TCL1B (TCL1 family AKT coactivator B)

Gene

• Entrez ID: 9623
• Gene name: TCL1 family AKT coactivator B
• Gene symbol: TCL1B
• Synonyms (NCBI Gene): SYN-1, TML1
• Chromosome: 14
• Chromosome location: 14q32.13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021345	hsa-miR-9-5p	Microarray	17612493
MIRT025631	hsa-miR-7-5p	Microarray	17612493
MIRT1416621	hsa-miR-1470	CLIP-seq
MIRT1416622	hsa-miR-3184	CLIP-seq
MIRT1416623	hsa-miR-3944-5p	CLIP-seq
MIRT1416624	hsa-miR-423-5p	CLIP-seq
MIRT1416625	hsa-miR-4286	CLIP-seq
MIRT1416626	hsa-miR-4420	CLIP-seq
MIRT1416627	hsa-miR-4667-3p	CLIP-seq
MIRT1416628	hsa-miR-4699-5p	CLIP-seq
MIRT2124927	hsa-miR-1207-5p	CLIP-seq
MIRT2124928	hsa-miR-1972	CLIP-seq
MIRT2124929	hsa-miR-214	CLIP-seq
MIRT2124930	hsa-miR-3194-5p	CLIP-seq
MIRT2124931	hsa-miR-3619-5p	CLIP-seq
MIRT2124932	hsa-miR-3918	CLIP-seq
MIRT2124933	hsa-miR-3926	CLIP-seq
MIRT2124934	hsa-miR-4291	CLIP-seq
MIRT2124935	hsa-miR-4530	CLIP-seq
MIRT2124936	hsa-miR-4640-5p	CLIP-seq
MIRT2124937	hsa-miR-4726-5p	CLIP-seq
MIRT2124938	hsa-miR-4763-3p	CLIP-seq
MIRT2124939	hsa-miR-761	CLIP-seq
MIRT2124940	hsa-miR-922	CLIP-seq
MIRT2124927	hsa-miR-1207-5p	CLIP-seq
MIRT2347374	hsa-miR-1287	CLIP-seq
MIRT2347375	hsa-miR-1827	CLIP-seq
MIRT2124928	hsa-miR-1972	CLIP-seq
MIRT2124929	hsa-miR-214	CLIP-seq
MIRT2347376	hsa-miR-3135b	CLIP-seq
MIRT2347377	hsa-miR-342-5p	CLIP-seq
MIRT2347378	hsa-miR-3612	CLIP-seq
MIRT2124931	hsa-miR-3619-5p	CLIP-seq
MIRT2124932	hsa-miR-3918	CLIP-seq
MIRT2347379	hsa-miR-4443	CLIP-seq
MIRT2124935	hsa-miR-4530	CLIP-seq
MIRT2124936	hsa-miR-4640-5p	CLIP-seq
MIRT2347380	hsa-miR-4664-5p	CLIP-seq
MIRT2124937	hsa-miR-4726-5p	CLIP-seq
MIRT2347381	hsa-miR-4738-3p	CLIP-seq
MIRT2124938	hsa-miR-4763-3p	CLIP-seq
MIRT2347382	hsa-miR-4793-3p	CLIP-seq
MIRT2347383	hsa-miR-4793-5p	CLIP-seq
MIRT2347384	hsa-miR-637	CLIP-seq
MIRT2347385	hsa-miR-650	CLIP-seq
MIRT2124939	hsa-miR-761	CLIP-seq
MIRT2347386	hsa-miR-892b	CLIP-seq
MIRT2347387	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0019901	Function	Protein kinase binding	IPI	10983986
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0035556	Process	Intracellular signal transduction	IDA	10983986
GO:0043539	Function	Protein serine/threonine kinase activator activity	IBA
GO:0043539	Function	Protein serine/threonine kinase activator activity	IDA	10983986
GO:0043539	Function	Protein serine/threonine kinase activator activity	IEA

Other IDs

• MIM: 603769
• HGNC: 11649
• e!Ensembl: ENSG00000213231

Protein

• UniProt ID: O95988
• Protein name: T-cell leukemia/lymphoma protein 1B (Oncogene TCL-1B) (Oncogene TCL1B) (SYN-1) (Syncytiotrophoblast-specific protein) (TCL1/MTCP1-like protein 1)
• Protein function: Enhances the phosphorylation and activation of AKT1 and AKT2.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01840	TCL1_MTCP1	1 → 124	TCL1/MTCP1 family	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in a variety of tissues including placenta and testis. {ECO:0000269|PubMed:10077617, ECO:0000269|PubMed:10344735}.
• Sequence:

  MASEASVRLGVPPGRLWIQRPGIYEDEEGRTWVTVVVRFNPSRREWARASQGSRYEPSIT
  VHLWQMAVHTRELLSSGQMPFSQLPAVWQLYPGRKYRAADSSFWEIADHGQIDSMEQLVL
  TYQPERKD

• Sequence length: 128

Pathways

KEGG:

PI3K-Akt signaling pathway