Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	9656
Gene name	Mediator of DNA damage checkpoint 1
Gene symbol	MDC1
Synonyms (NCBI Gene)	NFBD1
Chromosome	6
Chromosome location	6p21.33
Summary	The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase

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Show/Hide all (191)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023516	hsa-miR-1-3p	Proteomics	18668040
MIRT024535	hsa-miR-215-5p	Microarray	19074876
MIRT050762	hsa-miR-17-3p	CLASH	23622248
MIRT050697	hsa-miR-18a-5p	CLASH	23622248
MIRT044086	hsa-miR-361-5p	CLASH	23622248
MIRT043058	hsa-miR-324-5p	CLASH	23622248
MIRT043058	hsa-miR-324-5p	CLASH	23622248
MIRT041049	hsa-miR-505-3p	CLASH	23622248
MIRT040912	hsa-miR-18a-3p	CLASH	23622248
MIRT040462	hsa-miR-615-3p	CLASH	23622248
MIRT036863	hsa-miR-877-3p	CLASH	23622248
MIRT036863	hsa-miR-877-3p	CLASH	23622248
MIRT625804	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT625803	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT625802	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT625801	hsa-miR-4729	HITS-CLIP	23824327
MIRT625800	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT625799	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT625798	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT625797	hsa-miR-5696	HITS-CLIP	23824327
MIRT625796	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT625795	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT625794	hsa-miR-4474-3p	HITS-CLIP	23824327
MIRT625793	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT625804	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT625803	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT625802	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT625801	hsa-miR-4729	HITS-CLIP	23824327
MIRT625800	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT625799	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT625798	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT625797	hsa-miR-5696	HITS-CLIP	23824327
MIRT625796	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT625795	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT625794	hsa-miR-4474-3p	HITS-CLIP	23824327
MIRT625793	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT625804	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT625803	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT625802	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT625801	hsa-miR-4729	HITS-CLIP	23824327
MIRT625800	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT625799	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT625798	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT625797	hsa-miR-5696	HITS-CLIP	23824327
MIRT625796	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT625795	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT625794	hsa-miR-4474-3p	HITS-CLIP	23824327
MIRT625793	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT625799	hsa-miR-2115-5p	PAR-CLIP	27292025
MIRT625804	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT625803	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT625802	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT625801	hsa-miR-4729	HITS-CLIP	23824327
MIRT625800	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT625799	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT625798	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT625797	hsa-miR-5696	HITS-CLIP	23824327
MIRT625796	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT625795	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT625794	hsa-miR-4474-3p	HITS-CLIP	23824327
MIRT625793	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT625804	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT625803	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT625802	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT625801	hsa-miR-4729	HITS-CLIP	23824327
MIRT625800	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT625799	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT625798	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT625797	hsa-miR-5696	HITS-CLIP	23824327
MIRT625796	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT625795	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT625794	hsa-miR-4474-3p	HITS-CLIP	23824327
MIRT625793	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT625804	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT625803	hsa-miR-188-5p	HITS-CLIP	23824327
MIRT625802	hsa-miR-6866-3p	HITS-CLIP	23824327
MIRT625801	hsa-miR-4729	HITS-CLIP	23824327
MIRT625800	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT625799	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT625798	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT625797	hsa-miR-5696	HITS-CLIP	23824327
MIRT625796	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT625795	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT625794	hsa-miR-4474-3p	HITS-CLIP	23824327
MIRT625793	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT1138432	hsa-let-7a	CLIP-seq
MIRT1138433	hsa-let-7b	CLIP-seq
MIRT1138434	hsa-let-7c	CLIP-seq
MIRT1138435	hsa-let-7d	CLIP-seq
MIRT1138436	hsa-let-7e	CLIP-seq
MIRT1138437	hsa-let-7f	CLIP-seq
MIRT1138438	hsa-let-7g	CLIP-seq
MIRT1138439	hsa-let-7i	CLIP-seq
MIRT1138440	hsa-miR-1197	CLIP-seq
MIRT1138441	hsa-miR-3942-5p	CLIP-seq
MIRT1138442	hsa-miR-4257	CLIP-seq
MIRT1138443	hsa-miR-4266	CLIP-seq
MIRT1138444	hsa-miR-4458	CLIP-seq
MIRT1138445	hsa-miR-4481	CLIP-seq
MIRT1138446	hsa-miR-4500	CLIP-seq
MIRT1138447	hsa-miR-4642	CLIP-seq
MIRT1138448	hsa-miR-4695-5p	CLIP-seq
MIRT1138449	hsa-miR-4703-5p	CLIP-seq
MIRT1138450	hsa-miR-4745-5p	CLIP-seq
MIRT1138451	hsa-miR-4758-5p	CLIP-seq
MIRT1138452	hsa-miR-4779	CLIP-seq
MIRT1138453	hsa-miR-98	CLIP-seq
MIRT2039258	hsa-miR-3200-5p	CLIP-seq
MIRT2039259	hsa-miR-382	CLIP-seq
MIRT2039260	hsa-miR-3913-3p	CLIP-seq
MIRT2039261	hsa-miR-425	CLIP-seq
MIRT2039262	hsa-miR-4252	CLIP-seq
MIRT2039263	hsa-miR-4303	CLIP-seq
MIRT2039264	hsa-miR-4436a	CLIP-seq
MIRT2039265	hsa-miR-4716-5p	CLIP-seq
MIRT2039266	hsa-miR-4738-3p	CLIP-seq
MIRT2039267	hsa-miR-489	CLIP-seq
MIRT1138432	hsa-let-7a	CLIP-seq
MIRT1138433	hsa-let-7b	CLIP-seq
MIRT1138434	hsa-let-7c	CLIP-seq
MIRT1138435	hsa-let-7d	CLIP-seq
MIRT1138436	hsa-let-7e	CLIP-seq
MIRT1138437	hsa-let-7f	CLIP-seq
MIRT1138438	hsa-let-7g	CLIP-seq
MIRT1138439	hsa-let-7i	CLIP-seq
MIRT1138440	hsa-miR-1197	CLIP-seq
MIRT2269343	hsa-miR-2115	CLIP-seq
MIRT1138443	hsa-miR-4266	CLIP-seq
MIRT1138444	hsa-miR-4458	CLIP-seq
MIRT1138446	hsa-miR-4500	CLIP-seq
MIRT1138448	hsa-miR-4695-5p	CLIP-seq
MIRT2269344	hsa-miR-4744	CLIP-seq
MIRT1138452	hsa-miR-4779	CLIP-seq
MIRT1138453	hsa-miR-98	CLIP-seq
MIRT1138432	hsa-let-7a	CLIP-seq
MIRT1138433	hsa-let-7b	CLIP-seq
MIRT1138434	hsa-let-7c	CLIP-seq
MIRT1138435	hsa-let-7d	CLIP-seq
MIRT1138436	hsa-let-7e	CLIP-seq
MIRT1138437	hsa-let-7f	CLIP-seq
MIRT1138438	hsa-let-7g	CLIP-seq
MIRT1138439	hsa-let-7i	CLIP-seq
MIRT2568544	hsa-miR-1273f	CLIP-seq
MIRT2568545	hsa-miR-216a	CLIP-seq
MIRT2568546	hsa-miR-3121-3p	CLIP-seq
MIRT2568547	hsa-miR-3187-3p	CLIP-seq
MIRT2039258	hsa-miR-3200-5p	CLIP-seq
MIRT2568548	hsa-miR-3662	CLIP-seq
MIRT2568549	hsa-miR-374c	CLIP-seq
MIRT2039260	hsa-miR-3913-3p	CLIP-seq
MIRT2568550	hsa-miR-3973	CLIP-seq
MIRT2568551	hsa-miR-3976	CLIP-seq
MIRT2039261	hsa-miR-425	CLIP-seq
MIRT2039262	hsa-miR-4252	CLIP-seq
MIRT2568552	hsa-miR-4264	CLIP-seq
MIRT1138443	hsa-miR-4266	CLIP-seq
MIRT2039263	hsa-miR-4303	CLIP-seq
MIRT1138444	hsa-miR-4458	CLIP-seq
MIRT1138446	hsa-miR-4500	CLIP-seq
MIRT2568553	hsa-miR-4529-5p	CLIP-seq
MIRT2568554	hsa-miR-4661-5p	CLIP-seq
MIRT1138448	hsa-miR-4695-5p	CLIP-seq
MIRT2568555	hsa-miR-4735-5p	CLIP-seq
MIRT2039266	hsa-miR-4738-3p	CLIP-seq
MIRT2568556	hsa-miR-4775	CLIP-seq
MIRT1138452	hsa-miR-4779	CLIP-seq
MIRT2568557	hsa-miR-4797-3p	CLIP-seq
MIRT2039267	hsa-miR-489	CLIP-seq
MIRT2568558	hsa-miR-548a-5p	CLIP-seq
MIRT2568559	hsa-miR-548ab	CLIP-seq
MIRT2568560	hsa-miR-548ak	CLIP-seq
MIRT2568561	hsa-miR-548b-5p	CLIP-seq
MIRT2568562	hsa-miR-548c-5p	CLIP-seq
MIRT2568563	hsa-miR-548d-5p	CLIP-seq
MIRT2568564	hsa-miR-548h	CLIP-seq
MIRT2568565	hsa-miR-548i	CLIP-seq
MIRT2568566	hsa-miR-548j	CLIP-seq
MIRT2568567	hsa-miR-548w	CLIP-seq
MIRT2568568	hsa-miR-548y	CLIP-seq
MIRT2568569	hsa-miR-559	CLIP-seq
MIRT2568570	hsa-miR-590-3p	CLIP-seq
MIRT2568571	hsa-miR-655	CLIP-seq
MIRT1138453	hsa-miR-98	CLIP-seq
MIRT2039258	hsa-miR-3200-5p	CLIP-seq
MIRT2039260	hsa-miR-3913-3p	CLIP-seq
MIRT2039261	hsa-miR-425	CLIP-seq
MIRT2039262	hsa-miR-4252	CLIP-seq
MIRT2039263	hsa-miR-4303	CLIP-seq
MIRT2568554	hsa-miR-4661-5p	CLIP-seq
MIRT2039266	hsa-miR-4738-3p	CLIP-seq
MIRT2039267	hsa-miR-489	CLIP-seq

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Transcription factor	Regulation	Reference
BRCA1	Unknown	22942284
STAT3	Unknown	20804538

Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000076	Process	DNA replication checkpoint signaling	IDA	21482717
GO:0005515	Function	Protein binding	IPI	12607005, 16186822, 16377563, 17525332, 17577209, 18001824, 18001825, 18583988, 18678890, 19234442, 19804756, 20008512, 20159462, 20224574, 21293379, 24240613, 25064736, 29656893
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	15604234, 24217620, 24550317
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005694	Component	Chromosome	ISS
GO:0005925	Component	Focal adhesion	IDA
GO:0006281	Process	DNA repair	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0006974	Process	DNA damage response	IDA	30898438
GO:0006974	Process	DNA damage response	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0031573	Process	Mitotic intra-S DNA damage checkpoint signaling	TAS	17577209
GO:0035861	Component	Site of double-strand break	IDA	16377563, 18411307, 18582474, 18583988, 18678890, 30898438
GO:0085020	Process	Protein K6-linked ubiquitination	IDA	23115235
GO:0140463	Function	Chromatin-protein adaptor activity	IDA	18006705, 18411307, 18582474, 18583988, 18678890
GO:0140566	Function	Histone reader activity	IDA	16377563, 30898438
GO:1905168	Process	Positive regulation of double-strand break repair via homologous recombination	IDA	23115235
GO:1990166	Process	Protein localization to site of double-strand break	IDA	37674080
GO:1990166	Process	Protein localization to site of double-strand break	IDA	16377563, 18006705, 18411307, 18582474, 18583988, 18678890, 21482717, 30898438

MIM	HGNC	e!Ensembl
607593	21163	ENSG00000137337

Q14676

Protein name

Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)

Protein function

Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle (PubMed:12475977, PubMed:12499369, PubMed:12551934, PubMed:12607003, PubMed:12607004, P

PDB

2ADO , 2AZM , 2ETX , 3K05 , 3UEO , 3UMZ , 3UN0 , 3UNM , 3UNN , 3UOT , 9IF9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00498	FHA	54 → 124	FHA domain	Family
PF16770	RTT107_BRCT_5	1877 → 1970	Regulator of Ty1 transposition protein 107 BRCT domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in testis. {ECO:0000269|PubMed:12499369}.

Sequence

MEDTQAIDWDVEEEEETEQSSESLRCNVEPVGRLHIFSGAHGPEKDFPLHLGKNVVGRMP
DCSVALPFPSISKQHAEIEILAWDKAPILRDCGSLNGTQILRPPKVLSPGVSHRLRDQEL
ILFADLLCQYHRLDVSLPFVSRGPLTVEETPRVQGETQPQRLLLAEDSEEEVDFLSERRM
VKKSRTTSSSVIVPESDEEGHSPVLGGLGPPFAFNLNSDTDVEEGQQPATEEASSAARRG
ATVEAKQSEAEVVTEIQLEKDQPLVKERDNDTKVKRGAGNGVVPAGVILERSQPPGEDSD
TDVDDDSRPPGRPAEVHLERAQPFGFIDSDTDAEEERIPATPVVIPMKKRKIFHGVGTRG
PGAPGLAHLQESQAGSDTDVEEGKAPQAVPLEKSQASMVINSDTDDEEEVSAALTLAHLK
ESQPAIWNRDAEEDMPQRVVLLQRSQTTTERDSDTDVEEEELPVENREAVLKDHTKIRAL
VRAHSEKDQPPFGDSDDSVEADKSSPGIHLERSQASTTVDINTQVEKEVPPGSAIIHIKK
HQVSVEGTNQTDVKAVGGPAKLLVVSLEEAWPLHGDCETDAEEGTSLTASVVADVRKSQL
PAEGDAGAEWAAAVLKQERAHEVGAQGGPPVAQVEQDLPISRENLTDLVVDTDTLGESTQ
PQREGAQVPTGREREQHVGGTKDSEDNYGDSEDLDLQATQCFLENQGLEAVQSMEDEPTQ
AFMLTPPQELGPSHCSFQTTGTLDEPWEVLATQPFCLRESEDSETQPFDTHLEAYGPCLS
PPRAIPGDQHPESPVHTEPMGIQGRGRQTVDKVMGIPKETAERVGPERGPLERETEKLLP
ERQTDVTGEEELTKGKQDREQKQLLARDTQRQESDKNGESASPERDRESLKVEIETSEEI
QEKQVQKQTLPSKAFEREVERPVANRECDPAELEEKVPKVILERDTQRGEPEGGSQDQKG
QASSPTPEPGVGAGDLPGPTSAPVPSGSQSGGRGSPVSPRRHQKGLLNCKMPPAEKASRI
RAAEKVSRGDQESPDACLPPTVPEAPAPPQKPLNSQSQKHLAPPPLLSPLLPSIKPTVRK
TRQDGSQEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFPATSAAPEPHPSTSTAQPVTPK
PTSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTPE
TVVPTALELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPSTSTDQPV
TSEPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSSVK
TPETVVPTAPELQISTSTDQPVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPSTSTE
QPVTPEPTSRATRGRKNRSSGKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRS
SVKTPETVVPTAPELQPSTSTDQPVTPEPTSQATRGRTDRSSVKTPETVVPTAPELQASA
STDQPVTSEPTSRTTRGRKNRSSVKTPETVVPAAPELQPSTSTDQPVTPEPTSRATRGRT
NRSSVKTPESIVPIAPELQPSTSRNQLVTPEPTSRATRCRTNRSSVKTPEPVVPTAPEPH
PTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPVEPAASDLEPFTPTDQSVTPEAIAQGGQ
SKTLRSSTVRAMPVPTTPEFQSPVTTDQPISPEPITQPSCIKRQRAAGNPGSLAAPIDHK
PCSAPLEPKSQASRNQRWGAVRAAESLTAIPEPASPQLLETPIHASQIQKVEPAGRSRFT
PELQPKASQSRKRSLATMDSPPHQKQPQRGEVSQKTVIIKEEEEDTAEKPGKEEDVVTPK
PGKRKRDQAEEEPNRIPSRSLRRTKLNQESTAPKVLFTGVVDARGERAVLALGGSLAGSA
AEASHLVTDRIRRTVKFLCALGRGIPILSLDWLHQSRKAGFFLPPDEYVVTDPEQEKNFG
FSLQDALSRARERRLLEGYEIYVTPGVQPPPPQMGEIISCCGGTYLPSMPRSYKPQRVVI
TCPQDFPHCSIPLRVGLPLLSPEFLLTGVLKQEAKPEAFVLSPLEMSST

Sequence length

2089

Interactions

View interactions

	Reactome
			SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint

MDC1 (mediator of DNA damage checkpoint 1)