CROCC (ciliary rootlet coiled-coil, rootletin)

Gene

• Entrez ID: 9696
• Gene name: Ciliary rootlet coiled-coil, rootletin
• Gene symbol: CROCC
• Synonyms (NCBI Gene): CROCC1, ROLT, TAX1BP2
• Chromosome: 1
• Chromosome location: 1p36.13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT910429	hsa-miR-1915	CLIP-seq
MIRT910430	hsa-miR-331-3p	CLIP-seq
MIRT910431	hsa-miR-339-5p	CLIP-seq
MIRT910432	hsa-miR-4269	CLIP-seq
MIRT910433	hsa-miR-4645-5p	CLIP-seq
MIRT910434	hsa-miR-4673	CLIP-seq
MIRT910435	hsa-miR-4726-3p	CLIP-seq
MIRT1969912	hsa-miR-3928	CLIP-seq
MIRT2205926	hsa-miR-1202	CLIP-seq
MIRT2205927	hsa-miR-3194-5p	CLIP-seq
MIRT2205928	hsa-miR-3972	CLIP-seq
MIRT2205929	hsa-miR-4530	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001917	Component	Photoreceptor inner segment	IEA
GO:0003779	Function	Actin binding	IEA
GO:0005198	Function	Structural molecule activity	IEA
GO:0005198	Function	Structural molecule activity	ISS
GO:0005200	Function	Structural constituent of cytoskeleton	IEA
GO:0005515	Function	Protein binding	IPI	18086858, 30404835, 31974111
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IBA
GO:0005813	Component	Centrosome	IDA	21399614, 31974111
GO:0005813	Component	Centrosome	IEA
GO:0005814	Component	Centriole	IBA
GO:0005814	Component	Centriole	IDA	24421332
GO:0005814	Component	Centriole	IEA
GO:0005814	Component	Centriole	ISS
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0005929	Component	Cilium	IEA
GO:0007098	Process	Centrosome cycle	IBA
GO:0007098	Process	Centrosome cycle	IDA	16203858
GO:0008104	Process	Intracellular protein localization	IMP	18086858
GO:0010457	Process	Centriole-centriole cohesion	IMP	24554434
GO:0010669	Process	Epithelial structure maintenance	IEA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0019725	Process	Cellular homeostasis	IEA
GO:0019894	Function	Kinesin binding	IEA
GO:0019894	Function	Kinesin binding	ISS
GO:0030030	Process	Cell projection organization	IEA
GO:0032053	Process	Ciliary basal body organization	IEA
GO:0033365	Process	Protein localization to organelle	IMP	24554434
GO:0035253	Component	Ciliary rootlet	IEA
GO:0035253	Component	Ciliary rootlet	ISS
GO:0036064	Component	Ciliary basal body	IDA
GO:0042995	Component	Cell projection	IEA
GO:0045494	Process	Photoreceptor cell maintenance	IEA
GO:0045724	Process	Positive regulation of cilium assembly	IMP	27623382
GO:0051649	Process	Establishment of localization in cell	IEA
GO:0051656	Process	Establishment of organelle localization	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0097386	Component	Glial cell projection	IEA
GO:0097729	Component	9+2 motile cilium	IEA
GO:0120219	Component	Subapical part of cell	IEA
GO:1903566	Process	Positive regulation of protein localization to cilium	IMP	27623382

Other IDs

• MIM: 615776
• HGNC: 21299
• e!Ensembl: ENSG00000058453

Protein

• UniProt ID: Q5TZA2
• Protein name: Rootletin (Ciliary rootlet coiled-coil protein)
• Protein function: Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus (By similarity). Furthermore,
• PDB: 6L5H, 6L5J
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15035	Rootletin	156 → 334		Family

• Sequence:

  MSLGLARAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQITSLPALIREIVTRNLS
  QPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQ
  ALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKI
  LQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLR
  EQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLW
  RQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQ
  ALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVN
  KDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERTADAS
  NGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRG
  RYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANEL
  LSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRE
  LERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVEL
  ELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEA
  TVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLS
  RQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEAT
  RLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQE
  KASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQL
  QREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMG
  TRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQE
  QARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGE
  LRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKE
  AGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKES
  RRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQ
  LDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSAL
  RRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASP
  DLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAV
  AESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQ
  EKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQ
  ALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSA
  SLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVAD
  LELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAE
  KREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEA
  QRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHR
  QRVRGLEEQVSTLKGQLQQELRRSSAPFSPPSGPPEK

• Sequence length: 2017

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Gastric cancer	Uncertain significance	rs1237996165	RCV005937418
Premature ovarian insufficiency	Uncertain significance	rs550187548, rs368610396	RCV000766140 RCV000766141

Associations from Text Mining
Disease Name	Relationship Type	References
Colorectal Neoplasms	Associate	29784668, 37239344
Neoplasms	Associate	29784668, 37239344
Neoplasms	Inhibit	33110154
Rhabdoid Tumor	Associate	29784668