Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9638
Gene name Gene Name - the full gene name approved by the HGNC.	Fasciculation and elongation protein zeta 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FEZ1
Synonyms (NCBI Gene) Gene synonyms aliases	UNC-76
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q24.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fascicu

Show/Hide all(103)

miRTarBase ID	miRNA	Experiments
MIRT994896	hsa-miR-1227	CLIP-seq
MIRT994897	hsa-miR-1228	CLIP-seq
MIRT994898	hsa-miR-1827	CLIP-seq
MIRT994899	hsa-miR-2114	CLIP-seq
MIRT994900	hsa-miR-25	CLIP-seq
MIRT994901	hsa-miR-2681	CLIP-seq
MIRT994902	hsa-miR-299-3p	CLIP-seq
MIRT994903	hsa-miR-3122	CLIP-seq
MIRT994904	hsa-miR-3138	CLIP-seq
MIRT994905	hsa-miR-3160-5p	CLIP-seq
MIRT994906	hsa-miR-3176	CLIP-seq
MIRT994907	hsa-miR-3192	CLIP-seq
MIRT994908	hsa-miR-32	CLIP-seq
MIRT994909	hsa-miR-3613-3p	CLIP-seq
MIRT994910	hsa-miR-361-3p	CLIP-seq
MIRT994911	hsa-miR-363	CLIP-seq
MIRT994912	hsa-miR-3664-3p	CLIP-seq
MIRT994913	hsa-miR-367	CLIP-seq
MIRT994914	hsa-miR-3689a-3p	CLIP-seq
MIRT994915	hsa-miR-3689c	CLIP-seq
MIRT994916	hsa-miR-3689d	CLIP-seq
MIRT994917	hsa-miR-3913-5p	CLIP-seq
MIRT994918	hsa-miR-3922-3p	CLIP-seq
MIRT994919	hsa-miR-3929	CLIP-seq
MIRT994920	hsa-miR-3934	CLIP-seq
MIRT994921	hsa-miR-4325	CLIP-seq
MIRT994922	hsa-miR-4419b	CLIP-seq
MIRT994923	hsa-miR-4428	CLIP-seq
MIRT994924	hsa-miR-4433	CLIP-seq
MIRT994925	hsa-miR-4453	CLIP-seq
MIRT994926	hsa-miR-4459	CLIP-seq
MIRT994927	hsa-miR-4478	CLIP-seq
MIRT994928	hsa-miR-4486	CLIP-seq
MIRT994929	hsa-miR-4491	CLIP-seq
MIRT994930	hsa-miR-4538	CLIP-seq
MIRT994931	hsa-miR-4640-5p	CLIP-seq
MIRT994932	hsa-miR-4649-3p	CLIP-seq
MIRT994933	hsa-miR-4649-5p	CLIP-seq
MIRT994934	hsa-miR-4657	CLIP-seq
MIRT994935	hsa-miR-4695-5p	CLIP-seq
MIRT994936	hsa-miR-4722-5p	CLIP-seq
MIRT994937	hsa-miR-4726-5p	CLIP-seq
MIRT994938	hsa-miR-4728-5p	CLIP-seq
MIRT994939	hsa-miR-4759	CLIP-seq
MIRT994940	hsa-miR-4760-5p	CLIP-seq
MIRT994941	hsa-miR-4768-3p	CLIP-seq
MIRT994942	hsa-miR-4775	CLIP-seq
MIRT994943	hsa-miR-4798-3p	CLIP-seq
MIRT994944	hsa-miR-4800-5p	CLIP-seq
MIRT994945	hsa-miR-485-5p	CLIP-seq
MIRT994946	hsa-miR-490-3p	CLIP-seq
MIRT994947	hsa-miR-508-5p	CLIP-seq
MIRT994948	hsa-miR-510	CLIP-seq
MIRT994949	hsa-miR-512-5p	CLIP-seq
MIRT994950	hsa-miR-590-3p	CLIP-seq
MIRT994951	hsa-miR-661	CLIP-seq
MIRT994952	hsa-miR-766	CLIP-seq
MIRT994953	hsa-miR-92a	CLIP-seq
MIRT994954	hsa-miR-92b	CLIP-seq
MIRT994955	hsa-miR-940	CLIP-seq
MIRT2465294	hsa-miR-3137	CLIP-seq
MIRT2465295	hsa-miR-3935	CLIP-seq
MIRT2465296	hsa-miR-577	CLIP-seq
MIRT2532762	hsa-miR-1226	CLIP-seq
MIRT2532763	hsa-miR-1284	CLIP-seq
MIRT2532764	hsa-miR-1291	CLIP-seq
MIRT2532765	hsa-miR-1913	CLIP-seq
MIRT2532766	hsa-miR-3173-5p	CLIP-seq
MIRT2532767	hsa-miR-3189-5p	CLIP-seq
MIRT2532768	hsa-miR-324-3p	CLIP-seq
MIRT2532769	hsa-miR-324-5p	CLIP-seq
MIRT2532770	hsa-miR-3612	CLIP-seq
MIRT2532771	hsa-miR-3676	CLIP-seq
MIRT2532772	hsa-miR-4661-5p	CLIP-seq
MIRT2532773	hsa-miR-4716-3p	CLIP-seq
MIRT2532774	hsa-miR-4723-5p	CLIP-seq
MIRT2532775	hsa-miR-4758-3p	CLIP-seq
MIRT2532776	hsa-miR-4786-3p	CLIP-seq
MIRT2532777	hsa-miR-4789-5p	CLIP-seq
MIRT2532778	hsa-miR-548al	CLIP-seq
MIRT2532779	hsa-miR-634	CLIP-seq
MIRT2532780	hsa-miR-650	CLIP-seq
MIRT2532781	hsa-miR-767-5p	CLIP-seq
MIRT2532762	hsa-miR-1226	CLIP-seq
MIRT2532763	hsa-miR-1284	CLIP-seq
MIRT2532764	hsa-miR-1291	CLIP-seq
MIRT2532765	hsa-miR-1913	CLIP-seq
MIRT2532766	hsa-miR-3173-5p	CLIP-seq
MIRT2532767	hsa-miR-3189-5p	CLIP-seq
MIRT2532768	hsa-miR-324-3p	CLIP-seq
MIRT2532769	hsa-miR-324-5p	CLIP-seq
MIRT2532770	hsa-miR-3612	CLIP-seq
MIRT2532771	hsa-miR-3676	CLIP-seq
MIRT2532772	hsa-miR-4661-5p	CLIP-seq
MIRT2532773	hsa-miR-4716-3p	CLIP-seq
MIRT2532774	hsa-miR-4723-5p	CLIP-seq
MIRT2532775	hsa-miR-4758-3p	CLIP-seq
MIRT2532776	hsa-miR-4786-3p	CLIP-seq
MIRT2532777	hsa-miR-4789-5p	CLIP-seq
MIRT2532778	hsa-miR-548al	CLIP-seq
MIRT2532779	hsa-miR-634	CLIP-seq
MIRT2532780	hsa-miR-650	CLIP-seq
MIRT2532781	hsa-miR-767-5p	CLIP-seq

Show/Hide all(28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005080	Function	Protein kinase C binding	IEA
GO:0005515	Function	Protein binding	IPI	14690447, 15383276, 16169070, 17500595, 20547877, 22354037, 28514442, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IDA	25495476
GO:0005813	Component	Centrosome	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0007005	Process	Mitochondrion organization	IEA
GO:0007155	Process	Cell adhesion	TAS	9096408
GO:0007399	Process	Nervous system development	TAS	9096408
GO:0007411	Process	Axon guidance	TAS	9096408
GO:0010976	Process	Positive regulation of neuron projection development	IEA
GO:0016020	Component	Membrane	IEA
GO:0021766	Process	Hippocampus development	IEA
GO:0030010	Process	Establishment of cell polarity	IEA
GO:0030424	Component	Axon	IBA
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IEA
GO:0030426	Component	Growth cone	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043015	Function	Gamma-tubulin binding	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0051654	Process	Establishment of mitochondrion localization	IEA
GO:0061881	Process	Positive regulation of anterograde axonal transport of mitochondrion	IEA
GO:0071363	Process	Cellular response to growth factor stimulus	IEA
GO:1902902	Process	Negative regulation of autophagosome assembly	IMP	25495476

MIM	HGNC	e!Ensembl
604825	3659	ENSG00000149557

Protein

UniProt ID

Q99689

Protein name

Fasciculation and elongation protein zeta-1 (Zygin I) (Zygin-1)

Protein function

May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline trans

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07763	FEZ	58 → 297	FEZ-like protein	Family

Tissue specificity

TISSUE SPECIFICITY: Mainly expressed in brain.

Sequence

MEAPLVSLDEEFEDLRPSCSEDPEEKPQCFYGSSPHHLEDPSLSELENFSSEIISFKSME
DLVNEFDEKLNVCFRNYNAKTENLAPVKNQLQIQEEEETLQDEEVWDALTDNYIPSLSED
WRDPNIEALNGNCSDTEIHEKEEEEFNEKSENDSGINEEPLLTADQVIEEIEEMMQNSPD
PEEEEEVLEEEDGGETSSQADSVLLQEMQALTQTFNNNWSYEGLRHMSGSELTELLDQVE
GAIRDFSEELVQQLARRDELEFEKEVKNSFITVLIEVQNKQKEQRELMKKRRKEKGLSLQ
SSRIEKGNQMPLKRFSMEGISNILQSGIRQTFGSSGTDKQYLNTVIPYEKKASPPSVEDL
QMLTNILFAMKEDNEKVPTLLTDYILKVLCPT

Sequence length

392

Interactions

View interactions

	KEGG
	Viral life cycle - HIV-1

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Breast Neoplasms	Associate	11504921, 18686028, 35707265, 36936167, 39380996
Carcinoma Renal Cell	Associate	15357873
Carcinoma Small Cell	Inhibit	15735004
Disease	Associate	21853134
Esophageal Neoplasms	Inhibit	10097140
Heart Defects Congenital	Associate	34324492
HTLV I Infections	Associate	37219433
Infections	Associate	25818806, 37219433
Lung Neoplasms	Inhibit	15735004
Lymphatic Metastasis	Inhibit	15357873
Neoplasm Metastasis	Associate	18686028
Neoplasms	Associate	10097140, 30008265
Neoplasms	Inhibit	11504921, 15735004, 17659675, 18686028
Prostate cancer familial	Inhibit	15735004
Prostatic Neoplasms	Inhibit	10097140
Uveal melanoma	Associate	37725244

FEZ1 (fasciculation and elongation protein zeta 1)