Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9647
Gene name Gene Name - the full gene name approved by the HGNC.
Protein phosphatase, Mg2+/Mn2+ dependent 1F
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PPM1F
Synonyms (NCBI Gene) Gene synonyms aliases
CAMKP, CaMKPase, FEM-2, POPX2, hFEM-2
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q11.22
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange f
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006619 rno-miR-200c-3p Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot 22144583
MIRT006619 rno-miR-200c-3p Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot 22144583
MIRT030441 hsa-miR-24-3p Microarray 19748357
MIRT045175 hsa-miR-186-5p CLASH 23622248
MIRT043063 hsa-miR-324-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004722 Function Protein serine/threonine phosphatase activity IDA 11559703, 11864573, 15140879, 20801214
GO:0004722 Function Protein serine/threonine phosphatase activity IMP 20016286
GO:0004724 Function Magnesium-dependent protein serine/threonine phosphatase activity IBA 21873635
GO:0005515 Function Protein binding IPI 11559703, 11864573, 15140879, 18230650, 20801214, 24338362
GO:0005634 Component Nucleus IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
619309 19388 ENSG00000100034
Protein
UniProt ID P49593
Protein name Protein phosphatase 1F (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase) (CaM-kinase phosphatase) (CaMKPase) (Partner of PIX 2) (Protein fem-2 homolog) (hFem-2)
Protein function Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00481 PP2C 155 406 Protein phosphatase 2C Family
Sequence
MSSGAPQKSSPMASGAEETPGFLDTLLQDFPALLNPEDPLPWKAPGTVLSQEEVEGELAE
LAMGFLGSRKAPPPLAAALAHEAVSQLLQTDLSEFRKLPREEEEEEEDDDEEEKAPVTLL
DAQSLAQSFFNRLWEVAGQWQKQVPLAARASQRQWLVSIHAIRNTRRKMEDRHVSLPSFN
QLFGLSDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTDPEGALREAFRRTDQ
MFLRKAKRERLQSGTTGVCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEK
ARIEALGGFVSHMDCWRVNGTLAVSRAIGDVFQKPYVSGEADAASRALTGSEDYLLLACD
GFFDVVPHQEVVGLVQSHLTRQQGSGLRVAEELVAAARERGSHDNI
TVMVVFLRDPQELL
EGGNQGEGDPQAEGRRQDLPSSLPEPETQAPPRS
Sequence length 454
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Unknown
Disease term Disease name Evidence References Source
Attention Deficit Hyperactivity Disorder Attention Deficit Hyperactivity Disorder GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 22144583
Carcinoma Hepatocellular Associate 30470261
Cholangitis Sclerosing Associate 30250217
Depressive Disorder Associate 31446381
Glioblastoma Associate 35443151
Growth Disorders Associate 30250217
Hypothyroidism Associate 30250217
Liver Diseases Associate 30250217
Neoplasm Metastasis Associate 30470261, 35443151
Neoplasms Associate 22144583, 30470261, 35443151