Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9698
Gene name Gene Name - the full gene name approved by the HGNC.	Pumilio RNA binding family member 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PUM1
Synonyms (NCBI Gene) Gene synonyms aliases	HSPUM, NEDMSF, PUMH, PUMH1, PUML1, SCA47
Disease Acronyms (UniProt) Disease acronyms from UniProt database	NEDMSF, SCA47
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p35.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA bindin

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SNP ID	Visualize variation	Clinical significance	Consequence
rs771145682	T>A,C	Likely-pathogenic	Missense variant, coding sequence variant
rs1557539450	G>A	Likely-pathogenic	Coding sequence variant, missense variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016684	hsa-miR-423-3p	Sequencing	20371350
MIRT019509	hsa-miR-151a-3p	Sequencing	20371350
MIRT025121	hsa-miR-181a-5p	Sequencing	20371350
MIRT031662	hsa-miR-16-5p	Proteomics	18668040
MIRT032335	hsa-let-7b-5p	Proteomics	18668040
MIRT032335	hsa-let-7b-5p	CLASH	23622248
MIRT048648	hsa-miR-99a-5p	CLASH	23622248
MIRT045010	hsa-miR-186-5p	CLASH	23622248
MIRT043018	hsa-miR-324-5p	CLASH	23622248
MIRT042968	hsa-miR-324-3p	CLASH	23622248
MIRT038400	hsa-miR-296-3p	CLASH	23622248
MIRT506025	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT521559	hsa-miR-4528	HITS-CLIP	21572407
MIRT506026	hsa-miR-340-5p	HITS-CLIP	21572407
MIRT506024	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT506023	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT506026	hsa-miR-340-5p	HITS-CLIP	23313552
MIRT506024	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT506023	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT700482	hsa-miR-548e-5p	HITS-CLIP	23313552
MIRT700481	hsa-miR-4704-5p	HITS-CLIP	23313552
MIRT700480	hsa-miR-451b	HITS-CLIP	23313552
MIRT506025	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT700479	hsa-miR-571	HITS-CLIP	23313552
MIRT700478	hsa-miR-4696	HITS-CLIP	23313552
MIRT700477	hsa-miR-3618	HITS-CLIP	23313552
MIRT068001	hsa-miR-568	HITS-CLIP	23313552
MIRT700476	hsa-miR-5004-3p	HITS-CLIP	23313552
MIRT700475	hsa-miR-3149	HITS-CLIP	23313552
MIRT512623	hsa-miR-99a-3p	PAR-CLIP	20371350
MIRT512622	hsa-miR-99b-3p	PAR-CLIP	20371350
MIRT512621	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT512619	hsa-miR-7112-5p	PAR-CLIP	20371350
MIRT543671	hsa-miR-3920	PAR-CLIP	20371350
MIRT543670	hsa-miR-29a-5p	PAR-CLIP	20371350
MIRT068025	hsa-miR-508-3p	PAR-CLIP	20371350
MIRT249004	hsa-miR-219a-5p	PAR-CLIP	20371350
MIRT249013	hsa-miR-4782-3p	PAR-CLIP	20371350
MIRT249015	hsa-miR-6766-3p	PAR-CLIP	20371350
MIRT249009	hsa-miR-4445-5p	PAR-CLIP	20371350
MIRT512620	hsa-miR-4708-3p	PAR-CLIP	20371350
MIRT512618	hsa-miR-6809-5p	PAR-CLIP	20371350
MIRT543669	hsa-miR-760	PAR-CLIP	20371350
MIRT543668	hsa-miR-4283	PAR-CLIP	20371350
MIRT512623	hsa-miR-99a-3p	PAR-CLIP	20371350
MIRT512622	hsa-miR-99b-3p	PAR-CLIP	20371350
MIRT512621	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT512619	hsa-miR-7112-5p	PAR-CLIP	20371350
MIRT512620	hsa-miR-4708-3p	PAR-CLIP	20371350
MIRT512618	hsa-miR-6809-5p	PAR-CLIP	20371350
MIRT506025	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT521559	hsa-miR-4528	PAR-CLIP	21572407
MIRT506024	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT521558	hsa-miR-335-3p	PAR-CLIP	21572407
MIRT506023	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT512623	hsa-miR-99a-3p	PAR-CLIP	21572407
MIRT512622	hsa-miR-99b-3p	PAR-CLIP	21572407
MIRT512621	hsa-miR-651-3p	PAR-CLIP	21572407
MIRT512619	hsa-miR-7112-5p	PAR-CLIP	21572407
MIRT543671	hsa-miR-3920	PAR-CLIP	21572407
MIRT543670	hsa-miR-29a-5p	PAR-CLIP	21572407
MIRT068025	hsa-miR-508-3p	PAR-CLIP	21572407
MIRT249004	hsa-miR-219a-5p	PAR-CLIP	21572407
MIRT249013	hsa-miR-4782-3p	PAR-CLIP	21572407
MIRT249015	hsa-miR-6766-3p	PAR-CLIP	21572407
MIRT249009	hsa-miR-4445-5p	PAR-CLIP	21572407
MIRT512620	hsa-miR-4708-3p	PAR-CLIP	21572407
MIRT512618	hsa-miR-6809-5p	PAR-CLIP	21572407
MIRT543669	hsa-miR-760	PAR-CLIP	21572407
MIRT543668	hsa-miR-4283	PAR-CLIP	21572407
MIRT521559	hsa-miR-4528	PAR-CLIP	23446348
MIRT506026	hsa-miR-340-5p	PAR-CLIP	23446348
MIRT506024	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT521558	hsa-miR-335-3p	PAR-CLIP	23446348
MIRT506023	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT512623	hsa-miR-99a-3p	PAR-CLIP	23446348
MIRT512622	hsa-miR-99b-3p	PAR-CLIP	23446348
MIRT512621	hsa-miR-651-3p	PAR-CLIP	23446348
MIRT512619	hsa-miR-7112-5p	PAR-CLIP	23446348
MIRT512620	hsa-miR-4708-3p	PAR-CLIP	23446348
MIRT512618	hsa-miR-6809-5p	PAR-CLIP	23446348
MIRT506025	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT506026	hsa-miR-340-5p	PAR-CLIP	23446348
MIRT506024	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT506023	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT439855	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT439855	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT506026	hsa-miR-340-5p	qRT-PCR, Luciferase reporter assay, Western blot	25151966
MIRT506026	hsa-miR-340-5p	qRT-PCR, Luciferase reporter assay, Western blot	25151966
MIRT506026	hsa-miR-340-5p	qRT-PCR, Luciferase reporter assay, Western blot	25151966
MIRT249004	hsa-miR-219a-5p	PAR-CLIP	26701625
MIRT249004	hsa-miR-219a-5p	PAR-CLIP	26701625
MIRT249004	hsa-miR-219a-5p	PAR-CLIP	26701625
MIRT249004	hsa-miR-219a-5p	PAR-CLIP	26701625
MIRT543670	hsa-miR-29a-5p	PAR-CLIP	26701625
MIRT543670	hsa-miR-29a-5p	PAR-CLIP	26701625
MIRT543670	hsa-miR-29a-5p	PAR-CLIP	26701625
MIRT543670	hsa-miR-29a-5p	PAR-CLIP	26701625
MIRT543671	hsa-miR-3920	PAR-CLIP	26701625
MIRT543671	hsa-miR-3920	PAR-CLIP	26701625
MIRT543671	hsa-miR-3920	PAR-CLIP	26701625
MIRT543671	hsa-miR-3920	PAR-CLIP	26701625
MIRT543668	hsa-miR-4283	PAR-CLIP	26701625
MIRT543668	hsa-miR-4283	PAR-CLIP	26701625
MIRT543668	hsa-miR-4283	PAR-CLIP	26701625
MIRT249009	hsa-miR-4445-5p	PAR-CLIP	26701625
MIRT249009	hsa-miR-4445-5p	PAR-CLIP	26701625
MIRT249009	hsa-miR-4445-5p	PAR-CLIP	26701625
MIRT249009	hsa-miR-4445-5p	PAR-CLIP	26701625
MIRT512620	hsa-miR-4708-3p	PAR-CLIP	26701625
MIRT512620	hsa-miR-4708-3p	PAR-CLIP	26701625
MIRT512620	hsa-miR-4708-3p	PAR-CLIP	26701625
MIRT512620	hsa-miR-4708-3p	PAR-CLIP	26701625
MIRT249013	hsa-miR-4782-3p	PAR-CLIP	26701625
MIRT249013	hsa-miR-4782-3p	PAR-CLIP	26701625
MIRT249013	hsa-miR-4782-3p	PAR-CLIP	26701625
MIRT249013	hsa-miR-4782-3p	PAR-CLIP	26701625
MIRT068025	hsa-miR-508-3p	PAR-CLIP	26701625
MIRT068025	hsa-miR-508-3p	PAR-CLIP	26701625
MIRT068025	hsa-miR-508-3p	PAR-CLIP	26701625
MIRT068025	hsa-miR-508-3p	PAR-CLIP	26701625
MIRT512621	hsa-miR-651-3p	PAR-CLIP	26701625
MIRT512621	hsa-miR-651-3p	PAR-CLIP	26701625
MIRT512621	hsa-miR-651-3p	PAR-CLIP	26701625
MIRT512621	hsa-miR-651-3p	PAR-CLIP	26701625
MIRT249015	hsa-miR-6766-3p	PAR-CLIP	26701625
MIRT249015	hsa-miR-6766-3p	PAR-CLIP	26701625
MIRT249015	hsa-miR-6766-3p	PAR-CLIP	26701625
MIRT249015	hsa-miR-6766-3p	PAR-CLIP	26701625
MIRT512618	hsa-miR-6809-5p	PAR-CLIP	26701625
MIRT512618	hsa-miR-6809-5p	PAR-CLIP	26701625
MIRT512618	hsa-miR-6809-5p	PAR-CLIP	26701625
MIRT512618	hsa-miR-6809-5p	PAR-CLIP	26701625
MIRT512619	hsa-miR-7112-5p	PAR-CLIP	26701625
MIRT512619	hsa-miR-7112-5p	PAR-CLIP	26701625
MIRT512619	hsa-miR-7112-5p	PAR-CLIP	26701625
MIRT512619	hsa-miR-7112-5p	PAR-CLIP	26701625
MIRT543669	hsa-miR-760	PAR-CLIP	26701625
MIRT543669	hsa-miR-760	PAR-CLIP	26701625
MIRT543669	hsa-miR-760	PAR-CLIP	26701625
MIRT543669	hsa-miR-760	PAR-CLIP	26701625
MIRT512623	hsa-miR-99a-3p	PAR-CLIP	26701625
MIRT512623	hsa-miR-99a-3p	PAR-CLIP	26701625
MIRT512623	hsa-miR-99a-3p	PAR-CLIP	26701625
MIRT512623	hsa-miR-99a-3p	PAR-CLIP	26701625
MIRT512622	hsa-miR-99b-3p	PAR-CLIP	26701625
MIRT512622	hsa-miR-99b-3p	PAR-CLIP	26701625
MIRT512622	hsa-miR-99b-3p	PAR-CLIP	26701625
MIRT512622	hsa-miR-99b-3p	PAR-CLIP	26701625
MIRT506025	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT521559	hsa-miR-4528	HITS-CLIP	21572407
MIRT506026	hsa-miR-340-5p	HITS-CLIP	21572407
MIRT506024	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT506023	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT506026	hsa-miR-340-5p	HITS-CLIP	23313552
MIRT506024	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT506023	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT700482	hsa-miR-548e-5p	HITS-CLIP	23313552
MIRT700481	hsa-miR-4704-5p	HITS-CLIP	23313552
MIRT700480	hsa-miR-451b	HITS-CLIP	23313552
MIRT506025	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT700479	hsa-miR-571	HITS-CLIP	23313552
MIRT700478	hsa-miR-4696	HITS-CLIP	23313552
MIRT700477	hsa-miR-3618	HITS-CLIP	23313552
MIRT068001	hsa-miR-568	HITS-CLIP	23313552
MIRT700476	hsa-miR-5004-3p	HITS-CLIP	23313552
MIRT700475	hsa-miR-3149	HITS-CLIP	23313552
MIRT512623	hsa-miR-99a-3p	PAR-CLIP	20371350
MIRT512622	hsa-miR-99b-3p	PAR-CLIP	20371350
MIRT512621	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT512619	hsa-miR-7112-5p	PAR-CLIP	20371350
MIRT543671	hsa-miR-3920	PAR-CLIP	20371350
MIRT543670	hsa-miR-29a-5p	PAR-CLIP	20371350
MIRT068025	hsa-miR-508-3p	PAR-CLIP	20371350
MIRT249004	hsa-miR-219a-5p	PAR-CLIP	20371350
MIRT249013	hsa-miR-4782-3p	PAR-CLIP	20371350
MIRT249015	hsa-miR-6766-3p	PAR-CLIP	20371350
MIRT249009	hsa-miR-4445-5p	PAR-CLIP	20371350
MIRT512620	hsa-miR-4708-3p	PAR-CLIP	20371350
MIRT512618	hsa-miR-6809-5p	PAR-CLIP	20371350
MIRT543669	hsa-miR-760	PAR-CLIP	20371350
MIRT543668	hsa-miR-4283	PAR-CLIP	20371350
MIRT512623	hsa-miR-99a-3p	PAR-CLIP	20371350
MIRT512622	hsa-miR-99b-3p	PAR-CLIP	20371350
MIRT512621	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT512619	hsa-miR-7112-5p	PAR-CLIP	20371350
MIRT512620	hsa-miR-4708-3p	PAR-CLIP	20371350
MIRT512618	hsa-miR-6809-5p	PAR-CLIP	20371350
MIRT506025	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT521559	hsa-miR-4528	PAR-CLIP	21572407
MIRT506024	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT521558	hsa-miR-335-3p	PAR-CLIP	21572407
MIRT506023	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT512623	hsa-miR-99a-3p	PAR-CLIP	21572407
MIRT512622	hsa-miR-99b-3p	PAR-CLIP	21572407
MIRT512621	hsa-miR-651-3p	PAR-CLIP	21572407
MIRT512619	hsa-miR-7112-5p	PAR-CLIP	21572407
MIRT543671	hsa-miR-3920	PAR-CLIP	21572407
MIRT543670	hsa-miR-29a-5p	PAR-CLIP	21572407
MIRT068025	hsa-miR-508-3p	PAR-CLIP	21572407
MIRT249004	hsa-miR-219a-5p	PAR-CLIP	21572407
MIRT249013	hsa-miR-4782-3p	PAR-CLIP	21572407
MIRT249015	hsa-miR-6766-3p	PAR-CLIP	21572407
MIRT249009	hsa-miR-4445-5p	PAR-CLIP	21572407
MIRT512620	hsa-miR-4708-3p	PAR-CLIP	21572407
MIRT512618	hsa-miR-6809-5p	PAR-CLIP	21572407
MIRT543669	hsa-miR-760	PAR-CLIP	21572407
MIRT543668	hsa-miR-4283	PAR-CLIP	21572407
MIRT521559	hsa-miR-4528	PAR-CLIP	23446348
MIRT506026	hsa-miR-340-5p	PAR-CLIP	23446348
MIRT506024	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT521558	hsa-miR-335-3p	PAR-CLIP	23446348
MIRT506023	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT512623	hsa-miR-99a-3p	PAR-CLIP	23446348
MIRT512622	hsa-miR-99b-3p	PAR-CLIP	23446348
MIRT512621	hsa-miR-651-3p	PAR-CLIP	23446348
MIRT512619	hsa-miR-7112-5p	PAR-CLIP	23446348
MIRT512620	hsa-miR-4708-3p	PAR-CLIP	23446348
MIRT512618	hsa-miR-6809-5p	PAR-CLIP	23446348
MIRT506025	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT506026	hsa-miR-340-5p	PAR-CLIP	23446348
MIRT506024	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT506023	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT1276879	hsa-miR-129-5p	CLIP-seq
MIRT1276880	hsa-miR-1303	CLIP-seq
MIRT1276881	hsa-miR-144	CLIP-seq
MIRT1276882	hsa-miR-181a	CLIP-seq
MIRT1276883	hsa-miR-181b	CLIP-seq
MIRT1276884	hsa-miR-181c	CLIP-seq
MIRT1276885	hsa-miR-181d	CLIP-seq
MIRT1276886	hsa-miR-214	CLIP-seq
MIRT1276887	hsa-miR-300	CLIP-seq
MIRT1276888	hsa-miR-3146	CLIP-seq
MIRT1276889	hsa-miR-338-5p	CLIP-seq
MIRT1276890	hsa-miR-3613-3p	CLIP-seq
MIRT1276891	hsa-miR-3619-5p	CLIP-seq
MIRT1276892	hsa-miR-3647-3p	CLIP-seq
MIRT1276893	hsa-miR-381	CLIP-seq
MIRT1276894	hsa-miR-4262	CLIP-seq
MIRT1276895	hsa-miR-4275	CLIP-seq
MIRT1276896	hsa-miR-4645-3p	CLIP-seq
MIRT1276897	hsa-miR-4666-3p	CLIP-seq
MIRT1276898	hsa-miR-4731-3p	CLIP-seq
MIRT1276899	hsa-miR-4801	CLIP-seq
MIRT1276900	hsa-miR-518a-5p	CLIP-seq
MIRT1276901	hsa-miR-520d-5p	CLIP-seq
MIRT1276902	hsa-miR-524-5p	CLIP-seq
MIRT1276903	hsa-miR-527	CLIP-seq
MIRT1276904	hsa-miR-567	CLIP-seq
MIRT1276905	hsa-miR-761	CLIP-seq
MIRT1276906	hsa-miR-1228	CLIP-seq
MIRT1276907	hsa-miR-127-5p	CLIP-seq
MIRT1276879	hsa-miR-129-5p	CLIP-seq
MIRT1276908	hsa-miR-203	CLIP-seq
MIRT1276909	hsa-miR-2053	CLIP-seq
MIRT1276910	hsa-miR-2682	CLIP-seq
MIRT1276887	hsa-miR-300	CLIP-seq
MIRT1276911	hsa-miR-30a	CLIP-seq
MIRT1276912	hsa-miR-30b	CLIP-seq
MIRT1276913	hsa-miR-30c	CLIP-seq
MIRT1276914	hsa-miR-30d	CLIP-seq
MIRT1276915	hsa-miR-30e	CLIP-seq
MIRT1276888	hsa-miR-3146	CLIP-seq
MIRT1276916	hsa-miR-3182	CLIP-seq
MIRT1276917	hsa-miR-3202	CLIP-seq
MIRT1276918	hsa-miR-323-3p	CLIP-seq
MIRT1276889	hsa-miR-338-5p	CLIP-seq
MIRT1276919	hsa-miR-3682-5p	CLIP-seq
MIRT1276920	hsa-miR-3686	CLIP-seq
MIRT1276921	hsa-miR-371b-5p	CLIP-seq
MIRT1276922	hsa-miR-377	CLIP-seq
MIRT1276893	hsa-miR-381	CLIP-seq
MIRT1276923	hsa-miR-449c	CLIP-seq
MIRT1276897	hsa-miR-4666-3p	CLIP-seq
MIRT1276924	hsa-miR-4668-3p	CLIP-seq
MIRT1276925	hsa-miR-4705	CLIP-seq
MIRT1276926	hsa-miR-4712-5p	CLIP-seq
MIRT1276927	hsa-miR-4719	CLIP-seq
MIRT1276928	hsa-miR-4747-5p	CLIP-seq
MIRT1276929	hsa-miR-4761-5p	CLIP-seq
MIRT1276930	hsa-miR-5095	CLIP-seq
MIRT1276931	hsa-miR-515-5p	CLIP-seq
MIRT1276932	hsa-miR-548ac	CLIP-seq
MIRT1276933	hsa-miR-548c-3p	CLIP-seq
MIRT1276934	hsa-miR-548d-3p	CLIP-seq
MIRT1276935	hsa-miR-548l	CLIP-seq
MIRT1276936	hsa-miR-548n	CLIP-seq
MIRT1276937	hsa-miR-548z	CLIP-seq
MIRT1276938	hsa-miR-552	CLIP-seq
MIRT1276939	hsa-miR-563	CLIP-seq
MIRT1276904	hsa-miR-567	CLIP-seq
MIRT1276940	hsa-miR-569	CLIP-seq
MIRT1276941	hsa-miR-582-5p	CLIP-seq
MIRT1276942	hsa-miR-624	CLIP-seq
MIRT1276943	hsa-miR-633	CLIP-seq
MIRT1276944	hsa-miR-770-5p	CLIP-seq
MIRT1276945	hsa-miR-940	CLIP-seq
MIRT1276887	hsa-miR-300	CLIP-seq
MIRT1276893	hsa-miR-381	CLIP-seq
MIRT1276897	hsa-miR-4666-3p	CLIP-seq
MIRT2081490	hsa-miR-299-3p	CLIP-seq
MIRT2081491	hsa-miR-3136-5p	CLIP-seq
MIRT1276918	hsa-miR-323-3p	CLIP-seq
MIRT2081492	hsa-miR-409-5p	CLIP-seq
MIRT2081493	hsa-miR-4439	CLIP-seq
MIRT2081494	hsa-miR-4491	CLIP-seq
MIRT2081495	hsa-miR-450b-5p	CLIP-seq
MIRT2081496	hsa-miR-4657	CLIP-seq
MIRT2081497	hsa-miR-4709-5p	CLIP-seq
MIRT1276927	hsa-miR-4719	CLIP-seq
MIRT2081498	hsa-miR-4757-5p	CLIP-seq
MIRT2081499	hsa-miR-507	CLIP-seq
MIRT2081500	hsa-miR-557	CLIP-seq
MIRT1276904	hsa-miR-567	CLIP-seq
MIRT2081501	hsa-miR-663b	CLIP-seq
MIRT2081502	hsa-miR-943	CLIP-seq
MIRT1276906	hsa-miR-1228	CLIP-seq
MIRT2307452	hsa-miR-1284	CLIP-seq
MIRT2307453	hsa-miR-1290	CLIP-seq
MIRT2307454	hsa-miR-1294	CLIP-seq
MIRT2307455	hsa-miR-1323	CLIP-seq
MIRT1276881	hsa-miR-144	CLIP-seq
MIRT1276882	hsa-miR-181a	CLIP-seq
MIRT1276883	hsa-miR-181b	CLIP-seq
MIRT1276884	hsa-miR-181c	CLIP-seq
MIRT1276885	hsa-miR-181d	CLIP-seq
MIRT1276908	hsa-miR-203	CLIP-seq
MIRT1276886	hsa-miR-214	CLIP-seq
MIRT2307456	hsa-miR-219-5p	CLIP-seq
MIRT1276910	hsa-miR-2682	CLIP-seq
MIRT2081490	hsa-miR-299-3p	CLIP-seq
MIRT1276887	hsa-miR-300	CLIP-seq
MIRT1276911	hsa-miR-30a	CLIP-seq
MIRT1276912	hsa-miR-30b	CLIP-seq
MIRT1276913	hsa-miR-30c	CLIP-seq
MIRT1276914	hsa-miR-30d	CLIP-seq
MIRT1276915	hsa-miR-30e	CLIP-seq
MIRT2307457	hsa-miR-3126-5p	CLIP-seq
MIRT1276888	hsa-miR-3146	CLIP-seq
MIRT2307458	hsa-miR-3167	CLIP-seq
MIRT1276916	hsa-miR-3182	CLIP-seq
MIRT2307459	hsa-miR-3184	CLIP-seq
MIRT1276917	hsa-miR-3202	CLIP-seq
MIRT1276918	hsa-miR-323-3p	CLIP-seq
MIRT2307460	hsa-miR-337-3p	CLIP-seq
MIRT1276889	hsa-miR-338-5p	CLIP-seq
MIRT1276891	hsa-miR-3619-5p	CLIP-seq
MIRT1276892	hsa-miR-3647-3p	CLIP-seq
MIRT1276919	hsa-miR-3682-5p	CLIP-seq
MIRT1276920	hsa-miR-3686	CLIP-seq
MIRT1276921	hsa-miR-371b-5p	CLIP-seq
MIRT1276922	hsa-miR-377	CLIP-seq
MIRT1276893	hsa-miR-381	CLIP-seq
MIRT2307461	hsa-miR-411	CLIP-seq
MIRT2307462	hsa-miR-423-5p	CLIP-seq
MIRT1276894	hsa-miR-4262	CLIP-seq
MIRT2307463	hsa-miR-4272	CLIP-seq
MIRT1276895	hsa-miR-4275	CLIP-seq
MIRT2307464	hsa-miR-4314	CLIP-seq
MIRT2307465	hsa-miR-4419a	CLIP-seq
MIRT2307466	hsa-miR-4445	CLIP-seq
MIRT2081494	hsa-miR-4491	CLIP-seq
MIRT1276923	hsa-miR-449c	CLIP-seq
MIRT2307467	hsa-miR-4510	CLIP-seq
MIRT2307468	hsa-miR-4640-5p	CLIP-seq
MIRT1276896	hsa-miR-4645-3p	CLIP-seq
MIRT2081496	hsa-miR-4657	CLIP-seq
MIRT1276897	hsa-miR-4666-3p	CLIP-seq
MIRT1276924	hsa-miR-4668-3p	CLIP-seq
MIRT2307469	hsa-miR-4699-3p	CLIP-seq
MIRT1276925	hsa-miR-4705	CLIP-seq
MIRT2081497	hsa-miR-4709-5p	CLIP-seq
MIRT1276926	hsa-miR-4712-5p	CLIP-seq
MIRT2307470	hsa-miR-4726-5p	CLIP-seq
MIRT1276928	hsa-miR-4747-5p	CLIP-seq
MIRT2081498	hsa-miR-4757-5p	CLIP-seq
MIRT1276929	hsa-miR-4761-5p	CLIP-seq
MIRT2307471	hsa-miR-4781-3p	CLIP-seq
MIRT2307472	hsa-miR-4789-5p	CLIP-seq
MIRT1276930	hsa-miR-5095	CLIP-seq
MIRT1276931	hsa-miR-515-5p	CLIP-seq
MIRT1276933	hsa-miR-548c-3p	CLIP-seq
MIRT2307473	hsa-miR-548o	CLIP-seq
MIRT1276938	hsa-miR-552	CLIP-seq
MIRT1276939	hsa-miR-563	CLIP-seq
MIRT1276904	hsa-miR-567	CLIP-seq
MIRT1276941	hsa-miR-582-5p	CLIP-seq
MIRT1276942	hsa-miR-624	CLIP-seq
MIRT2081501	hsa-miR-663b	CLIP-seq
MIRT1276905	hsa-miR-761	CLIP-seq
MIRT1276944	hsa-miR-770-5p	CLIP-seq
MIRT2307474	hsa-miR-876-5p	CLIP-seq
MIRT1276945	hsa-miR-940	CLIP-seq
MIRT1276909	hsa-miR-2053	CLIP-seq
MIRT1276887	hsa-miR-300	CLIP-seq
MIRT1276918	hsa-miR-323-3p	CLIP-seq
MIRT1276893	hsa-miR-381	CLIP-seq
MIRT1276897	hsa-miR-4666-3p	CLIP-seq
MIRT1276900	hsa-miR-518a-5p	CLIP-seq
MIRT1276903	hsa-miR-527	CLIP-seq
MIRT1276904	hsa-miR-567	CLIP-seq
MIRT1276890	hsa-miR-3613-3p	CLIP-seq
MIRT1276918	hsa-miR-323-3p	CLIP-seq
MIRT2457480	hsa-miR-4279	CLIP-seq
MIRT2307455	hsa-miR-1323	CLIP-seq
MIRT2604996	hsa-miR-146a	CLIP-seq
MIRT2604997	hsa-miR-146b-5p	CLIP-seq
MIRT2604998	hsa-miR-186	CLIP-seq
MIRT2307456	hsa-miR-219-5p	CLIP-seq
MIRT2604999	hsa-miR-28-3p	CLIP-seq
MIRT2605000	hsa-miR-3143	CLIP-seq
MIRT2605001	hsa-miR-3159	CLIP-seq
MIRT2605002	hsa-miR-3174	CLIP-seq
MIRT2307459	hsa-miR-3184	CLIP-seq
MIRT1276918	hsa-miR-323-3p	CLIP-seq
MIRT2605003	hsa-miR-3672	CLIP-seq
MIRT2307462	hsa-miR-423-5p	CLIP-seq
MIRT2307466	hsa-miR-4445	CLIP-seq
MIRT2605004	hsa-miR-4635	CLIP-seq
MIRT1276927	hsa-miR-4719	CLIP-seq
MIRT1276929	hsa-miR-4761-5p	CLIP-seq
MIRT2605005	hsa-miR-543	CLIP-seq
MIRT2605006	hsa-miR-548aa	CLIP-seq
MIRT2307473	hsa-miR-548o	CLIP-seq
MIRT2605007	hsa-miR-589	CLIP-seq
MIRT1276942	hsa-miR-624	CLIP-seq
MIRT2605008	hsa-miR-651	CLIP-seq
MIRT2605009	hsa-miR-720	CLIP-seq
MIRT2605010	hsa-miR-921	CLIP-seq
MIRT2307455	hsa-miR-1323	CLIP-seq
MIRT2604996	hsa-miR-146a	CLIP-seq
MIRT2604997	hsa-miR-146b-5p	CLIP-seq
MIRT2604998	hsa-miR-186	CLIP-seq
MIRT2307456	hsa-miR-219-5p	CLIP-seq
MIRT2605000	hsa-miR-3143	CLIP-seq
MIRT2605001	hsa-miR-3159	CLIP-seq
MIRT2605002	hsa-miR-3174	CLIP-seq
MIRT2307459	hsa-miR-3184	CLIP-seq
MIRT1276918	hsa-miR-323-3p	CLIP-seq
MIRT2307462	hsa-miR-423-5p	CLIP-seq
MIRT2307466	hsa-miR-4445	CLIP-seq
MIRT2605004	hsa-miR-4635	CLIP-seq
MIRT1276927	hsa-miR-4719	CLIP-seq
MIRT1276929	hsa-miR-4761-5p	CLIP-seq
MIRT2605005	hsa-miR-543	CLIP-seq
MIRT2605006	hsa-miR-548aa	CLIP-seq
MIRT2307473	hsa-miR-548o	CLIP-seq
MIRT2605007	hsa-miR-589	CLIP-seq
MIRT1276942	hsa-miR-624	CLIP-seq
MIRT2605008	hsa-miR-651	CLIP-seq
MIRT2605010	hsa-miR-921	CLIP-seq

Show/Hide all(31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000932	Component	P-body	IDA	20818387
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IDA	26724866
GO:0003729	Function	MRNA binding	IBA	21873635
GO:0003730	Function	MRNA 3'-UTR binding	IBA	21873635
GO:0003730	Function	MRNA 3'-UTR binding	IDA	18776931, 20818387, 21572425, 25768905
GO:0005515	Function	Protein binding	IPI	23125361, 25340845, 32814053
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0007283	Process	Spermatogenesis	ISS
GO:0008344	Process	Adult locomotory behavior	ISS
GO:0010494	Component	Cytoplasmic stress granule	IDA	25340845
GO:0010608	Process	Posttranscriptional regulation of gene expression	IBA	21873635
GO:0010608	Process	Posttranscriptional regulation of gene expression	IDA	25100735
GO:0010608	Process	Posttranscriptional regulation of gene expression	IMP	28431233
GO:0016441	Process	Posttranscriptional gene silencing	ISS
GO:0035196	Process	Production of miRNAs involved in gene silencing by miRNA	IBA	21873635
GO:0035196	Process	Production of miRNAs involved in gene silencing by miRNA	IMP	28431233
GO:0035198	Function	MiRNA binding	IDA	28431233
GO:0043488	Process	Regulation of mRNA stability	IBA	21873635
GO:0043488	Process	Regulation of mRNA stability	IDA	26724866
GO:0048863	Process	Stem cell differentiation	ISS
GO:0051726	Process	Regulation of cell cycle	IDA	20818387
GO:0051983	Process	Regulation of chromosome segregation	IDA	26724866
GO:0060964	Process	Regulation of gene silencing by miRNA	TAS	18776931
GO:0061157	Process	MRNA destabilization	ISS
GO:1900246	Process	Positive regulation of RIG-I signaling pathway	IDA	25340845
GO:2000637	Process	Positive regulation of gene silencing by miRNA	IDA	20818387, 22345517

MIM	HGNC	e!Ensembl
607204	14957	ENSG00000134644

Protein

UniProt ID

Q14671

Protein name

Pumilio homolog 1 (HsPUM) (Pumilio-1)

Protein function

Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Respo

PDB

1IB2 , 1M8W , 1M8X , 1M8Y , 1M8Z , 2YJY , 3BSB , 3BSX , 3Q0L , 3Q0M , 3Q0N , 3Q0O , 3Q0P , 5YKH , 5YKI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00806	PUF	852 → 886	Pumilio-family RNA binding repeat	Repeat
PF00806	PUF	889 → 921	Pumilio-family RNA binding repeat	Repeat
PF00806	PUF	924 → 957	Pumilio-family RNA binding repeat	Repeat
PF00806	PUF	960 → 992	Pumilio-family RNA binding repeat	Repeat
PF00806	PUF	996 → 1030	Pumilio-family RNA binding repeat	Repeat
PF00806	PUF	1032 → 1066	Pumilio-family RNA binding repeat	Repeat
PF00806	PUF	1068 → 1102	Pumilio-family RNA binding repeat	Repeat
PF00806	PUF	1112 → 1145	Pumilio-family RNA binding repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain, heart, kidney, muscle, intestine and stomach. Not expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested. {ECO:0000269|PubMed:124

Sequence

MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGSQAQPQPAANQALAAGT
HSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTGDNIHAEH
QVRSMDELNHDFQALALEGRAMGEQLLPGKKFWETDESSKDGPKGIFLGDQWRDSAWGTS
DHSVSQPIMVQRRPGQSFHVNSEVNSVLSPRSESGGLGVSMVEYVLSSSPGDSCLRKGGF
GPRDADSDENDKGEKKNKGTFDGDKLGDLKEEGDVMDKTNGLPVQNGIDADVKDFSRTPG
NCQNSANEVDLLGPNQNGSEGLAQLTSTNGAKPVEDFSNMESQSVPLDPMEHVGMEPLQF
DYSGTQVPVDSAAATVGLFDYNSQQQLFQRPNALAVQQLTAAQQQQYALAAAHQPHIGLA
PAAFVPNPYIISAAPPGTDPYTAGLAAAATLGPAVVPHQYYGVTPWGVYPASLFQQQAAA
AAAATNSANQQTTPQAQQGQQQVLRGGASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFG
QGLAAGMPGYPVLAPAAYYDQTGALVVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAA
AAASANGAAGGLAGTTNGPFRPLGTQQPQPQPQQQPNNNLASSSFYGNNSLNSNSQSSSL
FSQGSAQPANTSLGFGSSSSLGATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKRT
SSSLTPIGHSFYNGLSFSSSPGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTNG
SGRYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNR
YPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATPAERQLVFNEILQAAYQLMVDVFGNY
VIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQNEMVRELDGH
VLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPD
QTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKFASN
VVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIV
MHKIRPHIATLRKYTYGKHILAKLEKYYMKNGVDLGPICGPPNGII

Sequence length

1186

Interactions

View interactions

	KEGG		Reactome
	Spinocerebellar ataxia		Golgi Associated Vesicle Biogenesis

Show/Hide Causal Diseases (4)

Disease term	Disease name	dbSNP ID	References
Causal
Cryptorchidism	Cryptorchidism	rs121912555, rs104894697, rs104894698, rs398122886	31859446
Developmental delay	Global developmental delay	rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291 View all (32 more)	31859446
Mental retardation	Intellectual Disability	rs5742905, rs267607136, rs267607137, rs2131714307, rs267607038, rs267607042, rs80338685, rs137853127, rs80338815, rs28940893, rs387906309, rs121908096, rs121908099, rs587784365, rs121918315 View all (1024 more)	31859446
Spinocerebellar ataxia	SPINOCEREBELLAR ATAXIA 47	rs80356538, rs80356539, rs56144125, rs28937887, rs80356544, rs80356540, rs80356542, rs1941485201, rs121918306, rs151344520, rs151344519, rs151344521, rs151344523, rs151344512, rs193922926 View all (203 more)	29474920

Show/Hide Unknown Diseases (4)

Disease term	Disease name	Evidence	Source
Unknown
Ptosis	Blepharoptosis, Ptosis		ClinVar
Gout	Gout		GWAS
Colorectal Cancer	Colorectal Cancer	In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1.	GWAS, CBGDA
Metabolic Syndrome	Metabolic Syndrome		GWAS

Show/Hide Text Mining Associations (19)

Disease Name	Relationship Type	References
Associations from Text Mining
Abortion Habitual	Associate	36439123
Breast Neoplasms	Associate	18042273, 18211679, 27526934, 33522650
Carcinogenesis	Associate	32316190
Carcinoma Non Small Cell Lung	Associate	30229827, 34097560
Colorectal Neoplasms	Associate	30755640
Endometrial Neoplasms	Associate	32439920
Infertility	Associate	29297114
Mental Disorders	Associate	37549439
Neoplasm Metastasis	Stimulate	37469018
Neoplasms	Associate	18211679, 34097560, 34487971, 37469018
Obesity	Associate	29145611
Osteoporosis	Associate	29145611
Parkinson Disease	Associate	30833663
Prostatic Neoplasms	Associate	33985534
Psoriasis	Associate	35371093
Stomach Neoplasms	Associate	37469018
Triple Negative Breast Neoplasms	Associate	18211679
Tuberculosis Osteoarticular	Associate	35371093
Uterine Cervical Neoplasms	Associate	36161300

PUM1 (pumilio RNA binding family member 1)