Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9639
Gene name Gene Name - the full gene name approved by the HGNC.	Rho guanine nucleotide exchange factor 10
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ARHGEF10
Synonyms (NCBI Gene) Gene synonyms aliases	GEF10, SNCV
Chromosome Chromosome number	8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	8p23.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Muta

Show/Hide all(3)

SNP ID	Visualize variation	Clinical significance	Consequence
rs28940281	C>T	Pathogenic	Coding sequence variant, missense variant
rs587777712	G>A,C	Likely-pathogenic, uncertain-significance	Missense variant, coding sequence variant
rs1585296361	G>T	Likely-pathogenic	Coding sequence variant, stop gained

Show/Hide all(230)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021449	hsa-miR-9-5p	Microarray	17612493
MIRT026698	hsa-miR-192-5p	Microarray	19074876
MIRT795223	hsa-miR-101	CLIP-seq
MIRT795224	hsa-miR-1184	CLIP-seq
MIRT795225	hsa-miR-1205	CLIP-seq
MIRT795226	hsa-miR-1253	CLIP-seq
MIRT795227	hsa-miR-1258	CLIP-seq
MIRT795228	hsa-miR-1290	CLIP-seq
MIRT795229	hsa-miR-132	CLIP-seq
MIRT795230	hsa-miR-1324	CLIP-seq
MIRT795231	hsa-miR-144	CLIP-seq
MIRT795232	hsa-miR-200b	CLIP-seq
MIRT795233	hsa-miR-200c	CLIP-seq
MIRT795234	hsa-miR-2053	CLIP-seq
MIRT795235	hsa-miR-212	CLIP-seq
MIRT795236	hsa-miR-224	CLIP-seq
MIRT795237	hsa-miR-2276	CLIP-seq
MIRT795238	hsa-miR-23a	CLIP-seq
MIRT795239	hsa-miR-23b	CLIP-seq
MIRT795240	hsa-miR-23c	CLIP-seq
MIRT795241	hsa-miR-2467-3p	CLIP-seq
MIRT795242	hsa-miR-25	CLIP-seq
MIRT795243	hsa-miR-3130-3p	CLIP-seq
MIRT795244	hsa-miR-3144-3p	CLIP-seq
MIRT795245	hsa-miR-3148	CLIP-seq
MIRT795246	hsa-miR-3152-3p	CLIP-seq
MIRT795247	hsa-miR-3155	CLIP-seq
MIRT795248	hsa-miR-3155b	CLIP-seq
MIRT795249	hsa-miR-3158-5p	CLIP-seq
MIRT795250	hsa-miR-3159	CLIP-seq
MIRT795251	hsa-miR-3186-5p	CLIP-seq
MIRT795252	hsa-miR-32	CLIP-seq
MIRT795253	hsa-miR-329	CLIP-seq
MIRT795254	hsa-miR-34b	CLIP-seq
MIRT795255	hsa-miR-361-3p	CLIP-seq
MIRT795256	hsa-miR-3620	CLIP-seq
MIRT795257	hsa-miR-362-3p	CLIP-seq
MIRT795258	hsa-miR-363	CLIP-seq
MIRT795259	hsa-miR-3650	CLIP-seq
MIRT795260	hsa-miR-367	CLIP-seq
MIRT795261	hsa-miR-3678-3p	CLIP-seq
MIRT795262	hsa-miR-3941	CLIP-seq
MIRT795263	hsa-miR-3978	CLIP-seq
MIRT795264	hsa-miR-4251	CLIP-seq
MIRT795265	hsa-miR-429	CLIP-seq
MIRT795266	hsa-miR-4299	CLIP-seq
MIRT795267	hsa-miR-4427	CLIP-seq
MIRT795268	hsa-miR-4438	CLIP-seq
MIRT795269	hsa-miR-4453	CLIP-seq
MIRT795270	hsa-miR-4456	CLIP-seq
MIRT795271	hsa-miR-4474-5p	CLIP-seq
MIRT795272	hsa-miR-4502	CLIP-seq
MIRT795273	hsa-miR-452	CLIP-seq
MIRT795274	hsa-miR-4528	CLIP-seq
MIRT795275	hsa-miR-4538	CLIP-seq
MIRT795276	hsa-miR-4670-3p	CLIP-seq
MIRT795277	hsa-miR-4676-3p	CLIP-seq
MIRT795278	hsa-miR-4695-5p	CLIP-seq
MIRT795279	hsa-miR-4712-5p	CLIP-seq
MIRT795280	hsa-miR-4713-5p	CLIP-seq
MIRT795281	hsa-miR-4717-3p	CLIP-seq
MIRT795282	hsa-miR-4724-5p	CLIP-seq
MIRT795283	hsa-miR-4729	CLIP-seq
MIRT795284	hsa-miR-4747-5p	CLIP-seq
MIRT795285	hsa-miR-4763-5p	CLIP-seq
MIRT795286	hsa-miR-4772-3p	CLIP-seq
MIRT795287	hsa-miR-4780	CLIP-seq
MIRT795288	hsa-miR-4793-3p	CLIP-seq
MIRT795289	hsa-miR-4800-3p	CLIP-seq
MIRT795290	hsa-miR-484	CLIP-seq
MIRT795291	hsa-miR-489	CLIP-seq
MIRT795292	hsa-miR-501-3p	CLIP-seq
MIRT795293	hsa-miR-502-3p	CLIP-seq
MIRT795294	hsa-miR-544	CLIP-seq
MIRT795295	hsa-miR-548q	CLIP-seq
MIRT795296	hsa-miR-550a	CLIP-seq
MIRT795297	hsa-miR-578	CLIP-seq
MIRT795298	hsa-miR-580	CLIP-seq
MIRT795299	hsa-miR-603	CLIP-seq
MIRT795300	hsa-miR-646	CLIP-seq
MIRT795301	hsa-miR-651	CLIP-seq
MIRT795302	hsa-miR-770-5p	CLIP-seq
MIRT795303	hsa-miR-885-5p	CLIP-seq
MIRT795304	hsa-miR-92a	CLIP-seq
MIRT795305	hsa-miR-92b	CLIP-seq
MIRT1934762	hsa-miR-1179	CLIP-seq
MIRT1934763	hsa-miR-1207-5p	CLIP-seq
MIRT1934764	hsa-miR-1252	CLIP-seq
MIRT795226	hsa-miR-1253	CLIP-seq
MIRT1934765	hsa-miR-1275	CLIP-seq
MIRT1934766	hsa-miR-1298	CLIP-seq
MIRT795230	hsa-miR-1324	CLIP-seq
MIRT1934767	hsa-miR-186	CLIP-seq
MIRT1934768	hsa-miR-214	CLIP-seq
MIRT1934769	hsa-miR-2392	CLIP-seq
MIRT795238	hsa-miR-23a	CLIP-seq
MIRT795239	hsa-miR-23b	CLIP-seq
MIRT795240	hsa-miR-23c	CLIP-seq
MIRT795242	hsa-miR-25	CLIP-seq
MIRT1934770	hsa-miR-29a	CLIP-seq
MIRT1934771	hsa-miR-29b	CLIP-seq
MIRT1934772	hsa-miR-29c	CLIP-seq
MIRT1934773	hsa-miR-302a	CLIP-seq
MIRT1934774	hsa-miR-302b	CLIP-seq
MIRT1934775	hsa-miR-302c	CLIP-seq
MIRT1934776	hsa-miR-302d	CLIP-seq
MIRT1934777	hsa-miR-302e	CLIP-seq
MIRT1934778	hsa-miR-3120-3p	CLIP-seq
MIRT1934779	hsa-miR-3143	CLIP-seq
MIRT795244	hsa-miR-3144-3p	CLIP-seq
MIRT795245	hsa-miR-3148	CLIP-seq
MIRT795250	hsa-miR-3159	CLIP-seq
MIRT1934780	hsa-miR-3166	CLIP-seq
MIRT795252	hsa-miR-32	CLIP-seq
MIRT795254	hsa-miR-34b	CLIP-seq
MIRT1934781	hsa-miR-3613-3p	CLIP-seq
MIRT1934782	hsa-miR-3619-5p	CLIP-seq
MIRT795258	hsa-miR-363	CLIP-seq
MIRT795260	hsa-miR-367	CLIP-seq
MIRT1934783	hsa-miR-372	CLIP-seq
MIRT1934784	hsa-miR-373	CLIP-seq
MIRT795263	hsa-miR-3978	CLIP-seq
MIRT1934785	hsa-miR-4267	CLIP-seq
MIRT1934786	hsa-miR-4274	CLIP-seq
MIRT1934787	hsa-miR-4291	CLIP-seq
MIRT1934788	hsa-miR-4310	CLIP-seq
MIRT1934789	hsa-miR-4422	CLIP-seq
MIRT1934790	hsa-miR-4433	CLIP-seq
MIRT795269	hsa-miR-4453	CLIP-seq
MIRT1934791	hsa-miR-4525	CLIP-seq
MIRT795274	hsa-miR-4528	CLIP-seq
MIRT795275	hsa-miR-4538	CLIP-seq
MIRT1934792	hsa-miR-4665-5p	CLIP-seq
MIRT1934793	hsa-miR-4714-3p	CLIP-seq
MIRT795281	hsa-miR-4717-3p	CLIP-seq
MIRT1934794	hsa-miR-4723-5p	CLIP-seq
MIRT795283	hsa-miR-4729	CLIP-seq
MIRT1934795	hsa-miR-4733-3p	CLIP-seq
MIRT1934796	hsa-miR-4736	CLIP-seq
MIRT795284	hsa-miR-4747-5p	CLIP-seq
MIRT1934797	hsa-miR-4763-3p	CLIP-seq
MIRT795285	hsa-miR-4763-5p	CLIP-seq
MIRT1934798	hsa-miR-4766-5p	CLIP-seq
MIRT1934799	hsa-miR-4773	CLIP-seq
MIRT795292	hsa-miR-501-3p	CLIP-seq
MIRT795293	hsa-miR-502-3p	CLIP-seq
MIRT1934800	hsa-miR-520a-3p	CLIP-seq
MIRT1934801	hsa-miR-520b	CLIP-seq
MIRT1934802	hsa-miR-520c-3p	CLIP-seq
MIRT1934803	hsa-miR-520d-3p	CLIP-seq
MIRT1934804	hsa-miR-520e	CLIP-seq
MIRT1934805	hsa-miR-543	CLIP-seq
MIRT795299	hsa-miR-603	CLIP-seq
MIRT1934806	hsa-miR-625	CLIP-seq
MIRT1934807	hsa-miR-652	CLIP-seq
MIRT1934808	hsa-miR-665	CLIP-seq
MIRT1934809	hsa-miR-761	CLIP-seq
MIRT795303	hsa-miR-885-5p	CLIP-seq
MIRT1934810	hsa-miR-922	CLIP-seq
MIRT795304	hsa-miR-92a	CLIP-seq
MIRT795305	hsa-miR-92b	CLIP-seq
MIRT2174570	hsa-miR-106a	CLIP-seq
MIRT2174571	hsa-miR-106b	CLIP-seq
MIRT1934762	hsa-miR-1179	CLIP-seq
MIRT795226	hsa-miR-1253	CLIP-seq
MIRT1934765	hsa-miR-1275	CLIP-seq
MIRT1934766	hsa-miR-1298	CLIP-seq
MIRT2174572	hsa-miR-17	CLIP-seq
MIRT795234	hsa-miR-2053	CLIP-seq
MIRT2174573	hsa-miR-20a	CLIP-seq
MIRT2174574	hsa-miR-20b	CLIP-seq
MIRT2174575	hsa-miR-2277-3p	CLIP-seq
MIRT795238	hsa-miR-23a	CLIP-seq
MIRT795239	hsa-miR-23b	CLIP-seq
MIRT795240	hsa-miR-23c	CLIP-seq
MIRT1934770	hsa-miR-29a	CLIP-seq
MIRT1934771	hsa-miR-29b	CLIP-seq
MIRT1934772	hsa-miR-29c	CLIP-seq
MIRT1934773	hsa-miR-302a	CLIP-seq
MIRT1934774	hsa-miR-302b	CLIP-seq
MIRT1934775	hsa-miR-302c	CLIP-seq
MIRT1934776	hsa-miR-302d	CLIP-seq
MIRT1934777	hsa-miR-302e	CLIP-seq
MIRT1934780	hsa-miR-3166	CLIP-seq
MIRT2174576	hsa-miR-338-3p	CLIP-seq
MIRT795254	hsa-miR-34b	CLIP-seq
MIRT2174577	hsa-miR-3607-3p	CLIP-seq
MIRT2174578	hsa-miR-3609	CLIP-seq
MIRT2174579	hsa-miR-3686	CLIP-seq
MIRT1934783	hsa-miR-372	CLIP-seq
MIRT1934784	hsa-miR-373	CLIP-seq
MIRT1934788	hsa-miR-4310	CLIP-seq
MIRT2174580	hsa-miR-4329	CLIP-seq
MIRT1934789	hsa-miR-4422	CLIP-seq
MIRT1934790	hsa-miR-4433	CLIP-seq
MIRT795269	hsa-miR-4453	CLIP-seq
MIRT1934791	hsa-miR-4525	CLIP-seq
MIRT795275	hsa-miR-4538	CLIP-seq
MIRT2174581	hsa-miR-4663	CLIP-seq
MIRT1934792	hsa-miR-4665-5p	CLIP-seq
MIRT795281	hsa-miR-4717-3p	CLIP-seq
MIRT1934794	hsa-miR-4723-5p	CLIP-seq
MIRT1934795	hsa-miR-4733-3p	CLIP-seq
MIRT795284	hsa-miR-4747-5p	CLIP-seq
MIRT795285	hsa-miR-4763-5p	CLIP-seq
MIRT2174582	hsa-miR-4796-3p	CLIP-seq
MIRT2174583	hsa-miR-512-3p	CLIP-seq
MIRT2174584	hsa-miR-519d	CLIP-seq
MIRT1934800	hsa-miR-520a-3p	CLIP-seq
MIRT1934801	hsa-miR-520b	CLIP-seq
MIRT1934802	hsa-miR-520c-3p	CLIP-seq
MIRT1934803	hsa-miR-520d-3p	CLIP-seq
MIRT1934804	hsa-miR-520e	CLIP-seq
MIRT2174585	hsa-miR-548ah	CLIP-seq
MIRT795298	hsa-miR-580	CLIP-seq
MIRT1934806	hsa-miR-625	CLIP-seq
MIRT1934808	hsa-miR-665	CLIP-seq
MIRT2174586	hsa-miR-93	CLIP-seq
MIRT795230	hsa-miR-1324	CLIP-seq
MIRT1934768	hsa-miR-214	CLIP-seq
MIRT1934769	hsa-miR-2392	CLIP-seq
MIRT795243	hsa-miR-3130-3p	CLIP-seq
MIRT795251	hsa-miR-3186-5p	CLIP-seq
MIRT1934782	hsa-miR-3619-5p	CLIP-seq
MIRT1934787	hsa-miR-4291	CLIP-seq
MIRT795268	hsa-miR-4438	CLIP-seq
MIRT795288	hsa-miR-4793-3p	CLIP-seq
MIRT1934807	hsa-miR-652	CLIP-seq
MIRT1934809	hsa-miR-761	CLIP-seq
MIRT1934810	hsa-miR-922	CLIP-seq

Show/Hide all(23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	16896804, 19635168, 20042462
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005515	Function	Protein binding	IPI	19635168
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IBA
GO:0005813	Component	Centrosome	IDA	19635168
GO:0005829	Component	Cytosol	NAS	16896804
GO:0005829	Component	Cytosol	TAS
GO:0019894	Function	Kinesin binding	IPI	19635168
GO:0022011	Process	Myelination in peripheral nervous system	IMP	14508709
GO:0030036	Process	Actin cytoskeleton organization	IBA
GO:0035025	Process	Positive regulation of Rho protein signal transduction	IDA	16896804
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0051298	Process	Centrosome duplication	IMP	19635168
GO:0051496	Process	Positive regulation of stress fiber assembly	IBA
GO:0051496	Process	Positive regulation of stress fiber assembly	IEA
GO:0051496	Process	Positive regulation of stress fiber assembly	IMP	16896804
GO:0090307	Process	Mitotic spindle assembly	IBA
GO:0090307	Process	Mitotic spindle assembly	IMP	19635168

MIM	HGNC	e!Ensembl
608136	14103	ENSG00000104728

Protein

UniProt ID

O15013

Protein name

Rho guanine nucleotide exchange factor 10

Protein function

May play a role in developmental myelination of peripheral nerves.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00621	RhoGEF	425 → 606	RhoGEF domain	Domain
PF19057	PH_19	629 → 778		Domain
PF19056	WD40_2	886 → 1368		Repeat

Sequence

MRPPGFLSRAPSLNRAERGIWSCSMDQREPLPPAPAENEMKYDTNNNEEEEGEQFDFDSG
DEIPEADRQAPSAPETGGAGASEAPAPTGGEDGAGAETTPVAEPTKLVLPMKVNPYSVID
ITPFQEDQPPTPVPSAEEENVGLHVPCGYLVPVPCGYAVPSNLPLLLPAYSSPVIICATS
LDEEAETPEVTEDRQPNSLSSEEPPTSEDQVGREDSALARWAADPANTAWMENPEEAIYD
DVPRENSDSEPDEMIYDDVENGDEGGNSSLEYGWSSSEFESYEEQSDSECKNGIPRSFLR
SNHKKQLSHDLTRLKEHYEKKMRDLMASTVGVVEIQQLRQKHELKMQKLVKAAKDGTKDG
LERTRAAVKRGRSFIRTKSLIAQDHRSSLEEEQNLFIDVDCKHPEAILTPMPEGLSQQQV
VRRYILGSVVDSEKNYVDALKRILEQYEKPLSEMEPKVLSERKLKTVFYRVKEILQCHSL
FQIALASRVSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAFL
EFLKQEQEASPDRTTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMALTELET
LAEKLNERKRDADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIETVYNDRGEIVK
TKERRVFMLNDVLMCATVSSRPSHDSRVMSSQRYLLKWSVPLGHVDAIEYGSSAGTGEHS
RHLAVHPPESLAVVANAKPNKVYMGPGQLYQDLQNLLHDLNVIGQITQLIGNLKGNYQNL
NQSVAHDWTSGLQRLILKKEDEIRAADCCRIQLQLPGKQDKSGRPTFFTAVFNTFTPAIK
ESWVNSLQMAKLALEEENHMGWFCVEDDGNHIKKEKHPLLVGHMPVMVAKQQEFKIECAA
YNPEPYLNNESQPDSFSTAHGFLWIGSCTHQMGQIAIVSFQNSTPKVIECFNVESRILCM
LYVPVEEKRREPGAPPDPETPAVRASDVPTICVGTEEGSISIYKSSQGSKKVRLQHFFTP
EKSTVMSLACTSQSLYAGLVNGAVASYARAPDGSWDSEPQKVIKLGVLPVRSLLMMEDTL
WAASGGQVFIISVETHAVEGQLEAHQEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETL
KHLQDINIATPVHNMLPGHQRLSVTSLLVCHGLLMVGTSLGVLVALPVPRLQGIPKVTGR
GMVSYHAHNSPVKFIVLATALHEKDKDKSRDSLAPGPEPQDEDQKDALPSGGAGSSLSQG
DPDAAIWLGDSLGSMTQKSDLSSSSGSLSLSHGSSSLEHRSEDSTIYDLLKDPVSLRSKA
RRAKKAKASSALVVCGGQGHRRVHRKARQPHQEELAPTVMVWQIPLLNI

Sequence length

1369

Interactions

View interactions

	Reactome
			NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

Show/Hide Unknown Diseases (8)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Charcot-Marie-Tooth Disease	Charcot-Marie-Tooth Disease	N/A	N/A	ClinVar
Colorectal Cancer	Colorectal cancer	N/A	N/A	GWAS
Dementia	Dementia	N/A	N/A	GWAS
Mental Depression	Clinical depression	N/A	N/A	GWAS
Multiple Sclerosis	Multiple sclerosis	N/A	N/A	GWAS
Peripheral Neuropathy	hereditary peripheral neuropathy, peripheral neuropathy	N/A	N/A	GenCC
Schizophrenia	Schizophrenia	N/A	N/A	GWAS
Slowed Nerve Conduction Velocity	autosomal dominant slowed nerve conduction velocity	N/A	N/A	ClinVar, GenCC

Show/Hide Text Mining Associations (23)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Acne Vulgaris	Associate	37018476
Amyotrophic Lateral Sclerosis	Stimulate	40033250
Autistic Disorder	Associate	36150388
Behcet Syndrome	Associate	33124559
Charcot Marie Tooth Disease	Associate	25164601, 26143528, 34169998
Chromosome 15q trisomy	Associate	34247824
Cleft Palate	Associate	31372216
Contracture	Associate	35260397
Developmental Disabilities	Associate	28901431
Diabetic Foot	Associate	35260397
Eyelid Diseases	Associate	35260397
Hypertriglyceridemia	Associate	29246731
Melanoma Cutaneous Malignant	Associate	28510328
Microcephaly	Associate	28901431
Muscular Atrophy	Associate	35260397
Neoplasms	Inhibit	18840272
Neoplasms	Associate	37489460
Neoplastic Syndromes Hereditary	Associate	32700628
Neurobehavioral Manifestations	Associate	28901431
Orbital Pseudotumor	Associate	35260397
Osteosarcoma	Associate	19635168
Peripheral Nervous System Diseases	Associate	25164601, 26143528
Stroke	Associate	21743172

ARHGEF10 (Rho guanine nucleotide exchange factor 10)