Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	9615
Gene name Gene Name - the full gene name approved by the HGNC.	Guanine deaminase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GDA
Synonyms (NCBI Gene) Gene synonyms aliases	CYPIN, GAH, GUANASE, NEDASIN
Chromosome Chromosome number	9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	9q21.13
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes an enzyme responsible for the hydrolytic deamination of guanine. Studies in rat ortholog suggest this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for this gene. [pro

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miRTarBase ID	miRNA	Experiments	Reference
MIRT006070	hsa-miR-492	Microarray, qRT-PCR	21319197
MIRT006070	hsa-miR-492	Microarray, qRT-PCR	21319197
MIRT006070	hsa-miR-492	Microarray, qRT-PCR	21319197
MIRT022762	hsa-miR-124-3p	Microarray	18668037
MIRT1015190	hsa-miR-4520a-3p	CLIP-seq
MIRT1015191	hsa-miR-4520b-3p	CLIP-seq
MIRT1015192	hsa-miR-4529-3p	CLIP-seq
MIRT1015193	hsa-miR-513a-3p	CLIP-seq
MIRT1015194	hsa-miR-1207-3p	CLIP-seq
MIRT1015195	hsa-miR-3156-5p	CLIP-seq
MIRT1015196	hsa-miR-3173-3p	CLIP-seq
MIRT1015197	hsa-miR-3609	CLIP-seq
MIRT1015198	hsa-miR-4424	CLIP-seq
MIRT1015199	hsa-miR-4428	CLIP-seq
MIRT1015200	hsa-miR-4504	CLIP-seq
MIRT1015201	hsa-miR-4528	CLIP-seq
MIRT1015202	hsa-miR-4653-3p	CLIP-seq
MIRT1015203	hsa-miR-4695-3p	CLIP-seq
MIRT1015204	hsa-miR-548ah	CLIP-seq
MIRT1015205	hsa-miR-548t	CLIP-seq
MIRT1015206	hsa-miR-3179	CLIP-seq
MIRT1015207	hsa-miR-3622b-5p	CLIP-seq
MIRT1015208	hsa-miR-3667-5p	CLIP-seq
MIRT1015209	hsa-miR-4642	CLIP-seq
MIRT1015210	hsa-miR-4731-3p	CLIP-seq
MIRT1015211	hsa-miR-4801	CLIP-seq
MIRT1015212	hsa-miR-548a-5p	CLIP-seq
MIRT1015213	hsa-miR-548ab	CLIP-seq
MIRT1015214	hsa-miR-548ak	CLIP-seq
MIRT1015215	hsa-miR-548b-5p	CLIP-seq
MIRT1015216	hsa-miR-548c-5p	CLIP-seq
MIRT1015217	hsa-miR-548d-5p	CLIP-seq
MIRT1015218	hsa-miR-548h	CLIP-seq
MIRT1015219	hsa-miR-548i	CLIP-seq
MIRT1015220	hsa-miR-548j	CLIP-seq
MIRT1015221	hsa-miR-548k	CLIP-seq
MIRT1015222	hsa-miR-548l	CLIP-seq
MIRT1015223	hsa-miR-548w	CLIP-seq
MIRT1015224	hsa-miR-548y	CLIP-seq
MIRT1015225	hsa-miR-559	CLIP-seq
MIRT2000577	hsa-miR-1305	CLIP-seq
MIRT2000578	hsa-miR-2117	CLIP-seq
MIRT2000579	hsa-miR-3124-3p	CLIP-seq
MIRT2000580	hsa-miR-3671	CLIP-seq
MIRT2000581	hsa-miR-3692	CLIP-seq
MIRT2000582	hsa-miR-421	CLIP-seq
MIRT2000583	hsa-miR-4517	CLIP-seq
MIRT2000584	hsa-miR-4733-5p	CLIP-seq
MIRT2000585	hsa-miR-607	CLIP-seq
MIRT2000586	hsa-miR-624	CLIP-seq
MIRT2234122	hsa-miR-1279	CLIP-seq
MIRT2234123	hsa-miR-3180-5p	CLIP-seq
MIRT2234124	hsa-miR-520a-5p	CLIP-seq
MIRT2234125	hsa-miR-525-5p	CLIP-seq
MIRT2450154	hsa-miR-3119	CLIP-seq
MIRT2450155	hsa-miR-3140-3p	CLIP-seq
MIRT2450156	hsa-miR-3660	CLIP-seq
MIRT2450157	hsa-miR-3940-5p	CLIP-seq
MIRT2450158	hsa-miR-3978	CLIP-seq
MIRT2450159	hsa-miR-4438	CLIP-seq
MIRT2450160	hsa-miR-4507	CLIP-seq
MIRT2450161	hsa-miR-4526	CLIP-seq
MIRT2450162	hsa-miR-4694-3p	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
SP1	Unknown	11369448

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005622	Component	Intracellular anatomical structure	TAS	10542258
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0006139	Process	Nucleobase-containing compound metabolic process	TAS	10075721
GO:0006147	Process	Guanine catabolic process	IEA
GO:0006195	Process	Purine nucleotide catabolic process	TAS
GO:0007399	Process	Nervous system development	TAS	10542258
GO:0008270	Function	Zinc ion binding	IBA	21873635
GO:0008892	Function	Guanine deaminase activity	IBA	21873635
GO:0019239	Function	Deaminase activity	IBA	21873635
GO:0046098	Process	Guanine metabolic process	IBA	21873635

MIM	HGNC	e!Ensembl
139260	4212	ENSG00000119125

Protein

UniProt ID

Q9Y2T3

Protein name

Guanine deaminase (Guanase) (Guanine aminase) (EC 3.5.4.3) (Guanine aminohydrolase) (GAH) (p51-nedasin)

Protein function

Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

PDB

2UZ9 , 3E0L , 4AQL

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01979	Amidohydro_1	73 → 447	Amidohydrolase family	Domain

Sequence

MCAAQMPPLAHIFRGTFVHSTWTCPMEVLRDHLLGVSDSGKIVFLEEASQQEKLAKEWCF
KPCEIRELSHHEFFMPGLVDTHIHASQYSFAGSSIDLPLLEWLTKYTFPAEHRFQNIDFA
EEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDKFGQRAFVGKVCMDLNDTFPEY
KETTEESIKETERFVSEMLQKNYSRVKPIVTPRFSLSCSETLMGELGNIAKTRDLHIQSH
ISENRDEVEAVKNLYPSYKNYTSVYDKNNLLTNKTVMAHGCYLSAEELNVFHERGASIAH
CPNSNLSLSSGFLNVLEVLKHEVKIGLGTDVAGGYSYSMLDAIRRAVMVSNILLINKVNE
KSLTLKEVFRLATLGGSQALGLDGEIGNFEVGKEFDAILINPKASDSPIDLFYGDFFGDI
SEAVIQKFLYLGDDRNIEEVYVGGKQVVPFSSSV

Sequence length

454

Interactions

View interactions

	KEGG		Reactome
	Purine metabolism Metabolic pathways Nucleotide metabolism		Purine catabolism

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Carcinoma	Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	12376462

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Associate	37247276
Glucosephosphate Dehydrogenase Deficiency	Associate	1174693
Keratosis	Associate	32215662
Keratosis Seborrheic	Associate	34830382
Melanosis	Stimulate	32517074
Pigmentation Disorders	Associate	32517074
Skin Diseases	Associate	32517074

GDA (guanine deaminase)