FEZ2 (fasciculation and elongation protein zeta 2)

Gene

• Entrez ID: 9637
• Gene name: Fasciculation and elongation protein zeta 2
• Gene symbol: FEZ2
• Synonyms (NCBI Gene): HUM3CL
• Chromosome: 2
• Chromosome location: 2p22.2
• Summary: This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [provided by RefSeq, Jul

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT528032	hsa-miR-4282	PAR-CLIP	22012620
MIRT528031	hsa-miR-634	PAR-CLIP	22012620
MIRT528030	hsa-miR-302a-5p	PAR-CLIP	22012620
MIRT528029	hsa-miR-3682-5p	PAR-CLIP	22012620
MIRT528027	hsa-miR-4477a	PAR-CLIP	22012620
MIRT528028	hsa-miR-3136-5p	PAR-CLIP	22012620
MIRT528026	hsa-miR-4439	PAR-CLIP	22012620
MIRT528025	hsa-miR-943	PAR-CLIP	22012620
MIRT159405	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT440644	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT159399	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT159405	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT440644	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT159398	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT159408	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT159400	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT159417	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT159399	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT528032	hsa-miR-4282	PAR-CLIP	22012620
MIRT528031	hsa-miR-634	PAR-CLIP	22012620
MIRT528030	hsa-miR-302a-5p	PAR-CLIP	22012620
MIRT528029	hsa-miR-3682-5p	PAR-CLIP	22012620
MIRT528027	hsa-miR-4477a	PAR-CLIP	22012620
MIRT528028	hsa-miR-3136-5p	PAR-CLIP	22012620
MIRT528026	hsa-miR-4439	PAR-CLIP	22012620
MIRT528025	hsa-miR-943	PAR-CLIP	22012620
MIRT994956	hsa-miR-155	CLIP-seq
MIRT994957	hsa-miR-3154	CLIP-seq
MIRT994958	hsa-miR-3163	CLIP-seq
MIRT994959	hsa-miR-323b-3p	CLIP-seq
MIRT994960	hsa-miR-4267	CLIP-seq
MIRT994961	hsa-miR-4330	CLIP-seq
MIRT994962	hsa-miR-451b	CLIP-seq
MIRT994963	hsa-miR-4663	CLIP-seq
MIRT994964	hsa-miR-4676-5p	CLIP-seq
MIRT994965	hsa-miR-4682	CLIP-seq
MIRT994966	hsa-miR-575	CLIP-seq
MIRT994967	hsa-miR-626	CLIP-seq
MIRT994968	hsa-miR-105	CLIP-seq
MIRT994969	hsa-miR-106a	CLIP-seq
MIRT994970	hsa-miR-106b	CLIP-seq
MIRT994971	hsa-miR-1197	CLIP-seq
MIRT994972	hsa-miR-1283	CLIP-seq
MIRT994973	hsa-miR-15a	CLIP-seq
MIRT994974	hsa-miR-15b	CLIP-seq
MIRT994975	hsa-miR-16	CLIP-seq
MIRT994976	hsa-miR-17	CLIP-seq
MIRT994977	hsa-miR-195	CLIP-seq
MIRT994978	hsa-miR-200b	CLIP-seq
MIRT994979	hsa-miR-200c	CLIP-seq
MIRT994980	hsa-miR-2053	CLIP-seq
MIRT994981	hsa-miR-20a	CLIP-seq
MIRT994982	hsa-miR-20b	CLIP-seq
MIRT994983	hsa-miR-216b	CLIP-seq
MIRT994984	hsa-miR-223	CLIP-seq
MIRT994985	hsa-miR-27a	CLIP-seq
MIRT994986	hsa-miR-27b	CLIP-seq
MIRT994987	hsa-miR-302a	CLIP-seq
MIRT994988	hsa-miR-302b	CLIP-seq
MIRT994989	hsa-miR-302c	CLIP-seq
MIRT994990	hsa-miR-302d	CLIP-seq
MIRT994991	hsa-miR-302e	CLIP-seq
MIRT994992	hsa-miR-3145-3p	CLIP-seq
MIRT994993	hsa-miR-3156-5p	CLIP-seq
MIRT994958	hsa-miR-3163	CLIP-seq
MIRT994994	hsa-miR-3647-3p	CLIP-seq
MIRT994995	hsa-miR-3671	CLIP-seq
MIRT994996	hsa-miR-372	CLIP-seq
MIRT994997	hsa-miR-373	CLIP-seq
MIRT994998	hsa-miR-374c	CLIP-seq
MIRT994999	hsa-miR-3921	CLIP-seq
MIRT995000	hsa-miR-3945	CLIP-seq
MIRT995001	hsa-miR-3977	CLIP-seq
MIRT995002	hsa-miR-412	CLIP-seq
MIRT995003	hsa-miR-424	CLIP-seq
MIRT995004	hsa-miR-4253	CLIP-seq
MIRT995005	hsa-miR-4280	CLIP-seq
MIRT995006	hsa-miR-429	CLIP-seq
MIRT995007	hsa-miR-433	CLIP-seq
MIRT995008	hsa-miR-4539	CLIP-seq
MIRT995009	hsa-miR-4643	CLIP-seq
MIRT995010	hsa-miR-4652-3p	CLIP-seq
MIRT995011	hsa-miR-4653-5p	CLIP-seq
MIRT995012	hsa-miR-4668-3p	CLIP-seq
MIRT995013	hsa-miR-4697-3p	CLIP-seq
MIRT995014	hsa-miR-4724-5p	CLIP-seq
MIRT995015	hsa-miR-4773	CLIP-seq
MIRT995016	hsa-miR-4778-3p	CLIP-seq
MIRT995017	hsa-miR-4778-5p	CLIP-seq
MIRT995018	hsa-miR-494	CLIP-seq
MIRT995019	hsa-miR-497	CLIP-seq
MIRT995020	hsa-miR-513a-5p	CLIP-seq
MIRT995021	hsa-miR-519d	CLIP-seq
MIRT995022	hsa-miR-520a-3p	CLIP-seq
MIRT995023	hsa-miR-520b	CLIP-seq
MIRT995024	hsa-miR-520c-3p	CLIP-seq
MIRT995025	hsa-miR-520d-3p	CLIP-seq
MIRT995026	hsa-miR-520e	CLIP-seq
MIRT995027	hsa-miR-539	CLIP-seq
MIRT995028	hsa-miR-545	CLIP-seq
MIRT995029	hsa-miR-548ac	CLIP-seq
MIRT995030	hsa-miR-548ae	CLIP-seq
MIRT995031	hsa-miR-548aj	CLIP-seq
MIRT995032	hsa-miR-548am	CLIP-seq
MIRT995033	hsa-miR-548d-3p	CLIP-seq
MIRT995034	hsa-miR-548k	CLIP-seq
MIRT995035	hsa-miR-548p	CLIP-seq
MIRT995036	hsa-miR-548t	CLIP-seq
MIRT995037	hsa-miR-548x	CLIP-seq
MIRT995038	hsa-miR-548z	CLIP-seq
MIRT995039	hsa-miR-569	CLIP-seq
MIRT995040	hsa-miR-607	CLIP-seq
MIRT995041	hsa-miR-633	CLIP-seq
MIRT995042	hsa-miR-642b	CLIP-seq
MIRT995043	hsa-miR-655	CLIP-seq
MIRT995044	hsa-miR-93	CLIP-seq
MIRT995045	hsa-miR-935	CLIP-seq
MIRT994969	hsa-miR-106a	CLIP-seq
MIRT994970	hsa-miR-106b	CLIP-seq
MIRT994976	hsa-miR-17	CLIP-seq
MIRT994981	hsa-miR-20a	CLIP-seq
MIRT994982	hsa-miR-20b	CLIP-seq
MIRT994987	hsa-miR-302a	CLIP-seq
MIRT994988	hsa-miR-302b	CLIP-seq
MIRT994989	hsa-miR-302c	CLIP-seq
MIRT994990	hsa-miR-302d	CLIP-seq
MIRT994991	hsa-miR-302e	CLIP-seq
MIRT994992	hsa-miR-3145-3p	CLIP-seq
MIRT994996	hsa-miR-372	CLIP-seq
MIRT994997	hsa-miR-373	CLIP-seq
MIRT995007	hsa-miR-433	CLIP-seq
MIRT995021	hsa-miR-519d	CLIP-seq
MIRT995022	hsa-miR-520a-3p	CLIP-seq
MIRT995023	hsa-miR-520b	CLIP-seq
MIRT995024	hsa-miR-520c-3p	CLIP-seq
MIRT995025	hsa-miR-520d-3p	CLIP-seq
MIRT995026	hsa-miR-520e	CLIP-seq
MIRT995028	hsa-miR-545	CLIP-seq
MIRT995035	hsa-miR-548p	CLIP-seq
MIRT995036	hsa-miR-548t	CLIP-seq
MIRT995044	hsa-miR-93	CLIP-seq
MIRT994968	hsa-miR-105	CLIP-seq
MIRT994969	hsa-miR-106a	CLIP-seq
MIRT994970	hsa-miR-106b	CLIP-seq
MIRT994971	hsa-miR-1197	CLIP-seq
MIRT2229089	hsa-miR-142-5p	CLIP-seq
MIRT2229090	hsa-miR-1468	CLIP-seq
MIRT2229091	hsa-miR-150	CLIP-seq
MIRT994976	hsa-miR-17	CLIP-seq
MIRT2229092	hsa-miR-186	CLIP-seq
MIRT2229093	hsa-miR-197	CLIP-seq
MIRT994978	hsa-miR-200b	CLIP-seq
MIRT994979	hsa-miR-200c	CLIP-seq
MIRT994981	hsa-miR-20a	CLIP-seq
MIRT994982	hsa-miR-20b	CLIP-seq
MIRT994983	hsa-miR-216b	CLIP-seq
MIRT994987	hsa-miR-302a	CLIP-seq
MIRT994988	hsa-miR-302b	CLIP-seq
MIRT994989	hsa-miR-302c	CLIP-seq
MIRT994990	hsa-miR-302d	CLIP-seq
MIRT994991	hsa-miR-302e	CLIP-seq
MIRT2229094	hsa-miR-3133	CLIP-seq
MIRT994992	hsa-miR-3145-3p	CLIP-seq
MIRT2229095	hsa-miR-340	CLIP-seq
MIRT2229096	hsa-miR-3591-5p	CLIP-seq
MIRT994995	hsa-miR-3671	CLIP-seq
MIRT2229097	hsa-miR-369-3p	CLIP-seq
MIRT994996	hsa-miR-372	CLIP-seq
MIRT994997	hsa-miR-373	CLIP-seq
MIRT2229098	hsa-miR-374a	CLIP-seq
MIRT2229099	hsa-miR-374b	CLIP-seq
MIRT994999	hsa-miR-3921	CLIP-seq
MIRT2229100	hsa-miR-4257	CLIP-seq
MIRT995005	hsa-miR-4280	CLIP-seq
MIRT995006	hsa-miR-429	CLIP-seq
MIRT995007	hsa-miR-433	CLIP-seq
MIRT995008	hsa-miR-4539	CLIP-seq
MIRT995011	hsa-miR-4653-5p	CLIP-seq
MIRT995012	hsa-miR-4668-3p	CLIP-seq
MIRT2229101	hsa-miR-4709-5p	CLIP-seq
MIRT2229102	hsa-miR-4713-5p	CLIP-seq
MIRT995021	hsa-miR-519d	CLIP-seq
MIRT995022	hsa-miR-520a-3p	CLIP-seq
MIRT995023	hsa-miR-520b	CLIP-seq
MIRT995024	hsa-miR-520c-3p	CLIP-seq
MIRT995025	hsa-miR-520d-3p	CLIP-seq
MIRT995026	hsa-miR-520e	CLIP-seq
MIRT2229103	hsa-miR-532-3p	CLIP-seq
MIRT995028	hsa-miR-545	CLIP-seq
MIRT2229104	hsa-miR-548a-5p	CLIP-seq
MIRT2229105	hsa-miR-548ab	CLIP-seq
MIRT2229106	hsa-miR-548ak	CLIP-seq
MIRT2229107	hsa-miR-548b-5p	CLIP-seq
MIRT2229108	hsa-miR-548c-5p	CLIP-seq
MIRT2229109	hsa-miR-548d-5p	CLIP-seq
MIRT2229110	hsa-miR-548h	CLIP-seq
MIRT2229111	hsa-miR-548i	CLIP-seq
MIRT2229112	hsa-miR-548j	CLIP-seq
MIRT995034	hsa-miR-548k	CLIP-seq
MIRT2229113	hsa-miR-548l	CLIP-seq
MIRT995035	hsa-miR-548p	CLIP-seq
MIRT995036	hsa-miR-548t	CLIP-seq
MIRT2229114	hsa-miR-548w	CLIP-seq
MIRT2229115	hsa-miR-548y	CLIP-seq
MIRT2229116	hsa-miR-559	CLIP-seq
MIRT2229117	hsa-miR-562	CLIP-seq
MIRT2229118	hsa-miR-580	CLIP-seq
MIRT2229119	hsa-miR-603	CLIP-seq
MIRT995040	hsa-miR-607	CLIP-seq
MIRT995041	hsa-miR-633	CLIP-seq
MIRT2229120	hsa-miR-659	CLIP-seq
MIRT995044	hsa-miR-93	CLIP-seq
MIRT994969	hsa-miR-106a	CLIP-seq
MIRT994970	hsa-miR-106b	CLIP-seq
MIRT994971	hsa-miR-1197	CLIP-seq
MIRT2532782	hsa-miR-1229	CLIP-seq
MIRT994972	hsa-miR-1283	CLIP-seq
MIRT2532783	hsa-miR-1323	CLIP-seq
MIRT2532784	hsa-miR-148a	CLIP-seq
MIRT2532785	hsa-miR-148b	CLIP-seq
MIRT2229091	hsa-miR-150	CLIP-seq
MIRT2532786	hsa-miR-152	CLIP-seq
MIRT994973	hsa-miR-15a	CLIP-seq
MIRT994974	hsa-miR-15b	CLIP-seq
MIRT994975	hsa-miR-16	CLIP-seq
MIRT994976	hsa-miR-17	CLIP-seq
MIRT994977	hsa-miR-195	CLIP-seq
MIRT2229093	hsa-miR-197	CLIP-seq
MIRT994981	hsa-miR-20a	CLIP-seq
MIRT994982	hsa-miR-20b	CLIP-seq
MIRT994987	hsa-miR-302a	CLIP-seq
MIRT994988	hsa-miR-302b	CLIP-seq
MIRT994989	hsa-miR-302c	CLIP-seq
MIRT994990	hsa-miR-302d	CLIP-seq
MIRT994991	hsa-miR-302e	CLIP-seq
MIRT994992	hsa-miR-3145-3p	CLIP-seq
MIRT2532787	hsa-miR-342-3p	CLIP-seq
MIRT2532788	hsa-miR-3613-3p	CLIP-seq
MIRT994994	hsa-miR-3647-3p	CLIP-seq
MIRT2532789	hsa-miR-3653	CLIP-seq
MIRT2532790	hsa-miR-3658	CLIP-seq
MIRT994996	hsa-miR-372	CLIP-seq
MIRT994997	hsa-miR-373	CLIP-seq
MIRT2532791	hsa-miR-3973	CLIP-seq
MIRT995001	hsa-miR-3977	CLIP-seq
MIRT995003	hsa-miR-424	CLIP-seq
MIRT995007	hsa-miR-433	CLIP-seq
MIRT2532792	hsa-miR-4420	CLIP-seq
MIRT2532793	hsa-miR-448	CLIP-seq
MIRT995009	hsa-miR-4643	CLIP-seq
MIRT2532794	hsa-miR-4659a-5p	CLIP-seq
MIRT2532795	hsa-miR-4659b-5p	CLIP-seq
MIRT995012	hsa-miR-4668-3p	CLIP-seq
MIRT2532796	hsa-miR-4680-3p	CLIP-seq
MIRT2229101	hsa-miR-4709-5p	CLIP-seq
MIRT2229102	hsa-miR-4713-5p	CLIP-seq
MIRT2532797	hsa-miR-4719	CLIP-seq
MIRT2532798	hsa-miR-4760-3p	CLIP-seq
MIRT2532799	hsa-miR-4760-5p	CLIP-seq
MIRT995015	hsa-miR-4773	CLIP-seq
MIRT2532800	hsa-miR-4776-3p	CLIP-seq
MIRT995016	hsa-miR-4778-3p	CLIP-seq
MIRT995017	hsa-miR-4778-5p	CLIP-seq
MIRT2532801	hsa-miR-485-3p	CLIP-seq
MIRT995018	hsa-miR-494	CLIP-seq
MIRT995019	hsa-miR-497	CLIP-seq
MIRT995021	hsa-miR-519d	CLIP-seq
MIRT995022	hsa-miR-520a-3p	CLIP-seq
MIRT995023	hsa-miR-520b	CLIP-seq
MIRT995024	hsa-miR-520c-3p	CLIP-seq
MIRT995025	hsa-miR-520d-3p	CLIP-seq
MIRT995026	hsa-miR-520e	CLIP-seq
MIRT2229103	hsa-miR-532-3p	CLIP-seq
MIRT995028	hsa-miR-545	CLIP-seq
MIRT2229104	hsa-miR-548a-5p	CLIP-seq
MIRT2229105	hsa-miR-548ab	CLIP-seq
MIRT2229106	hsa-miR-548ak	CLIP-seq
MIRT2229107	hsa-miR-548b-5p	CLIP-seq
MIRT2229108	hsa-miR-548c-5p	CLIP-seq
MIRT2229109	hsa-miR-548d-5p	CLIP-seq
MIRT2229110	hsa-miR-548h	CLIP-seq
MIRT2229111	hsa-miR-548i	CLIP-seq
MIRT2229112	hsa-miR-548j	CLIP-seq
MIRT2532802	hsa-miR-548o	CLIP-seq
MIRT995035	hsa-miR-548p	CLIP-seq
MIRT995036	hsa-miR-548t	CLIP-seq
MIRT2229114	hsa-miR-548w	CLIP-seq
MIRT2229115	hsa-miR-548y	CLIP-seq
MIRT2229116	hsa-miR-559	CLIP-seq
MIRT2229117	hsa-miR-562	CLIP-seq
MIRT2532803	hsa-miR-577	CLIP-seq
MIRT995042	hsa-miR-642b	CLIP-seq
MIRT2229120	hsa-miR-659	CLIP-seq
MIRT995044	hsa-miR-93	CLIP-seq
MIRT994971	hsa-miR-1197	CLIP-seq
MIRT2532782	hsa-miR-1229	CLIP-seq
MIRT994972	hsa-miR-1283	CLIP-seq
MIRT2532784	hsa-miR-148a	CLIP-seq
MIRT2532785	hsa-miR-148b	CLIP-seq
MIRT2229091	hsa-miR-150	CLIP-seq
MIRT2532786	hsa-miR-152	CLIP-seq
MIRT994973	hsa-miR-15a	CLIP-seq
MIRT994974	hsa-miR-15b	CLIP-seq
MIRT994975	hsa-miR-16	CLIP-seq
MIRT994977	hsa-miR-195	CLIP-seq
MIRT2229093	hsa-miR-197	CLIP-seq
MIRT2532787	hsa-miR-342-3p	CLIP-seq
MIRT2532788	hsa-miR-3613-3p	CLIP-seq
MIRT994994	hsa-miR-3647-3p	CLIP-seq
MIRT2532791	hsa-miR-3973	CLIP-seq
MIRT995001	hsa-miR-3977	CLIP-seq
MIRT995003	hsa-miR-424	CLIP-seq
MIRT2229100	hsa-miR-4257	CLIP-seq
MIRT2532792	hsa-miR-4420	CLIP-seq
MIRT2532793	hsa-miR-448	CLIP-seq
MIRT995009	hsa-miR-4643	CLIP-seq
MIRT2532794	hsa-miR-4659a-5p	CLIP-seq
MIRT2532795	hsa-miR-4659b-5p	CLIP-seq
MIRT995012	hsa-miR-4668-3p	CLIP-seq
MIRT2532796	hsa-miR-4680-3p	CLIP-seq
MIRT2229101	hsa-miR-4709-5p	CLIP-seq
MIRT2229102	hsa-miR-4713-5p	CLIP-seq
MIRT2532797	hsa-miR-4719	CLIP-seq
MIRT2532799	hsa-miR-4760-5p	CLIP-seq
MIRT2532800	hsa-miR-4776-3p	CLIP-seq
MIRT995016	hsa-miR-4778-3p	CLIP-seq
MIRT995017	hsa-miR-4778-5p	CLIP-seq
MIRT995018	hsa-miR-494	CLIP-seq
MIRT995019	hsa-miR-497	CLIP-seq
MIRT2680955	hsa-miR-513c	CLIP-seq
MIRT2680956	hsa-miR-514b-5p	CLIP-seq
MIRT2229103	hsa-miR-532-3p	CLIP-seq
MIRT2229104	hsa-miR-548a-5p	CLIP-seq
MIRT2229105	hsa-miR-548ab	CLIP-seq
MIRT2229106	hsa-miR-548ak	CLIP-seq
MIRT2229107	hsa-miR-548b-5p	CLIP-seq
MIRT2229108	hsa-miR-548c-5p	CLIP-seq
MIRT2229109	hsa-miR-548d-5p	CLIP-seq
MIRT2229110	hsa-miR-548h	CLIP-seq
MIRT2229111	hsa-miR-548i	CLIP-seq
MIRT2229112	hsa-miR-548j	CLIP-seq
MIRT2229114	hsa-miR-548w	CLIP-seq
MIRT2229115	hsa-miR-548y	CLIP-seq
MIRT2229116	hsa-miR-559	CLIP-seq
MIRT2532803	hsa-miR-577	CLIP-seq
MIRT995042	hsa-miR-642b	CLIP-seq
MIRT2229120	hsa-miR-659	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	14690447, 24705354, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IBA
GO:0007165	Process	Signal transduction	TAS	9096408
GO:0007399	Process	Nervous system development	TAS	9096408
GO:0007411	Process	Axon guidance	TAS	9096408
GO:0030424	Component	Axon	IBA
GO:1902902	Process	Negative regulation of autophagosome assembly	IMP	25495476

Other IDs

• MIM: 604826
• HGNC: 3660
• e!Ensembl: ENSG00000171055

Protein

• UniProt ID: Q9UHY8
• Protein name: Fasciculation and elongation protein zeta-2 (Zygin II) (Zygin-2)
• Protein function: Involved in axonal outgrowth and fasciculation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07763	FEZ	51 → 286	FEZ-like protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in nonneural tissues, such as heart, lung, spleen, muscle, testis, placenta and melanocytes.
• Sequence:

  MAADGDWQDFYEFQEPARSLLDQENCNASPEPGAEAGAEAGGGADGFPAPACSLEEKLSL
  CFRPSDPGAEPPRTAVRPITERSLLQGDEIWNALTDNYGNVMPVDWKSSHTRTLHLLTLN
  LSEKGVSDSLLFDTSDDEELREQLDMHSIIVSCVNDEPLFTADQVIEEIEEMMQESPDPE
  DDETPTQSDRLSMLSQEIQTLKRSSTGSYEERVKRLSVSELNEILEEIETAIKEYSEELV
  QQLALRDELEFEKEVKNSFISVLIEVQNKQKEHKETAKKKKKLKNGSSQNGKNERSHMPG
  TYLTTVIPYEKKNGPPSVEDLQILTKILRAMKEDSEKVPSLLTDYILKVLCPT

• Sequence length: 353