Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9644
Gene name Gene Name - the full gene name approved by the HGNC.
SH3 and PX domains 2A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SH3PXD2A
Synonyms (NCBI Gene) Gene synonyms aliases
FISH, SH3MD1, TKS5
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q24.33
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019047 hsa-miR-335-5p Microarray 18185580
MIRT020272 hsa-miR-130b-3p Sequencing 20371350
MIRT023125 hsa-miR-124-3p Microarray 18668037
MIRT028101 hsa-miR-93-5p Sequencing 20371350
MIRT028217 hsa-miR-33a-5p Sequencing 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001701 Process In utero embryonic development IEA
GO:0002020 Function Protease binding IEA
GO:0002102 Component Podosome IDA 18417249
GO:0005515 Function Protein binding IPI 16374509, 19755710, 20609497, 25825872
GO:0005546 Function Phosphatidylinositol-4,5-bisphosphate binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
619455 23664 ENSG00000107957
Protein
UniProt ID Q5TCZ1
Protein name SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains)
Protein function Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts
PDB 2DNU , 2EGA , 2EGC , 2EKH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00787 PX 30 124 PX domain Domain
PF00018 SH3_1 172 217 SH3 domain Domain
PF00018 SH3_1 273 317 SH3 domain Domain
PF00018 SH3_1 455 499 SH3 domain Domain
PF00018 SH3_1 848 891 SH3 domain Domain
Tissue specificity TISSUE SPECIFICITY: Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas. {ECO:0000269|PubMed:15710328}.
Sequence
MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPI
EGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRF
FEAR
PEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQ
ENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPA
TYLEAQNGTRDDSDINTSKTGEV
SKRRKAHLRRLDRRWTLGGMVNRQHSREEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNL
EGWWYIRYLGKEGWAPA
SYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKE
TPPAEGEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLAQGSPAVARIAPQRAQIS
SPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDK
NSGGWWYVQIGEKEGWAPA
SYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTG
ASESQDSPRKLKYEEPEYDIPAFGFDSEPELSEEPVEDRASGERRPAQPHRPSPASSLQR
ARFKVGESSEDVALEEETIYENEGFRPYAEDTLSARGSSGDSDSPGSSSLSLTRKNSPKS
GSPKSSSLLKLKAEKNAQAEMGKNHSSASFSSSITINTTCCSSSSSSSSSLSKTSGDLKP
RSASDAGIRGTPKVRAKKDADANAGLTSCPRAKPSVRPKPFLNRAESQSQEKMDISTLRR
QLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLITLPATTPPCPTKKEWEG
PATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENE
QPDPSGKELDTVPAKGRQNEGKSDSLEKIERRVQALNTVNQSKKATPPIPSKPPGGFGKT
SGTPAVKMRNGVRQVAVRPQSVFVSPPPKDNNLSCALRRNESLTATDGLRGVRRNSSFST
ARSAAAEAKGRLAERAASQGSDSPLLPAQRNSIPVSPVRPKPIEKSQFIHNNLKDVYVSI
ADYEGDEETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEKKN
Sequence length 1133
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Invadopodia formation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Atrial fibrillation Atrial Fibrillation rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557
View all (6 more)
28416822, 28416818, 30061737, 29892015, 29290336
Neurofibrosarcoma Neurofibrosarcoma rs137852604 27723760
Rheumatoid arthritis Rheumatoid Arthritis rs587776843 30891314
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
24936775
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 25918132 ClinVar, GWAS
Paroxysmal atrial fibrillation Paroxysmal atrial fibrillation 28416822 ClinVar
Atrial Fibrillation Atrial Fibrillation GWAS
Ischemic Stroke Ischemic Stroke GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 35562727, 37537521
Arthritis Psoriatic Associate 38003532
Cerebral Hemorrhage Associate 39298701
Cerebral Infarction Associate 36691064
Colitis Ulcerative Associate 37891214
Colorectal Neoplasms Stimulate 34131400
Colorectal Neoplasms Associate 36032659
Crohn Disease Associate 37891214
Diabetes Gestational Associate 29461653
Focal Epithelial Hyperplasia of the Oral Mucosa Associate 33879222