Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
968
Gene name Gene Name - the full gene name approved by the HGNC.
CD68 molecule
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CD68
Synonyms (NCBI Gene) Gene synonyms aliases
GP110, LAMP4, SCARD1
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17p13.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosome
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020775 hsa-miR-155-5p Western blot 21030878
MIRT650254 hsa-miR-4282 HITS-CLIP 23824327
MIRT650253 hsa-miR-5571-5p HITS-CLIP 23824327
MIRT650252 hsa-miR-3163 HITS-CLIP 23824327
MIRT650251 hsa-miR-1470 HITS-CLIP 23824327
Transcription factors
Transcription factor Regulation Reference
ELF1 Activation 12676954
ESR2 Unknown 11517296
IRF4 Repression 12676954
IRF8 Repression 12676954
SPI1 Repression 12676954
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002437 Process Inflammatory response to antigenic stimulus ISS
GO:0002605 Process Negative regulation of dendritic cell antigen processing and presentation ISS
GO:0005515 Function Protein binding IPI 32296183
GO:0005764 Component Lysosome ISS
GO:0005765 Component Lysosomal membrane IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
153634 1693 ENSG00000129226
Protein
UniProt ID P34810
Protein name Macrosialin (Gp110) (CD antigen CD68)
Protein function Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01299 Lamp 155 303 Lysosome-associated membrane glycoprotein (Lamp) Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, fac
Sequence
MRLAVLFSGALLGLLAAQGTGNDCPHKKSATLLPSFTVTPTVTESTGTTSHRTTKSHKTT
THRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTATSQGPSTATHSPATTSHGNAT
VHPTSNSTATSPGFTSSAHPEPPPPSPSPSPTSKETIGDYTWTNGSQPCVHLQAQIQIRV
MYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQKVVYLSY
MAVEYNVSFPHAAQWTFSAQNASLRDLQAPLGQSFSCSNSSIILSPAVHLDLLSLRLQAA
QLP
HTGVFGQSFSCPSDRSILLPLIIGLILLGLLALVLIAFCIIRRRPSAYQAL
Sequence length 354
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Lysosome   Neutrophil degranulation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis, Familial rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733
View all (171 more)
11796754
Cholestasis Cholestasis, Extrahepatic rs121909103, rs751511532, rs376368459, rs762702807, rs1578490102, rs1578499691, rs1578504946, rs1317656688, rs199791850, rs1452792080, rs1578491039 28789951
Hyperinsulinism Hyperinsulinism rs387906407, rs151344623, rs121913156, rs137853245, rs80356655, rs104894010, rs104894012, rs104894014, rs104894015, rs137852676, rs587783169, rs72559716, rs541269678, rs151344624, rs797045209
View all (23 more)
29035695
Lateral sclerosis AMYOTROPHIC LATERAL SCLEROSIS 1, Amyotrophic Lateral Sclerosis, Sporadic rs386134181, rs386134176, rs386134174, rs386134184, rs386134178, rs1693780539, rs1574698048 11796754
Unknown
Disease term Disease name Evidence References Source
Metabolic Syndrome Metabolic Syndrome GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abortion Habitual Associate 30942389
Abscess Associate 10435362
Acute Disease Associate 32651678
Adenocarcinoma Follicular Associate 26875556
Adenocarcinoma Mucinous Associate 34497449
Adenocarcinoma of Lung Associate 29722145, 37280312, 37880277
Adenoma Associate 29543850
Adenomyosis Associate 29264987
Adrenal Hyperplasia Congenital Associate 34616364
Adrenal Rest Tumor Associate 34616364