CD58 (CD58 molecule)

Gene

• Entrez ID: 965
• Gene name: CD58 molecule
• Gene symbol: CD58
• Synonyms (NCBI Gene): LFA-3, LFA3, ag3
• Chromosome: 1
• Chromosome location: 1p13.1
• Summary: This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively splice

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT875837	hsa-miR-149	CLIP-seq
MIRT875838	hsa-miR-4256	CLIP-seq
MIRT875839	hsa-miR-4267	CLIP-seq
MIRT875840	hsa-miR-4438	CLIP-seq
MIRT875841	hsa-miR-4725-5p	CLIP-seq
MIRT875842	hsa-miR-504	CLIP-seq
MIRT875843	hsa-miR-5095	CLIP-seq
MIRT875844	hsa-miR-1297	CLIP-seq
MIRT875845	hsa-miR-26a	CLIP-seq
MIRT875846	hsa-miR-26b	CLIP-seq
MIRT875847	hsa-miR-3977	CLIP-seq
MIRT875848	hsa-miR-4465	CLIP-seq
MIRT875849	hsa-miR-646	CLIP-seq
MIRT2446607	hsa-miR-139-5p	CLIP-seq
MIRT2446608	hsa-miR-214	CLIP-seq
MIRT2446609	hsa-miR-3120-3p	CLIP-seq
MIRT2446610	hsa-miR-3619-5p	CLIP-seq
MIRT2446611	hsa-miR-3945	CLIP-seq
MIRT2446612	hsa-miR-4253	CLIP-seq
MIRT2446613	hsa-miR-4446-3p	CLIP-seq
MIRT2446614	hsa-miR-4506	CLIP-seq
MIRT2446615	hsa-miR-761	CLIP-seq
MIRT2499740	hsa-miR-1323	CLIP-seq
MIRT2499741	hsa-miR-155	CLIP-seq
MIRT2499742	hsa-miR-2277-3p	CLIP-seq
MIRT2499743	hsa-miR-3129-3p	CLIP-seq
MIRT2499744	hsa-miR-3613-3p	CLIP-seq
MIRT2499745	hsa-miR-369-3p	CLIP-seq
MIRT2499746	hsa-miR-374a	CLIP-seq
MIRT2499747	hsa-miR-374b	CLIP-seq
MIRT2499748	hsa-miR-382	CLIP-seq
MIRT2499749	hsa-miR-548o	CLIP-seq
MIRT2499740	hsa-miR-1323	CLIP-seq
MIRT2499741	hsa-miR-155	CLIP-seq
MIRT2677737	hsa-miR-2116	CLIP-seq
MIRT2499742	hsa-miR-2277-3p	CLIP-seq
MIRT2499743	hsa-miR-3129-3p	CLIP-seq
MIRT2499744	hsa-miR-3613-3p	CLIP-seq
MIRT2499745	hsa-miR-369-3p	CLIP-seq
MIRT2499746	hsa-miR-374a	CLIP-seq
MIRT2499747	hsa-miR-374b	CLIP-seq
MIRT2499748	hsa-miR-382	CLIP-seq
MIRT2677738	hsa-miR-4273	CLIP-seq
MIRT2677739	hsa-miR-4460	CLIP-seq
MIRT2677740	hsa-miR-4659a-3p	CLIP-seq
MIRT2677741	hsa-miR-4659b-3p	CLIP-seq
MIRT2677742	hsa-miR-4677-5p	CLIP-seq
MIRT2677743	hsa-miR-4727-3p	CLIP-seq
MIRT2677744	hsa-miR-4778-3p	CLIP-seq
MIRT2499749	hsa-miR-548o	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
NFKB1	Activation	9733827
NFKBIA	Repression	9733827
RELA	Activation	9733827

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005102	Function	Signaling receptor binding	IBA
GO:0005102	Function	Signaling receptor binding	IPI	17344209
GO:0005515	Function	Protein binding	IPI	7544493, 10380930, 28813417
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS	7544493
GO:0005886	Component	Plasma membrane	TAS
GO:0006955	Process	Immune response	IBA
GO:0009986	Component	Cell surface	IBA
GO:0009986	Component	Cell surface	IDA	15345303
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0030667	Component	Secretory granule membrane	TAS
GO:0032757	Process	Positive regulation of interleukin-8 production	IMP	19109405
GO:0034113	Process	Heterotypic cell-cell adhesion	IBA
GO:0034113	Process	Heterotypic cell-cell adhesion	IDA	15345303
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0071346	Process	Cellular response to type II interferon	IDA	19109405
GO:0071356	Process	Cellular response to tumor necrosis factor	IDA	19109405
GO:0098609	Process	Cell-cell adhesion	NAS	7544493
GO:0101003	Component	Ficolin-1-rich granule membrane	TAS

Other IDs

• MIM: 153420
• HGNC: 1688
• e!Ensembl: ENSG00000116815

Protein

• UniProt ID: P19256
• Protein name: Lymphocyte function-associated antigen 3 (Ag3) (Surface glycoprotein LFA-3) (CD antigen CD58)
• Protein function: Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presentin
• PDB: 1CCZ, 1CI5, 1QA9
• Sequence:

  MVAGSDAGRALGVLSVVCLLHCFGFISCFSQQIYGVVYGNVTFHVPSNVPLKEVLWKKQK
  DKVAELENSEFRAFSSFKNRVYLDTVSGSLTIYNLTSSDEDEYEMESPNITDTMKFFLYV
  LESLPSPTLTCALTNGSIEVQCMIPEHYNSHRGLIMYSWDCPMEQCKRNSTSIYFKMEND
  LPQKIQCTLSNPLFNTTSSIILTTCIPSSGHSRHRYALIPIPLAVITTCIVLYMNGILKC
  DRKPDRTNSN

• Sequence length: 250

Pathways

KEGG:

Cell adhesion molecules
Epstein-Barr virus infection

Reactome:

Cell surface interactions at the vascular wall
Neutrophil degranulation