NCOR2 (nuclear receptor corepressor 2)

Gene

• Entrez ID: 9612
• Gene name: Nuclear receptor corepressor 2
• Gene symbol: NCOR2
• Synonyms (NCBI Gene): CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1
• Chromosome: 12
• Chromosome location: 12q24.31
• Summary: This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as pa

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005454	hsa-miR-10a-5p	qRT-PCR, Western blot	21212796
MIRT005455	hsa-miR-10b-5p	qRT-PCR, Western blot	21212796
MIRT006651	hsa-miR-16-5p	Luciferase reporter assay	22292036
MIRT006651	hsa-miR-16-5p	Luciferase reporter assay	22292036
MIRT021376	hsa-miR-9-5p	Microarray	17612493
MIRT050519	hsa-miR-20a-5p	CLASH	23622248
MIRT038284	hsa-miR-130b-5p	CLASH	23622248
MIRT035758	hsa-miR-2110	CLASH	23622248
MIRT053093	hsa-miR-125b-5p	Luciferase reporter assay, Western blot	23514806
MIRT054500	hsa-miR-100-5p	Immunoblot, Immunohistochemistry, Luciferase reporter assay, qRT-PCR	24244722
MIRT054824	hsa-miR-30c-5p	qRT-PCR, Western blot	24623846
0	hsa-miR-30c-5p	Luciferase reporter assay, qRT-PCR, Western blot	24623846
0	hsa-miR-30c-5p	Luciferase reporter assay, qRT-PCR, Western blot	24623846
MIRT487147	hsa-miR-1321	PAR-CLIP	23592263
MIRT487148	hsa-miR-4739	PAR-CLIP	23592263
MIRT487146	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT487145	hsa-miR-6871-5p	PAR-CLIP	23592263
MIRT487144	hsa-miR-6087	PAR-CLIP	23592263
MIRT487143	hsa-miR-4419a	PAR-CLIP	23592263
MIRT487142	hsa-miR-4510	PAR-CLIP	23592263
MIRT487141	hsa-miR-6127	PAR-CLIP	23592263
MIRT487140	hsa-miR-6129	PAR-CLIP	23592263
MIRT487139	hsa-miR-6130	PAR-CLIP	23592263
MIRT487138	hsa-miR-6133	PAR-CLIP	23592263
MIRT487137	hsa-miR-2277-5p	PAR-CLIP	23592263
MIRT487136	hsa-miR-658	PAR-CLIP	23592263
MIRT487135	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT487134	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT487133	hsa-miR-25-5p	PAR-CLIP	23592263
MIRT487132	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT487131	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT487130	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT487128	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT487129	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT487127	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT487126	hsa-miR-3178	PAR-CLIP	23592263
MIRT487125	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT487124	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT487123	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT487122	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT487121	hsa-miR-3689c	PAR-CLIP	23592263
MIRT487120	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT487119	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT487117	hsa-miR-4459	PAR-CLIP	23592263
MIRT487118	hsa-miR-6757-5p	PAR-CLIP	23592263
MIRT005455	hsa-miR-10b-5p	3'LIFE	25074381
MIRT727096	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT727095	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT006651	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT727094	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT005455	hsa-miR-10b-5p	3'LIFE	25074381
MIRT487147	hsa-miR-1321	PAR-CLIP	23592263
MIRT487148	hsa-miR-4739	PAR-CLIP	23592263
MIRT487146	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT487145	hsa-miR-6871-5p	PAR-CLIP	23592263
MIRT487144	hsa-miR-6087	PAR-CLIP	23592263
MIRT487143	hsa-miR-4419a	PAR-CLIP	23592263
MIRT487142	hsa-miR-4510	PAR-CLIP	23592263
MIRT487141	hsa-miR-6127	PAR-CLIP	23592263
MIRT487140	hsa-miR-6129	PAR-CLIP	23592263
MIRT487139	hsa-miR-6130	PAR-CLIP	23592263
MIRT487138	hsa-miR-6133	PAR-CLIP	23592263
MIRT487137	hsa-miR-2277-5p	PAR-CLIP	23592263
MIRT487136	hsa-miR-658	PAR-CLIP	23592263
MIRT487135	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT487134	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT487133	hsa-miR-25-5p	PAR-CLIP	23592263
MIRT487132	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT487131	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT487130	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT487128	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT487129	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT487127	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT487126	hsa-miR-3178	PAR-CLIP	23592263
MIRT487125	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT487124	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT487123	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT487122	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT487121	hsa-miR-3689c	PAR-CLIP	23592263
MIRT487120	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT487119	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT487117	hsa-miR-4459	PAR-CLIP	23592263
MIRT487118	hsa-miR-6757-5p	PAR-CLIP	23592263
MIRT1177571	hsa-miR-1193	CLIP-seq
MIRT1177572	hsa-miR-125a-5p	CLIP-seq
MIRT1177573	hsa-miR-125b	CLIP-seq
MIRT1177574	hsa-miR-1539	CLIP-seq
MIRT1177575	hsa-miR-15a	CLIP-seq
MIRT1177576	hsa-miR-15b	CLIP-seq
MIRT1177577	hsa-miR-16	CLIP-seq
MIRT1177578	hsa-miR-184	CLIP-seq
MIRT1177579	hsa-miR-195	CLIP-seq
MIRT1177580	hsa-miR-200b	CLIP-seq
MIRT1177581	hsa-miR-200c	CLIP-seq
MIRT1177582	hsa-miR-30a	CLIP-seq
MIRT1177583	hsa-miR-30b	CLIP-seq
MIRT1177584	hsa-miR-30c	CLIP-seq
MIRT1177585	hsa-miR-30d	CLIP-seq
MIRT1177586	hsa-miR-30e	CLIP-seq
MIRT1177587	hsa-miR-3130-3p	CLIP-seq
MIRT1177588	hsa-miR-3134	CLIP-seq
MIRT1177589	hsa-miR-3180	CLIP-seq
MIRT1177590	hsa-miR-3180-3p	CLIP-seq
MIRT1177591	hsa-miR-3194-5p	CLIP-seq
MIRT1177592	hsa-miR-3196	CLIP-seq
MIRT1177593	hsa-miR-331-3p	CLIP-seq
MIRT1177594	hsa-miR-3620	CLIP-seq
MIRT1177595	hsa-miR-3646	CLIP-seq
MIRT1177596	hsa-miR-378	CLIP-seq
MIRT1177597	hsa-miR-378b	CLIP-seq
MIRT1177598	hsa-miR-378c	CLIP-seq
MIRT1177599	hsa-miR-378d	CLIP-seq
MIRT1177600	hsa-miR-378e	CLIP-seq
MIRT1177601	hsa-miR-378f	CLIP-seq
MIRT1177602	hsa-miR-378h	CLIP-seq
MIRT1177603	hsa-miR-378i	CLIP-seq
MIRT1177604	hsa-miR-3918	CLIP-seq
MIRT1177605	hsa-miR-3940-3p	CLIP-seq
MIRT1177606	hsa-miR-3974	CLIP-seq
MIRT1177607	hsa-miR-422a	CLIP-seq
MIRT1177608	hsa-miR-424	CLIP-seq
MIRT1177609	hsa-miR-429	CLIP-seq
MIRT1177610	hsa-miR-4294	CLIP-seq
MIRT1177611	hsa-miR-4319	CLIP-seq
MIRT1177612	hsa-miR-4467	CLIP-seq
MIRT1177613	hsa-miR-4527	CLIP-seq
MIRT1177614	hsa-miR-4532	CLIP-seq
MIRT1177615	hsa-miR-4534	CLIP-seq
MIRT1177616	hsa-miR-4635	CLIP-seq
MIRT1177617	hsa-miR-4638-3p	CLIP-seq
MIRT1177618	hsa-miR-4640-5p	CLIP-seq
MIRT1177619	hsa-miR-4726-5p	CLIP-seq
MIRT1177620	hsa-miR-4756-3p	CLIP-seq
MIRT1177621	hsa-miR-4793-3p	CLIP-seq
MIRT1177622	hsa-miR-4804-5p	CLIP-seq
MIRT1177623	hsa-miR-497	CLIP-seq
MIRT1177624	hsa-miR-887	CLIP-seq
MIRT1177625	hsa-miR-924	CLIP-seq
MIRT1177571	hsa-miR-1193	CLIP-seq
MIRT1177626	hsa-miR-1234	CLIP-seq
MIRT1177627	hsa-miR-1266	CLIP-seq
MIRT1177574	hsa-miR-1539	CLIP-seq
MIRT1177575	hsa-miR-15a	CLIP-seq
MIRT1177576	hsa-miR-15b	CLIP-seq
MIRT1177577	hsa-miR-16	CLIP-seq
MIRT1177579	hsa-miR-195	CLIP-seq
MIRT1177580	hsa-miR-200b	CLIP-seq
MIRT1177581	hsa-miR-200c	CLIP-seq
MIRT1177588	hsa-miR-3134	CLIP-seq
MIRT1177628	hsa-miR-3189-3p	CLIP-seq
MIRT1177594	hsa-miR-3620	CLIP-seq
MIRT1177595	hsa-miR-3646	CLIP-seq
MIRT1177629	hsa-miR-3667-3p	CLIP-seq
MIRT1177608	hsa-miR-424	CLIP-seq
MIRT1177630	hsa-miR-4283	CLIP-seq
MIRT1177609	hsa-miR-429	CLIP-seq
MIRT1177631	hsa-miR-4448	CLIP-seq
MIRT1177615	hsa-miR-4534	CLIP-seq
MIRT1177616	hsa-miR-4635	CLIP-seq
MIRT1177620	hsa-miR-4756-3p	CLIP-seq
MIRT1177623	hsa-miR-497	CLIP-seq
MIRT1177632	hsa-miR-502-5p	CLIP-seq
MIRT1177633	hsa-miR-510	CLIP-seq
MIRT1177634	hsa-miR-555	CLIP-seq
MIRT1177635	hsa-miR-615-5p	CLIP-seq
MIRT1177624	hsa-miR-887	CLIP-seq
MIRT1177636	hsa-miR-1197	CLIP-seq
MIRT1177626	hsa-miR-1234	CLIP-seq
MIRT1177637	hsa-miR-1268	CLIP-seq
MIRT1177638	hsa-miR-1268b	CLIP-seq
MIRT1177575	hsa-miR-15a	CLIP-seq
MIRT1177576	hsa-miR-15b	CLIP-seq
MIRT1177577	hsa-miR-16	CLIP-seq
MIRT1177579	hsa-miR-195	CLIP-seq
MIRT1177580	hsa-miR-200b	CLIP-seq
MIRT1177581	hsa-miR-200c	CLIP-seq
MIRT1177629	hsa-miR-3667-3p	CLIP-seq
MIRT1177608	hsa-miR-424	CLIP-seq
MIRT1177609	hsa-miR-429	CLIP-seq
MIRT1177616	hsa-miR-4635	CLIP-seq
MIRT1177620	hsa-miR-4756-3p	CLIP-seq
MIRT1177639	hsa-miR-4781-5p	CLIP-seq
MIRT1177623	hsa-miR-497	CLIP-seq
MIRT1177634	hsa-miR-555	CLIP-seq
MIRT1177635	hsa-miR-615-5p	CLIP-seq
MIRT1177640	hsa-miR-744	CLIP-seq
MIRT1177624	hsa-miR-887	CLIP-seq
MIRT1177604	hsa-miR-3918	CLIP-seq
MIRT2051361	hsa-miR-1275	CLIP-seq
MIRT2051362	hsa-miR-133a	CLIP-seq
MIRT2051363	hsa-miR-133b	CLIP-seq
MIRT1177582	hsa-miR-30a	CLIP-seq
MIRT1177583	hsa-miR-30b	CLIP-seq
MIRT1177584	hsa-miR-30c	CLIP-seq
MIRT1177585	hsa-miR-30d	CLIP-seq
MIRT1177586	hsa-miR-30e	CLIP-seq
MIRT1177587	hsa-miR-3130-3p	CLIP-seq
MIRT1177589	hsa-miR-3180	CLIP-seq
MIRT1177590	hsa-miR-3180-3p	CLIP-seq
MIRT1177628	hsa-miR-3189-3p	CLIP-seq
MIRT1177591	hsa-miR-3194-5p	CLIP-seq
MIRT1177592	hsa-miR-3196	CLIP-seq
MIRT1177629	hsa-miR-3667-3p	CLIP-seq
MIRT1177604	hsa-miR-3918	CLIP-seq
MIRT1177605	hsa-miR-3940-3p	CLIP-seq
MIRT1177606	hsa-miR-3974	CLIP-seq
MIRT1177630	hsa-miR-4283	CLIP-seq
MIRT1177610	hsa-miR-4294	CLIP-seq
MIRT1177631	hsa-miR-4448	CLIP-seq
MIRT2051364	hsa-miR-4525	CLIP-seq
MIRT1177613	hsa-miR-4527	CLIP-seq
MIRT1177614	hsa-miR-4532	CLIP-seq
MIRT1177618	hsa-miR-4640-5p	CLIP-seq
MIRT2051365	hsa-miR-4665-5p	CLIP-seq
MIRT2051366	hsa-miR-4723-5p	CLIP-seq
MIRT1177619	hsa-miR-4726-5p	CLIP-seq
MIRT1177620	hsa-miR-4756-3p	CLIP-seq
MIRT2051367	hsa-miR-4760-3p	CLIP-seq
MIRT1177621	hsa-miR-4793-3p	CLIP-seq
MIRT1177632	hsa-miR-502-5p	CLIP-seq
MIRT2051368	hsa-miR-625	CLIP-seq
MIRT2051369	hsa-miR-664	CLIP-seq
MIRT1177625	hsa-miR-924	CLIP-seq
MIRT2280478	hsa-miR-3613-3p	CLIP-seq
MIRT1177629	hsa-miR-3667-3p	CLIP-seq
MIRT2051367	hsa-miR-4760-3p	CLIP-seq
MIRT2051362	hsa-miR-133a	CLIP-seq
MIRT2051363	hsa-miR-133b	CLIP-seq
MIRT1177574	hsa-miR-1539	CLIP-seq
MIRT2280479	hsa-miR-3193	CLIP-seq
MIRT1177616	hsa-miR-4635	CLIP-seq
MIRT2280480	hsa-miR-4765	CLIP-seq
MIRT1177635	hsa-miR-615-5p	CLIP-seq
MIRT1177624	hsa-miR-887	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
NFKB1	Unknown	17876798
RELA	Unknown	17876798
SPEN	Unknown	11331609

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	10097068
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	12628926, 18052923, 19955185, 20388878
GO:0000785	Component	Chromatin	IBA
GO:0000785	Component	Chromatin	IDA	20388878
GO:0000785	Component	Chromatin	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IEA
GO:0003714	Function	Transcription corepressor activity	IBA
GO:0003714	Function	Transcription corepressor activity	IDA	18052923
GO:0003714	Function	Transcription corepressor activity	IEA
GO:0003714	Function	Transcription corepressor activity	IMP	12628926, 20812024
GO:0005112	Function	Notch binding	IPI	10713164
GO:0005515	Function	Protein binding	IPI	9605924, 10395741, 10713164, 10809664, 11013263, 11739383, 14985122, 15016912, 16129689, 16893456, 16924111, 16980585, 19786558, 20195357, 20467437, 20543827, 20812024, 20956942, 21240272, 21258344, 21475249, 21624135, 22230954, 23518351, 23752268, 24268649, 24449765, 25303530, 3034
GO:0005634	Component	Nucleus	IC	18052923
GO:0005634	Component	Nucleus	IDA	10097068, 12628926
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0007595	Process	Lactation	IEA
GO:0008047	Function	Enzyme activator activity	IDA	22230954
GO:0010565	Process	Regulation of ketone metabolic process	IEA
GO:0010565	Process	Regulation of ketone metabolic process	IMP	19955185
GO:0016020	Component	Membrane	HDA	19946888
GO:0016363	Component	Nuclear matrix	IDA	21328542
GO:0016604	Component	Nuclear body	IDA	16030140
GO:0016604	Component	Nuclear body	IEA
GO:0016922	Function	Nuclear receptor binding	IEA
GO:0017053	Component	Transcription repressor complex	IDA	11804585
GO:0021549	Process	Cerebellum development	IEA
GO:0032355	Process	Response to estradiol	IEA
GO:0032991	Component	Protein-containing complex	IEA
GO:0035259	Function	Nuclear glucocorticoid receptor binding	IEA
GO:0042826	Function	Histone deacetylase binding	IEA
GO:0042826	Function	Histone deacetylase binding	IPI	11804585, 16924111
GO:0042974	Function	Nuclear retinoic acid receptor binding	IEA
GO:0044849	Process	Estrous cycle	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IMP	20812024
GO:0046965	Function	Nuclear retinoid X receptor binding	IEA
GO:0060766	Process	Negative regulation of androgen receptor signaling pathway	IEA
GO:0060766	Process	Negative regulation of androgen receptor signaling pathway	IMP	20812024
GO:1902894	Process	Negative regulation of miRNA transcription	IEA
GO:1902894	Process	Negative regulation of miRNA transcription	IMP	20388878

Other IDs

• MIM: 600848
• HGNC: 7673
• e!Ensembl: ENSG00000196498

Protein

• UniProt ID: Q9Y618
• Protein name: Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)
• Protein function: Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription (PubMed:10077563, PubMed:10097068, PubMed:18212045
• PDB: 1KKQ, 1R2B, 1XC5, 2GPV, 2L5G, 2LTP, 2ODD, 2RT5, 3R29, 3R2A, 4A69, 4OAR, 5X8Q, 5X8X, 5ZOO, 5ZOP, 6A22, 6IVX, 6PDZ, 7SQA, 8AQM, 8AQN, 8B8W, 8B8X, 8B8Y, 8B8Z, 8B90, 8B91, 8B92, 8B93, 8B94, 8B95, 8X7E
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15784	GPS2_interact	141 → 229	G-protein pathway suppressor 2-interacting domain	Family
  PF00249	Myb_DNA-binding	612 → 657	Myb-like DNA-binding domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous (PubMed:10077563). High levels of expression are detected in lung, spleen and brain (PubMed:10077563). {ECO:0000269|PubMed:10077563}.
• Sequence:

  MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQ
  PQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRP
  SPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD
  REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEA
  AHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQ
  RYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG
  LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPM
  KVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYK
  SLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN
  DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQ
  SAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQ
  NLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEE
  AEALHASGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPP
  GPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEG
  EEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGS
  GRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKP
  LDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPR
  GKSRSPAPPADKEAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPP
  GHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEH
  AKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTAL
  GSVPGGSITKGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSPSRLDRGRE
  DSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGR
  AISSASIEGLMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLRREAKLLKR
  EGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREELRHTPELP
  LAPRPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVMADARALE
  RACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAGHLPRGSPV
  TTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSG
  VDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRGYPDTAALE
  NRQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHL
  PVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDR
  DRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGGGGGSSSRPASHSHAHQHSPI
  SPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGG
  TLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRP
  LVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGY
  HGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHL
  PHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPL
  YSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIE
  PVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAMV
  KSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMGLE
  AIIRKALMGKYDQWEESPPLSANAFNPLNASASLPAAMPITAADGRSDHTLTSPGGGGKA
  KVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDRPSSAGSTPFP
  YNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYETLSDSE

• Sequence length: 2514

Pathways

KEGG:

Notch signaling pathway
Epstein-Barr virus infection

Reactome:

PPARA activates gene expression
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
HCMV Early Events
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis

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Associated diseases

Causal
Disease merge term	Disease name	dbSNP ID	References
Multiple myeloma	multiple myeloma	rs1593107841	N/A

Unknown
Disease merge term	Disease name	Evidence	References	Source
Alzheimer disease	Alzheimer's disease or family history of Alzheimer's disease	N/A	N/A	GWAS
Atrial Fibrillation	Atrial fibrillation	N/A	N/A	GWAS
Diabetes	Type 2 diabetes	N/A	N/A	GWAS
Hypertension	Hypertension	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS
Multiple Sclerosis	Multiple sclerosis	N/A	N/A	GWAS
Myocardial Infarction	Myocardial infarction	N/A	N/A	GWAS
Neuroticism	Neuroticism	N/A	N/A	GWAS
Osteoarthritis Of Hip	Osteoarthritis (hip)	N/A	N/A	GWAS
Rhabdomyosarcoma	Rhabdomyosarcoma	Although individual knockout of NCOR1 and NCOR2 resulted in limited myogenic differentiation, likely because of functional redundancy, double knockout of NCOR1 and NCOR2 in a panel of six RMS cell lines (RD, 381T, SMS-CTR, Rh3, Rh5, and Rh30) resulted in	27956629	CBGDA
Schizophrenia	Schizophrenia	N/A	N/A	GWAS
Uterine Fibroids	Uterine fibroids	N/A	N/A	GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Associate	33865348
Asthma	Associate	37802634
Astrocytoma	Associate	21143702
Ataxia Telangiectasia	Associate	23652012
Bicuspid Aortic Valve Disease	Associate	36071494
Bone Neoplasms	Associate	35181586
Breast Neoplasms	Associate	19183483, 19904269, 20003447, 20392877, 23015261, 24971610, 29023534, 35618935
Carcinoma Hepatocellular	Associate	16434963, 30680848
Carcinoma Intraductal Noninfiltrating	Associate	22887771
Carcinoma Neuroendocrine	Associate	34245124
Carcinoma Non Small Cell Lung	Associate	21118496
Carcinoma Ovarian Epithelial	Stimulate	37131060
Cardiomyopathies	Associate	32196466
Cocaine Related Disorders	Associate	23958962
Diabetes Mellitus Type 1	Associate	24204704
DiGeorge Syndrome	Associate	31830774
Drug Related Side Effects and Adverse Reactions	Associate	35962345
Familial Primary Pulmonary Hypertension	Associate	36899621
Fibular hypoplasia and complex brachydactyly	Associate	34145290
Giant Cell Tumor of Bone	Associate	35181586
Glioblastoma	Associate	32945237
Glioma	Associate	20957337, 21143702
Heart Diseases	Associate	35748249
HIV Infections	Associate	21083371
Inflammation	Associate	23221346, 23861398, 35618935
Leukemia	Associate	15729358
Leukemia Promyelocytic Acute	Associate	9256429, 9765306
Ludwig's Angina	Associate	15334463
Lymphoma B Cell	Associate	14690607
Lymphoma B Cell Marginal Zone	Associate	29481902
Lymphoma Large B Cell Diffuse	Associate	36215154
Lymphoma Non Hodgkin	Associate	15930272
Malocclusion Angle Class III	Associate	34039391
Melanoma Cutaneous Malignant	Associate	25953768
Mental Disorders	Associate	27468165
Multiple Myeloma	Associate	34864816
Muscular Atrophy Spinal	Associate	25821969
Myotonic Dystrophy	Associate	34371182
Neoplasms	Associate	12502735, 19904269, 24096568, 24623846, 33865348, 34145290, 34245124, 35039565, 35181586, 35618935
Neoplasms	Stimulate	15300237
Neoplasms	Inhibit	15930272
Neuroblastoma	Associate	10094499, 21212796
Obesity	Associate	23221346, 33198820
Osteoarthritis	Associate	15334463
Osteoarthritis Knee	Associate	16453284
Osteophyte	Associate	15334463
Ovarian Neoplasms	Associate	31973910, 37131060, 37512088
Polycystic Kidney Autosomal Dominant	Associate	29687770
Polycystic Ovary Syndrome	Associate	31089932
Prostatic Neoplasms	Associate	15300237, 21178266, 35286517
Prostatic Neoplasms Castration Resistant	Associate	35286517
Pulmonary Arterial Hypertension	Stimulate	35960497
Respiratory Distress Syndrome	Associate	32185610
Rett Syndrome	Associate	28348241
Soft Tissue Neoplasms	Associate	33742141
Squamous Cell Carcinoma of Head and Neck	Associate	27349552, 29470550
Stomach Neoplasms	Associate	32373223, 35039565
Thyroid Cancer Papillary	Associate	32940102
Weight Loss	Associate	23221346, 33198820