Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9651
Gene name Gene Name - the full gene name approved by the HGNC.	Phospholipase C eta 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PLCH2
Synonyms (NCBI Gene) Gene synonyms aliases	PLC-L4, PLC-eta2, PLCL4, PLCeta2
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p36.32
Summary Summary of gene provided in NCBI Entrez Gene.	PLCH2 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol (Zhou et al., 2005 [PubMed 16107

Show/Hide all(50)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029064	hsa-miR-26b-5p	Microarray	19088304
MIRT043301	hsa-miR-331-3p	CLASH	23622248
MIRT2070585	hsa-miR-1321	CLIP-seq
MIRT2070586	hsa-miR-1909	CLIP-seq
MIRT2070587	hsa-miR-4419a	CLIP-seq
MIRT2070588	hsa-miR-4459	CLIP-seq
MIRT2070589	hsa-miR-4510	CLIP-seq
MIRT2070590	hsa-miR-4688	CLIP-seq
MIRT2070591	hsa-miR-4722-5p	CLIP-seq
MIRT2070592	hsa-miR-4739	CLIP-seq
MIRT2070593	hsa-miR-4756-5p	CLIP-seq
MIRT2070594	hsa-miR-4779	CLIP-seq
MIRT2070595	hsa-miR-486-3p	CLIP-seq
MIRT2297706	hsa-miR-1207-5p	CLIP-seq
MIRT2070585	hsa-miR-1321	CLIP-seq
MIRT2297707	hsa-miR-1827	CLIP-seq
MIRT2070586	hsa-miR-1909	CLIP-seq
MIRT2297708	hsa-miR-3612	CLIP-seq
MIRT2070587	hsa-miR-4419a	CLIP-seq
MIRT2070588	hsa-miR-4459	CLIP-seq
MIRT2070589	hsa-miR-4510	CLIP-seq
MIRT2297709	hsa-miR-4684-5p	CLIP-seq
MIRT2070590	hsa-miR-4688	CLIP-seq
MIRT2070591	hsa-miR-4722-5p	CLIP-seq
MIRT2070592	hsa-miR-4739	CLIP-seq
MIRT2070593	hsa-miR-4756-5p	CLIP-seq
MIRT2297710	hsa-miR-4763-3p	CLIP-seq
MIRT2297711	hsa-miR-4768-5p	CLIP-seq
MIRT2070594	hsa-miR-4779	CLIP-seq
MIRT2070595	hsa-miR-486-3p	CLIP-seq
MIRT2297712	hsa-miR-548ad	CLIP-seq
MIRT2297713	hsa-miR-650	CLIP-seq
MIRT2297714	hsa-miR-940	CLIP-seq
MIRT2297706	hsa-miR-1207-5p	CLIP-seq
MIRT2070585	hsa-miR-1321	CLIP-seq
MIRT2297707	hsa-miR-1827	CLIP-seq
MIRT2070586	hsa-miR-1909	CLIP-seq
MIRT2297708	hsa-miR-3612	CLIP-seq
MIRT2070587	hsa-miR-4419a	CLIP-seq
MIRT2070588	hsa-miR-4459	CLIP-seq
MIRT2070589	hsa-miR-4510	CLIP-seq
MIRT2070590	hsa-miR-4688	CLIP-seq
MIRT2070591	hsa-miR-4722-5p	CLIP-seq
MIRT2070592	hsa-miR-4739	CLIP-seq
MIRT2070593	hsa-miR-4756-5p	CLIP-seq
MIRT2297710	hsa-miR-4763-3p	CLIP-seq
MIRT2070594	hsa-miR-4779	CLIP-seq
MIRT2070595	hsa-miR-486-3p	CLIP-seq
MIRT2297713	hsa-miR-650	CLIP-seq
MIRT2297714	hsa-miR-940	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004435	Function	Phosphatidylinositol phospholipase C activity	IBA	21873635
GO:0004435	Function	Phosphatidylinositol phospholipase C activity	IDA	18361507
GO:0005509	Function	Calcium ion binding	IEA
GO:0005575	Component	Cellular_component	ND
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0016042	Process	Lipid catabolic process	IEA
GO:0043647	Process	Inositol phosphate metabolic process	TAS
GO:0046488	Process	Phosphatidylinositol metabolic process	IEA
GO:0048015	Process	Phosphatidylinositol-mediated signaling	IBA	21873635
GO:0048015	Process	Phosphatidylinositol-mediated signaling	IDA	18361507

MIM	HGNC	e!Ensembl
612836	29037	ENSG00000149527

Protein

UniProt ID

O75038

Protein name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-2) (Phosphoinositide phospholipase C-like 4) (PLC-L4) (Phospholipase C-like protein 4) (Phospholipase C-eta-2) (PLC-eta2)

Protein function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:18361507). This phospholipase activity is very se

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16457	PH_12	41 → 155	Pleckstrin homology domain	Domain
PF09279	EF-hand_like	234 → 319	Phosphoinositide-specific phospholipase C, efhand-like	Domain
PF00388	PI-PLC-X	328 → 472	Phosphatidylinositol-specific phospholipase C, X domain	Family
PF00387	PI-PLC-Y	626 → 738	Phosphatidylinositol-specific phospholipase C, Y domain	Family
PF00168	C2	758 → 867	C2 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in retina and kidney. {ECO:0000269|PubMed:16107206}.

Sequence

MSGPWPSPDSRTKGTVAWLAEVLLWVGGSVVLSSEWQLGPLVERCMGAMQEGMQMVKLRG
GSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSEGRQSEVFQRYPDGSFDPNC
CFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDE
ADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMST
RRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQDIIEQFEPCPENKSKGLL
GIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYA
WVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIE
NHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANISED
AEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLIKESKIRDCEDPNNFS
VSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSKLKKAASVEEGD
EGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDIEMEAASSWQVSSFSETKAH
QILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLN
RAKFSANGGCGYVLKPGCMCQGVFNPNSEDPLPGQLKKQLVLRIISGQQLPKPRDSMLGD
RGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETLVFMVHMPEIALVRFLVWDH
DPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQALGLKGLFLR
GPKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVA
DDVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPA
AVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRS
QPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHR
DSVSSSSSMSSSDTVIDLSLPSLGLGRSRENLAGAHMGRLPPRPHSASAARPDLPPVTKS
KSNPNLRATGQRPPIPDELQPRSLAPRMAGLPFRPPWGCLSLVGVQDCPVAAKSKSLGDL
TADDFAPSFEGGSRRLSHSLGLPGGTRRVSGPGVRRDTLTEQLRWLTVFQQAGDITSPTS
LGPAGEGVAGGPGFVRRSSSRSHSRVRAIASRARQAQERQQRLQGLGRQGPPEEERGTPE
GACSVGHEGSVDAPAPSKGALGPASAAAENLVLLRL

Sequence length

1416

Interactions

View interactions

	KEGG		Reactome
	Inositol phosphate metabolism Metabolic pathways		Synthesis of IP3 and IP4 in the cytosol

Show/Hide Causal Diseases (3)

Disease term	Disease name	dbSNP ID	References
Causal
Azoospermia	Azoospermia	rs200969445, rs144567652, rs765353898	22197933
Non-obstructive azoospermia	Non-obstructive azoospermia	rs587777872, rs879253743, rs1600840291, rs1600877766, rs753462162, rs1588618614, rs1602684496, rs377712900	22197933
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	25056061, 26198764, 29483656, 31268507

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining
Bladder Exstrophy	Associate	34355505

PLCH2 (phospholipase C eta 2)