Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9627
Gene name Gene Name - the full gene name approved by the HGNC.	Synuclein alpha interacting protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SNCAIP
Synonyms (NCBI Gene) Gene synonyms aliases	SYPH1, Sph1
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q23.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a ro

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miRTarBase ID	miRNA	Experiments
MIRT1375424	hsa-miR-300	CLIP-seq
MIRT1375425	hsa-miR-381	CLIP-seq
MIRT1375426	hsa-miR-4666-3p	CLIP-seq
MIRT1375427	hsa-miR-4789-5p	CLIP-seq
MIRT1375428	hsa-miR-548n	CLIP-seq
MIRT2628930	hsa-miR-1252	CLIP-seq
MIRT2628931	hsa-miR-1321	CLIP-seq
MIRT2628932	hsa-miR-149	CLIP-seq
MIRT2628933	hsa-miR-1913	CLIP-seq
MIRT2628934	hsa-miR-2110	CLIP-seq
MIRT2628935	hsa-miR-218	CLIP-seq
MIRT2628936	hsa-miR-24	CLIP-seq
MIRT2628937	hsa-miR-28-5p	CLIP-seq
MIRT2628938	hsa-miR-3064-5p	CLIP-seq
MIRT2628939	hsa-miR-3115	CLIP-seq
MIRT2628940	hsa-miR-3139	CLIP-seq
MIRT2628941	hsa-miR-3153	CLIP-seq
MIRT2628942	hsa-miR-3159	CLIP-seq
MIRT2628943	hsa-miR-3160-3p	CLIP-seq
MIRT2628944	hsa-miR-3167	CLIP-seq
MIRT2628945	hsa-miR-324-3p	CLIP-seq
MIRT2628946	hsa-miR-3661	CLIP-seq
MIRT2628947	hsa-miR-3675-5p	CLIP-seq
MIRT2628948	hsa-miR-3908	CLIP-seq
MIRT2628949	hsa-miR-4271	CLIP-seq
MIRT2628950	hsa-miR-4284	CLIP-seq
MIRT2628951	hsa-miR-4522	CLIP-seq
MIRT2628952	hsa-miR-4659a-3p	CLIP-seq
MIRT2628953	hsa-miR-4659b-3p	CLIP-seq
MIRT2628954	hsa-miR-4663	CLIP-seq
MIRT2628955	hsa-miR-4695-3p	CLIP-seq
MIRT2628956	hsa-miR-4705	CLIP-seq
MIRT2628957	hsa-miR-4718	CLIP-seq
MIRT2628958	hsa-miR-4725-3p	CLIP-seq
MIRT2628959	hsa-miR-4728-3p	CLIP-seq
MIRT2628960	hsa-miR-4739	CLIP-seq
MIRT2628961	hsa-miR-4756-5p	CLIP-seq
MIRT2628962	hsa-miR-4762-5p	CLIP-seq
MIRT2628963	hsa-miR-4766-3p	CLIP-seq
MIRT2628964	hsa-miR-4794	CLIP-seq
MIRT2628965	hsa-miR-491-3p	CLIP-seq
MIRT2628966	hsa-miR-545	CLIP-seq
MIRT2628967	hsa-miR-548p	CLIP-seq
MIRT2628968	hsa-miR-631	CLIP-seq
MIRT2628969	hsa-miR-636	CLIP-seq
MIRT2628970	hsa-miR-708	CLIP-seq
MIRT2628971	hsa-miR-876-5p	CLIP-seq
MIRT2628930	hsa-miR-1252	CLIP-seq
MIRT2628931	hsa-miR-1321	CLIP-seq
MIRT2628932	hsa-miR-149	CLIP-seq
MIRT2628933	hsa-miR-1913	CLIP-seq
MIRT2628934	hsa-miR-2110	CLIP-seq
MIRT2628935	hsa-miR-218	CLIP-seq
MIRT2628936	hsa-miR-24	CLIP-seq
MIRT2628937	hsa-miR-28-5p	CLIP-seq
MIRT2628938	hsa-miR-3064-5p	CLIP-seq
MIRT2628939	hsa-miR-3115	CLIP-seq
MIRT2628940	hsa-miR-3139	CLIP-seq
MIRT2628941	hsa-miR-3153	CLIP-seq
MIRT2628943	hsa-miR-3160-3p	CLIP-seq
MIRT2628945	hsa-miR-324-3p	CLIP-seq
MIRT2628946	hsa-miR-3661	CLIP-seq
MIRT2628947	hsa-miR-3675-5p	CLIP-seq
MIRT2628948	hsa-miR-3908	CLIP-seq
MIRT2628949	hsa-miR-4271	CLIP-seq
MIRT2628950	hsa-miR-4284	CLIP-seq
MIRT2628951	hsa-miR-4522	CLIP-seq
MIRT2628954	hsa-miR-4663	CLIP-seq
MIRT2628955	hsa-miR-4695-3p	CLIP-seq
MIRT2628956	hsa-miR-4705	CLIP-seq
MIRT2628957	hsa-miR-4718	CLIP-seq
MIRT2628958	hsa-miR-4725-3p	CLIP-seq
MIRT2628959	hsa-miR-4728-3p	CLIP-seq
MIRT2628960	hsa-miR-4739	CLIP-seq
MIRT2628961	hsa-miR-4756-5p	CLIP-seq
MIRT2628962	hsa-miR-4762-5p	CLIP-seq
MIRT2628963	hsa-miR-4766-3p	CLIP-seq
MIRT2628964	hsa-miR-4794	CLIP-seq
MIRT2628965	hsa-miR-491-3p	CLIP-seq
MIRT2628966	hsa-miR-545	CLIP-seq
MIRT2628967	hsa-miR-548p	CLIP-seq
MIRT2628968	hsa-miR-631	CLIP-seq
MIRT2628969	hsa-miR-636	CLIP-seq
MIRT2628970	hsa-miR-708	CLIP-seq

Show/Hide all(15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	10319874, 11590439, 11956199, 12044636, 12364339, 19762560
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	14506261
GO:0005829	Component	Cytosol	TAS
GO:0008021	Component	Synaptic vesicle	TAS	21563316
GO:0008219	Process	Cell death	IDA	16595633
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	15728840
GO:0036464	Component	Cytoplasmic ribonucleoprotein granule	IDA
GO:0042417	Process	Dopamine metabolic process	IDA	14506261
GO:0042734	Component	Presynaptic membrane	NAS	11956199
GO:0042802	Function	Identical protein binding	IPI	19762560
GO:0043025	Component	Neuronal cell body	NAS	11956199
GO:0044267	Process	Cellular protein metabolic process	TAS
GO:0046928	Process	Regulation of neurotransmitter secretion	IDA	14506261
GO:0090083	Process	Regulation of inclusion body assembly	IDA	15603737

MIM	HGNC	e!Ensembl
603779	11139	ENSG00000064692

Protein

UniProt ID

Q9Y6H5

Protein name

Synphilin-1 (Sph1) (Alpha-synuclein-interacting protein)

Protein function

Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform

PDB

2KES

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12796	Ank_2	322 → 416	Ankyrin repeats (3 copies)	Repeat
PF12796	Ank_2	406 → 487	Ankyrin repeats (3 copies)	Repeat
PF16700	SNCAIP_SNCA_bd	512 → 557	Synphilin-1 alpha-Synuclein-binding domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in brain (at protein level). Widely expressed, with highest levels in brain, heart and placenta. {ECO:0000269|PubMed:10319874, ECO:0000269|PubMed:16595633}.

Sequence

MEAPEYLDLDEIDFSDDISYSVTSLKTIPELCRRCDTQNEDRSVSSSSWNCGISTLITNT
QKPTGIADVYSKFRPVKRVSPLKHQPETLENNESDDQKNQKVVEYQKGGESDLGPQPQEL
GPGDGVGGPPGKSSEPSTSLGELEHYDLDMDEILDVPYIKSSQQLASFTKVTSEKRILGL
CTTINGLSGKACSTGSSESSSSNMAPFCVLSPVKSPHLRKASAVIHDQHKLSTEETEISP
PLVKCGSAYEPENQSKDFLNKTFSDPHGRKVEKTTPDCQLRAFHLQSSAAESKPEEQVSG
LNRTSSQGPEERSEYLKKVKSILNIVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQ
GHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDF
PSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYG
ANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQVVKLTKQLKEQTVERVTLQ
NQLQQFLEAQKSEGKSLPSSPSSPSSPASRKSQWKSPDADDDSVAKSKPGVQEGIQVLGS
LSASSRARPKAKDEDSDKILRQLLGKEISENVCTQEKLSLEFQDAQASSRNSKKIPLEKR
ELKLARLRQLMQRSLSESDTDSNNSEDPKTTPVRKADRPRPQPIVESVESMDSAESLHLM
IKKHTLASGGRRFPFSIKASKSLDGHSPSPTSESSEPDLESQYPGSGSIPPNQPSGDPQQ
PSPDSTAAQKVATSPKSALKSPSSKRRTSQNLKLRVTFEEPVVQMEQPSLELNGEKDKDK
GRTLQRTSTSNESGDQLKRPFGAFRSIMETLSGNQNNNNNYQAANQLKTSTLPLTSLGRK
TDAKGNPASSASKGKNKAA

Sequence length

919

Interactions

View interactions

	KEGG		Reactome
	Parkinson disease Pathways of neurodegeneration - multiple diseases		Amyloid fiber formation

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Parkinson disease	Parkinsonian Disorders, PARKINSON DISEASE, LATE-ONSET	rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432 View all (84 more)

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Mental depression	Depressive disorder	ClinVar
Renal Carcinoma	Renal Carcinoma	GWAS

Show/Hide Text Mining Associations (15)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Associate	35633541
Carcinoma Renal Cell	Associate	33062672
Drug Related Side Effects and Adverse Reactions	Associate	14627698
Hyperphagia	Associate	25545246
Lewy Body Disease	Associate	11331421, 15728840, 16174773, 18366718, 26465922
Medulloblastoma	Associate	22832581
Multiple System Atrophy	Associate	26465922
Neoplasms	Associate	35633541
Neurodegenerative Diseases	Associate	33562355
Obesity	Associate	25545246
Parkinson Disease	Associate	11331421, 14756800, 15728840, 16595633, 18366718, 18635553, 20604806, 21130735, 22832581, 26465922, 34148545, 39766295, 40369541
Plaque Amyloid	Associate	21130735
Spinocerebellar Degenerations	Associate	19211984
Synucleinopathies	Associate	16595633, 26465922
Urologic Diseases	Associate	34573432

SNCAIP (synuclein alpha interacting protein)