Gene Gene information from NCBI Gene database.
Entrez ID 9686
Gene name Vestigial like family member 4
Gene symbol VGLL4
Synonyms (NCBI Gene)
VGL-4
Chromosome 3
Chromosome location 3p25.3-p25.2
miRNA miRNA information provided by mirtarbase database.
824
miRTarBase ID miRNA Experiments Reference
MIRT019746 hsa-miR-375 Microarray 20215506
MIRT052473 hsa-let-7a-5p CLASH 23622248
MIRT051646 hsa-let-7e-5p CLASH 23622248
MIRT438320 hsa-miR-222-3p ChIP-seqImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 26045994
MIRT438320 hsa-miR-222-3p ChIP-seqImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 26045994
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13
GO ID Ontology Definition Evidence Reference
GO:0001223 Function Transcription coactivator binding IBA
GO:0005515 Function Protein binding IPI 21044950, 24525233, 28051067, 32296183, 33961781
GO:0005634 Component Nucleus IEA
GO:0005634 Component Nucleus ISS
GO:0006355 Process Regulation of DNA-templated transcription IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
618692 28966 ENSG00000144560
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14135
Protein name Transcription cofactor vestigial-like protein 4 (Vgl-4)
Protein function May act as a specific coactivator for the mammalian TEFs.
PDB 8YTF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15245 VGLL4 4 224 Transcription cofactor vestigial-like protein 4 Family
Sequence
Sequence length 290
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
EBV-positive nodal T- and NK-cell lymphoma Likely benign rs754575118 RCV004558043
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Atherosclerosis Associate 33456372
Breast Neoplasms Associate 30760814, 36606584
Carcinoma Hepatocellular Associate 29950605, 32323824
Carcinoma Squamous Cell Inhibit 34004031
Cardiovascular Diseases Associate 33456372
Corneal Endothelial Cell Loss Inhibit 33456372
Endometrial Neoplasms Associate 26689674
Inflammation Associate 33456372
Neoplasms Associate 30760814, 32323824, 33456372, 35766997
Neoplasms Inhibit 34004031