RAPGEF2 (Rap guanine nucleotide exchange factor 2)

Gene

• Entrez ID: 9693
• Gene name: Rap guanine nucleotide exchange factor 2
• Gene symbol: RAPGEF2
• Synonyms (NCBI Gene): CNrasGEF, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, RA-GEF-1, RAGEF, Rap-GEP, nRap GEP
• Chromosome: 4
• Chromosome location: 4q32.1
• Summary: Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve a

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017869	hsa-miR-335-5p	Microarray	18185580
MIRT020791	hsa-miR-155-5p	Reporter assay;Other	20584899
MIRT023803	hsa-miR-1-3p	Microarray	18668037
MIRT045434	hsa-miR-149-5p	CLASH	23622248
MIRT039795	hsa-miR-615-3p	CLASH	23622248
MIRT093335	hsa-miR-10a-5p	PAR-CLIP	20371350
MIRT093336	hsa-miR-10b-5p	PAR-CLIP	20371350
MIRT093344	hsa-miR-5002-5p	PAR-CLIP	20371350
MIRT093342	hsa-miR-3620-3p	PAR-CLIP	20371350
MIRT093337	hsa-miR-339-5p	PAR-CLIP	20371350
MIRT093345	hsa-miR-6748-3p	PAR-CLIP	20371350
MIRT093334	hsa-miR-29b-2-5p	PAR-CLIP	20371350
MIRT561673	hsa-miR-3942-3p	PAR-CLIP	20371350
MIRT093340	hsa-miR-659-3p	PAR-CLIP	20371350
MIRT561672	hsa-miR-335-3p	PAR-CLIP	20371350
MIRT561671	hsa-miR-4720-5p	PAR-CLIP	20371350
MIRT212035	hsa-miR-8066	PAR-CLIP	20371350
MIRT570130	hsa-miR-7152-3p	PAR-CLIP	20371350
MIRT093335	hsa-miR-10a-5p	PAR-CLIP	20371350
MIRT093336	hsa-miR-10b-5p	PAR-CLIP	20371350
MIRT093344	hsa-miR-5002-5p	PAR-CLIP	20371350
MIRT093342	hsa-miR-3620-3p	PAR-CLIP	20371350
MIRT093337	hsa-miR-339-5p	PAR-CLIP	20371350
MIRT093345	hsa-miR-6748-3p	PAR-CLIP	20371350
MIRT093334	hsa-miR-29b-2-5p	PAR-CLIP	20371350
MIRT561673	hsa-miR-3942-3p	PAR-CLIP	20371350
MIRT093340	hsa-miR-659-3p	PAR-CLIP	20371350
MIRT561672	hsa-miR-335-3p	PAR-CLIP	20371350
MIRT561671	hsa-miR-4720-5p	PAR-CLIP	20371350
MIRT164476	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT164477	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT093335	hsa-miR-10a-5p	PAR-CLIP	20371350
MIRT093336	hsa-miR-10b-5p	PAR-CLIP	20371350
MIRT093344	hsa-miR-5002-5p	PAR-CLIP	20371350
MIRT093342	hsa-miR-3620-3p	PAR-CLIP	20371350
MIRT093337	hsa-miR-339-5p	PAR-CLIP	20371350
MIRT093345	hsa-miR-6748-3p	PAR-CLIP	20371350
MIRT093334	hsa-miR-29b-2-5p	PAR-CLIP	20371350
MIRT561673	hsa-miR-3942-3p	PAR-CLIP	20371350
MIRT093340	hsa-miR-659-3p	PAR-CLIP	20371350
MIRT561672	hsa-miR-335-3p	PAR-CLIP	20371350
MIRT561671	hsa-miR-4720-5p	PAR-CLIP	20371350
MIRT212035	hsa-miR-8066	PAR-CLIP	20371350
MIRT570130	hsa-miR-7152-3p	PAR-CLIP	20371350
MIRT093335	hsa-miR-10a-5p	PAR-CLIP	20371350
MIRT093336	hsa-miR-10b-5p	PAR-CLIP	20371350
MIRT093344	hsa-miR-5002-5p	PAR-CLIP	20371350
MIRT093342	hsa-miR-3620-3p	PAR-CLIP	20371350
MIRT093337	hsa-miR-339-5p	PAR-CLIP	20371350
MIRT093345	hsa-miR-6748-3p	PAR-CLIP	20371350
MIRT093334	hsa-miR-29b-2-5p	PAR-CLIP	20371350
MIRT561673	hsa-miR-3942-3p	PAR-CLIP	20371350
MIRT093340	hsa-miR-659-3p	PAR-CLIP	20371350
MIRT561672	hsa-miR-335-3p	PAR-CLIP	20371350
MIRT561671	hsa-miR-4720-5p	PAR-CLIP	20371350
MIRT1290638	hsa-miR-103b	CLIP-seq
MIRT1290639	hsa-miR-1180	CLIP-seq
MIRT1290640	hsa-miR-1197	CLIP-seq
MIRT1290641	hsa-miR-1203	CLIP-seq
MIRT1290642	hsa-miR-1243	CLIP-seq
MIRT1290643	hsa-miR-1245b-5p	CLIP-seq
MIRT1290644	hsa-miR-1253	CLIP-seq
MIRT1290645	hsa-miR-1256	CLIP-seq
MIRT1290646	hsa-miR-1295	CLIP-seq
MIRT1290647	hsa-miR-1324	CLIP-seq
MIRT1290648	hsa-miR-1470	CLIP-seq
MIRT1290649	hsa-miR-155	CLIP-seq
MIRT1290650	hsa-miR-15a	CLIP-seq
MIRT1290651	hsa-miR-15b	CLIP-seq
MIRT1290652	hsa-miR-16	CLIP-seq
MIRT1290653	hsa-miR-1911	CLIP-seq
MIRT1290654	hsa-miR-195	CLIP-seq
MIRT1290655	hsa-miR-19a	CLIP-seq
MIRT1290656	hsa-miR-19b	CLIP-seq
MIRT1290657	hsa-miR-203	CLIP-seq
MIRT1290658	hsa-miR-2113	CLIP-seq
MIRT1290659	hsa-miR-2115	CLIP-seq
MIRT1290660	hsa-miR-221	CLIP-seq
MIRT1290661	hsa-miR-222	CLIP-seq
MIRT1290662	hsa-miR-23a	CLIP-seq
MIRT1290663	hsa-miR-23b	CLIP-seq
MIRT1290664	hsa-miR-23c	CLIP-seq
MIRT1290665	hsa-miR-24	CLIP-seq
MIRT1290666	hsa-miR-296-3p	CLIP-seq
MIRT1290667	hsa-miR-302a	CLIP-seq
MIRT1290668	hsa-miR-302b	CLIP-seq
MIRT1290669	hsa-miR-302c	CLIP-seq
MIRT1290670	hsa-miR-302d	CLIP-seq
MIRT1290671	hsa-miR-302e	CLIP-seq
MIRT1290672	hsa-miR-30a	CLIP-seq
MIRT1290673	hsa-miR-30b	CLIP-seq
MIRT1290674	hsa-miR-30c	CLIP-seq
MIRT1290675	hsa-miR-30d	CLIP-seq
MIRT1290676	hsa-miR-30e	CLIP-seq
MIRT1290677	hsa-miR-3117-3p	CLIP-seq
MIRT1290678	hsa-miR-3120-5p	CLIP-seq
MIRT1290679	hsa-miR-3121-3p	CLIP-seq
MIRT1290680	hsa-miR-3124-5p	CLIP-seq
MIRT1290681	hsa-miR-3138	CLIP-seq
MIRT1290682	hsa-miR-3142	CLIP-seq
MIRT1290683	hsa-miR-3143	CLIP-seq
MIRT1290684	hsa-miR-3169	CLIP-seq
MIRT1290685	hsa-miR-3180-5p	CLIP-seq
MIRT1290686	hsa-miR-3187-3p	CLIP-seq
MIRT1290687	hsa-miR-3194-3p	CLIP-seq
MIRT1290688	hsa-miR-331-3p	CLIP-seq
MIRT1290689	hsa-miR-3529	CLIP-seq
MIRT1290690	hsa-miR-3614-3p	CLIP-seq
MIRT1290691	hsa-miR-3664-3p	CLIP-seq
MIRT1290692	hsa-miR-369-3p	CLIP-seq
MIRT1290693	hsa-miR-372	CLIP-seq
MIRT1290694	hsa-miR-373	CLIP-seq
MIRT1290695	hsa-miR-374a	CLIP-seq
MIRT1290696	hsa-miR-374b	CLIP-seq
MIRT1290697	hsa-miR-379	CLIP-seq
MIRT1290698	hsa-miR-3944-5p	CLIP-seq
MIRT1290699	hsa-miR-410	CLIP-seq
MIRT1290700	hsa-miR-424	CLIP-seq
MIRT1290701	hsa-miR-425	CLIP-seq
MIRT1290702	hsa-miR-4275	CLIP-seq
MIRT1290703	hsa-miR-4294	CLIP-seq
MIRT1290704	hsa-miR-431	CLIP-seq
MIRT1290705	hsa-miR-4328	CLIP-seq
MIRT1290706	hsa-miR-4330	CLIP-seq
MIRT1290707	hsa-miR-4436a	CLIP-seq
MIRT1290708	hsa-miR-4436b-3p	CLIP-seq
MIRT1290709	hsa-miR-4451	CLIP-seq
MIRT1290710	hsa-miR-4457	CLIP-seq
MIRT1290711	hsa-miR-4461	CLIP-seq
MIRT1290712	hsa-miR-4468	CLIP-seq
MIRT1290713	hsa-miR-4515	CLIP-seq
MIRT1290714	hsa-miR-4524	CLIP-seq
MIRT1290715	hsa-miR-4528	CLIP-seq
MIRT1290716	hsa-miR-4529-5p	CLIP-seq
MIRT1290717	hsa-miR-4536	CLIP-seq
MIRT1290718	hsa-miR-4650-3p	CLIP-seq
MIRT1290719	hsa-miR-4652-3p	CLIP-seq
MIRT1290720	hsa-miR-4664-3p	CLIP-seq
MIRT1290721	hsa-miR-4667-3p	CLIP-seq
MIRT1290722	hsa-miR-4677-3p	CLIP-seq
MIRT1290723	hsa-miR-4700-3p	CLIP-seq
MIRT1290724	hsa-miR-4704-3p	CLIP-seq
MIRT1290725	hsa-miR-4722-3p	CLIP-seq
MIRT1290726	hsa-miR-4731-3p	CLIP-seq
MIRT1290727	hsa-miR-4732-5p	CLIP-seq
MIRT1290728	hsa-miR-4733-5p	CLIP-seq
MIRT1290729	hsa-miR-4747-5p	CLIP-seq
MIRT1290730	hsa-miR-4759	CLIP-seq
MIRT1290731	hsa-miR-4761-3p	CLIP-seq
MIRT1290732	hsa-miR-4786-3p	CLIP-seq
MIRT1290733	hsa-miR-4786-5p	CLIP-seq
MIRT1290734	hsa-miR-4801	CLIP-seq
MIRT1290735	hsa-miR-485-3p	CLIP-seq
MIRT1290736	hsa-miR-497	CLIP-seq
MIRT1290737	hsa-miR-501-3p	CLIP-seq
MIRT1290738	hsa-miR-502-3p	CLIP-seq
MIRT1290739	hsa-miR-503	CLIP-seq
MIRT1290740	hsa-miR-510	CLIP-seq
MIRT1290741	hsa-miR-511	CLIP-seq
MIRT1290742	hsa-miR-512-5p	CLIP-seq
MIRT1290743	hsa-miR-516a-3p	CLIP-seq
MIRT1290744	hsa-miR-519a	CLIP-seq
MIRT1290745	hsa-miR-519b-3p	CLIP-seq
MIRT1290746	hsa-miR-519c-3p	CLIP-seq
MIRT1290747	hsa-miR-520a-3p	CLIP-seq
MIRT1290748	hsa-miR-520a-5p	CLIP-seq
MIRT1290749	hsa-miR-520b	CLIP-seq
MIRT1290750	hsa-miR-520c-3p	CLIP-seq
MIRT1290751	hsa-miR-520d-3p	CLIP-seq
MIRT1290752	hsa-miR-520e	CLIP-seq
MIRT1290753	hsa-miR-525-5p	CLIP-seq
MIRT1290754	hsa-miR-543	CLIP-seq
MIRT1290755	hsa-miR-548v	CLIP-seq
MIRT1290756	hsa-miR-577	CLIP-seq
MIRT1290757	hsa-miR-580	CLIP-seq
MIRT1290758	hsa-miR-633	CLIP-seq
MIRT1290759	hsa-miR-642a	CLIP-seq
MIRT1290760	hsa-miR-646	CLIP-seq
MIRT1290761	hsa-miR-665	CLIP-seq
MIRT1290762	hsa-miR-671-5p	CLIP-seq
MIRT1290763	hsa-miR-759	CLIP-seq
MIRT1290764	hsa-miR-769-5p	CLIP-seq
MIRT1290765	hsa-miR-885-3p	CLIP-seq
MIRT1290766	hsa-miR-891b	CLIP-seq
MIRT1290639	hsa-miR-1180	CLIP-seq
MIRT1290641	hsa-miR-1203	CLIP-seq
MIRT1290642	hsa-miR-1243	CLIP-seq
MIRT1290643	hsa-miR-1245b-5p	CLIP-seq
MIRT1290646	hsa-miR-1295	CLIP-seq
MIRT1290655	hsa-miR-19a	CLIP-seq
MIRT1290656	hsa-miR-19b	CLIP-seq
MIRT2086472	hsa-miR-2110	CLIP-seq
MIRT1290660	hsa-miR-221	CLIP-seq
MIRT1290661	hsa-miR-222	CLIP-seq
MIRT1290679	hsa-miR-3121-3p	CLIP-seq
MIRT1290682	hsa-miR-3142	CLIP-seq
MIRT1290685	hsa-miR-3180-5p	CLIP-seq
MIRT1290690	hsa-miR-3614-3p	CLIP-seq
MIRT2086473	hsa-miR-3614-5p	CLIP-seq
MIRT2086474	hsa-miR-3668	CLIP-seq
MIRT2086475	hsa-miR-3689d	CLIP-seq
MIRT2086476	hsa-miR-383	CLIP-seq
MIRT1290699	hsa-miR-410	CLIP-seq
MIRT2086477	hsa-miR-4267	CLIP-seq
MIRT2086478	hsa-miR-4271	CLIP-seq
MIRT2086479	hsa-miR-4289	CLIP-seq
MIRT2086480	hsa-miR-432	CLIP-seq
MIRT1290707	hsa-miR-4436a	CLIP-seq
MIRT2086481	hsa-miR-4443	CLIP-seq
MIRT1290712	hsa-miR-4468	CLIP-seq
MIRT2086482	hsa-miR-4474-5p	CLIP-seq
MIRT2086483	hsa-miR-4533	CLIP-seq
MIRT1290720	hsa-miR-4664-3p	CLIP-seq
MIRT2086484	hsa-miR-4667-5p	CLIP-seq
MIRT2086485	hsa-miR-4684-5p	CLIP-seq
MIRT2086486	hsa-miR-4700-5p	CLIP-seq
MIRT2086487	hsa-miR-4725-3p	CLIP-seq
MIRT1290729	hsa-miR-4747-5p	CLIP-seq
MIRT2086488	hsa-miR-4764-5p	CLIP-seq
MIRT2086489	hsa-miR-4772-5p	CLIP-seq
MIRT2086490	hsa-miR-4778-3p	CLIP-seq
MIRT2086491	hsa-miR-502-5p	CLIP-seq
MIRT1290741	hsa-miR-511	CLIP-seq
MIRT1290755	hsa-miR-548v	CLIP-seq
MIRT2086492	hsa-miR-890	CLIP-seq
MIRT2086493	hsa-miR-9	CLIP-seq
MIRT2086494	hsa-miR-942	CLIP-seq
MIRT2311498	hsa-miR-10a	CLIP-seq
MIRT2311499	hsa-miR-10b	CLIP-seq
MIRT2311500	hsa-miR-1183	CLIP-seq
MIRT1290640	hsa-miR-1197	CLIP-seq
MIRT1290641	hsa-miR-1203	CLIP-seq
MIRT2311501	hsa-miR-1207-5p	CLIP-seq
MIRT2311502	hsa-miR-1244	CLIP-seq
MIRT2311503	hsa-miR-1247	CLIP-seq
MIRT1290644	hsa-miR-1253	CLIP-seq
MIRT1290645	hsa-miR-1256	CLIP-seq
MIRT2311504	hsa-miR-1286	CLIP-seq
MIRT1290647	hsa-miR-1324	CLIP-seq
MIRT2311505	hsa-miR-145	CLIP-seq
MIRT1290648	hsa-miR-1470	CLIP-seq
MIRT1290650	hsa-miR-15a	CLIP-seq
MIRT1290651	hsa-miR-15b	CLIP-seq
MIRT1290652	hsa-miR-16	CLIP-seq
MIRT1290653	hsa-miR-1911	CLIP-seq
MIRT1290654	hsa-miR-195	CLIP-seq
MIRT1290655	hsa-miR-19a	CLIP-seq
MIRT1290656	hsa-miR-19b	CLIP-seq
MIRT2311506	hsa-miR-200b	CLIP-seq
MIRT2311507	hsa-miR-200c	CLIP-seq
MIRT1290662	hsa-miR-23a	CLIP-seq
MIRT1290663	hsa-miR-23b	CLIP-seq
MIRT1290664	hsa-miR-23c	CLIP-seq
MIRT1290665	hsa-miR-24	CLIP-seq
MIRT1290666	hsa-miR-296-3p	CLIP-seq
MIRT1290679	hsa-miR-3121-3p	CLIP-seq
MIRT1290680	hsa-miR-3124-5p	CLIP-seq
MIRT1290683	hsa-miR-3143	CLIP-seq
MIRT2311508	hsa-miR-3154	CLIP-seq
MIRT2311509	hsa-miR-3160-5p	CLIP-seq
MIRT2311510	hsa-miR-3170	CLIP-seq
MIRT2311511	hsa-miR-3173-3p	CLIP-seq
MIRT2311512	hsa-miR-3175	CLIP-seq
MIRT2311513	hsa-miR-3179	CLIP-seq
MIRT2311514	hsa-miR-3185	CLIP-seq
MIRT1290686	hsa-miR-3187-3p	CLIP-seq
MIRT2311515	hsa-miR-3189-3p	CLIP-seq
MIRT1290688	hsa-miR-331-3p	CLIP-seq
MIRT2311516	hsa-miR-3620	CLIP-seq
MIRT2311517	hsa-miR-3650	CLIP-seq
MIRT2311518	hsa-miR-3656	CLIP-seq
MIRT2311519	hsa-miR-3673	CLIP-seq
MIRT2311520	hsa-miR-3688-5p	CLIP-seq
MIRT1290692	hsa-miR-369-3p	CLIP-seq
MIRT2311521	hsa-miR-3913-3p	CLIP-seq
MIRT1290700	hsa-miR-424	CLIP-seq
MIRT1290701	hsa-miR-425	CLIP-seq
MIRT2086479	hsa-miR-4289	CLIP-seq
MIRT2311522	hsa-miR-429	CLIP-seq
MIRT1290703	hsa-miR-4294	CLIP-seq
MIRT2311523	hsa-miR-4318	CLIP-seq
MIRT2311524	hsa-miR-4326	CLIP-seq
MIRT1290705	hsa-miR-4328	CLIP-seq
MIRT1290706	hsa-miR-4330	CLIP-seq
MIRT2311525	hsa-miR-4420	CLIP-seq
MIRT2311526	hsa-miR-4434	CLIP-seq
MIRT1290707	hsa-miR-4436a	CLIP-seq
MIRT1290710	hsa-miR-4457	CLIP-seq
MIRT1290712	hsa-miR-4468	CLIP-seq
MIRT2311527	hsa-miR-4484	CLIP-seq
MIRT2311528	hsa-miR-4514	CLIP-seq
MIRT2311529	hsa-miR-4516	CLIP-seq
MIRT1290714	hsa-miR-4524	CLIP-seq
MIRT1290715	hsa-miR-4528	CLIP-seq
MIRT1290716	hsa-miR-4529-5p	CLIP-seq
MIRT2311530	hsa-miR-4530	CLIP-seq
MIRT2311531	hsa-miR-4659a-5p	CLIP-seq
MIRT2311532	hsa-miR-4659b-5p	CLIP-seq
MIRT1290721	hsa-miR-4667-3p	CLIP-seq
MIRT1290722	hsa-miR-4677-3p	CLIP-seq
MIRT2311533	hsa-miR-4692	CLIP-seq
MIRT2311534	hsa-miR-4693-5p	CLIP-seq
MIRT2311535	hsa-miR-4694-3p	CLIP-seq
MIRT2311536	hsa-miR-4699-5p	CLIP-seq
MIRT1290723	hsa-miR-4700-3p	CLIP-seq
MIRT2311537	hsa-miR-4701-5p	CLIP-seq
MIRT1290724	hsa-miR-4704-3p	CLIP-seq
MIRT1290725	hsa-miR-4722-3p	CLIP-seq
MIRT1290726	hsa-miR-4731-3p	CLIP-seq
MIRT1290728	hsa-miR-4733-5p	CLIP-seq
MIRT2311538	hsa-miR-4736	CLIP-seq
MIRT1290729	hsa-miR-4747-5p	CLIP-seq
MIRT2311539	hsa-miR-4763-3p	CLIP-seq
MIRT2311540	hsa-miR-4776-3p	CLIP-seq
MIRT2086490	hsa-miR-4778-3p	CLIP-seq
MIRT1290732	hsa-miR-4786-3p	CLIP-seq
MIRT1290733	hsa-miR-4786-5p	CLIP-seq
MIRT2311541	hsa-miR-4793-3p	CLIP-seq
MIRT1290734	hsa-miR-4801	CLIP-seq
MIRT2311542	hsa-miR-489	CLIP-seq
MIRT1290736	hsa-miR-497	CLIP-seq
MIRT2311543	hsa-miR-499-3p	CLIP-seq
MIRT2311544	hsa-miR-499a-3p	CLIP-seq
MIRT2086491	hsa-miR-502-5p	CLIP-seq
MIRT1290739	hsa-miR-503	CLIP-seq
MIRT1290740	hsa-miR-510	CLIP-seq
MIRT1290741	hsa-miR-511	CLIP-seq
MIRT1290742	hsa-miR-512-5p	CLIP-seq
MIRT2311545	hsa-miR-513b	CLIP-seq
MIRT2311546	hsa-miR-522	CLIP-seq
MIRT2311547	hsa-miR-541	CLIP-seq
MIRT1290754	hsa-miR-543	CLIP-seq
MIRT2311548	hsa-miR-548an	CLIP-seq
MIRT2311549	hsa-miR-588	CLIP-seq
MIRT1290758	hsa-miR-633	CLIP-seq
MIRT2311550	hsa-miR-634	CLIP-seq
MIRT1290759	hsa-miR-642a	CLIP-seq
MIRT2311551	hsa-miR-642b	CLIP-seq
MIRT2311552	hsa-miR-644	CLIP-seq
MIRT1290760	hsa-miR-646	CLIP-seq
MIRT2311553	hsa-miR-654-5p	CLIP-seq
MIRT2311554	hsa-miR-659	CLIP-seq
MIRT2311555	hsa-miR-663b	CLIP-seq
MIRT1290762	hsa-miR-671-5p	CLIP-seq
MIRT1290764	hsa-miR-769-5p	CLIP-seq
MIRT2311556	hsa-miR-892a	CLIP-seq
MIRT2393488	hsa-miR-1	CLIP-seq
MIRT1290650	hsa-miR-15a	CLIP-seq
MIRT1290651	hsa-miR-15b	CLIP-seq
MIRT1290652	hsa-miR-16	CLIP-seq
MIRT1290654	hsa-miR-195	CLIP-seq
MIRT2393489	hsa-miR-206	CLIP-seq
MIRT1290662	hsa-miR-23a	CLIP-seq
MIRT1290663	hsa-miR-23b	CLIP-seq
MIRT1290664	hsa-miR-23c	CLIP-seq
MIRT1290666	hsa-miR-296-3p	CLIP-seq
MIRT2311519	hsa-miR-3673	CLIP-seq
MIRT1290700	hsa-miR-424	CLIP-seq
MIRT1290712	hsa-miR-4468	CLIP-seq
MIRT1290714	hsa-miR-4524	CLIP-seq
MIRT1290715	hsa-miR-4528	CLIP-seq
MIRT1290722	hsa-miR-4677-3p	CLIP-seq
MIRT1290736	hsa-miR-497	CLIP-seq
MIRT1290739	hsa-miR-503	CLIP-seq
MIRT2393490	hsa-miR-613	CLIP-seq
MIRT1290758	hsa-miR-633	CLIP-seq
MIRT1290760	hsa-miR-646	CLIP-seq
MIRT2432442	hsa-miR-3065-5p	CLIP-seq
MIRT1290640	hsa-miR-1197	CLIP-seq
MIRT1290647	hsa-miR-1324	CLIP-seq
MIRT1290665	hsa-miR-24	CLIP-seq
MIRT1290707	hsa-miR-4436a	CLIP-seq
MIRT1290710	hsa-miR-4457	CLIP-seq
MIRT1290723	hsa-miR-4700-3p	CLIP-seq
MIRT1290725	hsa-miR-4722-3p	CLIP-seq
MIRT1290726	hsa-miR-4731-3p	CLIP-seq
MIRT1290734	hsa-miR-4801	CLIP-seq
MIRT1290644	hsa-miR-1253	CLIP-seq
MIRT2457749	hsa-miR-3153	CLIP-seq
MIRT2311508	hsa-miR-3154	CLIP-seq
MIRT2311512	hsa-miR-3175	CLIP-seq
MIRT2311513	hsa-miR-3179	CLIP-seq
MIRT2311514	hsa-miR-3185	CLIP-seq
MIRT2311526	hsa-miR-4434	CLIP-seq
MIRT2311529	hsa-miR-4516	CLIP-seq
MIRT1290638	hsa-miR-103b	CLIP-seq
MIRT1290640	hsa-miR-1197	CLIP-seq
MIRT2607956	hsa-miR-1207-3p	CLIP-seq
MIRT2607957	hsa-miR-127-5p	CLIP-seq
MIRT2607958	hsa-miR-1283	CLIP-seq
MIRT1290647	hsa-miR-1324	CLIP-seq
MIRT2607959	hsa-miR-141	CLIP-seq
MIRT1290649	hsa-miR-155	CLIP-seq
MIRT2607960	hsa-miR-1910	CLIP-seq
MIRT1290655	hsa-miR-19a	CLIP-seq
MIRT1290656	hsa-miR-19b	CLIP-seq
MIRT2607961	hsa-miR-200a	CLIP-seq
MIRT1290658	hsa-miR-2113	CLIP-seq
MIRT1290665	hsa-miR-24	CLIP-seq
MIRT1290678	hsa-miR-3120-5p	CLIP-seq
MIRT1290683	hsa-miR-3143	CLIP-seq
MIRT2607962	hsa-miR-3148	CLIP-seq
MIRT1290689	hsa-miR-3529	CLIP-seq
MIRT2607963	hsa-miR-3688-3p	CLIP-seq
MIRT1290692	hsa-miR-369-3p	CLIP-seq
MIRT1290695	hsa-miR-374a	CLIP-seq
MIRT1290696	hsa-miR-374b	CLIP-seq
MIRT1290697	hsa-miR-379	CLIP-seq
MIRT2086476	hsa-miR-383	CLIP-seq
MIRT1290699	hsa-miR-410	CLIP-seq
MIRT2607964	hsa-miR-4274	CLIP-seq
MIRT1290702	hsa-miR-4275	CLIP-seq
MIRT2607965	hsa-miR-4282	CLIP-seq
MIRT1290707	hsa-miR-4436a	CLIP-seq
MIRT2607966	hsa-miR-4436b-5p	CLIP-seq
MIRT1290709	hsa-miR-4451	CLIP-seq
MIRT1290710	hsa-miR-4457	CLIP-seq
MIRT2607967	hsa-miR-4517	CLIP-seq
MIRT2607968	hsa-miR-4519	CLIP-seq
MIRT1290714	hsa-miR-4524	CLIP-seq
MIRT2311530	hsa-miR-4530	CLIP-seq
MIRT1290717	hsa-miR-4536	CLIP-seq
MIRT1290718	hsa-miR-4650-3p	CLIP-seq
MIRT1290719	hsa-miR-4652-3p	CLIP-seq
MIRT2607969	hsa-miR-4668-3p	CLIP-seq
MIRT2607970	hsa-miR-4680-3p	CLIP-seq
MIRT2607971	hsa-miR-4699-3p	CLIP-seq
MIRT1290723	hsa-miR-4700-3p	CLIP-seq
MIRT1290725	hsa-miR-4722-3p	CLIP-seq
MIRT1290726	hsa-miR-4731-3p	CLIP-seq
MIRT1290727	hsa-miR-4732-5p	CLIP-seq
MIRT2086489	hsa-miR-4772-5p	CLIP-seq
MIRT1290734	hsa-miR-4801	CLIP-seq
MIRT1290737	hsa-miR-501-3p	CLIP-seq
MIRT1290738	hsa-miR-502-3p	CLIP-seq
MIRT1290741	hsa-miR-511	CLIP-seq
MIRT1290754	hsa-miR-543	CLIP-seq
MIRT2607972	hsa-miR-548a-3p	CLIP-seq
MIRT2607973	hsa-miR-548c-3p	CLIP-seq
MIRT2607974	hsa-miR-548e	CLIP-seq
MIRT2607975	hsa-miR-548f	CLIP-seq
MIRT1290756	hsa-miR-577	CLIP-seq
MIRT2311550	hsa-miR-634	CLIP-seq
MIRT1290766	hsa-miR-891b	CLIP-seq
MIRT1290638	hsa-miR-103b	CLIP-seq
MIRT1290640	hsa-miR-1197	CLIP-seq
MIRT2689334	hsa-miR-1245b-3p	CLIP-seq
MIRT2607957	hsa-miR-127-5p	CLIP-seq
MIRT2607958	hsa-miR-1283	CLIP-seq
MIRT1290647	hsa-miR-1324	CLIP-seq
MIRT2607959	hsa-miR-141	CLIP-seq
MIRT1290648	hsa-miR-1470	CLIP-seq
MIRT1290649	hsa-miR-155	CLIP-seq
MIRT2607960	hsa-miR-1910	CLIP-seq
MIRT1290655	hsa-miR-19a	CLIP-seq
MIRT1290656	hsa-miR-19b	CLIP-seq
MIRT2607961	hsa-miR-200a	CLIP-seq
MIRT2689335	hsa-miR-2054	CLIP-seq
MIRT2086472	hsa-miR-2110	CLIP-seq
MIRT1290658	hsa-miR-2113	CLIP-seq
MIRT1290665	hsa-miR-24	CLIP-seq
MIRT1290678	hsa-miR-3120-5p	CLIP-seq
MIRT1290683	hsa-miR-3143	CLIP-seq
MIRT1290686	hsa-miR-3187-3p	CLIP-seq
MIRT1290688	hsa-miR-331-3p	CLIP-seq
MIRT1290689	hsa-miR-3529	CLIP-seq
MIRT2689336	hsa-miR-3617	CLIP-seq
MIRT1290697	hsa-miR-379	CLIP-seq
MIRT2689337	hsa-miR-380	CLIP-seq
MIRT1290699	hsa-miR-410	CLIP-seq
MIRT2689338	hsa-miR-411	CLIP-seq
MIRT2689339	hsa-miR-4263	CLIP-seq
MIRT2086478	hsa-miR-4271	CLIP-seq
MIRT2607964	hsa-miR-4274	CLIP-seq
MIRT1290702	hsa-miR-4275	CLIP-seq
MIRT2607965	hsa-miR-4282	CLIP-seq
MIRT1290705	hsa-miR-4328	CLIP-seq
MIRT1290707	hsa-miR-4436a	CLIP-seq
MIRT2607966	hsa-miR-4436b-5p	CLIP-seq
MIRT1290709	hsa-miR-4451	CLIP-seq
MIRT1290710	hsa-miR-4457	CLIP-seq
MIRT1290712	hsa-miR-4468	CLIP-seq
MIRT2607968	hsa-miR-4519	CLIP-seq
MIRT1290714	hsa-miR-4524	CLIP-seq
MIRT1290716	hsa-miR-4529-5p	CLIP-seq
MIRT2086483	hsa-miR-4533	CLIP-seq
MIRT1290717	hsa-miR-4536	CLIP-seq
MIRT1290718	hsa-miR-4650-3p	CLIP-seq
MIRT1290719	hsa-miR-4652-3p	CLIP-seq
MIRT1290721	hsa-miR-4667-3p	CLIP-seq
MIRT2086484	hsa-miR-4667-5p	CLIP-seq
MIRT2607971	hsa-miR-4699-3p	CLIP-seq
MIRT1290723	hsa-miR-4700-3p	CLIP-seq
MIRT2086486	hsa-miR-4700-5p	CLIP-seq
MIRT1290725	hsa-miR-4722-3p	CLIP-seq
MIRT2086487	hsa-miR-4725-3p	CLIP-seq
MIRT1290726	hsa-miR-4731-3p	CLIP-seq
MIRT1290727	hsa-miR-4732-5p	CLIP-seq
MIRT1290729	hsa-miR-4747-5p	CLIP-seq
MIRT2689340	hsa-miR-4799-5p	CLIP-seq
MIRT1290734	hsa-miR-4801	CLIP-seq
MIRT1290737	hsa-miR-501-3p	CLIP-seq
MIRT1290738	hsa-miR-502-3p	CLIP-seq
MIRT1290741	hsa-miR-511	CLIP-seq
MIRT1290754	hsa-miR-543	CLIP-seq
MIRT2689341	hsa-miR-548b-3p	CLIP-seq
MIRT2689342	hsa-miR-552	CLIP-seq
MIRT2689343	hsa-miR-576-5p	CLIP-seq
MIRT1290756	hsa-miR-577	CLIP-seq
MIRT2689344	hsa-miR-641	CLIP-seq
MIRT1290759	hsa-miR-642a	CLIP-seq
MIRT1290766	hsa-miR-891b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	NAS	10934204
GO:0001568	Process	Blood vessel development	ISS
GO:0001764	Process	Neuron migration	ISS
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	10608883, 10801446, 12391161, 16272156
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005096	Function	GTPase activator activity	IDA	10934204
GO:0005096	Function	GTPase activator activity	IEA
GO:0005509	Function	Calcium ion binding	NAS	10934204
GO:0005515	Function	Protein binding	IPI	10548487, 10608844, 11168587, 11359771, 11598133, 12391161, 15161933, 23885123, 35271311
GO:0005737	Component	Cytoplasm	IDA	11359771, 17724123
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005770	Component	Late endosome	IDA	17724123
GO:0005770	Component	Late endosome	IEA
GO:0005829	Component	Cytosol	IDA	22797597
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	NAS	10934204
GO:0005911	Component	Cell-cell junction	ISS
GO:0005923	Component	Bicellular tight junction	IDA	23885123
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	23800469
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA	23800469
GO:0007218	Process	Neuropeptide signaling pathway	IDA	23800469
GO:0007264	Process	Small GTPase-mediated signal transduction	IEA
GO:0007264	Process	Small GTPase-mediated signal transduction	TAS	10608883, 10934204
GO:0007265	Process	Ras protein signal transduction	IBA
GO:0007399	Process	Nervous system development	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	16272156
GO:0010975	Process	Regulation of neuron projection development	IEA
GO:0010976	Process	Positive regulation of neuron projection development	ISS
GO:0016020	Component	Membrane	IDA	10608883
GO:0016020	Component	Membrane	IEA
GO:0016324	Component	Apical plasma membrane	IBA
GO:0016324	Component	Apical plasma membrane	IDA	22797597
GO:0016324	Component	Apical plasma membrane	IEA
GO:0019933	Process	CAMP-mediated signaling	NAS	10934204
GO:0019992	Function	Diacylglycerol binding	NAS	10934204
GO:0021591	Process	Ventricular system development	ISS
GO:0021884	Process	Forebrain neuron development	ISS
GO:0030033	Process	Microvillus assembly	IEA
GO:0030139	Component	Endocytic vesicle	IBA
GO:0030139	Component	Endocytic vesicle	IDA	22797597
GO:0030154	Process	Cell differentiation	IEA
GO:0030165	Function	PDZ domain binding	IDA	10548487, 11168587, 12391161
GO:0030552	Function	CAMP binding	IDA	10548487, 10608844, 11359771
GO:0030552	Function	CAMP binding	IDA	10801446
GO:0030553	Function	CGMP binding	IDA	10608844, 11359771
GO:0031175	Process	Neuron projection development	IDA	23800469
GO:0031547	Process	Brain-derived neurotrophic factor receptor signaling pathway	ISS
GO:0031697	Function	Beta-1 adrenergic receptor binding	IDA	12391161
GO:0032092	Process	Positive regulation of protein binding	ISS
GO:0032486	Process	Rap protein signal transduction	IMP	21840392
GO:0032991	Component	Protein-containing complex	ISS
GO:0035556	Process	Intracellular signal transduction	TAS	10608883
GO:0038180	Process	Nerve growth factor signaling pathway	ISS
GO:0043005	Component	Neuron projection	ISS
GO:0043025	Component	Neuronal cell body	ISS
GO:0043547	Process	Positive regulation of GTPase activity	IDA	10548487, 10608844, 10801446, 11359771, 16272156, 17724123, 23800469
GO:0043547	Process	Positive regulation of GTPase activity	IMP	21840392
GO:0045202	Component	Synapse	ISS
GO:0045860	Process	Positive regulation of protein kinase activity	IDA	11359771, 23800469
GO:0048022	Process	Negative regulation of melanin biosynthetic process	ISS
GO:0048167	Process	Regulation of synaptic plasticity	ISS
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	11359771
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0050699	Function	WW domain binding	IDA	10548487, 11598133
GO:0050774	Process	Negative regulation of dendrite morphogenesis	IDA	16272156
GO:0061028	Process	Establishment of endothelial barrier	IMP	21840392
GO:0070161	Component	Anchoring junction	IEA
GO:0070300	Function	Phosphatidic acid binding	IDA	22797597
GO:0070300	Function	Phosphatidic acid binding	IEA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	16272156, 23800469
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IEA
GO:0071320	Process	Cellular response to cAMP	IDA	10801446, 16272156, 21840392, 23800469
GO:0071321	Process	Cellular response to cGMP	IDA	10801446
GO:0071880	Process	Adenylate cyclase-activating adrenergic receptor signaling pathway	IDA	12391161
GO:0072659	Process	Protein localization to plasma membrane	IEA
GO:0090557	Process	Establishment of endothelial intestinal barrier	IMP	23885123
GO:1901888	Process	Regulation of cell junction assembly	IMP	21840392
GO:1903698	Process	Positive regulation of microvillus assembly	IGI	22797597
GO:1990090	Process	Cellular response to nerve growth factor stimulus	ISS
GO:2000481	Process	Positive regulation of cAMP-dependent protein kinase activity	IDA	16272156
GO:2000670	Process	Positive regulation of dendritic cell apoptotic process	IDA	16272156
GO:2001214	Process	Positive regulation of vasculogenesis	ISS
GO:2001224	Process	Positive regulation of neuron migration	ISS

Other IDs

• MIM: 609530
• HGNC: 16854
• e!Ensembl: ENSG00000109756

Protein

• UniProt ID: Q9Y4G8
• Protein name: Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1)
• Protein function: Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in
• PDB: 6QDT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00618	RasGEF_N	270 → 357	RasGEF N-terminal motif	Domain
  PF00595	PDZ	386 → 465	PDZ domain	Domain
  PF00788	RA	606 → 692	Ras association (RalGDS/AF-6) domain	Domain
  PF00617	RasGEF	720 → 898	RasGEF domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in primary neuronal and endocrine cells (at protein level). Highest expression levels in brain. Lower expression levels in heart, kidney, lung, placenta and blood leukocytes. {ECO:0000269|PubMed:10934204, ECO:0000269|PubMed:1
• Sequence:

  MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS
  DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD
  DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS
  VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK
  NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL
  TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN
  LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS
  KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE
  KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT
  RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS
  ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE
  GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE
  VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN
  QLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDL
  QDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMI
  AKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSS
  FLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSE
  TSPVAPRAGSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINS
  PQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDNF
  SDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVETNLGMGRMERRTMIEPDQY
  SLGSYAPMSEGRGLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNI
  QTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQA
  QSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEETKPVPMPAHIAV
  ASSTTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVAR
  SSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV

• Sequence length: 1499

Pathways

KEGG:

MAPK signaling pathway
Rap1 signaling pathway
Tight junction

Reactome:

RAF/MAP kinase cascade

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Epilepsy, familial adult myoclonic, 7	Benign; Uncertain significance	rs77229150, rs59463532, rs11320537, rs1135004, rs1462693799, rs796445221, rs1732314095, rs1764342195	RCV001794882 RCV001794883 RCV001794884 RCV001794885 RCV001794886 RCV003989101 RCV003990264 RCV001262370 RCV001291759

Associations from Text Mining
Disease Name	Relationship Type	References
Aneuploidy	Associate	25332235
Death	Associate	32596987
Dyslexia Acquired	Associate	32596987
Neoplasms	Associate	25332235
Olfaction Disorders	Associate	27878761
Pediatric acute onset neuropsychiatric syndrome	Associate	27878761
Pneumonia	Associate	27508494