon	IDA	32855215
GO:0034341	Process	Response to type II interferon	IEA
GO:0035691	Process	Macrophage migration inhibitory factor signaling pathway	IEA
GO:0035692	Component	Macrophage migration inhibitory factor receptor complex	IDA	17045821
GO:0035692	Component	Macrophage migration inhibitory factor receptor complex	IEA
GO:0035693	Component	NOS2-CD74 complex	IEA
GO:0035718	Function	Macrophage migration inhibitory factor binding	IBA
GO:0035718	Function	Macrophage migration inhibitory factor binding	IEA
GO:0035718	Function	Macrophage migration inhibitory factor binding	IPI	17045821
GO:0042289	Function	MHC class II protein binding	IBA
GO:0042289	Function	MHC class II protein binding	IEA
GO:0042289	Function	MHC class II protein binding	ISS
GO:0042289	Function	MHC class II protein binding	NAS	10981873
GO:0042609	Function	CD4 receptor binding	IPI	24942581
GO:0042613	Component	MHC class II protein complex	IEA
GO:0042613	Component	MHC class II protein complex	ISS
GO:0042658	Function	MHC class II protein binding, via antigen binding groove	IDA	7477400
GO:0042802	Function	Identical protein binding	TAS	12782713
GO:0043030	Process	Regulation of macrophage activation	NAS	12782713
GO:0043066	Process	Negative regulation of apoptotic process	IDA	12782713
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IDA	24942581
GO:0043202	Component	Lysosomal lumen	TAS
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	24942581
GO:0043410	Process	Positive regulation of MAPK cascade	IEA
GO:0043518	Process	Negative regulation of DNA damage response, signal transduction by p53 class mediator	IBA
GO:0043518	Process	Negative regulation of DNA damage response, signal transduction by p53 class mediator	IDA	17045821
GO:0043518	Process	Negative regulation of DNA damage response, signal transduction by p53 class mediator	IEA
GO:0044183	Function	Protein folding chaperone	IDA	7477400
GO:0045058	Process	T cell selection	NAS	10981873
GO:0045059	Process	Positive thymic T cell selection	IEA
GO:0045060	Process	Negative thymic T cell selection	IEA
GO:0045581	Process	Negative regulation of T cell differentiation	IEA
GO:0045582	Process	Positive regulation of T cell differentiation	IEA
GO:0045657	Process	Positive regulation of monocyte differentiation	IDA	24942581
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	24942581
GO:0046597	Process	Host-mediated suppression of symbiont invasion	IDA	32855215
GO:0046598	Process	Positive regulation of viral entry into host cell	IDA	24942581
GO:0048146	Process	Positive regulation of fibroblast proliferation	IMP	12782713
GO:0050821	Process	Protein stabilization	ISS
GO:0050998	Function	Nitric-oxide synthase binding	IEA
GO:0060907	Process	Positive regulation of macrophage cytokine production	IBA
GO:0060907	Process	Positive regulation of macrophage cytokine production	IEA
GO:0060907	Process	Positive regulation of macrophage cytokine production	ISS
GO:0065003	Process	Protein-containing complex assembly	IEA
GO:0065003	Process	Protein-containing complex assembly	ISS
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070206	Process	Protein trimerization	IEA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IBA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	17045821, 24942581
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IEA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IMP	12782713
GO:0090023	Process	Positive regulation of neutrophil chemotaxis	IEA
GO:0090023	Process	Positive regulation of neutrophil chemotaxis	ISS
GO:0098553	Component	Lumenal side of endoplasmic reticulum membrane	TAS
GO:1902166	Process	Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IBA
GO:1902166	Process	Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IEA
GO:1902166	Process	Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP	17045821
GO:2000343	Process	Positive regulation of chemokine (C-X-C motif) ligand 2 production	IEA
GO:2000343	Process	Positive regulation of chemokine (C-X-C motif) ligand 2 production	ISS
GO:2000448	Process	Positive regulation of macrophage migration inhibitory factor signaling pathway	IMP	19665027

MIM	HGNC	e!Ensembl
142790	1697	ENSG00000019582

Protein

UniProt ID

P04233

Protein name

HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)]

Protein function

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/

PDB

1A6A , 1ICF , 1IIE , 1L3H , 1MUJ , 3PDO , 3PGC , 3PGD , 3QXA , 3QXD , 4AEN , 4AH2 , 4X5W , 5KSU , 5KSV , 7YX9 , 7YXB , 7Z0Q , 8VRW , 8VSJ , 8VSP , 9CYL , 9CYM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09307	MHC2-interact	17 → 129	CLIP, MHC2 interacting	Domain
PF08831	MHCassoc_trimer	136 → 204	Class II MHC-associated invariant chain trimerisation domain	Domain
PF00086	Thyroglobulin_1	208 → 271	Thyroglobulin type-1 repeat	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in urine (at protein level). {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313, ECO:0000269|PubMed:37453717}.; TISSUE SPECIFICITY: [Isoform p41]: In B cells, represents 10% of total CD74 expression. {ECO:0000269|PubMed

Sequence

MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLL
LAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPM
GALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLP
LQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPVPM

Sequence length

296

Interactions

View interactions

	KEGG		Reactome
	Antigen processing and presentation Tuberculosis Herpes simplex virus 1 infection		Cell surface interactions at the vascular wall MHC class II antigen presentation

CD74 (CD74 molecule)