Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9668
Gene name Gene Name - the full gene name approved by the HGNC.
Zinc finger protein 432
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ZNF432
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.41
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT044843 hsa-miR-320a CLASH 23622248
MIRT043010 hsa-miR-324-3p CLASH 23622248
MIRT035850 hsa-miR-1260a CLASH 23622248
MIRT706582 hsa-miR-1245a HITS-CLIP 21572407
MIRT706580 hsa-miR-8079 HITS-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0005515 Function Protein binding IPI 32296183
GO:0005634 Component Nucleus IBA 21873635
GO:0005654 Component Nucleoplasm IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
620554 20810 ENSG00000256087
Protein
UniProt ID O94892
Protein name Zinc finger protein 432
Protein function Homologous recombination repressor that functions as a poly(ADP-ribose) (PAR) reader regulating DNA damage response and PARP inhibition. Once recruited to DNA lesions via DNA-, in a PAR-dependent mechanism, stimulates PARP1 activity (PubMed:3782
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01352 KRAB 7 48 KRAB box Family
PF00096 zf-C2H2 205 227 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 233 255 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 261 283 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 289 311 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 317 339 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 345 367 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 373 395 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 401 423 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 429 451 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 457 479 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 485 507 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 513 535 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 541 563 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 597 619 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 625 647 Zinc finger, C2H2 type Domain
Sequence
MINAQELLTLEDVTVEFTWEEWQLLGPFQKDLYRDVMLEIYSNLLSMGYQVSKPDALSKL
ERGEEPWTMEDERHSRICPENNEVDDHLQDHLENQRMLKSVEQYHEHNAFGNTASQTKSL
CLFRENHDTFELYIKTLKSNLSLVNQNKSCEINNSTKFSGDGKSFLHGNYEELYSAAKFS
VSTKANSTKSQVSKHQRTHEIEKNHVCSECGKAFVKKSQLTDHERVHTGEKPYGCTLCAK
VFSRKSRLNEHQRIH
KREKSFICSECGKVFTMKSRLIEHQRTHTGEKPYICNECGKGFPG
KRNLIVHQRNH
TGEKSYICSECGKGFTGKSMLIIHQRTHTGEKPYICSECGKGFTTKHYV
IIHQRNH
TGEKPYICNECGKGFTMKSRMIEHQRTHTGEKPYICSECGKGFPRKSNLIVHQ
RNH
TVEKSYLCSECGKGFTVKSMLIIHQRTHTGEKPYTCSECGKGFPLKSRLIVHQRTHT
GEKPYRCSECGKGFIVNSGLMLHQRTHTGEKPYICNECGKGFAFKSNLVVHQRTHTGEKP
FMCSECGKGFTMKRYLIVHQQIHTEEKSCICSECGRGFAKETELALHKQVHTGEKPYGCN
ECGKGFTMKSRLIVHQRTH
TGEKPFVCSECRKAFSSKRNLIVHQRTHNGNKP
Sequence length 652
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Generic Transcription Pathway
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
18507500
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
18507500
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
18507500
Colorectal neoplasms Colorectal Neoplasms rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049
View all (1682 more)
18507500
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 24280104 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Asthma Associate 24280104
Status Asthmaticus Associate 24280104