GUCA1C (guanylate cyclase activator 1C)

Gene

• Entrez ID: 9626
• Gene name: Guanylate cyclase activator 1C
• Gene symbol: GUCA1C
• Synonyms (NCBI Gene): GCAP3
• Chromosome: 3
• Chromosome location: 3q13.13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1038382	hsa-miR-302a	CLIP-seq
MIRT1038383	hsa-miR-302b	CLIP-seq
MIRT1038384	hsa-miR-302c	CLIP-seq
MIRT1038385	hsa-miR-302d	CLIP-seq
MIRT1038386	hsa-miR-302e	CLIP-seq
MIRT1038387	hsa-miR-372	CLIP-seq
MIRT1038388	hsa-miR-373	CLIP-seq
MIRT1038389	hsa-miR-4457	CLIP-seq
MIRT1038390	hsa-miR-513b	CLIP-seq
MIRT1038391	hsa-miR-519a	CLIP-seq
MIRT1038392	hsa-miR-519b-3p	CLIP-seq
MIRT1038393	hsa-miR-519c-3p	CLIP-seq
MIRT1038394	hsa-miR-520a-3p	CLIP-seq
MIRT1038395	hsa-miR-520b	CLIP-seq
MIRT1038396	hsa-miR-520c-3p	CLIP-seq
MIRT1038397	hsa-miR-520d-3p	CLIP-seq
MIRT1038398	hsa-miR-520e	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IBA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0007165	Process	Signal transduction	TAS	10037746
GO:0007601	Process	Visual perception	TAS	10037746
GO:0008048	Function	Calcium sensitive guanylate cyclase activator activity	IBA
GO:0008048	Function	Calcium sensitive guanylate cyclase activator activity	TAS	10037746
GO:0009966	Process	Regulation of signal transduction	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0097381	Component	Photoreceptor disc membrane	IEA
GO:0097381	Component	Photoreceptor disc membrane	TAS

Other IDs

• MIM: 605128
• HGNC: 4680
• e!Ensembl: ENSG00000138472

Protein

• UniProt ID: O95843
• Protein name: Guanylyl cyclase-activating protein 3 (GCAP 3) (Guanylate cyclase activator 1C)
• Protein function: Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in
• PDB: 2GGZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00036	EF-hand_1	92 → 120	EF hand	Domain

• Tissue specificity: TISSUE SPECIFICITY: Retina.
• Sequence:

  MGNGKSIAGDQKAVPTQETHVWYRTFMMEYPSGLQTLHEFKTLLGLQGLNQKANKHIDQV
  YNTFDTNKDGFVDFLEFIAAVNLIMQEKMEQKLKWYFKLYDADGNGSIDKNELLDMFMAV
  QALNGQQTLSPEEFINLVFHKIDINNDGELTLEEFINGMAKDQDLLEIVYKSFDFSNVLR
  VICNGKQPDMETDSSKSPDKAGLGKVKMK

• Sequence length: 209

Pathways

KEGG:

Phototransduction

Reactome:

Inactivation, recovery and regulation of the phototransduction cascade