UniProt ID |
Q5TCZ1
|
Protein name |
SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) |
Protein function |
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts |
PDB |
2DNU
,
2EGA
,
2EGC
,
2EKH
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00787
|
PX |
30 → 124 |
PX domain |
Domain |
PF00018
|
SH3_1 |
172 → 217 |
SH3 domain |
Domain |
PF00018
|
SH3_1 |
273 → 317 |
SH3 domain |
Domain |
PF00018
|
SH3_1 |
455 → 499 |
SH3 domain |
Domain |
PF00018
|
SH3_1 |
848 → 891 |
SH3 domain |
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas. {ECO:0000269|PubMed:15710328}. |
Sequence |
|
Sequence length |
1133 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Atrial fibrillation |
Atrial Fibrillation |
rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557, rs587777558, rs587777559, rs587777560, rs886037778, rs769405762, rs770372675 View all (6 more) |
28416822, 28416818, 30061737, 29892015, 29290336 |
Neurofibrosarcoma |
Neurofibrosarcoma |
rs137852604 |
27723760 |
Rheumatoid arthritis |
Rheumatoid Arthritis |
rs587776843 |
30891314 |
Schizophrenia |
Schizophrenia |
rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 View all (12 more) |
24936775 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Asthma |
Asthma |
|
25918132 |
ClinVar, GWAS |
Paroxysmal atrial fibrillation |
Paroxysmal atrial fibrillation |
|
28416822 |
ClinVar |
Atrial Fibrillation |
Atrial Fibrillation |
|
|
GWAS |
Ischemic Stroke |
Ischemic Stroke |
|
|
GWAS |
Uterine Fibroids |
Uterine Fibroids |
|
|
GWAS |
Cardioembolic Stroke |
Cardioembolic Stroke |
|
|
GWAS |
|
|