GDA (guanine deaminase)

Gene

• Entrez ID: 9615
• Gene name: Guanine deaminase
• Gene symbol: GDA
• Synonyms (NCBI Gene): CYPIN, GAH, GUANASE, NEDASIN
• Chromosome: 9
• Chromosome location: 9q21.13
• Summary: This gene encodes an enzyme responsible for the hydrolytic deamination of guanine. Studies in rat ortholog suggest this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for this gene. [pro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT006070	hsa-miR-492	Microarray, qRT-PCR	21319197
MIRT006070	hsa-miR-492	Microarray, qRT-PCR	21319197
MIRT006070	hsa-miR-492	Microarray, qRT-PCR	21319197
MIRT022762	hsa-miR-124-3p	Microarray	18668037
MIRT1015190	hsa-miR-4520a-3p	CLIP-seq
MIRT1015191	hsa-miR-4520b-3p	CLIP-seq
MIRT1015192	hsa-miR-4529-3p	CLIP-seq
MIRT1015193	hsa-miR-513a-3p	CLIP-seq
MIRT1015194	hsa-miR-1207-3p	CLIP-seq
MIRT1015195	hsa-miR-3156-5p	CLIP-seq
MIRT1015196	hsa-miR-3173-3p	CLIP-seq
MIRT1015197	hsa-miR-3609	CLIP-seq
MIRT1015198	hsa-miR-4424	CLIP-seq
MIRT1015199	hsa-miR-4428	CLIP-seq
MIRT1015200	hsa-miR-4504	CLIP-seq
MIRT1015201	hsa-miR-4528	CLIP-seq
MIRT1015202	hsa-miR-4653-3p	CLIP-seq
MIRT1015203	hsa-miR-4695-3p	CLIP-seq
MIRT1015204	hsa-miR-548ah	CLIP-seq
MIRT1015205	hsa-miR-548t	CLIP-seq
MIRT1015206	hsa-miR-3179	CLIP-seq
MIRT1015207	hsa-miR-3622b-5p	CLIP-seq
MIRT1015208	hsa-miR-3667-5p	CLIP-seq
MIRT1015209	hsa-miR-4642	CLIP-seq
MIRT1015210	hsa-miR-4731-3p	CLIP-seq
MIRT1015211	hsa-miR-4801	CLIP-seq
MIRT1015212	hsa-miR-548a-5p	CLIP-seq
MIRT1015213	hsa-miR-548ab	CLIP-seq
MIRT1015214	hsa-miR-548ak	CLIP-seq
MIRT1015215	hsa-miR-548b-5p	CLIP-seq
MIRT1015216	hsa-miR-548c-5p	CLIP-seq
MIRT1015217	hsa-miR-548d-5p	CLIP-seq
MIRT1015218	hsa-miR-548h	CLIP-seq
MIRT1015219	hsa-miR-548i	CLIP-seq
MIRT1015220	hsa-miR-548j	CLIP-seq
MIRT1015221	hsa-miR-548k	CLIP-seq
MIRT1015222	hsa-miR-548l	CLIP-seq
MIRT1015223	hsa-miR-548w	CLIP-seq
MIRT1015224	hsa-miR-548y	CLIP-seq
MIRT1015225	hsa-miR-559	CLIP-seq
MIRT2000577	hsa-miR-1305	CLIP-seq
MIRT2000578	hsa-miR-2117	CLIP-seq
MIRT2000579	hsa-miR-3124-3p	CLIP-seq
MIRT2000580	hsa-miR-3671	CLIP-seq
MIRT2000581	hsa-miR-3692	CLIP-seq
MIRT2000582	hsa-miR-421	CLIP-seq
MIRT2000583	hsa-miR-4517	CLIP-seq
MIRT2000584	hsa-miR-4733-5p	CLIP-seq
MIRT2000585	hsa-miR-607	CLIP-seq
MIRT2000586	hsa-miR-624	CLIP-seq
MIRT2234122	hsa-miR-1279	CLIP-seq
MIRT2234123	hsa-miR-3180-5p	CLIP-seq
MIRT2234124	hsa-miR-520a-5p	CLIP-seq
MIRT2234125	hsa-miR-525-5p	CLIP-seq
MIRT2450154	hsa-miR-3119	CLIP-seq
MIRT2450155	hsa-miR-3140-3p	CLIP-seq
MIRT2450156	hsa-miR-3660	CLIP-seq
MIRT2450157	hsa-miR-3940-5p	CLIP-seq
MIRT2450158	hsa-miR-3978	CLIP-seq
MIRT2450159	hsa-miR-4438	CLIP-seq
MIRT2450160	hsa-miR-4507	CLIP-seq
MIRT2450161	hsa-miR-4526	CLIP-seq
MIRT2450162	hsa-miR-4694-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SP1	Unknown	11369448

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000255	Process	Allantoin metabolic process	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006139	Process	Nucleobase-containing compound metabolic process	TAS	10075721
GO:0006147	Process	Guanine catabolic process	IEA
GO:0006161	Process	Deoxyguanosine catabolic process	IEA
GO:0007399	Process	Nervous system development	TAS	10542258
GO:0008270	Function	Zinc ion binding	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008270	Function	Zinc ion binding	TAS	10075721
GO:0008892	Function	Guanine deaminase activity	IBA
GO:0008892	Function	Guanine deaminase activity	IEA
GO:0008892	Function	Guanine deaminase activity	TAS	10075721
GO:0016787	Function	Hydrolase activity	IEA
GO:0016810	Function	Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IEA
GO:0043605	Process	Amide catabolic process	IEA
GO:0046038	Process	GMP catabolic process	IEA
GO:0046055	Process	DGMP catabolic process	IEA
GO:0046098	Process	Guanine metabolic process	IBA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 139260
• HGNC: 4212
• e!Ensembl: ENSG00000119125

Protein

• UniProt ID: Q9Y2T3
• Protein name: Guanine deaminase (Guanase) (Guanine aminase) (EC 3.5.4.3) (Guanine aminohydrolase) (GAH) (p51-nedasin)
• Protein function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.
• PDB: 2UZ9, 3E0L, 4AQL
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01979	Amidohydro_1	73 → 447	Amidohydrolase family	Domain

• Sequence:

  MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF
  KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA
  EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY
  KETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSH
  ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH
  CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE
  KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI
  SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV

• Sequence length: 454

Pathways

KEGG:

Purine metabolism
Metabolic pathways
Nucleotide metabolism

Reactome:

Purine catabolism