Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9689
Gene name Gene Name - the full gene name approved by the HGNC.
Basic leucine zipper and W2 domains 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
BZW1
Synonyms (NCBI Gene) Gene synonyms aliases
5MP2, BZAP45, Nbla10236
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q33.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT031563 hsa-miR-16-5p Proteomics 18668040
MIRT050244 hsa-miR-25-3p CLASH 23622248
MIRT052785 hsa-miR-1260b CLASH 23622248
MIRT705176 hsa-miR-4293 HITS-CLIP 23313552
MIRT352034 hsa-miR-4459 HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005737 Component Cytoplasm IDA 10942595, 25468996
GO:0016020 Component Membrane HDA 19946888
GO:0045296 Function Cadherin binding HDA 25468996
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
619252 18380 ENSG00000082153
Protein
UniProt ID Q7L1Q6
Protein name eIF5-mimic protein 2 (Basic leucine zipper and W2 domain-containing protein 1) (Protein Orf)
Protein function Translation initiation regulator which represses repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:29470543, PubMed:34260931)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02020 W2 337 414 eIF4-gamma/eIF5/eIF2-epsilon Family
Sequence
MNNQKQQKPTLSGQRFKTRKRDEKERFDPTQFQDCIIQGLTETGTDLEAVAKFLDASGAK
LDYRRYAETLFDILVAGGMLAPGGTLADDMMRTDVCVFAAQEDLETMQAFAQVFNKLIRR
YKYLEKGFEDEVKKLLLFLKGFSESERNKLAMLTGVLLANGTLNASILNSLYNENLVKEG
VSAAFAVKLFKSWINEKDINAVAASLRKVSMDNRLMELFPANKQSVEHFTKYFTEAGLKE
LSEYVRNQQTIGARKELQKELQEQMSRGDPFKDIILYVKEEMKKNNIPEPVVIGIVWSSV
MSTVEWNKKEELVAEQAIKHLKQYSPLLAAFTTQGQSELTLLLKIQEYCYDNIHFMKAFQ
KIVVLFYKAEVLSEEPILKWYKDAHVAKGKSVFLEQMKKFVEWLKNAEEESESE
AEEGD
Sequence length 419
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Melanoma melanoma rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340
View all (64 more)
22535842
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 31601833
Carcinoma Non Small Cell Lung Associate 31601833
Lung Neoplasms Associate 31601833
Neoplasm Metastasis Associate 32855654
Ovarian Neoplasms Associate 32945505