Gene Gene information from NCBI Gene database.
Entrez ID 9695
Gene name ER degradation enhancing alpha-mannosidase like protein 1
Gene symbol EDEM1
Synonyms (NCBI Gene)
EDEM
Chromosome 3
Chromosome location 3p26.1
miRNA miRNA information provided by mirtarbase database.
912
miRTarBase ID miRNA Experiments Reference
MIRT005824 hsa-miR-204-5p Luciferase reporter assayMicroarrayqRT-PCR 21282569
MIRT018268 hsa-miR-335-5p Microarray 18185580
MIRT028385 hsa-miR-32-5p Sequencing 20371350
MIRT048731 hsa-miR-96-5p CLASH 23622248
MIRT048443 hsa-miR-100-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
28
GO ID Ontology Definition Evidence Reference
GO:0004571 Function Mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IDA 12610306
GO:0004571 Function Mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IMP 25092655
GO:0004571 Function Mannosyl-oligosaccharide 1,2-alpha-mannosidase activity TAS
GO:0005509 Function Calcium ion binding IEA
GO:0005515 Function Protein binding IPI 16449189, 19524542, 19934218
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607673 18967 ENSG00000134109
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q92611
Protein name ER degradation-enhancing alpha-mannosidase-like protein 1
Protein function Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01532 Glyco_hydro_47 137 586 Glycosyl hydrolase family 47 Domain
Sequence
Sequence length 657
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Protein processing in endoplasmic reticulum   XBP1(S) activates chaperone genes
ER Quality Control Compartment (ERQC)
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Clear cell carcinoma of kidney Uncertain significance rs146114575 RCV005937460
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 35029906
Adrenoleukodystrophy Associate 28666219
Breast Neoplasms Associate 24470074
Carcinoma Hepatocellular Associate 30281916
COVID 19 Stimulate 34224022
Depressive Disorder Major Stimulate 24703171
Glioblastoma Associate 39652629, 40073403
Hypoxia Brain Associate 40073403
Intervertebral Disc Degeneration Associate 16629899
Melanoma Associate 22905195, 28445987