Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	9645
Gene name	Microtubule associated monooxygenase, calponin and LIM domain containing 2
Gene symbol	MICAL2
Synonyms (NCBI Gene)	Ebitein1MICAL-2MICAL2PV1MICAL2PV2MICALCLmical-cL
Chromosome	11
Chromosome location	11p15.3
Summary	The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been a

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022138	hsa-miR-124-3p	Microarray	18668037
MIRT487741	hsa-miR-4773	PAR-CLIP	20371350
MIRT487740	hsa-miR-5188	PAR-CLIP	20371350
MIRT487739	hsa-miR-4251	PAR-CLIP	20371350
MIRT487738	hsa-miR-6857-3p	PAR-CLIP	20371350
MIRT487737	hsa-miR-589-5p	PAR-CLIP	20371350
MIRT487736	hsa-miR-146a-5p	PAR-CLIP	20371350
MIRT487735	hsa-miR-146b-5p	PAR-CLIP	20371350
MIRT487734	hsa-miR-7153-5p	PAR-CLIP	20371350
MIRT487733	hsa-miR-4740-5p	PAR-CLIP	20371350
MIRT487741	hsa-miR-4773	PAR-CLIP	20371350
MIRT487740	hsa-miR-5188	PAR-CLIP	20371350
MIRT487739	hsa-miR-4251	PAR-CLIP	20371350
MIRT487738	hsa-miR-6857-3p	PAR-CLIP	20371350
MIRT487737	hsa-miR-589-5p	PAR-CLIP	20371350
MIRT487736	hsa-miR-146a-5p	PAR-CLIP	20371350
MIRT487735	hsa-miR-146b-5p	PAR-CLIP	20371350
MIRT487734	hsa-miR-7153-5p	PAR-CLIP	20371350
MIRT487733	hsa-miR-4740-5p	PAR-CLIP	20371350
MIRT487741	hsa-miR-4773	PAR-CLIP	20371350
MIRT487740	hsa-miR-5188	PAR-CLIP	20371350
MIRT487739	hsa-miR-4251	PAR-CLIP	20371350
MIRT487738	hsa-miR-6857-3p	PAR-CLIP	20371350
MIRT487737	hsa-miR-589-5p	PAR-CLIP	20371350
MIRT487736	hsa-miR-146a-5p	PAR-CLIP	20371350
MIRT487735	hsa-miR-146b-5p	PAR-CLIP	20371350
MIRT487734	hsa-miR-7153-5p	PAR-CLIP	20371350
MIRT487733	hsa-miR-4740-5p	PAR-CLIP	20371350
MIRT487741	hsa-miR-4773	PAR-CLIP	20371350
MIRT487740	hsa-miR-5188	PAR-CLIP	20371350
MIRT487739	hsa-miR-4251	PAR-CLIP	20371350
MIRT487738	hsa-miR-6857-3p	PAR-CLIP	20371350
MIRT487737	hsa-miR-589-5p	PAR-CLIP	20371350
MIRT487736	hsa-miR-146a-5p	PAR-CLIP	20371350
MIRT487735	hsa-miR-146b-5p	PAR-CLIP	20371350
MIRT487734	hsa-miR-7153-5p	PAR-CLIP	20371350
MIRT487733	hsa-miR-4740-5p	PAR-CLIP	20371350
MIRT569151	hsa-miR-5739	PAR-CLIP	20371350
MIRT569150	hsa-miR-3692-5p	PAR-CLIP	20371350
MIRT569149	hsa-miR-5580-5p	PAR-CLIP	20371350
MIRT569148	hsa-miR-25-5p	PAR-CLIP	20371350
MIRT569147	hsa-miR-342-5p	PAR-CLIP	20371350
MIRT569146	hsa-miR-4664-5p	PAR-CLIP	20371350
MIRT569145	hsa-miR-4466	PAR-CLIP	20371350
MIRT569144	hsa-miR-675-5p	PAR-CLIP	20371350
MIRT569143	hsa-miR-6850-5p	PAR-CLIP	20371350
MIRT569142	hsa-miR-4730	PAR-CLIP	20371350
MIRT487741	hsa-miR-4773	PAR-CLIP	23592263
MIRT487740	hsa-miR-5188	PAR-CLIP	23592263
MIRT487739	hsa-miR-4251	PAR-CLIP	23592263
MIRT487738	hsa-miR-6857-3p	PAR-CLIP	23592263
MIRT487737	hsa-miR-589-5p	PAR-CLIP	23592263
MIRT487736	hsa-miR-146a-5p	PAR-CLIP	23592263
MIRT487735	hsa-miR-146b-5p	PAR-CLIP	23592263
MIRT487734	hsa-miR-7153-5p	PAR-CLIP	23592263
MIRT487733	hsa-miR-4740-5p	PAR-CLIP	23592263
MIRT487732	hsa-miR-4293	PAR-CLIP	23592263
MIRT487731	hsa-miR-4436a	PAR-CLIP	23592263
MIRT487730	hsa-miR-5000-3p	PAR-CLIP	23592263
MIRT487728	hsa-miR-4324	PAR-CLIP	23592263
MIRT487729	hsa-miR-4329	PAR-CLIP	23592263
MIRT487727	hsa-miR-6786-3p	PAR-CLIP	23592263
MIRT487741	hsa-miR-4773	PAR-CLIP	20371350
MIRT487740	hsa-miR-5188	PAR-CLIP	20371350
MIRT487739	hsa-miR-4251	PAR-CLIP	20371350
MIRT487738	hsa-miR-6857-3p	PAR-CLIP	20371350
MIRT487737	hsa-miR-589-5p	PAR-CLIP	20371350
MIRT487736	hsa-miR-146a-5p	PAR-CLIP	20371350
MIRT487735	hsa-miR-146b-5p	PAR-CLIP	20371350
MIRT487734	hsa-miR-7153-5p	PAR-CLIP	20371350
MIRT487733	hsa-miR-4740-5p	PAR-CLIP	20371350
MIRT487741	hsa-miR-4773	PAR-CLIP	20371350
MIRT487740	hsa-miR-5188	PAR-CLIP	20371350
MIRT487739	hsa-miR-4251	PAR-CLIP	20371350
MIRT487738	hsa-miR-6857-3p	PAR-CLIP	20371350
MIRT487737	hsa-miR-589-5p	PAR-CLIP	20371350
MIRT487736	hsa-miR-146a-5p	PAR-CLIP	20371350
MIRT487735	hsa-miR-146b-5p	PAR-CLIP	20371350
MIRT487734	hsa-miR-7153-5p	PAR-CLIP	20371350
MIRT487733	hsa-miR-4740-5p	PAR-CLIP	20371350
MIRT487741	hsa-miR-4773	PAR-CLIP	20371350
MIRT487740	hsa-miR-5188	PAR-CLIP	20371350
MIRT487739	hsa-miR-4251	PAR-CLIP	20371350
MIRT487738	hsa-miR-6857-3p	PAR-CLIP	20371350
MIRT487737	hsa-miR-589-5p	PAR-CLIP	20371350
MIRT487736	hsa-miR-146a-5p	PAR-CLIP	20371350
MIRT487735	hsa-miR-146b-5p	PAR-CLIP	20371350
MIRT487734	hsa-miR-7153-5p	PAR-CLIP	20371350
MIRT487733	hsa-miR-4740-5p	PAR-CLIP	20371350
MIRT487741	hsa-miR-4773	PAR-CLIP	20371350
MIRT487740	hsa-miR-5188	PAR-CLIP	20371350
MIRT487739	hsa-miR-4251	PAR-CLIP	20371350
MIRT487738	hsa-miR-6857-3p	PAR-CLIP	20371350
MIRT487737	hsa-miR-589-5p	PAR-CLIP	20371350
MIRT487736	hsa-miR-146a-5p	PAR-CLIP	20371350
MIRT487735	hsa-miR-146b-5p	PAR-CLIP	20371350
MIRT487734	hsa-miR-7153-5p	PAR-CLIP	20371350
MIRT487733	hsa-miR-4740-5p	PAR-CLIP	20371350
MIRT569151	hsa-miR-5739	PAR-CLIP	20371350
MIRT569150	hsa-miR-3692-5p	PAR-CLIP	20371350
MIRT569149	hsa-miR-5580-5p	PAR-CLIP	20371350
MIRT569148	hsa-miR-25-5p	PAR-CLIP	20371350
MIRT569147	hsa-miR-342-5p	PAR-CLIP	20371350
MIRT569146	hsa-miR-4664-5p	PAR-CLIP	20371350
MIRT569145	hsa-miR-4466	PAR-CLIP	20371350
MIRT569144	hsa-miR-675-5p	PAR-CLIP	20371350
MIRT569143	hsa-miR-6850-5p	PAR-CLIP	20371350
MIRT569142	hsa-miR-4730	PAR-CLIP	20371350
MIRT487741	hsa-miR-4773	PAR-CLIP	23592263
MIRT487740	hsa-miR-5188	PAR-CLIP	23592263
MIRT487739	hsa-miR-4251	PAR-CLIP	23592263
MIRT487738	hsa-miR-6857-3p	PAR-CLIP	23592263
MIRT487737	hsa-miR-589-5p	PAR-CLIP	23592263
MIRT487736	hsa-miR-146a-5p	PAR-CLIP	23592263
MIRT487735	hsa-miR-146b-5p	PAR-CLIP	23592263
MIRT487734	hsa-miR-7153-5p	PAR-CLIP	23592263
MIRT487733	hsa-miR-4740-5p	PAR-CLIP	23592263
MIRT487732	hsa-miR-4293	PAR-CLIP	23592263
MIRT487731	hsa-miR-4436a	PAR-CLIP	23592263
MIRT487730	hsa-miR-5000-3p	PAR-CLIP	23592263
MIRT487728	hsa-miR-4324	PAR-CLIP	23592263
MIRT487729	hsa-miR-4329	PAR-CLIP	23592263
MIRT487727	hsa-miR-6786-3p	PAR-CLIP	23592263
MIRT2042145	hsa-miR-3616-3p	CLIP-seq
MIRT2042146	hsa-miR-3929	CLIP-seq
MIRT2042147	hsa-miR-4419b	CLIP-seq
MIRT2042148	hsa-miR-4478	CLIP-seq
MIRT2042149	hsa-miR-4695-5p	CLIP-seq
MIRT2042150	hsa-miR-4779	CLIP-seq
MIRT2042151	hsa-miR-485-5p	CLIP-seq
MIRT2042152	hsa-miR-765	CLIP-seq
MIRT2271877	hsa-miR-3607-3p	CLIP-seq
MIRT2042145	hsa-miR-3616-3p	CLIP-seq
MIRT2271878	hsa-miR-3646	CLIP-seq
MIRT2271879	hsa-miR-3688-5p	CLIP-seq
MIRT2042146	hsa-miR-3929	CLIP-seq
MIRT2271880	hsa-miR-3974	CLIP-seq
MIRT2042147	hsa-miR-4419b	CLIP-seq
MIRT2042148	hsa-miR-4478	CLIP-seq
MIRT2042149	hsa-miR-4695-5p	CLIP-seq
MIRT2042150	hsa-miR-4779	CLIP-seq
MIRT2042151	hsa-miR-485-5p	CLIP-seq
MIRT2271881	hsa-miR-644	CLIP-seq
MIRT2042152	hsa-miR-765	CLIP-seq
MIRT2390869	hsa-miR-1273f	CLIP-seq
MIRT2390870	hsa-miR-143	CLIP-seq
MIRT2390871	hsa-miR-3150a-3p	CLIP-seq
MIRT2390872	hsa-miR-3175	CLIP-seq
MIRT2271877	hsa-miR-3607-3p	CLIP-seq
MIRT2271878	hsa-miR-3646	CLIP-seq
MIRT2042146	hsa-miR-3929	CLIP-seq
MIRT2271880	hsa-miR-3974	CLIP-seq
MIRT2390873	hsa-miR-3975	CLIP-seq
MIRT2042147	hsa-miR-4419b	CLIP-seq
MIRT2042148	hsa-miR-4478	CLIP-seq
MIRT2042149	hsa-miR-4695-5p	CLIP-seq
MIRT2390874	hsa-miR-4708-5p	CLIP-seq
MIRT2390875	hsa-miR-4770	CLIP-seq
MIRT2042150	hsa-miR-4779	CLIP-seq
MIRT2042151	hsa-miR-485-5p	CLIP-seq
MIRT2042152	hsa-miR-765	CLIP-seq
MIRT2390876	hsa-miR-939	CLIP-seq

Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001947	Process	Heart looping	ISS
GO:0003779	Function	Actin binding	IDA	24440334
GO:0003779	Function	Actin binding	IEA
GO:0003779	Function	Actin binding	ISS
GO:0004497	Function	Monooxygenase activity	IDA	29343822
GO:0004497	Function	Monooxygenase activity	IEA
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005634	Component	Nucleus	IDA	24440334
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005884	Component	Actin filament	IDA	29343822
GO:0007010	Process	Cytoskeleton organization	IDA	24440334
GO:0007507	Process	Heart development	ISS
GO:0016174	Function	NAD(P)H oxidase H2O2-forming activity	IEA
GO:0016491	Function	Oxidoreductase activity	IDA	24440334
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016709	Function	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	IEA
GO:0016709	Function	Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	ISS
GO:0019417	Process	Sulfur oxidation	IEA
GO:0019417	Process	Sulfur oxidation	ISS
GO:0030042	Process	Actin filament depolymerization	IDA	24440334, 29343822
GO:0030042	Process	Actin filament depolymerization	IEA
GO:0030042	Process	Actin filament depolymerization	ISS
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	24440334
GO:0046872	Function	Metal ion binding	IEA
GO:0051019	Function	Mitogen-activated protein kinase binding	IEA
GO:0051019	Function	Mitogen-activated protein kinase binding	ISS
GO:0071949	Function	FAD binding	IEA
GO:0071949	Function	FAD binding	ISS
GO:0120501	Function	F-actin monooxygenase activity	IEA

MIM	HGNC	e!Ensembl
608881	24693	ENSG00000133816

O94851

Protein name

[F-actin]-monooxygenase MICAL2 (EC 1.14.13.225) (MICAL C-terminal-like protein) (Mical-cL) (Molecule interacting with CasL protein 2) (MICAL-2)

Protein function

Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:24

PDB

2E9K , 5SZH , 5SZI , 5SZJ , 5SZK

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01494	FAD_binding_3	86 → 141	FAD binding domain	Family
PF00307	CH	517 → 623	Calponin homology (CH) domain	Domain
PF00412	LIM	1002 → 1060	LIM domain	Domain

Sequence

MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTW
KAKALWYKLDKRGSHKEYKRGKSCTNTKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDS
FSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVN
VEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGK
LAIAITANFINRNSTAEAKVEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFV
MTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNH
YGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFD
TAWMVKSWNQGTPPLELLAERESLYRLLPQTTPENINKNFEQYTLDPGTRYPNLNSHCVR
PHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTD
LTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMA
SAQEPDKLSMVMYLSKFYELFRGTPLRPVDSWRKNYGENADLSLAKSSISNNYLNLTFPR
KRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMAN
QLLAKFEESTRNPSLMKQERRVSGIGKPVLCSSSGPPVHSCCPKPEEATPSPSPPLKRQF
PSVVVTGHVLRELKQVSAGSECLSRPWRARAKSDLQLGGTENFATLPSTRPRAQALSGVL
WRLQQVEEKILQKRAQNLANREFHTKNIKEKAAHLASMFGHGDFPQNKLLSKGLSHTHPP
SPPSRLPSPDPAASSSPSTVDSASPARKEKKSPSGFHFHPSHLRTVHPQLTVGKVSSGIG
AAAEVLVNLYMNDHRPKAQATSPDLESMRKSFPLNLGGSDTCYFCKKRVYVMERLSAEGH
FFHRECFRCSICATTLRLAAYTFDCDEGKFYCKPHFIHCKTNSKQRKRRAELKQQREEEA
TWQEQEAPRRDTPTESSCAVAAIGTLEGSPPVHFSLPVLHPLLG

Sequence length

1124

Interactions

View interactions

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Breast ductal adenocarcinoma	Uncertain significance	rs869025227	RCV000207204
Clear cell carcinoma of kidney	Uncertain significance	rs144642828	RCV005928896
Lung cancer	Benign	rs35387130	RCV005910331
Malignant tumor of esophagus	Uncertain significance	rs144642828	RCV005928895
Thymoma	Benign	rs35387130	RCV005910330

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Calcinosis Cutis	Associate	26689989
Endometrial Neoplasms	Associate	29951943
Nasopharyngeal Carcinoma	Associate	35461306
Neoplasms	Associate	26689989
Non Muscle Invasive Bladder Neoplasms	Associate	22724020
Stomach Diseases	Associate	26689989, 36064550
Stomach Neoplasms	Associate	34650666, 36064550
Urinary Bladder Neoplasms	Associate	22724020

MICAL2 (microtubule associated monooxygenase, calponin and LIM domain containing 2)